Neutralization of Nogo-A Enhances Synaptic Plasticity in the Rodent Motor Cortex and Improves Motor Learning in Vivo

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Neuroscience

• Publication date

  2014-06-25

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1523/JNEUROSCI.3817-13.2014PMID 24966370PMCID PMC4147625
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Testosterone Depletion in Adult Male Rats Increases Mossy Fiber Transmission, LTP, and Sprouting in Area CA3 of Hippocampus

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• Anatomical plasticity of adult brain is titrated by Nogo Receptor 1.

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• REPETITIVE MOTOR LEARNING INDUCES COORDINATED FORMATION OF CLUSTERED DENDRITIC SPINES IN VIVO

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• The nogo receptor family restricts synapse number in the developing hippocampus.

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• Faculty Opinions recommendation of Repetitive motor learning induces coordinated formation of clustered dendritic spines in vivo.

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• Distinct Roles of Nogo-A and Nogo Receptor 1 in the Homeostatic Regulation of Adult Neural Stem Cell Function and Neuroblast Migration

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• Anti-Nogo-A and training: can one plus one equal three?

  2012cited by this paper
• Myelin associated inhibitors: a link between injury-induced and experience-dependent plasticity.

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• Neurotrophin regulation of neural circuit development and function

  2012cited by this paper
• Neuronal Nogo-A negatively regulates dendritic morphology and synaptic transmission in the cerebellum

  2012influential reference
• Neuronal Nogo‐A regulates glutamate receptor subunit expression in hippocampal neurons

  2011cited by this paper
• PSD-95 and PSD-93 Play Critical But Distinct Roles in Synaptic Scaling Up and Down

  2011cited by this paper
• NogoA restricts synaptic plasticity in the adult hippocampus on a fast time scale

  2011influential reference
• Cerebellar motor learning versus cerebellar motor timing: the climbing fibre story

  2011cited by this paper
• Experience-dependent structural plasticity in the cortex.

  2011cited by this paper
• Spine plasticity in the motor cortex.

  2011influential reference
• Nogo-A Stabilizes the Architecture of Hippocampal Neurons

  2010influential reference
• Global Deprivation of Brain-Derived Neurotrophic Factor in the CNS Reveals an Area-Specific Requirement for Dendritic Growth

  2010cited by this paper
• The dual role of the extracellular matrix in synaptic plasticity and homeostasis

  2010cited by this paper
• Constitutive Genetic Deletion of the Growth Regulator Nogo-A Induces Schizophrenia-Related Endophenotypes

  2010cited by this paper
• Functions of Nogo proteins and their receptors in the nervous system

  2010influential reference
• Dendritic Spine Alterations in Neocortical Pyramidal Neurons following Postnatal Neuronal Nogo-A Knockdown

  2010cited by this paper
• Oligodendrocyte-Myelin Glycoprotein and Nogo Negatively Regulate Activity-Dependent Synaptic Plasticity

  2010influential reference
• Bidirectional modulation of synaptic functions by Eph/ephrin signaling

  2009cited by this paper
• Rapid formation and selective stabilization of synapses for enduring motor memories

  2009cited by this paper
• GPR50 interacts with neuronal NOGO-A and affects neurite outgrowth.

  2009cited by this paper
• Neuronal Nogo-A Modulates Growth Cone Motility via Rho-GTP/LIMK1/Cofilin in the Unlesioned Adult Nervous System*

  2009cited by this paper
• Experience-dependent structural synaptic plasticity in the mammalian brain

  2009influential reference
• Central Nervous System Regeneration Inhibitors and their Intracellular Substrates

  2009cited by this paper
• Stably maintained dendritic spines are associated with lifelong memories

  2009cited by this paper
• Differential effects of anti-Nogo-A antibody treatment and treadmill training in rats with incomplete spinal cord injury.

  2009cited by this paper
• Nogo receptor 1 regulates formation of lasting memories

  2009cited by this paper
• Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter.

  2008influential reference
• Experience leaves a lasting structural trace in cortical circuits

  2008cited by this paper
• Neutralization of the membrane protein Nogo‐A enhances growth and reactive sprouting in established organotypic hippocampal slice cultures

  2008cited by this paper
• Transient Spine Expansion and Learning-Induced Plasticity in Layer 1 Primary Motor Cortex

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  2008cited by this paper
• Diolistics: incorporating fluorescent dyes into biological samples using a gene gun

  2007cited by this paper
• Plasticity of the synaptic modification range.

  2007influential reference
• Disinhibition of neurite growth to repair the injured adult CNS: Focusing on Nogo

  2007cited by this paper
• Exercise decreases myelin‐associated glycoprotein expression in the spinal cord and positively modulates neuronal growth

  2007cited by this paper
• Learning Induces Long-Term Potentiation in the Hippocampus

  2006cited by this paper
• Intrathecally infused antibodies against Nogo-A penetrate the CNS and downregulate the endogenous neurite growth inhibitor Nogo-A.

  2006cited by this paper
• Experience-dependent and cell-type-specific spine growth in the neocortex

  2006cited by this paper
• PirB Restricts Ocular-Dominance Plasticity in Visual Cortex

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• Normal motor learning during pharmacological prevention of Purkinje cell long-term depression.

  2005cited by this paper
• Nogo‐A antibody improves regeneration and locomotion of spinal cord–injured rats

  2005cited by this paper
• Experience-Driven Plasticity of Visual Cortex Limited by Myelin and Nogo Receptor

  2005cited by this paper
• Skilled motor learning does not enhance long-term depression in the motor cortex in vivo.

  2005cited by this paper
• The actin cytoskeleton: integrating form and function at the synapse.

  2005cited by this paper
• The p75 Neurotrophin Receptor Negatively Modulates Dendrite Complexity and Spine Density in Hippocampal Neurons

  2005cited by this paper
• Activation of p75NTR by proBDNF facilitates hippocampal long-term depression

  2005cited by this paper
• The neurotrophin receptor p75NTR modulates long-term depression and regulates the expression of AMPA receptor subunits in the hippocampus.

  2005cited by this paper
• Nogo-66 receptor prevents raphespinal and rubrospinal axon regeneration and limits functional recovery from spinal cord injury.

  2004cited by this paper
• Short and long-term motor skill learning in an accelerated rotarod training paradigm.

  2004cited by this paper
• Characterization of motor skill and instrumental learning time scales in a skilled reaching task in rat.

  2004cited by this paper
• Hippocampal plasticity requires postsynaptic ephrinBs

  2004cited by this paper
• Activity-induced and developmental downregulation of the Nogo receptor

  2003cited by this paper
• Nogo-A Inhibits Neurite Outgrowth and Cell Spreading with Three Discrete Regions

  2003influential reference
• Bidirectional synaptic plasticity: from theory to reality.

  2003cited by this paper
• Rho Kinase Inhibition Enhances Axonal Regeneration in the Injured CNS

  2003cited by this paper
• Selectivity in neurotrophin signaling: theme and variations.

  2003cited by this paper
• Intraneuronal localization of Nogo‐A in the rat

  2003cited by this paper
• N-methyl-d-aspartate receptor blockade during development lowers long-term potentiation threshold without affecting dynamic range of CA3-CA1 synapses

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  2002cited by this paper
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• Motor learning-dependent synaptogenesis is localized to functionally reorganized motor cortex.

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• Patterns of Nogo mRNA and Protein Expression in the Developing and Adult Rat and After CNS Lesions

  2002influential reference
• Nogo-66 receptor antagonist peptide promotes axonal regeneration

  2002cited by this paper
• NOGO mRNA expression in adult and fetal human and rat nervous tissue and in weight drop injury.

  2001cited by this paper
• Cerebellar long-term depression: characterization, signal transduction, and functional roles.

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• Cortical plasticity: It's all the range!

  2001cited by this paper
• The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses

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• Actin-based plasticity in dendritic spines.

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• Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP.

  2000cited by this paper
• Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1

  2000cited by this paper
• Learning-induced LTP in neocortex.

  2000influential reference
• GABAB‐receptor splice variants GB1a and GB1b in rat brain: developmental regulation, cellular distribution and extrasynaptic localization

  1999cited by this paper
• Strengthening of horizontal cortical connections following skill learning

  1998influential reference
• Rapid actin-based plasticity in dendritic spines.

  1998cited by this paper
• The acquisition of skilled motor performance: fast and slow experience-driven changes in primary motor cortex.

  1998cited by this paper
• A Simple Silver-Gold Intensification Procedure for Double DAB Labeling Studies in Electron Microscopy

  1997cited by this paper
• Synaptogenesis and FOS Expression in the Motor Cortex of the Adult Rat after Motor Skill Learning

  1996cited by this paper
• Long‐term Depression of Horizontal Connections in Rat Motor Cortex

  1996cited by this paper
• Conditions for the induction of long-term potentiation in layer II/III horizontal connections of the rat motor cortex.

  1996influential reference
• Experience-dependent modification of synaptic plasticity in visual cortex

  1996cited by this paper
• Mechanisms of LTP induction in rat motor cortex in vitro.

  1995cited by this paper
• Changes in paired-pulse facilitation suggest presynaptic involvement in long-term potentiation

  1994cited by this paper
• Imaging

  1994influential reference
• Regulation of growth cone behavior by calcium

  1991cited by this paper
• The structure of skilled forelimb reaching in the rat: a proximally driven movement with a single distal rotatory component.

  1990cited by this paper
• A rapid, sensitive histochemical stain for myelin in frozen brain sections.

  1990cited by this paper
• Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors

  1990cited by this paper
• Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter.

  1988cited by this paper
• Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

  1986cited by this paper
• Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex

  1982cited by this paper

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• Repair mechanisms of the central nervous system: From axon sprouting to remyelination

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  2024cites this paper
• A multichannel microfluidic device for revealing the neurotoxic effects of Bisphenol S on cerebral organoids under low-dose constant exposure.

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• Intranasal delivery of full-length anti-Nogo-A antibody: A potential alternative route for therapeutic antibodies to central nervous system targets

  2023cites this paper
• Unveiling the modulation of Nogo Receptor in Neuroregeneration and plasticity: Novel aspects and future horizon in a new frontier.

  2023cites this paper
• Coenzyme Q10 supplementation improves the motor function of middle-aged mice by restoring the neuronal activity of the motor cortex

  2023cites this paper
• The role of RNA splicing factor PTBP1 in neuronal development.

  2023cites this paper
• Microglial Nogo delays recovery following traumatic brain injury in mice.

  2023influential citation
• Nogo-A neutralization in the central nervous system with a blood-brain barrier-penetrating antibody.

  2023cites this paper
• Neuronal Plasticity and Age-Related Functional Decline in the Motor Cortex

  2023cites this paper
• Cortical circuit dynamics underlying motor skill learning: from rodents to humans

  2023cites this paper
• Nogo-A is secreted in extracellular vesicles, occurs in blood and can influence vascular permeability

  2023cites this paper
• Cytology, architecture, development, and connections of the primate striatum: Hints for human pathology.

  2022cites this paper
• Inhibition of Nogo-A rescues synaptic plasticity and associativity in APP/PS1 animal model of Alzheimer's disease.

  2022cites this paper
• The Implication of Reticulons (RTNs) in Neurodegenerative Diseases: From Molecular Mechanisms to Potential Diagnostic and Therapeutic Approaches

  2021influential citation
• Oligodendrogenesis and myelination regulate cortical development, plasticity and circuit function.

  2021cites this paper
• Exercise-induced Nogo-A influences rodent motor learning in a time-dependent manner

  2021cites this paper
• Astrocytes as a target for Nogo‐A and implications for synapse formation in vitro and in a model of acute demyelination

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  2020cites this paper
• Axonal regeneration and functional recovery driven by endogenous Nogo receptor antagonist LOTUS in a rat model of unilateral pyramidotomy.

  2020cites this paper
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  2020cites this paper
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  2020cites this paper
• Analysis of axon divergence at the optic chiasm in nogo-a knockout mice.

  2020cites this paper
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  2020cites this paper
• Long-term motor skill training with individually adjusted progressive difficulty enhances learning and promotes corticospinal plasticity

  2020cites this paper
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  2019cites this paper
• Fast Regulation of GABAAR Diffusion Dynamics by Nogo-A Signaling.

  2019influential citation
• A Nogo-Like Signaling Perspective from Birth to Adulthood and in Old Age: Brain Expression Patterns of Ligands, Receptors and Modulators

  2018cites this paper
• Loss of Nogo-A, encoded by the schizophrenia risk gene Rtn4, reduces mGlu3 expression and causes hyperexcitability in hippocampal CA3 circuits

  2018cites this paper
• The Extracellular Environment of the CNS: Influence on Plasticity, Sprouting, and Axonal Regeneration after Spinal Cord Injury

  2018cites this paper
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  2018cites this paper
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  2018influential citation
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017influential citation
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  2017cites this paper
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  2016cites this paper
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  2016influential citation
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
• Identi fi cation of MANF as a protein interacting with RTN 1-C

  2015cites this paper
• Acquisition of a High-precision Skilled Forelimb Reaching Task in Rats.

  2015cites this paper
• Attractive and repulsive factors act through multi-subunit receptor complexes to regulate nerve fiber growth

  2015influential citation
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  2015cites this paper
• Identification of MANF as a protein interacting with RTN1-C.

  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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