A novel self-lipid antigen targets human T cells against CD1c+ leukemias

CD1c self-reactive T cells recognize a novel class of self-lipids that are accumulated on leukemia cells.

• Publication year

  2014

• Venue

  Journal of Experimental Medicine

• Publication date

  2014-06-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/jem.20140410PMID 24935257PMCID 4076585
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Acute Lymphoblastic Leukemia in Children and Adolescents

  2018cited by this paper
• Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer

  2012cited by this paper
• Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus

  2012cited by this paper
• Hematopoiesis: a human perspective.

  2012cited by this paper
• Cancer Exome Analysis Reveals a T Cell Dependent Mechanism of Cancer Immunoediting

  2012cited by this paper
• Anti-tumor potential of type-I NKT cells against CD1d-positive and CD1d-negative tumors in humans.

  2011cited by this paper
• A mycolic acid-specific CD1-restricted T cell population contributes to acute and memory immune responses in human tuberculosis infection.

  2011cited by this paper
• Biology, risk stratification, and therapy of pediatric acute leukemias: an update.

  2011cited by this paper
• High‐frequency and adaptive‐like dynamics of human CD1 self‐reactive T cells

  2011cited by this paper
• Long-term survival and late deaths after allogeneic hematopoietic cell transplantation.

  2011cited by this paper
• Harnessing natural killer T (NKT) cells in human myeloma: progress and challenges.

  2011cited by this paper
• Tumor-Specific Antigens and Immunologic Adjuvants in Cancer Immunotherapy

  2011cited by this paper
• Peroxisomes, lipid metabolism and lipotoxicity.

  2010cited by this paper
• Molecularly defined vaccines for cancer immunotherapy, and protective T cell immunity.

  2010cited by this paper
• Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis.

  2010cited by this paper
• An Efficient Strategy to Induce and Maintain In Vitro Human T Cells Specific for Autologous Non-Small Cell Lung Carcinoma

  2010cited by this paper
• CD1a-autoreactive T cells are a normal component of the human αβ T cell repertoire

  2010cited by this paper
• An extremely simple method for extraction of lysophospholipids and phospholipids from blood samples

  2010cited by this paper
• Loss of mismatched HLA in leukemia after stem-cell transplantation.

  2009cited by this paper
• Overexpression of peroxiredoxin I and thioredoxin1 in human breast carcinoma

  2009cited by this paper
• Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

  2009cited by this paper
• Lysophosphatidylmethanol is a pan lysophosphatidic acid receptor agonist and is produced by autotaxin in blood.

  2009cited by this paper
• Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I-II study.

  2009cited by this paper
• Loss of Mismatched HLA in Leukemia after Stem-Cell Transplantation

  2009cited by this paper
• Harnessing invariant NKT cells in vaccination strategies

  2009cited by this paper
• The contrasting roles of NKT cells in tumor immunity.

  2009cited by this paper
• Acute myeloid leukemia.

  2008cited by this paper
• Graft-versus-leukemia effects of transplantation and donor lymphocytes.

  2008cited by this paper
• Inflammation-associated lysophospholipids as ligands for CD1d-restricted T cells in human cancer.

  2008cited by this paper
• Cancer cell metabolism: Warburg and beyond.

  2008cited by this paper
• G-protein-coupled receptors and cancer

  2007cited by this paper
• Differentiation of 1-O-alk-1′-enyl-2-acyl and 1-O-alkyl-2-acyl Glycerophospholipids by Multiple-Stage Linear Ion-Trap Mass Spectrometry with Electrospray Ionization

  2007cited by this paper
• Regulation and biological activities of the autotaxin-LPA axis.

  2007cited by this paper
• Endogenous phosphatidylcholine and a long spacer ligand stabilize the lipid‐binding groove of CD1b

  2006cited by this paper
• Human T cell responses against melanoma.

  2006cited by this paper
• Emergence of antitumor cytolytic T cells is associated with maintenance of hematologic remission in children with acute myeloid leukemia.

  2006cited by this paper
• Peroxisomes and oxidative stress.

  2006cited by this paper
• Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections

  2005cited by this paper
• Recognition of bacterial glycosphingolipids by natural killer T cells

  2005cited by this paper
• CD1a-, b-, and c-Restricted TCRs Recognize Both Self and Foreign Antigens1

  2005cited by this paper
• T cell activation by lipopeptide antigens.

  2005cited by this paper
• Cell wall glycosphingolipids of Sphingomonas paucimobilis are CD1d‐specific ligands for NKT cells

  2005cited by this paper
• Bacterial infections promote T cell recognition of self-glycolipids.

  2005cited by this paper
• Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells.

  2005cited by this paper
• Acute graft-versus-host disease: from the bench to the bedside.

  2005cited by this paper
• Suicide gene therapy of graft-versus-host disease induced by central memory human T lymphocytes.

  2005cited by this paper
• Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias.

  2005cited by this paper
• A Subset of Liver NK T Cells Is Activated during Leishmania donovani Infection by CD1d-bound Lipophosphoglycan

  2004cited by this paper
• Acute lymphoblastic leukemia.

  2004cited by this paper
• Diacylated Sulfoglycolipids Are Novel Mycobacterial Antigens Stimulating CD1-restricted T Cells during Infection with Mycobacterium tuberculosis

  2004cited by this paper
• New CFSE-based assay to determine susceptibility to lysis by cytotoxic T cells of leukemic precursor cells within a heterogeneous target cell population.

  2004cited by this paper
• Acute myeloid leukemia

  2004cited by this paper
• CD1: antigen presentation and T cell function.

  2004cited by this paper
• The emerging role of lysophosphatidic acid in cancer

  2003cited by this paper
• Electrospray mass spectrometry of phospholipids.

  2003cited by this paper
• Cross-presentation of Disialoganglioside GD3 to Natural Killer T Cells

  2003cited by this paper
• CD1a and CD1b surface expression is independent from de novo synthesized glycosphingolipids

  2003cited by this paper
• Minimal residual disease in adolescent (older than 14 years) and adult acute lymphoblastic leukemias: early immunophenotypic evaluation has high clinical value.

  2003cited by this paper
• CD1-dependent dendritic cell instruction

  2002cited by this paper
• Presentation of the Same Glycolipid by Different CD1 Molecules

  2002cited by this paper
• Immune responses to tumour antigens: implications for antigen specific immunotherapy of cancer.

  2001cited by this paper
• The alphabeta T cell response to self-glycolipids shows a novel mechanism of CD1b loading and a requirement for complex oligosaccharides.

  2000cited by this paper
• Murine CD1d-restricted T cell recognition of cellular lipids.

  2000cited by this paper
• The αβ T Cell Response to Self-Glycolipids Shows a Novel Mechanism of CD1b Loading and a Requirement for Complex Oligosaccharides

  2000cited by this paper
• CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection

  2000cited by this paper
• Self glycolipids as T‐cell autoantigens

  1999cited by this paper
• The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids.

  1999cited by this paper
• STRUCTURAL DETERMINATION OF LYSOPHOSPHOLIPID REGIOISOMERS BY ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRY

  1996cited by this paper
• In vivo persistence of expanded clones specific for bacterial antigens within the human T cell receptor alpha/beta CD4-8- subset

  1993cited by this paper
• Tumor-specific antigens.

  1980cited by this paper
• [Tumor-specific antigens].

  1965cited by this paper

• Current developments in T-cell receptor therapy for acute myeloid leukemia

  2025cites this paper
• Unconventional T cells in anti-cancer immunity

  2025cites this paper
• CD1-restricted T cells: are unconventional allies the key to future TB vaccines?

  2025cites this paper
• Sideways lipid presentation by the antigen-presenting molecule CD1c

  2025cites this paper
• Sideways lipid presentation by the antigen-presenting molecule CD1c

  2025cites this paper
• A CD1c lipid agnostic T cell receptor bispecific engager redirects T cells against CD1c+ cells

  2025cites this paper
• A structural perspective of how T cell receptors recognize the CD1 family of lipid antigen–presenting molecules

  2024cites this paper
• Bootstrap Evaluation of Association Matrices (BEAM) for Integrating Multiple Omics Profiles with Multiple Outcomes

  2024cites this paper
• Tricking the Trickster: Precision Medicine Approaches to Counteract Leukemia Immune Escape after Transplant.

  2024cites this paper
• MAITs and their mates: “Innate-like” behaviors in conventional and unconventional T cells

  2023cites this paper
• Pan‐cancer analysis identifies CD300 molecules as potential immune regulators and promising therapeutic targets in acute myeloid leukemia

  2022cites this paper
• Allogeneic Tumor Antigen-Specific T Cells for Broadly Applicable Adoptive Cell Therapy of Cancer.

  2022cites this paper
• Engineering γδ T Cells: Recognizing and Activating on Their Own Way

  2022cites this paper
• γδ T Cells for Leukemia Immunotherapy: New and Expanding Trends

  2021cites this paper
• CD36 family members are TCR-independent ligands for CD1 antigen–presenting molecules

  2021cites this paper
• Human T cells engineered with a leukemia lipid-specific TCR enables donor-unrestricted recognition of CD1c-expressing leukemia

  2021cites this paper
• Current Understanding of the Roles of CD1a-Restricted T Cells in the Immune System

  2021cites this paper
• γδ T Cells in Merkel Cell Carcinomas Have a Proinflammatory Profile Prognostic of Patient Survival

  2021cites this paper
• Exploiting CD1-restricted T cells for clinical benefit.

  2021cites this paper
• Proceedings From the First International Workshop at Sidra Medicine: “Engineered Immune Cells in Cancer Immunotherapy (EICCI): From Discovery to Off-the-Shelf Development”, 15th–16th February 2019, Doha, Qatar

  2021cites this paper
• Does CD1a Expression Influence T Cell Function in Patients With Langerhans Cell Histiocytosis?

  2021cites this paper
• Role of Group 1 CD1-Restricted T Cells in Host Defense and Inflammatory Diseases.

  2021cites this paper
• γδ T Cells in Tumor Microenvironment.

  2020cites this paper
• Tumor Lipids of Pediatric Papillary Renal Cell Carcinoma Stimulate Unconventional T Cells

  2020cites this paper
• Biased MAIT TCR Usage Poised for Limited Antigen Diversity?

  2020cites this paper
• T-Cell Gene Therapy in Cancer Immunotherapy: Why It Is No Longer Just CARs on The Road

  2020cites this paper
• Immune escape and immunotherapy of acute myeloid leukemia.

  2020cites this paper
• Crystal structures of lysophospholipid-bound MHC class I molecules

  2020cites this paper
• Using agonists for iNKT cells in cancer therapy.

  2020cites this paper
• Off-the-Shelf Allogeneic T Cell Therapies for Cancer: Opportunities and Challenges Using Naturally Occurring “Universal” Donor T Cells

  2020cites this paper
• Genomic landscape of the immune microenvironments of brain metastases in breast cancer

  2020cites this paper
• Prognostic Value of CD1B in Localised Prostate Cancer

  2019cites this paper
• The Dynamics of the Skin’s Immune System

  2019cites this paper
• Impacts of the MHC class I-like XNC10 and innate-like T cells on tumor tolerance and rejection in the amphibian Xenopus.

  2019cites this paper
• Capturing the antigen landscape: HLA-E, CD1 and MR1.

  2019cites this paper
• Evolutionary Underpinnings of Innate-Like T Cell Interactions with Cancer

  2019cites this paper
• Editorial: Role of CD1- and MR1-Restricted T Cells in Immunity and Disease

  2019cites this paper
• A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids

  2019cites this paper
• Translating gammadelta (γδ) T cells and their receptors into cancer cell therapies

  2019cites this paper
• Functional characterization of peroxisome biogenic proteins Pex5 and Pex7 of Drosophila

  2018cites this paper
• T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids

  2018cites this paper
• Unconventional T Cell Targets for Cancer Immunotherapy.

  2018cites this paper
• The versatility of the CD1 lipid antigen presentation pathway

  2018cites this paper
• Phospholipid signaling in innate immune cells.

  2018cites this paper
• A Subset of Human Autoreactive CD1c-Restricted T Cells Preferentially Expresses TRBV4-1+ TCRs

  2018cites this paper
• The Conventional Nature of Non-MHC-Restricted T Cells

  2018cites this paper
• A Diverse Lipid Antigen–Specific TCR Repertoire Is Clonally Expanded during Active Tuberculosis

  2018cites this paper
• Linking CD1-Restricted T Cells With Autoimmunity and Dyslipidemia: Lipid Levels Matter

  2018cites this paper
• Potential advantages of CD1‐restricted T cell immunotherapy in cancer

  2018cites this paper
• Role of non‐classical T cells in skin immunity

  2018cites this paper
• The intricacies of self‐lipid antigen presentation by CD1b

  2018cites this paper
• Harnessing the CD1 restricted T cell response for leukemia adoptive immunotherapy.

  2017cites this paper
• CD1: A Singed Cat of the Three Antigen Presentation Systems

  2017cites this paper
• Epigenome-wide association study of rheumatoid arthritis identifies differentially methylated loci in B cells

  2017cites this paper
• Molecular features of lipid-based antigen presentation by group 1 CD1 molecules.

  2017cites this paper
• Novel Antigen Targets for Immunotherapy of Acute Myeloid Leukemia.

  2017influential citation
• Unbiased definition of a shared T-cell receptor motif enables population-based studies of tuberculosis

  2017cites this paper
• CD1b-autoreactive T cells contribute to hyperlipidemia-induced skin inflammation in mice

  2017cites this paper
• Leprosy as a model to understand cancer immunosurveillance and T cell anergy

  2016cites this paper
• CD1c(+) myeloid dendritic cells in myeloid neoplasia

  2016cites this paper
• CD1b-autoreactive T cells recognize phospholipid antigens and contribute to antitumor immunity against a CD1b+ T cell lymphoma

  2016cites this paper
• Targeting Innate-Like T Cells in Tuberculosis

  2016cites this paper
• Molecular Analysis of Lipid-Reactive Vδ1 γδ T Cells Identified by CD1c Tetramers

  2016influential citation
• Cholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cells

  2016cites this paper
• CD1-Restricted T Cells at the Crossroad of Innate and Adaptive Immunity

  2016cites this paper
• Donor-unrestricted T cells in the human CD1 system

  2016cites this paper
• Lysosomal Lipases PLRP2 and LPLA2 Process Mycobacterial Multi-acylated Lipids and Generate T Cell Stimulatory Antigens.

  2016cites this paper
• The Immunology of CD1- and MR1-Restricted T Cells.

  2016cites this paper
• Utilizing cell-based therapeutics to overcome immune evasion in hematologic malignancies.

  2016cites this paper
• Functional studies on human γδ T cells and their interactions with dendritic cells and B cells

  2016cites this paper
• T Cells Identified by CD 1 c Tetramers δγ 1 δ Molecular Analysis of Lipid-Reactive V

  2016influential citation
• Role of Group 1 CD1-Restricted T Cells in Infectious Disease

  2015influential citation
• Extraction and Identification of T Cell Stimulatory Self-lipid Antigens

  2015cites this paper
• Glycolipid Presentation by CD1

  2015cites this paper
• Group 1 CD1-restricted T cells and the pathophysiological implications of self-lipid antigen recognition.

  2015cites this paper
• Phospholipid signals of microbial infection for the human immune system

  2015cites this paper
• The burgeoning family of unconventional T cells

  2015cites this paper
• Targeting leukemia by CD1c-restricted T cells specific for a novel lipid antigen

  2015cites this paper
• Recognition of Microbial Glycolipids by Natural Killer T Cells

  2015cites this paper
• Adoptive T Cell Therapy Targeting CD1 and MR1

  2015cites this paper
• The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy

  2015cites this paper
• Activation of human T cells by CD1 and self-lipids.

  2015cites this paper
• Improving the safety of cell therapy with the TK-suicide gene

  2015cites this paper
• Regulation of Lipid Specific and Vitamin Specific Non-MHC Restricted T Cells by Antigen Presenting Cells and Their Therapeutic Potentials

  2015cites this paper
• Cholesteryl esters stabilise human CD1c conformations for recognition by self-reactive T cells

  2015cites this paper
• The T cell antigen receptor: the Swiss army knife of the immune system

  2015cites this paper
• Adipose Tissue–Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation

  2015cites this paper
• Activation of human T cells by CD1 and self‐lipids

  2015cites this paper
• Adoptive T‐cell therapy for cancer: The era of engineered T cells

  2015cites this paper
• The T-Cell Response to Lipid Antigens of Mycobacterium tuberculosis

  2014cites this paper