Adoptive T Cell Therapy Targeting CD1 and MR1

Adoptive T cell immunotherapy has demonstrated clinically relevant efficacy in treating malignant and infectious diseases. However, much of these therapies have been focused on enhancing, or generating de novo, effector functions of conventional T cells recognizing HLA molecules. Given the heterogeneity of HLA alleles, mismatched patients are ineligible for current HLA-restricted adoptive T cell therapies. CD1 and MR1 are class I-like monomorphic molecules and their restricted T cells possess unique T cell receptor specificity against entirely different classes of antigens. CD1 and MR1 molecules present lipid and vitamin B metabolite antigens, respectively, and offer a new front of targets for T cell therapies. This review will cover the recent progress in the basic research of CD1, MR1, and their restricted T cells that possess translational potential.

• Publication year

  2015

• Venue

  Frontiers in Immunology

• Publication date

  2015-05-20

• Fields of study

  Medicine

• Identifiers
  DOI 10.3389/fimmu.2015.00247PMID 26052329PMCID 4440381
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Type II NKT-TFH cells against Gaucher lipids regulate B-cell immunity and inflammation.

  2015cited by this paper
• αβ T cell antigen receptor recognition of CD1a presenting self lipid ligands

  2015cited by this paper
• MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage

  2014cited by this paper
• Lipid presentation by human CD1 molecules and the diverse T cell populations that respond to them.

  2014cited by this paper
• Activation of iNKT cells by a distinct constituent of the endogenous glucosylceramide fraction

  2014cited by this paper
• Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by αβ T cells

  2014cited by this paper
• IL-10-producing NKT10 cells are a distinct regulatory invariant NKT cell subset.

  2014cited by this paper
• Adoptive immunotherapy for cancer or viruses.

  2014cited by this paper
• A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells

  2014cited by this paper
• CD1d expression in renal cell carcinoma is associated with higher relapse rates, poorer cancer-specific and overall survival

  2014cited by this paper
• Biology of CD1- and MR1-restricted T cells.

  2014cited by this paper
• Uncoupling T‐cell expansion from effector differentiation in cell‐based immunotherapy

  2014cited by this paper
• Invariant NKT cells with chimeric antigen receptor provide a novel platform for safe and effective cancer immunotherapy.

  2014cited by this paper
• MAITs, MR1 and vitamin B metabolites.

  2014cited by this paper
• T-cell activation by transitory neo-antigens derived from distinct microbial pathways

  2014cited by this paper
• The identification of the endogenous ligands of natural killer T cells reveals the presence of mammalian α-linked glycosylceramides.

  2014cited by this paper
• Acquisition of innate-like microbial reactivity in mucosal tissues during human fetal MAIT-cell development

  2014cited by this paper
• A novel self-lipid antigen targets human T cells against CD1c+ leukemias

  2014cited by this paper
• Human cell‐based artificial antigen‐presenting cells for cancer immunotherapy

  2014cited by this paper
• Exploiting the curative potential of adoptive T‐cell therapy for cancer

  2014cited by this paper
• Correction: Corrigendum: Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRβ repertoire

  2014cited by this paper
• CD1d-lipid antigen recognition by the γδ TCR

  2013cited by this paper
• CD1a autoreactive T cells recognize natural skin oils that function as headless antigens

  2013influential reference
• Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

  2013influential reference
• A conserved human T cell population targets mycobacterial antigens presented by CD1b

  2013cited by this paper
• Recognition of vitamin B metabolites by mucosal-associated invariant T cells

  2013cited by this paper
• Clinical regressions and broad immune activation following combination therapy targeting human NKT cells in myeloma.

  2013cited by this paper
• The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins

  2013cited by this paper
• CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketide antigens

  2013cited by this paper
• Lipidomic analysis of phospholipids from human mammary epithelial and breast cancer cell lines

  2013cited by this paper
• Medulloblastoma expresses CD1d and can be targeted for immunotherapy with NKT cells.

  2013cited by this paper
• Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells

  2013cited by this paper
• Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs

  2013cited by this paper
• Cutting Edge: CD1d Restriction and Th1/Th2/Th17 Cytokine Secretion by Human Vδ3 T Cells

  2013cited by this paper
• Comprehensive lipidome profiling of isogenic primary and metastatic colon adenocarcinoma cell lines.

  2012cited by this paper
• MR1 presents microbial vitamin B metabolites to MAIT cells

  2012cited by this paper
• The majority of CD1d‐sulfatide‐specific T cells in human blood use a semiinvariant Vδ1 TCR

  2012cited by this paper
• Hepatitis B virus–induced lipid alterations contribute to natural killer T cell–dependent protective immunity

  2012cited by this paper
• Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus

  2012cited by this paper
• Lysophospholipid presentation by CD1d and recognition by a human Natural Killer T‐cell receptor

  2012cited by this paper
• Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor

  2012cited by this paper
• Adoptive immunotherapy for cancer: harnessing the T cell response

  2012cited by this paper
• Type II Natural Killer T cells recognize sulfatide self-antigens using features of both innate-like and conventional T cells

  2012cited by this paper
• Induction of HLA-DP4–Restricted Anti-Survivin Th1 and Th2 Responses Using an Artificial Antigen-Presenting Cell

  2011cited by this paper
• Herpes Simplex Virus 1 Glycoprotein B and US3 Collaborate To Inhibit CD1d Antigen Presentation and NKT Cell Function

  2011cited by this paper
• A mycolic acid-specific CD1-restricted T cell population contributes to acute and memory immune responses in human tuberculosis infection.

  2011cited by this paper
• Induction of NKT cell-specific immune responses in cancer tissues after NKT cell-targeted adoptive immunotherapy.

  2011cited by this paper
• Borrelia burgdorferi infection regulates CD1 expression in human cells and tissues via IL1‐β

  2011cited by this paper
• Invariant NKT cells recognize glycolipids from pathogenic Gram-positive bacteria

  2011cited by this paper
• Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors

  2011cited by this paper
• Endogenous MHC-Related Protein 1 Is Transiently Expressed on the Plasma Membrane in a Conformation That Activates Mucosal-Associated Invariant T Cells

  2011cited by this paper
• High‐frequency and adaptive‐like dynamics of human CD1 self‐reactive T cells

  2011influential reference
• A molecular basis for NKT cell recognition of CD1d-self-antigen.

  2011cited by this paper
• Establishment of Antitumor Memory in Humans Using in Vitro–Educated CD8+ T Cells

  2011influential reference
• Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells.

  2011cited by this paper
• Invariant natural killer T cells recognize lipid self-antigen induced by microbial danger signals

  2011cited by this paper
• A semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen–recognition properties

  2011cited by this paper
• CD1a-autoreactive T cells are a normal component of the human αβ T cell repertoire

  2010cited by this paper
• Innate-Like Control of Human iNKT Cell Autoreactivity via the Hypervariable CDR3β Loop

  2010cited by this paper
• A panel of human cell-based artificial APC enables the expansion of long-lived antigen-specific CD4+ T cells restricted by prevalent HLA-DR alleles.

  2010cited by this paper
• Recognition of Lyso-Phospholipids by Human Natural Killer T Lymphocytes

  2009cited by this paper
• Valpha24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages.

  2009cited by this paper
• α-Galactosylceramide in Chronic Hepatitis B Infection: Results from a Randomized Placebo-Controlled Phase I/ II Trial

  2009cited by this paper
• A Phase I-II Study of α-Galactosylceramide-Pulsed IL-2/GM-CSF-Cultured Peripheral Blood Mononuclear Cells in Patients with Advanced and Recurrent Non-Small Cell Lung Cancer1

  2009cited by this paper
• Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen.

  2009cited by this paper
• Combination therapy of in vitro‐expanded natural killer T cells and α‐galactosylceramide‐pulsed antigen‐presenting cells in patients with recurrent head and neck carcinoma

  2009cited by this paper
• Determination of Cellular Lipids Bound to Human CD1d Molecules

  2009cited by this paper
• Phase I study of α-galactosylceramide-pulsed antigen presenting cells administration to the nasal submucosa in unresectable or recurrent head and neck cancer

  2008cited by this paper
• CD1d-restricted iNKT cells, the 'Swiss-Army knife' of the immune system.

  2008cited by this paper
• Expression of CD1d and Ligand-Induced Cytokine Production Are Tissue Specific in Mucosal Epithelia of the Human Lower Reproductive Tract

  2008cited by this paper
• Regulation of multiple myeloma survival and progression by CD1d.

  2008cited by this paper
• Phase I study of alpha-galactosylceramide-pulsed antigen presenting cells administration to the nasal submucosa in unresectable or recurrent head and neck cancer.

  2008cited by this paper
• CD1d–lipid-antigen recognition by the semi-invariant NKT T-cell receptor

  2007cited by this paper
• Immune surveillance of tumors.

  2007cited by this paper
• Randomized placebo controlled phase I/II trial of alpha-galactosylceramide for the treatment of chronic hepatitis C.

  2007cited by this paper
• The unique role of natural killer T cells in the response to microorganisms

  2007cited by this paper
• CD1 expression on antigen-presenting cells.

  2007cited by this paper
• Long-Lived Antitumor CD8+ Lymphocytes for Adoptive Therapy Generated Using an Artificial Antigen-Presenting Cell

  2007cited by this paper
• A Phase I Study of In vitro Expanded Natural Killer T Cells in Patients with Advanced and Recurrent Non–Small Cell Lung Cancer

  2006cited by this paper
• Cell wall glycosphingolipids of Sphingomonas paucimobilis are CD1d‐specific ligands for NKT cells

  2005cited by this paper
• CD1d expression on B-precursor acute lymphoblastic leukemia subsets with poor prognosis

  2005cited by this paper
• Human immunodeficiency virus gp120 downregulates CD1d cell surface expression.

  2005cited by this paper
• A phase I study of alpha-galactosylceramide (KRN7000)-pulsed dendritic cells in patients with advanced and recurrent non-small cell lung cancer.

  2005cited by this paper
• A Phase I Study of α-Galactosylceramide (KRN7000)–Pulsed Dendritic Cells in Patients with Advanced and Recurrent Non–Small Cell Lung Cancer

  2005cited by this paper
• T cell activation by lipopeptide antigens.

  2005cited by this paper
• Glycolipid antigen induces long-term natural killer T cell anergy in mice.

  2005cited by this paper
• Lysosomal Glycosphingolipid Recognition by NKT Cells

  2004cited by this paper
• The DNA sequence and analysis of human chromosome 6

  2003cited by this paper
• Expression of CD1d by myelomonocytic leukemias provides a target for cytotoxic NKT cells

  2003cited by this paper
• Epidermal Langerhans cells efficiently mediate CD1a-dependent presentation of microbial lipid antigens to T cells.

  2003cited by this paper
• Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1

  2003cited by this paper
• DNA sequence and analysis of human chromosome 9

  2003cited by this paper
• Valpha24-JalphaQ-independent, CD1d-restricted recognition of alpha-galactosylceramide by human CD4(+) and CD8alphabeta(+) T lymphocytes.

  2002cited by this paper
• Vα24-JαQ-Independent, CD1d-Restricted Recognition of α-Galactosylceramide by Human CD4+ and CD8αβ+ T Lymphocytes1

  2002cited by this paper
• A phase I study of the natural killer T-cell ligand alpha-galactosylceramide (KRN7000) in patients with solid tumors.

  2002cited by this paper
• Self-Recognition of Cd1 by γ/δ T Cells

  2000cited by this paper
• CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection

  2000cited by this paper
• CD1d-mediated Recognition of an α-Galactosylceramide by Natural Killer T Cells Is Highly Conserved through Mammalian Evolution

  1998cited by this paper
• Genomics, isoforms, expression, and phylogeny of the MHC class I-related MR1 gene.

  1998cited by this paper
• Structural requirements for glycolipid antigen recognition by CD1b-restricted T cells.

  1997cited by this paper

• MAIT cells promote cancer progression and regulatory T cell accumulation in bladder tumor microenvironment

  2025cites this paper
• Classic Costimulatory Interactions in MAIT Cell Responses: From Gene Expression to Immune Regulation.

  2023cites this paper
• Recurrence prediction of lung adenocarcinoma using an immune gene expression and clinical data trained and validated support vector machine classifier

  2023cites this paper
• In silico identification and characterization of small molecule binding to the CD1d immunoreceptor

  2023cites this paper
• Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells

  2022cites this paper
• MAIT Cells: Partners or Enemies in Cancer Immunotherapy?

  2021cites this paper
• Identifying, Isolation, and Functional Use of Human Liver iNKT Cells.

  2021cites this paper
• MAIT Cells in COVID-19: Heroes, Villains, or Both?

  2020cites this paper
• Enumeration, functional responses and cytotoxic capacity of MAIT cells in newly diagnosed and relapsed multiple myeloma

  2018cites this paper
• A Subset of Human Autoreactive CD1c-Restricted T Cells Preferentially Expresses TRBV4-1+ TCRs

  2018cites this paper
• IAP Antagonists Enhance Cytokine Production from Mouse and Human iNKT Cells

  2017cites this paper
• Mucosa-associated invariant T cells infiltrate hepatic metastases in patients with colorectal carcinoma but are rendered dysfunctional within and adjacent to tumor microenvironment

  2017cites this paper
• Key Residues at Third CDR3β Position Impact Structure and Antigen Recognition of Human Invariant NK TCRs

  2017cites this paper
• Mucosal-Associated Invariant T Cells: New Insights into Antigen Recognition and Activation

  2017cites this paper
• Functional studies on human γδ T cells and their interactions with dendritic cells and B cells

  2016cites this paper
• Mouse and Human CD1d-Self-Lipid Complexes Are Recognized Differently by Murine Invariant Natural Killer T Cell Receptors

  2016cites this paper
• Antigen‐specific impairment of adoptive T‐cell therapy against cancer: players, mechanisms, solutions and a hypothesis

  2016cites this paper
• THE ESTABLISHMENT OF EFFICIENT METHODS TO CULTURE IMMUNOSUPPRESSIVE MESENCHYMAL STROMAL CELLS FROM CORD BLOOD AND BONE MARROW

  2016cites this paper
• This information is current as Human Invariant NK TCRs ofImpact Structure and Antigen Recognition Position β Key Residues at Third CDR 3

  2016cites this paper
• Editorial: CD1- and MR1-Restricted T Cells in Antimicrobial Immunity

  2015cites this paper