Regulation of human epidermal stem cell proliferation and senescence requires polycomb- dependent and -independent functions of Cbx4.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Cell Stem Cell

• Publication date

  2011-09-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.stem.2011.07.013PMID 21885019
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Patterning as a signature of human epidermal stem cell regulation

  2011cited by this paper
• Interaction Proteomics Analysis of Polycomb Proteins Defines Distinct PRC1 Complexes in Mammalian Cells*

  2011cited by this paper
• Polycomb complexes act redundantly to repress genomic repeats and genes.

  2010cited by this paper
• The SUMO E3 Ligase Activity of Pc2 Is Coordinated through a SUMO Interaction Motif

  2010cited by this paper
• Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

  2010cited by this paper
• Polycomb group protein-mediated repression of transcription.

  2010cited by this paper
• SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development.

  2010influential reference
• DNMT1 Maintains Progenitor Function in Self-Renewing Somatic Tissue

  2010influential reference
• The essence of senescence.

  2010cited by this paper
• Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination.

  2010cited by this paper
• Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer.

  2010cited by this paper
• Bmi-1 extends the life span of normal human oral keratinocytes by inhibiting the TGF-beta signaling.

  2010cited by this paper
• Polycomb group complexes--many combinations, many functions.

  2009cited by this paper
• Senescent keratinocytes die by autophagic programmed cell death.

  2009cited by this paper
• The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.

  2009cited by this paper
• Epidermal stem cell diversity and quiescence

  2009cited by this paper
• Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells.

  2009influential reference
• Finding one's niche in the skin.

  2009cited by this paper
• Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration

  2008cited by this paper
• Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3.

  2008cited by this paper
• Epidermal Notch signalling: differentiation, cancer and adhesion

  2008influential reference
• Ubiquitin E3 Ligase Ring1b/Rnf2 of Polycomb Repressive Complex 1 Contributes to Stable Maintenance of Mouse Embryonic Stem Cells

  2008cited by this paper
• DNA methyltransferase 3B acts as a co-repressor of the human polycomb protein hPc2 to repress fibroblast growth factor receptor 3 transcription.

  2008cited by this paper
• Pc2 and SUMOylation.

  2007cited by this paper
• A single type of progenitor cell maintains normal epidermis

  2007influential reference
• Polycomb Group proteins: an evolutionary perspective.

  2007cited by this paper
• Establishment of 3D organotypic cultures using human neonatal epidermal cells

  2007cited by this paper
• BMP2 and BMP6 control p57(Kip2) expression and cell growth arrest/terminal differentiation in normal primary human epidermal keratinocytes.

  2007cited by this paper
• Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A‐ARF locus

  2007cited by this paper
• The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells.

  2007cited by this paper
• Ring1B is crucial for the regulation of developmental control genes and PRC1 proteins but not X inactivation in embryonic cells

  2007cited by this paper
• The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors.

  2006cited by this paper
• Regulation of the INK4b–ARF–INK4a tumour suppressor locus: all for one or one for all

  2006cited by this paper
• Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing

  2006cited by this paper
• Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1

  2006cited by this paper
• p63 regulates proliferation and differentiation of developmentally mature keratinocytes.

  2006cited by this paper
• Epidermal stem cells: an update.

  2006cited by this paper
• Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence

  2006cited by this paper
• Extensive tissue-regenerative capacity of neonatal human keratinocyte stem cells and their progeny.

  2004cited by this paper
• Role of histone H2A ubiquitination in Polycomb silencing

  2004cited by this paper
• Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche.

  2004cited by this paper
• Location and phenotype of human adult keratinocyte stem cells of the skin.

  2004cited by this paper
• Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27.

  2004cited by this paper
• Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation.

  2004cited by this paper
• Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains.

  2003cited by this paper
• Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenes.

  2003cited by this paper
• Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment

  2003cited by this paper
• Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis

  2003cited by this paper
• Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition

  2003cited by this paper
• Faculty Opinions recommendation of The polycomb protein Pc2 is a SUMO E3.

  2003cited by this paper
• Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites.

  2002cited by this paper
• Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.

  2002cited by this paper
• The Core of the Polycomb Repressive Complex Is Compositionally and Functionally Conserved in Flies and Humans

  2002cited by this paper
• Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing

  2002cited by this paper
• Linking the Rb and polycomb pathways.

  2001cited by this paper
• The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

  1999cited by this paper
• The spatial relationship between stem cells and their progeny in the basal layer of human epidermis: a new view based on whole-mount labelling and lineage analysis.

  1999cited by this paper
• Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype.

  1998cited by this paper
• c-Myc promotes differentiation of human epidermal stem cells.

  1997cited by this paper
• Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis

  1997cited by this paper
• Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm.

  1995cited by this paper
• Stem cell patterning and fate in human epidermis.

  1995cited by this paper
• Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression.

  1993cited by this paper
• Three clonal types of keratinocyte with different capacities for multiplication.

  1987cited by this paper

• CBX4 facilitates EV71 replication by SUMOylation and stabilizing 3D polymerase

  2026cites this paper
• Epigenetics in Skin Homeostasis and Ageing

  2025cites this paper
• Canonical and non-canonical PRC1 differentially contribute to regulation of neural stem cell fate

  2025cites this paper
• Epigenetic regulatory protein chromobox family regulates multiple signalling pathways and mechanisms in cancer

  2025cites this paper
• CBX4 regulation of senescence and associated diseases: molecular pathways and mechanisms.

  2025cites this paper
• Epigenetic regulation in metabolic diseases and neuronal regeneration: Mechanisms, interactions, and therapeutic perspectives

  2025cites this paper
• Identification of HTRA4 as a Transcriptional Target of p63 in Trophoblast.

  2024cites this paper
• Canonical and non-canonical PRC1 differentially contribute to the regulation of neural stem cell fate

  2024cites this paper
• Polycomb function in early mouse development

  2024cites this paper
• CBX4 plays a bidirectional role in transcriptional regulation and lung adenocarcinoma progression

  2024cites this paper
• CBX4 counteracts cellular senescence to desensitize gastric cancer cells to chemotherapy by inducing YAP1 SUMOylation.

  2024cites this paper
• Critical role of epigenetic modification in the pathogenesis of atopic dermatitis.

  2023cites this paper
• Assessment of the Cardiac Noncoding Transcriptome by Single-Cell RNA Sequencing Identifies FIXER, a Conserved Profibrogenic Long Noncoding RNA

  2023cites this paper
• CBX4 promotes antitumor immunity by suppressing Pdcd1 expression in T cells

  2023cites this paper
• Biomarkers of aging

  2023cites this paper
• Synergistic roles of CBX4 chromo and SIM domains in regulating senescence of primary human osteoarthritic chondrocytes

  2023cites this paper
• Stem cell heterogeneity, plasticity, and regulation.

  2023cites this paper
• Cancer associated fibroblasts promote cancer stemness by inducing expression of the chromatin modifying protein CBX4 in squamous cell carcinoma.

  2023cites this paper
• Comprehensive Analysis of the Expression and Prognosis of chromobox Family Members in Breast Cancer.

  2023cites this paper
• Molecular basis of polycomb group protein-mediated fetal hemoglobin repression.

  2023cites this paper
• CBX4 contributes to HIV‐1 latency by forming phase‐separated nuclear bodies and SUMOylating EZH2

  2022cites this paper
• Chromobox Family Proteins as Putative Biomarkers for Breast Cancer Management: A Preliminary Study Based on Bioinformatics Analysis and qRT-PCR Validation

  2022cites this paper
• Context-specific Polycomb mechanisms in development

  2022cites this paper
• pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation

  2022cites this paper
• Distinct interactors define the p63 transcriptional signature in epithelial development or cancer

  2022cites this paper
• Toward Elucidating Epigenetic and Metabolic Regulation of Stem Cell Lineage Plasticity in Skin Aging

  2022cites this paper
• MicroRNA-6838-5p suppresses the self-renewal and metastasis of human liver cancer stem cells through downregulating CBX4 expression and inactivating ERK signaling

  2022cites this paper
• Chromobox homolog 4 overexpression inhibits TNF-α-induced matrix catabolism and senescence by suppressing activation of NF-κB signaling pathway in nucleus pulposus cells

  2022cites this paper
• Epigenetic Mechanisms of Epidermal Differentiation

  2022cites this paper
• CBX4 Regulates Replicative Senescence of WI-38 Fibroblasts

  2022cites this paper
• Inhibiting CBX4 efficiently protects hepatocellular carcinoma cells against sorafenib resistance

  2021cites this paper
• CBX4 Provides an Alternate Mode of Colon Cancer Development via Potential Influences on Circadian Rhythm and Immune Infiltration

  2021cites this paper
• Repeated translocation of a supergene underlying rapid sex chromosome turnover in Takifugu pufferfish

  2021cites this paper
• Epigenetic and metabolic regulation of epidermal homeostasis

  2021cites this paper
• The CBX family of proteins in transcriptional repression and memory

  2020cites this paper
• p63-related signaling at a glance

  2020cites this paper
• A review of epigenetic regulation in wound healing: Implications for the future of wound care

  2020cites this paper
• Transcriptional and signalling regulation of skin epithelial stem cells in homeostasis, wounds and cancer

  2020cites this paper
• Characterization of In Vitro Differentiation of Human Primary Keratinocytes by RNA-Seq Analysis.

  2020cites this paper
• Inhibiting CBX4 efficiently suppress YAP nucleus translocation in hepatocellular carcinoma cells to protect against sorafenib resistance

  2020cites this paper
• CBX4 transcriptionally suppresses KLF6 via interaction with HDAC1 to exert oncogenic activities in clear cell renal cell carcinoma

  2020cites this paper
• The CBX family of proteins in transcriptional repression and memory

  2020cites this paper
• Biological Functions of Chromobox (CBX) Proteins in Stem Cell Self-Renewal, Lineage-Commitment, Cancer and Development.

  2020cites this paper
• EZH2 regulates the correlation between skin regeneration and the duration of mechanical stretch.

  2020cites this paper
• Chromatin Targeting of HIPK2 Leads to Acetylation-Dependent Chromatin Decondensation

  2020cites this paper
• Epigenetic control in skin development, homeostasis and injury repair

  2019cites this paper
• Beyond EZH2: is the polycomb protein CBX2 an emerging target for anti-cancer therapy?

  2019cites this paper
• Diverse gene regulatory mechanisms mediated by Polycomb group proteins during neural development.

  2019cites this paper
• Functional Network Analysis Reveals the Relevance of SKIIP in the Regulation of Alternative Splicing by p38 SAPK

  2019cites this paper
• Tailored chromatin modulation to promote tissue regeneration.

  2019cites this paper
• Maintenance of Nucleolar Homeostasis by CBX4 Alleviates Senescence and Osteoarthritis.

  2019cites this paper
• CBX2 Inhibits Neurite Development by Regulating Neuron-Specific Genes Expression

  2018cites this paper
• Epigenetic Regulation of Skin Development and Regeneration

  2018cites this paper
• The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level

  2018cites this paper
• Polycomb Proteins and their Roles in Skin Development and Regeneration

  2018cites this paper
• Cbx4 Sumoylates Prdm16 to Regulate Adipose Tissue Thermogenesis.

  2018cites this paper
• Epigenetic and Transcriptional Pre-patterning—An Emerging Theme in Cortical Neurogenesis

  2018cites this paper
• Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms

  2018cites this paper
• All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

  2018cites this paper
• Epigenetic Regulation of Skin Wound Healing

  2018cites this paper
• Sumoylation in Development and Differentiation.

  2017cites this paper
• CSNK1a1 Regulates PRMT1 to Maintain the Progenitor State in Self-Renewing Somatic Tissue.

  2017cites this paper
• SUMO and Chromatin Remodeling.

  2017cites this paper
• Melanocytic Nevi and the Genetic and Epigenetic Control of Oncogene-Induced Senescence.

  2017cites this paper
• ZIKV infection effects changes in gene splicing, isoform composition and lncRNA expression in human neural progenitor cells

  2017cites this paper
• The Role of p16INK4a Pathway in Human Epidermal Stem Cell Self-Renewal, Aging and Cancer

  2017cites this paper
• Cellular responses to HSV-1 infection are linked to specific types of alterations in the host transcriptome

  2016cites this paper
• CBX4 Suppresses Metastasis via Recruitment of HDAC3 to the Runx2 Promoter in Colorectal Carcinoma.

  2016cites this paper
• Design and characterization of chemical probes targeting the chromodomains of Polycomb Repressive Complex I

  2016cites this paper
• Post-Transcriptional Mechanisms Regulating Epidermal Stem and Progenitor Cell Self-Renewal and Differentiation.

  2016cites this paper
• Oncogenic Ras: A double-edged sword for human epidermal stem and transient amplifying cells

  2016cites this paper
• Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epidermal Stem Cell Homeostasis.

  2016cites this paper
• Epigenetic control of adult stem cell function

  2016cites this paper
• Repressing the Keratinocyte Genome: How the Polycomb Complex Subunits Operate in Concert to Control Skin and Hair Follicle Development.

  2016cites this paper
• Chromobox Homolog 4 is Positively Correlated to Tumor Growth, Survival and Activation of HIF-1α Signaling in Human Osteosarcoma under Normoxic Condition

  2016cites this paper
• The evolutionary landscape of PRC1 core components in green lineage

  2016cites this paper
• Chromatin and Polycomb: Biology and bioinformatics

  2016cites this paper
• Cbx4: A new guardian of p63’s domain of epidermal control

  2016cites this paper
• Epidermal Differentiation Complex: A Review on Its Epigenetic Regulation and Potential Drug Targets

  2016cites this paper
• BMI1 inhibits senescence and enhances the immunomodulatory properties of human mesenchymal stem cells via the direct suppression of MKP-1/DUSP1

  2016cites this paper
• Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium

  2016influential citation
• Human epidermal stem cells: Role in adverse skin reactions and carcinogenesis from radiation.

  2016cites this paper
• Nanog down-regulates the Wnt signaling pathway via β-catenin phosphorylation during epidermal stem cell proliferation and differentiation

  2015cites this paper
• HIV-1 Infection Accelerates Age According to the Epigenetic Clock

  2015cites this paper
• Stem cell heterogeneity and plasticity in epithelia.

  2015cites this paper
• Acceleration of Age-Associated Methylation Patterns in HIV-1-Infected Adults

  2015cites this paper
• MicroRNA let-7b-regulated epidermal stem cell proliferation in hypertrophied anal papillae

  2015influential citation
• Epigenetic Mechanisms in Cellular Reprogramming

  2015cites this paper
• Identification of biomechanical force as a novel inducer of epithelial-mesenchymal transition features in mechanical stretched skin.

  2015cites this paper
• Human Keratinocytes have two interconvertible modes of proliferation

  2015cites this paper
• MicroRNA-195 functions as a tumor suppressor by inhibiting CBX4 in hepatocellular carcinoma.

  2015cites this paper
• Polycomb group proteins – epigenetic repressors with emerging roles in melanocytes and melanoma

  2015cites this paper
• Epigenetic regulation of adult stem cell function

  2015cites this paper
• The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer*♦

  2015cites this paper
• TCDD-induced activation of aryl hydrocarbon receptor regulates the skin stem cell population.

  2015cites this paper
• Epigenetic Regulation of Pluripotency by Polycomb Group Proteins

  2015cites this paper
• Heterogeneous Stem Cells in Skin Homeostatis and Wound Repair

  2015cites this paper
• Abstract. microRNA-195 (miR-195) plays important roles in tumor metastasis and angiogenesis, yet its function and mechanism of action in hepatocellular carcinoma (HCC)

  2015cites this paper
• Polycomb Complexes: Chromatin Regulators Required for Cell Diversity and Tissue Homeostasis

  2014cites this paper
• The role of polycomb group proteins in hematopoietic stem cell (HSC) self-renewal and leukemogenesis

  2014cites this paper