Stem cell heterogeneity and plasticity in epithelia.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Cell Stem Cell

• Publication date

  2015-05-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.stem.2015.04.014PMID 25957902
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Commensal–dendritic-cell interaction specifies a unique protective skin immune signature

  2015cited by this paper
• Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts.

  2015cited by this paper
• Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells

  2015cited by this paper
• Helicobacter pylori Activates and Expands Lgr5(+) Stem Cells Through Direct Colonization of the Gastric Glands.

  2015cited by this paper
• Fundamental properties of unperturbed haematopoiesis from stem cells in vivo

  2015cited by this paper
• Identification and isolation of a dermal lineage with intrinsic fibrogenic potential

  2015cited by this paper
• Single-cell transcriptome analysis reveals dynamic changes in lncRNA expression during reprogramming.

  2015cited by this paper
• Innate sensing of microbial products promotes wound-induced skin cancer

  2015cited by this paper
• Dermal adipocytes protect against invasive Staphylococcus aureus skin infection

  2015cited by this paper
• Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice

  2015cited by this paper
• Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2

  2014cited by this paper
• Highly Multiplexed Subcellular RNA Sequencing in Situ

  2014cited by this paper
• Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes.

  2014cited by this paper
• ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes

  2014cited by this paper
• Mechanisms regulating skin immunity and inflammation

  2014cited by this paper
• Lung microbiota promotes tolerance to allergens in neonates via PD-L1

  2014cited by this paper
• Mammary stem cells have myoepithelial cell properties

  2014cited by this paper
• Liver stem cells, where art thou?

  2014cited by this paper
• Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function.

  2014cited by this paper
• Clonal dynamics of native haematopoiesis

  2014cited by this paper
• Glial origin of mesenchymal stem cells in a tooth model system

  2014cited by this paper
• In situ identification of bipotent stem cells in the mammary gland

  2014cited by this paper
• Induced pluripotent stem cells in dermatology: potentials, advances, and limitations.

  2014cited by this paper
• Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression

  2014cited by this paper
• Modeling human development and disease in pluripotent stem cell-derived gastric organoids

  2014cited by this paper
• Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity

  2014cited by this paper
• The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy.

  2014cited by this paper
• Intestinal crypt homeostasis revealed at single stem cell level by in vivo live-imaging

  2014influential reference
• Reconstructing lineage hierarchies of the distal lung epithelium using single cell RNA-seq

  2014cited by this paper
• Mammalian skin cell biology: At the interface between laboratory and clinic

  2014cited by this paper
• Purification and Ex Vivo Expansion of Fully Functional Salivary Gland Stem Cells

  2014cited by this paper
• The cytosolic bacterial peptidoglycan sensor Nod2 affords stem cell protection and links microbes to gut epithelial regeneration.

  2014cited by this paper
• Single-cell trajectory detection uncovers progression and regulatory coordination in human B cell development.

  2014cited by this paper
• University of Groningen Purification and Ex Vivo Expansion of Fully Functional Salivary Gland Stem Cells

  2014cited by this paper
• Transit-amplifying cells orchestrate stem cell activity and tissue regeneration.

  2014cited by this paper
• Mammary morphogenesis and regeneration require the inhibition of EMT at terminal end buds by Ovol2 transcriptional repressor.

  2014cited by this paper
• Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change

  2014cited by this paper
• Identification of multipotent luminal progenitor cells in human prostate organoid cultures.

  2014cited by this paper
• p63+Krt5+ distal airway stem cells are essential for lung regeneration

  2014cited by this paper
• Fibroblast heterogeneity in the cancer wound

  2014cited by this paper
• Modulating the stem cell niche for tissue regeneration

  2014cited by this paper
• Epidermal Wnt/β-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors

  2014cited by this paper
• Cellular heterogeneity in the mouse esophagus implicates the presence of a nonquiescent epithelial stem cell population.

  2014cited by this paper
• Evidence against a Stem Cell Origin of New Hepatocytes in a Common Mouse Model of Chronic Liver Injury

  2014cited by this paper
• Mammary stem cells and the differentiation hierarchy: current status and perspectives

  2014cited by this paper
• Defining a mesenchymal progenitor niche at single-cell resolution

  2014cited by this paper
• Single-Cell Analysis of Proxy Reporter Allele-Marked Epithelial Cells Establishes Intestinal Stem Cell Hierarchy

  2014cited by this paper
• Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon

  2014cited by this paper
• Architectural niche organization by LHX2 is linked to hair follicle stem cell function.

  2013cited by this paper
• Wnt activation in nail epithelium couples nail growth to digit regeneration

  2013cited by this paper
• Intestinal label-retaining cells are secretory precursors expressing Lgr5

  2013cited by this paper
• Single-cell gene expression profiling reveals functional heterogeneity of undifferentiated human epidermal cells

  2013cited by this paper
• Mechano-transduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer associated fibroblasts

  2013cited by this paper
• Dedifferentiation of committed epithelial cells into stem cells in vivo

  2013cited by this paper
• Distinct fibroblast lineages determine dermal architecture in skin development and repair

  2013cited by this paper
• Spatial organization within a niche as a determinant of stem cell fate

  2013cited by this paper
• Defining Stem Cell Dynamics in Models of Intestinal Tumor Initiation

  2013cited by this paper
• Unravelling stem cell dynamics by lineage tracing

  2013cited by this paper
• DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus

  2013cited by this paper
• Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding

  2013cited by this paper
• Super-enhancers in the control of cell identity and disease.

  2013cited by this paper
• Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion

  2013cited by this paper
• The Epidermis Comprises Autonomous Compartments Maintained by Distinct Stem Cell Populations

  2013cited by this paper
• Interfollicular Epidermal Stem Cells Self-Renew via Autocrine Wnt Signaling

  2013cited by this paper
• Robust cellular reprogramming occurs spontaneously during liver regeneration.

  2013cited by this paper
• The Interfollicular Epidermis of Adult Mouse Tail Comprises Two Distinct Cell Lineages that Are Differentially Regulated by Wnt, Edaradd, and Lrig1

  2013cited by this paper
• Brief Report: Intravital Imaging of Cancer Stem Cell Plasticity in Mammary Tumors

  2012cited by this paper
• Distinct contribution of stem and progenitor cells to epidermal maintenance

  2012cited by this paper
• Dll1+ secretory progenitor cells revert to stem cells upon crypt damage

  2012cited by this paper
• The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor.

  2012cited by this paper
• Defining the mode of tumour growth by clonal analysis

  2012cited by this paper
• Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling.

  2012cited by this paper
• DNA methylation dynamics during in vivo differentiation of blood and skin stem cells.

  2012cited by this paper
• Diverse epigenetic strategies interact to control epidermal differentiation

  2012cited by this paper
• Thymic epithelial cells: working class heroes for T cell development and repertoire selection.

  2012cited by this paper
• Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas

  2012cited by this paper
• The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

  2012cited by this paper
• The basement membrane of hair follicle stem cells is a muscle cell niche.

  2011cited by this paper
• Genome-wide maps of histone modifications unwind in vivo chromatin states of the hair follicle lineage.

  2011cited by this paper
• Regulation of human epidermal stem cell proliferation and senescence requires polycomb- dependent and -independent functions of Cbx4.

  2011cited by this paper
• Cell-extracellular matrix interactions in normal and diseased skin.

  2011cited by this paper
• Germ-layer and lineage-restricted stem/progenitors regenerate the mouse digit tip

  2011cited by this paper
• Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium.

  2011cited by this paper
• Adipocyte lineage cells contribute to the skin stem cell niche to drive hair cycling.

  2011cited by this paper
• The skin microbiome

  2011cited by this paper
• Interconversion Between Intestinal Stem Cell Populations in Distinct Niches

  2011cited by this paper
• A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

  2011cited by this paper
• Single-molecule transcript counting of stem-cell markers in the mouse intestine

  2011cited by this paper
• The histone methyltransferase Setd8 acts in concert with c-Myc and is required to maintain skin

  2011cited by this paper
• Distinct stem cells contribute to mammary gland development and maintenance

  2011cited by this paper
• Jarid2 regulates mouse epidermal stem cell activation and differentiation

  2011cited by this paper
• Ex vivo organ culture of human hair follicles: a model epithelial-neuroectodermal-mesenchymal interaction system.

  2011cited by this paper
• Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells.

  2010cited by this paper
• The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program.

  2010cited by this paper
• Prospects for stem cell transplantation in the treatment of hepatic disease

  2010cited by this paper
• Coexistence of Quiescent and Active Adult Stem Cells in Mammals

  2010cited by this paper
• Conversion of Adult Pancreatic α-cells to β-cells After Extreme β-cell Loss

  2010cited by this paper
• Regulated Fluctuations in Nanog Expression Mediate Cell Fate Decisions in Embryonic Stem Cells

  2009cited by this paper
• Single Lgr5 stem cells build crypt–villus structures in vitro without a mesenchymal niche

  2009cited by this paper
• Epigenetic reprogramming during wound healing: loss of polycomb‐mediated silencing may enable upregulation of repair genes

  2009cited by this paper

• Omics-based decoding of molecular and metabolic crosstalk in the skin barrier ecosystem.

  2026cites this paper
• Peptide RL‐QN15 Regulates Functions of Epidermal Stem Cells to Accelerate Skin Wound Regeneration via the FZD8/β‐Catenin Axis

  2025cites this paper
• Mapping the Regenerative Pattern in the Human Tympanic Membrane

  2025cites this paper
• Expansion of Human Epidermal Keratinocytes in Co-culture with Human Feeder Cells.

  2025cites this paper
• Recent advances in the role of neuroregulation in skin wound healing

  2025cites this paper
• High-dimensional mass cytometry reveals stemness state heterogeneity in pancreatic ductal adenocarcinoma

  2024cites this paper
• Bridging tissue repair and epithelial carcinogenesis: epigenetic memory and field cancerization

  2024cites this paper
• Cell death as an architect of adult skin stem cell niches

  2024cites this paper
• Quantitative phase imaging with temporal kinetics predicts hematopoietic stem cell diversity

  2024cites this paper
• Engineered exosomes as a prospective therapy for diabetic foot ulcers

  2024cites this paper
• The TMEM63B Channel Facilitates Intestinal Motility and Enhances Proliferation of Intestinal Stem Cells

  2024cites this paper
• Cellular plasticity and fate determination in gastric carcinogenesis

  2024cites this paper
• Single-cell expression profile of Drosophila ovarian follicle stem cells illuminates spatial differentiation in the germarium

  2023cites this paper
• Tissue memory relies on stem cell priming in distal undamaged areas

  2023cites this paper
• Bioengineered MSC-derived exosomes in skin wound repair and regeneration

  2023cites this paper
• THE ACTIVATION OF THE DERMIS EXTRACELLULAR MATRIX SYNTHESIS AFTER THE THERMAL BURN

  2023cites this paper
• Lifelong tissue memory relies on spatially organised dedicated progenitors located distally from the injury

  2023cites this paper
• Multi-omics analyses identify transcription factor interplay in corneal epithelial fate determination and disease

  2023cites this paper
• Signalling-state dependent drug-tolerance in head and neck squamous cell carcinoma

  2023cites this paper
• Multiplicity of stem cell memories of inflammation and tissue repair in epithelia.

  2023cites this paper
• Phytochemical Screening, Characterization of Bioactive Component from Plant Phragmites Karka (Retz.)Trin Ex Steud.and its Biological Evaluation with Reference to Wound Healing Activity

  2023cites this paper
• Identification of the regulatory circuit governing corneal epithelial fate determination and disease

  2023cites this paper
• Recent updates in nanotechnological advances for wound healing: A narrative review

  2023cites this paper
• Myc-dependent dedifferentiation of Gata6+ epidermal cells resembles reversal of terminal differentiation

  2023cites this paper
• Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin

  2023cites this paper
• “PHRAGMITES KARKA EXTRACT” TO TREAT WOUNDS HEALING REVIEW

  2023cites this paper
• Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus

  2023cites this paper
• Autophagy critically controls skin inflammation and apoptosis-induced stem cell activation

  2023cites this paper
• Cellular Heterogeneity and Plasticity of Skin Epithelial Cells in Wound Healing and Tumorigenesis

  2022cites this paper
• Thermal injury healing in the context of neocollagenogenesis induction: preclinical randomized experimental study

  2022cites this paper
• Homogenic Evaluation for Spatial Distribution in Osteoclast Differentiation

  2022cites this paper
• Sebaceous immunobiology - skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations

  2022cites this paper
• Modelling adult stem cells and their niche in health and disease with epithelial organoids.

  2022cites this paper
• Pgc-1α controls epidermal stem cell fate and skin repair by sustaining NAD+ homeostasis during aging

  2022cites this paper
• Identification of Human Breast Adipose Tissue Progenitors Displaying Distinct Differentiation Potentials and Interactions with Cancer Cells

  2022cites this paper
• Cellular Senescence in Acute and Chronic Wound Repair.

  2022cites this paper
• Determination of expression profiles for Drosophila ovarian Follicle Stem Cells (FSCs) using single-cell RNA sequencing

  2022cites this paper
• Liquid Biopsies: Flowing Biomarkers.

  2022cites this paper
• ARTS, an unusual septin, regulates tumorigenesis by promoting apoptosis.

  2022cites this paper
• Evolution of mechanisms controlling epithelial morphogenesis across animals: new insights from dissociation-reaggregation experiments in the sponge Oscarella lobularis

  2021cites this paper
• Stem and progenitor cells in sebaceous gland development, homeostasis and pathologies

  2021cites this paper
• TEM, SEM, and STEM-based immuno-CLEM workflows offer complementary advantages

  2021cites this paper
• Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development.

  2021cites this paper
• Novel, Fully Characterised Bovine Taste Bud Cells of Fungiform Papillae

  2021cites this paper
• Regenerative Engineering Approaches to Scar-Free Skin Regeneration

  2021cites this paper
• The anti‐apoptotic Bcl‐2 protein regulates hair follicle stem cell function

  2021cites this paper
• Stem cells commit to differentiation following multiple induction events in the Drosophila testis

  2021cites this paper
• A stem cell population at the anorectal junction maintains homeostasis and participates in tissue regeneration

  2021cites this paper
• Nutraceuticals in dermal diseases

  2021cites this paper
• Inflation-collapse dynamics drive patterning and morphogenesis in intestinal organoids.

  2021cites this paper
• Germ cells commit somatic stem cells to differentiation following priming by PI3K/Tor activity in the Drosophila testis

  2021cites this paper
• Epigenomic profiling of stem cells within the pilosebaceous unit identifies PRDM16 as a regulator of sebaceous gland homeostasis

  2021cites this paper
• Nanoscale microenvironment engineering for expanding human hair follicle stem cell and revealing their plasticity

  2021cites this paper
• Universality of clonal dynamics poses fundamental limits to identify stem cell self-renewal strategies

  2020cites this paper
• Tracing the Dynamics of Stem Cell Fate.

  2020cites this paper
• Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development

  2020cites this paper
• Cellular Heterogeneity in Pressure and Growth Emerges from Tissue Topology and Geometry.

  2020cites this paper
• Interplay among p21Waf1/Cip1, MUSASHI-1 and Krüppel-like factor 4 in activation of Bmi1-CreER reserve intestinal stem cells after gamma radiation-induced injury

  2020cites this paper
• Profiling Cell Signaling Networks at Single-cell Resolution

  2020cites this paper
• Visualization of individual cell division history in complex tissues using iCOUNT

  2020cites this paper
• Differential expression of α6 and β1 integrins reveals epidermal heterogeneity at single‐cell resolution

  2020cites this paper
• Hair follicle stem cell progeny heal blisters while pausing skin development

  2020cites this paper
• Universal principles of lineage architecture and stem cell identity in renewing tissues

  2020cites this paper
• Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer

  2020cites this paper
• Single-Cell Chromatin Analysis of Mammary Gland Development Reveals Cell-State Transcriptional Regulators and Lineage Relationships

  2019cites this paper
• Sox10 Regulates Plasticity of Epithelial Progenitors toward Secretory Units of Exocrine Glands

  2019cites this paper
• Adult human pancreatic acinar cells dedifferentiate into an embryonic progenitor-like state in 3D suspension culture

  2019cites this paper
• Skin Tissue Engineering: Methods and Protocols

  2019cites this paper
• Plasticity and Potency of Mammary Stem Cell Subsets During Mammary Gland Development

  2019cites this paper
• Single-cell chromatin accessibility analysis of mammary gland development reveals cell state transcriptional regulators and cellular lineage relationships

  2019cites this paper
• Promotion of Human Epidermal Keratinocyte Expansion in Feeder Cell Co-culture.

  2019cites this paper
• Lobular architecture of human adipose tissue defines the niche and fate of progenitor cells

  2019cites this paper
• Exploring single cells in space and time during tissue development, homeostasis and regeneration

  2019cites this paper
• Epidermal stem cells in wound healing and their clinical applications

  2019cites this paper
• Radial glial cells in the adult dentate gyrus : what are they and where do they come from ?

  2019cites this paper
• Developmental plasticity of epithelial stem cells in tooth and taste bud renewal

  2019cites this paper
• The Simplest Protocol for Rapid and Long-Term Culture of Primary Epidermal Keratinocytes from Human and Mouse.

  2019cites this paper
• Peptide‐Functionalized Hydrogels Modulate Integrin Expression and Stemness in Adult Human Epidermal Keratinocytes

  2019cites this paper
• IRF2 is a master regulator of human keratinocyte stem cell fate

  2019cites this paper
• Investigation of epigenetic regulators important for tumour initiation and maintenance

  2019cites this paper
• Long-Term In Vitro Expansion of Epithelial Stem Cells Enabled by Pharmacological Inhibition of PAK1-ROCK-Myosin II and TGF-β Signaling

  2018cites this paper
• The protein kinase p38α destabilizes p63 to limit epidermal stem cell frequency and tumorigenic potential

  2018cites this paper
• Plasticity of differentiated cells in wound repair and tumorigenesis, part II: skin and intestine

  2018cites this paper
• Identification of dynamic undifferentiated cell states within the male germline

  2018cites this paper
• Human colorectal cancer initiation is bidirectional, and cell growth, metabolic genes and transporter genes are early drivers of tumorigenesis.

  2018cites this paper
• Defining Adult Stem Cells by Function, not by Phenotype.

  2018cites this paper
• Stem cells, niches and scaffolds: Applications to burns and wound care

  2018cites this paper
• Homeostasis, regeneration and tumour formation in the mammalian epidermis.

  2018cites this paper
• A matter of life and death: stem cell survival in tissue regeneration and tumour formation

  2018cites this paper
• Tympanic Membrane Derived Stem Cell-Like Cultures for Tissue Regeneration

  2018cites this paper
• Radial glial cells in the adult dentate gyrus: what are they and where do they come from?

  2018cites this paper
• Decoding the heterogeneity of skin in homeostasis and regeneration at single-cell resolution

  2018cites this paper
• Epidermal aspects of type VII collagen: Implications for dystrophic epidermolysis bullosa and epidermolysis bullosa acquisita

  2018cites this paper
• Risk of Human Papillomavirus Infection in Cancer-Prone Individuals: What We Know

  2018cites this paper
• Hoxc-Dependent Mesench ymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration Graphical

  2018cites this paper
• Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration.

  2018cites this paper
• Cellular heterogeneity in pressure and growth emerges from tissue topology and geometry

  2018cites this paper
• Germline Stem Cell Heterogeneity Supports Homeostasis in Drosophila

  2018cites this paper
• Buried myoepithelial stem cells as a reservoir for repairing the exposed airway epithelium.

  2018cites this paper
• Analysis for the Heterogeneity of Liver Progenitor Cells.

  2018cites this paper