The Neutrophil’s Choice: Phagocytose vs Make Neutrophil Extracellular Traps

Neutrophils recognize particulate substrates of microbial or endogenous origin and react by sequestering the cargo via phagocytosis or by releasing neutrophil extracellular traps (NETs) outside the cell, thus modifying and alerting the environment and bystander leukocytes. The signals that determine the choice between phagocytosis and the generation of NETs are still poorly characterized. Neutrophils that had phagocytosed bulky particulate substrates, such as apoptotic cells and activated platelets, appear to be “poised” in an unresponsive state. Environmental conditions, the metabolic, adhesive and activation state of the phagocyte, and the size of and signals associated with the tethered phagocytic cargo influence the choice of the neutrophils, prompting either phagocytic clearance or the generation of NETs. The choice is dichotomic and apparently irreversible. Defects in phagocytosis may foster the intravascular generation of NETs, thus promoting vascular inflammation and morbidities associated with diseases characterized by defective phagocytic clearance, such as systemic lupus erythematosus. There is a strong potential for novel treatments based on new knowledge of the events determining the inflammatory and pro-thrombotic function of inflammatory leukocytes.

• Publication year

  2018

• Venue

  Frontiers in Immunology

• Publication date

  2018-02-20

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.3389/fimmu.2018.00288PMID 29515586PMCID 5826238
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A key role for Rac and Pak signaling in neutrophil extracellular traps (NETs) formation defines a new potential therapeutic target

  2018cited by this paper
• Low molecular weight heparins prevent the induction of autophagy of activated neutrophils and the formation of neutrophil extracellular traps

  2017cited by this paper
• Dying cells actively regulate adaptive immune responses

  2017cited by this paper
• Regulated in development and DNA damage responses 1 (REDD1) links stress with IL‐1&bgr;–mediated familial Mediterranean fever attack through autophagy‐driven neutrophil extracellular traps

  2017cited by this paper
• The peritoneum: healing, immunity, and diseases

  2017cited by this paper
• The many ways tissue phagocytes respond to dying cells

  2017cited by this paper
• Reactive Oxygen Species Localization Programs Inflammation to Clear Microbes of Different Size

  2017cited by this paper
• Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells

  2017cited by this paper
• Diverse stimuli engage different neutrophil extracellular trap pathways

  2017cited by this paper
• Acetylated Histones in Apoptotic Microparticles Drive the Formation of Neutrophil Extracellular Traps in Active Lupus Nephritis

  2017cited by this paper
• Macrophage-released ADAMTS1 promotes muscle stem cell activation

  2017cited by this paper
• The long pentraxin PTX3: A prototypical sensor of tissue injury and a regulator of homeostasis

  2017cited by this paper
• Molecular Pathophysiology of Gout.

  2017cited by this paper
• JNK Activation Turns on LPS- and Gram-Negative Bacteria-Induced NADPH Oxidase-Dependent Suicidal NETosis

  2017cited by this paper
• DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis

  2017cited by this paper
• NETopathies? Unraveling the Dark Side of Old Diseases through Neutrophils

  2017cited by this paper
• Mechanisms involved in the triggering of neutrophil extracellular traps (NETs) by Candida glabrata during planktonic and biofilm growth

  2017cited by this paper
• Mesenchymal Stromal Cells Modulate Macrophages in Clinically Relevant Lung Injury Models by Extracellular Vesicle Mitochondrial Transfer

  2017cited by this paper
• Neutrophils in Homeostasis, Immunity, and Cancer.

  2017cited by this paper
• Exosome and Microvesicle-Enriched Fractions Isolated from Mesenchymal Stem Cells by Gradient Separation Showed Different Molecular Signatures and Functions on Renal Tubular Epithelial Cells

  2017cited by this paper
• Neutrophil extracellular traps in immunity and disease

  2017influential reference
• Missing in action—The meaning of cell death in tissue damage and inflammation

  2017cited by this paper
• Evolution of Cancer Stem-like Cells in Endocrine-Resistant Metastatic Breast Cancers Is Mediated by Stromal Microvesicles.

  2017cited by this paper
• High‐mobility group box 1 protein orchestrates responses to tissue damage via inflammation, innate and adaptive immunity, and tissue repair

  2017cited by this paper
• Macrophage-derived IL-1β enhances monosodium urate crystal-triggered NET formation

  2017cited by this paper
• Propagation of thrombosis by neutrophils and extracellular nucleosome networks

  2017cited by this paper
• Anti-inflammatory Mechanisms Triggered by Apoptotic Cells during Their Clearance

  2017cited by this paper
• Mesenchymal stem cells sense mitochondria released from damaged cells as danger signals to activate their rescue properties

  2017cited by this paper
• Inner Mitochondrial Membrane Disruption Links Apoptotic and Agonist-Initiated Phosphatidylserine Externalization in Platelets

  2017cited by this paper
• P2Y6 Receptor Antagonist MRS2578 Inhibits Neutrophil Activation and Aggregated Neutrophil Extracellular Trap Formation Induced by Gout-Associated Monosodium Urate Crystals

  2017cited by this paper
• Biochemical Underpinnings of Immune Cell Metabolic Phenotypes

  2017cited by this paper
• Migrating Platelets Are Mechano-scavengers that Collect and Bundle Bacteria.

  2017cited by this paper
• Neutrophil stunning by metoprolol reduces infarct size

  2017cited by this paper
• ROS and glutathionylation balance cytoskeletal dynamics in neutrophil extracellular trap formation

  2017cited by this paper
• Discovery of specialized pro-resolving mediators marks the dawn of resolution physiology and pharmacology.

  2017cited by this paper
• Host DNases prevent vascular occlusion by neutrophil extracellular traps

  2017cited by this paper
• The Biology and Underlying Mechanisms of Cross-Presentation of Exogenous Antigens on MHC-I Molecules.

  2017cited by this paper
• Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth.

  2017cited by this paper
• An emerging role for neutrophil extracellular traps in noninfectious disease

  2017influential reference
• Anti-TNFα agents curb platelet activation in patients with rheumatoid arthritis

  2016cited by this paper
• Exposure of phosphatidylserine on the cell surface

  2016cited by this paper
• The assessment of serum-mediated phagocytosis of necrotic material by polymorphonuclear leukocytes to diagnose and predict the clinical features of systemic lupus erythematosus: an observational longitudinal study

  2016cited by this paper
• Adipose-Derived Stem Cells Induce Angiogenesis via Microvesicle Transport of miRNA-31

  2016cited by this paper
• Disruption of a Regulatory Network Consisting of Neutrophils and Platelets Fosters Persisting Inflammation in Rheumatic Diseases

  2016cited by this paper
• Blood-borne phagocytes internalize urate microaggregates and prevent intravascular NETosis by urate crystals

  2016cited by this paper
• The Dynamics of Apoptotic Cell Clearance.

  2016influential reference
• Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice.

  2016cited by this paper
• NETosing Neutrophils Activate Complement Both on Their Own NETs and Bacteria via Alternative and Non-alternative Pathways

  2016cited by this paper
• Molecular mechanisms regulating secretory organelles and endosomes in neutrophils and their implications for inflammation

  2016cited by this paper
• Apoptotic cell recognition receptors and scavenger receptors

  2016influential reference
• Innate sensing of oxidation-specific epitopes in health and disease

  2016cited by this paper
• Platelet‐neutrophil complex formation—a detailed in vitro analysis of murine and human blood samples

  2016cited by this paper
• Neutrophils and neutrophil extracellular traps orchestrate initiation and resolution of inflammation.

  2016cited by this paper
• High-mobility group box 1 potentiates antineutrophil cytoplasmic antibody-inducing neutrophil extracellular traps formation

  2016cited by this paper
• The life cycle of phagosomes: formation, maturation, and resolution

  2016cited by this paper
• Transfer of mitochondria from astrocytes to neurons after stroke

  2016cited by this paper
• Role of platelets in neutrophil extracellular trap (NET) production and tissue injury.

  2016cited by this paper
• Leukocytes recruited by tumor-derived HMGB1 sustain peritoneal carcinomatosis

  2016cited by this paper
• Milk fat globule-EGF factor 8 suppresses the aberrant immune response of systemic lupus erythematosus-derived neutrophils and associated tissue damage

  2016cited by this paper
• Blood coagulation in immunothrombosis-At the frontline of intravascular immunity.

  2016cited by this paper
• Neutrophil extracellular traps - the dark side of neutrophils.

  2016influential reference
• Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer

  2016cited by this paper
• At the Bench: Neutrophil extracellular traps (NETs) highlight novel aspects of innate immune system involvement in autoimmune diseases

  2016influential reference
• DAMP and DIC: The role of extracellular DNA and DNA-binding proteins in the pathogenesis of DIC.

  2016cited by this paper
• Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation

  2016cited by this paper
• Platelet-Derived Ectosomes Reduce NK Cell Function

  2016cited by this paper
• Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis

  2016cited by this paper
• Ménage-à-Trois: The Ratio of Bicarbonate to CO2 and the pH Regulate the Capacity of Neutrophils to Form NETs

  2016cited by this paper
• High mobility group box 1 skews macrophage polarization and negatively influences phagocytosis of apoptotic cells.

  2016cited by this paper
• The Gas6-Axl Protein Interaction Mediates Endothelial Uptake of Platelet Microparticles*

  2016influential reference
• Cell death, clearance and immunity in the skeletal muscle

  2016cited by this paper
• Recent advances in understanding neutrophils

  2016cited by this paper
• Phosphatidylserine-mediated platelet clearance by endothelium decreases platelet aggregates and procoagulant activity in sepsis

  2016cited by this paper
• Required Role of Apoptotic Myogenic Precursors and Toll‐like Receptor Stimulation for the Establishment of Autoimmune Myositis in Experimental Murine Models

  2015cited by this paper
• The role of neutrophils in the pathogenesis of systemic lupus erythematosus

  2015cited by this paper
• Tissue Factor Expressed by Neutrophils: Another Piece in the Vascular Inflammation Puzzle

  2015influential reference
• Expression of functional tissue factor by neutrophil extracellular traps in culprit artery of acute myocardial infarction

  2015cited by this paper
• Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

  2015cited by this paper
• Platelet-derived HMGB1 is a critical mediator of thrombosis.

  2015cited by this paper
• Why does the gout attack stop? A roadmap for the immune pathogenesis of gout

  2015cited by this paper
• The Role of Cell Death in the Pathogenesis of SLE: Is Pyroptosis the Missing Link?

  2015cited by this paper
• Circulating microparticles carry oxidation-specific epitopes and are recognized by natural IgM antibodies1[S]

  2015cited by this paper
• Parietal and intravascular innate mechanisms of vascular inflammation

  2015influential reference
• Instructive influences of phagocytic clearance of dying cells on neutrophil extracellular trap generation

  2015cited by this paper
• Vessel‐associated myogenic precursors control macrophage activation and clearance of apoptotic cells

  2015cited by this paper
• Damage‐associated molecular pattern–activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury

  2015cited by this paper
• SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx

  2015cited by this paper
• Circulating Apoptotic Microparticles in Systemic Lupus Erythematosus Patients Drive the Activation of Dendritic Cell Subsets and Prime Neutrophils for NETosis

  2015cited by this paper
• 5‐Fluorouracil causes leukocytes attraction in the peritoneal cavity by activating autophagy and HMGB1 release in colon carcinoma cells

  2015cited by this paper
• Coronary neutrophil extracellular trap burden and deoxyribonuclease activity in ST-elevation acute coronary syndrome are predictors of ST-segment resolution and infarct size.

  2015cited by this paper
• Activated platelets present high mobility group box 1 to neutrophils, inducing autophagy and promoting the extrusion of neutrophil extracellular traps

  2014influential reference
• A Myeloperoxidase-Containing Complex Regulates Neutrophil Elastase Release and Actin Dynamics during NETosis

  2014cited by this paper
• Intravascular immunity as a key to systemic vasculitis: a work in progress, gaining momentum

  2014cited by this paper
• Targeting platelet-neutrophil interactions in giant-cell arteritis.

  2014cited by this paper
• Neutrophil extracellular traps regulate IL-1β-mediated inflammation in familial Mediterranean fever

  2014cited by this paper
• Secretoglobin 1A1 and 1A1A Differentially Regulate Neutrophil Reactive Oxygen Species Production, Phagocytosis and Extracellular Trap Formation

  2014cited by this paper
• Contribution of Defective PS Recognition and Efferocytosis to Chronic Inflammation and Autoimmunity

  2014cited by this paper
• Neutrophils sense microbial size and selectively release neutrophil extracellular traps in response to large pathogens

  2014cited by this paper
• Oxidatively modified phosphatidylserines on the surface of apoptotic cells are essential phagocytic ‘eat-me’ signals: cleavage and inhibition of phagocytosis by Lp-PLA2

  2014cited by this paper
• Peptidylarginine Deiminase Inhibition Reduces Vascular Damage and Modulates Innate Immune Responses in Murine Models of Atherosclerosis

  2014cited by this paper

• NETosis in ischemic stroke: Mechanisms, implications, and therapeutic prospects.

  2026cites this paper
• Neutrophil extracellular traps and microglia/macrophages interactions in stroke: from thromboinflammation to immunotherapy.

  2026cites this paper
• Neutrophil extracellular traps in diseases of the female reproductive organs

  2025cites this paper
• Mitochondrial metabolism is rapidly re-activated in mature neutrophils to support stimulation-induced response

  2025cites this paper
• Immune-regulating extracellular vesicles: a new frontier in autoimmune disease therapy

  2025cites this paper
• From current landscape to future horizon in stem cell therapy for tissue regeneration and wound healing: bridging the gap

  2025cites this paper
• Inflammatory neutrophil responses and T cell activation in ART-treated SIVmac239-infected rhesus macaques

  2025cites this paper
• Apolipoprotein L1 risk alleles: extravasation of T. brucei and insights into lupus nephritis pathogenicity—a scoping review

  2025influential citation
• Platelets as drivers of immunothrombosis in rheumatic diseases

  2025cites this paper
• Neutrophil Extracellular Traps and Endometriosis: Insights from a Case-Control Study

  2025cites this paper
• Empagliflozin attenuates sorafenib-promoted renal ferroptosis and inflammation by targeting cyclooxygenase-2/prostaglandin E2 axis.

  2025cites this paper
• Phospholipase D1 is a critical mediator of neutrophil extracellular trap formation and venous thrombosis

  2025cites this paper
• Hematological alterations by gender and age linked to mercury exposure in residents of the Colombian Atrato River artisanal gold mining region.

  2025cites this paper
• NETosis in Alzheimer’s Disease: Understanding the Role of Neutrophil Extracellular Traps (NETs) in Neuroinflammation and Disease Pathogenesis

  2025cites this paper
• Unraveling NETosis: From Immune Mechanisms to Therapeutic Innovations

  2025cites this paper
• Mitochondrial metabolism is rapidly re-activated in mature neutrophils to support stimulation-induced response.

  2025cites this paper
• Pathogenic and Protective Roles of Neutrophils in Chlamydia trachomatis Infection

  2025cites this paper
• Platelet mitochondrial transfer via extracellular vesicles modulates neutrophil phenotype and function.

  2025cites this paper
• Micrurus lemniscatus venom stimulates leukocyte functions in vivo

  2025cites this paper
• Targeting neutrophil dysfunction in acute lung injury: Insights from active components of Chinese medicine.

  2025cites this paper
• Atypical hemolytic uremic syndrome: a case report and review of thrombotic mechanisms

  2025cites this paper
• A major Toxoplasma serine protease inhibitor protects the parasite against gut-derived serine proteases and NETosis damage

  2025cites this paper
• Advances in neutrophil extracellular traps and ferroptosis in sepsis-induced cardiomyopathy

  2025cites this paper
• HMGB1 promotes neutrophil PD-L1 expression through TLR2 and mediates T cell apoptosis leading to immunosuppression in sepsis.

  2024cites this paper
• Inflammasomes and idiopathic inflammatory myopathies

  2024cites this paper
• Proteomic Profile Regulated by the Immunomodulatory Jusvinza Drug in Neutrophils Isolated from Rheumatoid Arthritis Patients

  2024cites this paper
• Conceptual Contextualization of Neutrophilic Dermatoses

  2024cites this paper
• Cytoplasmic DNA and AIM2 inflammasome in RA: where they come from and where they go?

  2024cites this paper
• Functional plasticity shapes neutrophil response to Leishmania major infection in susceptible and resistant strains of mice

  2024cites this paper
• Carbohydrate metabolism in supporting and regulating neutrophil effector functions.

  2024cites this paper
• Platelet HMGB1 Steers Intravascular Immunity and Thrombosis.

  2024cites this paper
• Neutrophil Extracellular Traps: A Crucial Factor in Post-Surgical Abdominal Adhesion Formation

  2024cites this paper
• Neutrophils versus Protozoan Parasites: Plasmodium, Trichomonas, Leishmania, Trypanosoma, and Entameoba

  2024cites this paper
• Extracellular traps development in canine neutrophils induced by infective stage Toxocara canis larvae.

  2024cites this paper
• Neutrophil extracellular traps formation: effect of Leishmania major promastigotes and salivary gland homogenates of Phlebotomus papatasi in human neutrophil culture

  2024cites this paper
• Targeting Neutrophil Extracellular Traps in Gouty Arthritis: Insights into Pathogenesis and Therapeutic Potential

  2024cites this paper
• Minimal Bacterial Cell JCVI-syn3B as a Chassis to Investigate Interactions between Bacteria and Mammalian Cells

  2024cites this paper
• Macrophages coordinate immune response to laser-induced injury via extracellular traps

  2024cites this paper
• Neutrophil hitchhiking: Riding the drug delivery wave to treat diseases

  2024cites this paper
• Cisplatin Toxicity Causes Neutrophil-Mediated Inflammation in Zebrafish Larvae

  2024cites this paper
• Effect of antiplatelet therapy after COVID-19 diagnosis: A systematic review with meta-analysis and trial sequential analysis

  2024cites this paper
• Can Serum Histone H4 Level Be a Biomarker in Ulcerative Colitis?

  2024cites this paper
• Encapsulated Streptococcus suis impairs optimal neutrophil functions which are not rescued by priming with colony-stimulating factors

  2024cites this paper
• Clearance of apoptotic cells by neutrophils in inflammation and cancer

  2024cites this paper
• Fusobacterium nucleatum-triggered neutrophil extracellular traps facilitate colorectal carcinoma progression

  2023cites this paper
• Global research trends and focus on the link between rheumatoid arthritis and neutrophil extracellular traps: a bibliometric analysis from 1985 to 2023

  2023cites this paper
• The perspectives of NETosis on the progression of obesity and obesity-related diseases: mechanisms and applications

  2023cites this paper
• Neutrophil extracellular traps in intracerebral hemorrhage: implications for pathogenesis and therapeutic targets

  2023cites this paper
• Balancing the functions of DNA extracellular traps in intracellular parasite infections: implications for host defense, disease pathology and therapy

  2023cites this paper
• The role of neutrophil extracellular traps and proinflammatory damage-associated molecular patterns in idiopathic inflammatory myopathies.

  2023cites this paper
• COVID-19 morbidity in lower versus higher income populations underscores the need to restore lost biodiversity of eukaryotic symbionts

  2023cites this paper
• Release of neutrophil extracellular traps in response to Candida albicans yeast, as a secondary defense mechanism activated by phagocytosis

  2023cites this paper
• Neutrophil extracellular traps in autoimmune diseases: Analysis of the knowledge map

  2023cites this paper
• Beta 2 glycoprotein I and neutrophil extracellular traps: Potential bridge between innate and adaptive immunity in anti-phospholipid syndrome

  2023cites this paper
• Fibrinolytic therapy in patients with COVID-19 and ARDS: protocol for a systematic review and meta-analysis

  2023cites this paper
• The molecular mechanism of neutrophil extracellular traps and its role in bone and joint disease

  2023cites this paper
• Neutrophil extracellular traps formation and clearance is enhanced in fever and attenuated in hypothermia

  2023cites this paper
• New Insights into Neutrophil Extracellular Trap (NETs) Formation from Porcine Neutrophils in Response to Bacterial Infections

  2022cites this paper
• Neutrophil degranulation, NETosis and platelet degranulation pathway genes are co-induced in whole blood up to six months before tuberculosis diagnosis

  2022cites this paper
• Lipid metabolism and neutrophil function.

  2022cites this paper
• Stroke-derived neutrophils demonstrate higher formation potential and impaired resolution of CD66b + driven neutrophil extracellular traps

  2022cites this paper
• Personalised immunotherapy in sepsis: a scoping review protocol

  2022cites this paper
• Tissue-resident memory T cells in gastrointestinal cancer immunology and immunotherapy: ready for prime time?

  2022cites this paper
• Metamorphosis of neutrophil transcriptional programme during Leishmania infection

  2022cites this paper
• Neutrophil Functional Heterogeneity and Implications for Viral Infections and Treatments

  2022cites this paper
• Synergistic Antibacterial Effect of Zinc Oxide Nanoparticles and Polymorphonuclear Neutrophils

  2022cites this paper
• Efficacy and safety of neoadjuvant sintilimab, oxaliplatin and capecitabine in patients with locally advanced, resectable gastric or gastroesophageal junction adenocarcinoma: early results of a phase 2 study

  2022cites this paper
• The interaction between nanoparticles and immune system: application in the treatment of inflammatory diseases

  2022cites this paper
• On the Origin of Neutrophil Extracellular Traps in COVID-19

  2022cites this paper
• CD4+ T-cell cooperation promoted pathogenic function of activated naïve B cells of patients with SLE

  2022cites this paper
• A Host-Directed Approach to the Detection of Infection in Hard-to-Heal Wounds

  2022influential citation
• Immune checkpoint silencing using RNAi-incorporated nanoparticles enhances antitumor immunity and therapeutic efficacy compared with antibody-based approaches

  2022cites this paper
• TiO2 nanoparticles abrogate the protective effect of the Crohn’s disease-associated variation within the PTPN22 gene locus

  2022cites this paper
• Altered distribution, activation and increased IL-17 production of mucosal-associated invariant T cells in patients with acute respiratory distress syndrome

  2022cites this paper
• Emerging Role of Neutrophil Extracellular Traps in Gastrointestinal Tumors: A Narrative Review

  2022cites this paper
• Development of 89Zr-anti-CD103 PET imaging for non-invasive assessment of cancer reactive T cell infiltration

  2022cites this paper
• Myeloperoxidase: Regulation of Neutrophil Function and Target for Therapy

  2022cites this paper
• Crosslinking of membrane CD13 in human neutrophils mediates phagocytosis and production of reactive oxygen species, neutrophil extracellular traps and proinflammatory cytokines

  2022cites this paper
• Fungal microbiome (mycobiome) and virome of the lacrimal sac in patients with PANDO: the lacriome paper 5

  2022cites this paper
• Differential expansion of T peripheral helper cells in early rheumatoid arthritis and osteoarthritis synovium

  2022cites this paper
• NLRP3 Inflammasome Simultaneously Involved in Autophagy and Phagocytosis of THP-1 Cells to Clear Aged Erythrocytes

  2022cites this paper
• Minimal cell JCVI-syn3B as a chassis to reveal the mechanisms behind Mycoplasma host–pathogen interactions

  2022cites this paper
• Phase 1 study of C-CAR088, a novel humanized anti-BCMA CAR T-cell therapy in relapsed/refractory multiple myeloma

  2022cites this paper
• The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis

  2022cites this paper
• Molecular mechanisms and therapeutic target of NETosis in diseases

  2022cites this paper
• Hepatectomy-induced apoptotic extracellular vesicles stimulate neutrophils to secrete regenerative growth factors.

  2022cites this paper
• Immunomodulatory and anti-inflammatory effects of Phellinus linteus mycelium

  2021cites this paper
• Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor

  2021cites this paper
• Differences in TCR repertoire and T cell activation underlie the divergent outcomes of antitumor immune responses in tumor-eradicating versus tumor-progressing hosts

  2021cites this paper
• Orchestration of Neutrophil Extracellular Traps (Nets), a Unique Innate Immune Function during Chronic Obstructive Pulmonary Disease (COPD) Development

  2021cites this paper
• Effect of antiplatelet treatments on patients with COVID-19 infection: A systematic review and meta-analysis

  2021cites this paper
• Neutrophil dysfunction in bronchiectasis: an emerging role for immunometabolism

  2021cites this paper
• Circulating Neutrophil Dysfunction in HBV-Related Acute-on-Chronic Liver Failure

  2021cites this paper
• COVID-19 illness and autoimmune diseases: recent insights

  2021cites this paper
• Roles of neutrophil granule proteins in orchestrating inflammation and immunity

  2021cites this paper
• Releasing the brakes of tumor immunity with anti-PD-L1 and pushing its accelerator with L19–IL2 cures poorly immunogenic tumors when combined with radiotherapy

  2021cites this paper
• CXCR6 deficiency impairs cancer vaccine efficacy and CD8+ resident memory T-cell recruitment in head and neck and lung tumors

  2021cites this paper
• Seminal plasma, and not sperm, induces time and concentration-dependent neutrophil extracellular trap release in donkeys.

  2021cites this paper
• Identification of the difference of neutrophils in different locations in RA patients

  2021cites this paper
• The nature of the immune response in microbial-associated and sterile intraamniotic inflammation

  2021cites this paper