The RAD6 Pathway: Control of DNA Damage Bypass and Mutagenesis by Ubiquitin and SUMO

No abstract is available for this paper.

• Publication year

  2005

• Venue

  ChemBioChem

• Publication date

  2005-10-07

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1002/cbic.200500139PMID 16142820
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Proliferating Cell Nuclear Antigen Promotes Translesion Synthesis by DNA Polymerase ζ*

  2005cited by this paper
• Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p.

  2005cited by this paper
• SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase

  2005cited by this paper
• Differential Regulation of Rad18 through Rad6-dependent Mono- and Polyubiquitination*

  2005cited by this paper
• How to Activate a Damage-Tolerant Polymerase

  2004cited by this paper
• Interaction of hREV1 with three human Y‐family DNA polymerases

  2004cited by this paper
• SUMO: a regulator of gene expression and genome integrity

  2004cited by this paper
• Recombination and mutagenesis in rad6 mutants of Saccharomyces cerevisiae: Evidence for multiple functions of the RAD6 gene

  2004cited by this paper
• Yeast MPH1 gene functions in an error-free DNA damage bypass pathway that requires genes from Homologous recombination, but not from postreplicative repair.

  2004cited by this paper
• Polyubiquitin chains: polymeric protein signals.

  2004cited by this paper
• Rad18 guides polη to replication stalling sites through physical interaction and PCNA monoubiquitination

  2004cited by this paper
• The novel functions of ubiquitination in signaling.

  2004cited by this paper
• SUMO and ubiquitin in the nucleus: different functions, similar mechanisms?

  2004cited by this paper
• How to activate a damage-tolerant polymerase: consequences of PCNA modifications by ubiquitin and SUMO.

  2004cited by this paper
• Switching from high-fidelity replicases to low-fidelity lesion-bypass polymerases.

  2004cited by this paper
• SUMO and transcriptional regulation.

  2004cited by this paper
• Relevance and irrelevance of DNA damage response to radiotherapy.

  2004cited by this paper
• Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage.

  2004cited by this paper
• Regulation of the Fanconi anemia pathway by monoubiquitination.

  2003cited by this paper
• Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins.

  2003cited by this paper
• SUMO: ligases, isopeptidases and nuclear pores.

  2003cited by this paper
• Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation

  2003cited by this paper
• Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis

  2003cited by this paper
• Xeroderma pigmentosum variant and error-prone DNA polymerases.

  2003cited by this paper
• Replication of damaged DNA in mammalian cells: new solutions to an old problem.

  2002cited by this paper
• How DNA lesions are turned into mutations within cells?

  2002cited by this paper
• Natural substrates of the proteasome and their recognition by the ubiquitin system.

  2002cited by this paper
• Histone ubiquitination: a tagging tail unfolds?

  2002cited by this paper
• Error-prone repair DNA polymerases in prokaryotes and eukaryotes.

  2002cited by this paper
• Recombinational repair and restart of damaged replication forks

  2002cited by this paper
• Degradation or Maintenance: Actions of the Ubiquitin System on Eukaryotic Chromatin

  2002cited by this paper
• Roles of mouse UBC13 in DNA postreplication repair and Lys63-linked ubiquitination.

  2002cited by this paper
• Identification of a protein essential for a major pathway used by human cells to avoid UV- induced DNA damage

  2002cited by this paper
• Eukaryotic DNA polymerases.

  2002cited by this paper
• The nonmutagenic repair of broken replication forks via recombination.

  2002cited by this paper
• RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO

  2002cited by this paper
• Genome maintenance mechanisms for preventing cancer

  2001cited by this paper
• Managing DNA polymerases: Coordinating DNA replication, DNA repair, and DNA recombination

  2001cited by this paper
• Molecular cloning and functional characterization of two murine cDNAs which encode Ubc variants involved in DNA repair and mutagenesis.

  2001cited by this paper
• Mutations in recombinational repair and in checkpoint control genes suppress the lethal combination of srs2Delta with other DNA repair genes in Saccharomyces cerevisiae.

  2001cited by this paper
• The Y-family of DNA polymerases.

  2001cited by this paper
• DNA damage-induced mutagenesis : a novel target for cancer prevention.

  2001cited by this paper
• The srs2 suppressor of UV sensitivity acts specifically on the RAD5- and MMS2-dependent branch of the RAD6 pathway.

  2001cited by this paper
• Rescue of arrested replication forks by homologous recombination

  2001cited by this paper
• Mutagenesis in eukaryotes dependent on DNA polymerase zeta and Rev1p.

  2001cited by this paper
• Two RING finger proteins mediate cooperation between ubiquitin‐conjugating enzymes in DNA repair

  2000cited by this paper
• SUMO--nonclassical ubiquitin.

  2000cited by this paper
• RING finger proteins: mediators of ubiquitin ligase activity.

  2000cited by this paper
• Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases

  2000cited by this paper
• Lesions in DNA: hurdles for polymerases.

  2000cited by this paper
• Characterization of mRAD18Sc, a mouse homolog of the yeast postreplication repair gene RAD18.

  2000cited by this paper
• Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain.

  2000cited by this paper
• The puzzle of PCNA's many partners

  2000cited by this paper
• The ubiquitin system

  2000cited by this paper
• Evolution and function of ubiquitin-like protein-conjugation systems

  2000cited by this paper
• Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens.

  2000cited by this paper
• A radical solution to death

  2000cited by this paper
• The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases.

  2000cited by this paper
• Novel DNA polymerases offer clues to the molecular basis of mutagenesis.

  1999cited by this paper
• A plethora of lesion-replicating DNA polymerases.

  1999cited by this paper
• Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair.

  1999cited by this paper
• SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation.

  1998cited by this paper
• The ubiquitin system.

  1998cited by this paper
• MMS2, encoding a ubiquitin-conjugating-enzyme-like protein, is a member of the yeast error-free postreplication repair pathway.

  1998cited by this paper
• Yeast DNA Repair Proteins Rad6 and Rad18 Form a Heterodimer That Has Ubiquitin Conjugating, DNA Binding, and ATP Hydrolytic Activities*

  1997cited by this paper
• Proliferating cell nuclear antigen: More than a clamp for DNA polymerases

  1997cited by this paper
• The RAD5 gene product is involved in the avoidance of non-homologous end-joining of DNA double strand breaks in the yeast Saccharomyces cerevisiae.

  1997cited by this paper
• Ubiquitin Lys63 is involved in ubiquitination of a yeast plasma membrane protein

  1997cited by this paper
• Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA.

  1995cited by this paper
• Differential replication of a single, UV-induced lesion in the leading or lagging strand by a human cell extract: fork uncoupling or gap formation.

  1995cited by this paper
• A ubiquitin mutant with specific defects in DNA repair and multiubiquitination

  1995cited by this paper
• Yeast DNA repair protein RAD5 that promotes instability of simple repetitive sequences is a DNA-dependent ATPase.

  1994cited by this paper
• Specific complex formation between yeast RAD6 and RAD18 proteins: a potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites.

  1994cited by this paper
• The RAD6 DNA repair pathway in Saccharomyces cerevisiae: What does it do, and how does it do it?

  1994cited by this paper
• Purification and characterization of the SRS2 DNA helicase of the yeast Saccharomyces cerevisiae.

  1993cited by this paper
• Saccharomyces cerevisiae RAD5-encoded DNA repair protein contains DNA helicase and zinc-binding sequence motifs and affects the stability of simple repetitive sequences in the genome

  1992cited by this paper
• A similar defect in UV-induced mutagenesis conferred by the rad6 and rad18 mutations of Saccharomyces cerevisiae.

  1991cited by this paper
• The hyper-gene conversion hpr5-1 mutation of Saccharomyces cerevisiae is an allele of the SRS2/RADH gene.

  1991cited by this paper
• Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6.

  1991cited by this paper
• The SRS2 suppressor of rad6 mutations of Saccharomyces cerevisiae acts by channeling DNA lesions into the RAD52 DNA repair pathway.

  1990cited by this paper
• A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein.

  1989cited by this paper
• RADH, a gene of Saccharomyces cerevisiae encoding a putative DNA helicase involved in DNA repair. Characteristics of radH mutants and sequence of the gene.

  1989cited by this paper
• The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme

  1987cited by this paper
• DNA synthesis in UV-irradiated yeast.

  1981cited by this paper
• Metabolic suppressors of trimethoprim and ultraviolet light sensitivities of Saccharomyces cerevisiae rad6 mutants

  1979cited by this paper
• UV mutagenesis in radiation-sensitive strains of yeast.

  1976cited by this paper
• Lack of chemically induced mutation in repair-deficient mutants of yeast.

  1974cited by this paper
• The isolation, genetics and survival characteristics of ultraviolet light-sensitive mutants in yeast.

  1968cited by this paper

• Opposing regulation by Rev1 of DNA polymerase zeta activity on damaged versus undamaged DNA

  2026cites this paper
• Mechanism and regulation of secondary immunoglobulin diversification

  2023cites this paper
• RAD6 inhibition enhances paclitaxel sensitivity of triple negative breast cancer cells by aggravating mitotic spindle damage

  2022cites this paper
• PARP1 recruits DNA translocases to restrain DNA replication and facilitate DNA repair

  2022cites this paper
• A Genome-Wide Screen for Genes Affecting Spontaneous Direct-Repeat Recombination in Saccharomyces cerevisiae

  2020cites this paper
• The HLTF–PARP1 interaction in the progression and stability of damaged replication forks caused by methyl methanesulfonate

  2020cites this paper
• RAD6B is a major mediator of triple negative breast cancer cisplatin resistance: Regulation of translesion synthesis/Fanconi anemia crosstalk and BRCA1 independence.

  2020cites this paper
• Mutating for Good: DNA Damage Responses During Somatic Hypermutation

  2019cites this paper
• Title Rapid unwinding of triplet repeat hairpins by Srs 2 helicase ofSaccharomyces cerevisiae

  2018cites this paper
• Genetic analysis reveals functions of atypical polyubiquitin chains

  2018cites this paper
• Ubiquitin‐conjugating enzyme E2 B regulates the ubiquitination of O6‐methylguanine‐DNA methyltransferase and BCNU sensitivity in human nasopharyngeal carcinoma cells

  2018cites this paper
• Host factors that promote retrotransposon integration are similar in distantly related eukaryotes

  2017cites this paper
• Functions of SUMO in the Maintenance of Genome Stability.

  2017cites this paper
• Pharmacological targeting of RAD6 enzyme-mediated translesion synthesis overcomes resistance to platinum-based drugs

  2017cites this paper
• AtRAD5A is a DNA translocase harboring a HIRAN domain which confers binding to branched DNA structures and is required for DNA repair in vivo.

  2016cites this paper
• Telomere Capping Protein Stn1p Require the RAD6-Mediated Ubiquitination Pathway for DNA Repair and Function in Global DNA Replication

  2016cites this paper
• RAD18 polymorphisms are associated with platinum-based chemotherapy toxicity in Chinese patients with non-small cell lung cancer

  2016cites this paper
• Annexin A1 localization and its relevance to cancer.

  2016cites this paper
• Geminivirale Infektion in Interaktion mit DNA-Reparatur- und Schadenstoleranz

  2015cites this paper
• Crosstalk between translesion synthesis, Fanconi anemia network, and homologous recombination repair pathways in interstrand DNA crosslink repair and development of chemoresistance.

  2015cites this paper
• Impaired mitochondrial Fe-S cluster biogenesis activates the DNA damage response through different signaling mediators

  2015cites this paper
• Chronic treatment with cisplatin induces replication-dependent sister chromatid recombination to confer cisplatin-resistant phenotype in nasopharyngeal carcinoma

  2014cites this paper
• An investigation into the function of the SUMOylation of Nse2 and PCNA in S. pombe

  2014cites this paper
• Dietary flavonoids bind to mono-ubiquitinated annexin A1 in nuclei, and inhibit chemical induced mutagenesis.

  2014influential citation
• Análisis del papel de los componentes de la ruta RAD6/RAD18 de Saccharomyces cerevisiae en la tolerancia al daño en el DNA durante la replicación cromosómica

  2014cites this paper
• Genomic stability disorders: from budding yeast to humans.

  2013cites this paper
• Cell individuality in adhesin expression of Candida glabrata

  2012influential citation
• Genome instability induced by structured DNA and replication fork restart

  2012cites this paper
• Chronic low-dose ultraviolet-induced mutagenesis in nucleotide excision repair-deficient cells

  2012cites this paper
• Replication-independent repair of DNA interstrand crosslinks.

  2012influential citation
• Mono-Ubiquitination of Nuclear Annexin A1 and Mutagenesis

  2012influential citation
• Proteins that modulate trinucleotide repeat expansions in human cells

  2012cites this paper
• Identification and Functional Studies of Arabidopsis thaliana Ubc13-interacting E3 Ubiquitin Ligases

  2012cites this paper
• DNA repair defects sensitize cells to anticodon nuclease yeast killer toxins

  2011cites this paper
• Clearance of roadblocks in replication fork restart

  2011cites this paper
• Characterization and expression analysis of the SNF2 family genes in response to phytohormones and abiotic stresses in rice

  2011cites this paper
• Tumour suppressor ING1b maintains genomic stability upon replication stress

  2011cites this paper
• Human RAD18 Interacts with Ubiquitylated Chromatin Components and Facilitates RAD9 Recruitment to DNA Double Strand Breaks

  2011cites this paper
• Regulation of tolerance to DNA alkylating damage by Dot1 and Rad53 in Saccharomyces cerevisiae.

  2010cites this paper
• Ubc13 dosage is critical for immunoglobulin gene conversion and gene targeting in vertebrate cells

  2010cites this paper
• Meiotic and mitotic functions of mammalian RAD 18 in DNA double-strand break repair

  2010cites this paper
• Carcinogenic heavy metals replace Ca2+ for DNA binding and annealing activities of mono-ubiquitinated annexin A1 homodimer.

  2010cites this paper
• Photosensitization induced by the antibacterial fluoroquinolone Rufloxacin leads to mutagenesis in yeast.

  2010cites this paper
• 1 Regulation of Tolerance to DNA Alkylating Damage by Dot 1 and Rad 53 in Saccharomyces cerevisiae

  2010cites this paper
• The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages

  2010cites this paper
• Genetic evidence for a role of Saccharomyces cerevisiae Mph1 in recombinational DNA repair under replicative stress

  2010cites this paper
• The Smc5/6 Complex and Esc2 Influence Multiple Replication-associated Recombination Processes in Saccharomyces cerevisiae

  2010cites this paper
• Ubiquitylation of the 9-1-1 checkpoint clamp is independent of rad6-rad18 and DNA damage.

  2010cites this paper
• Ubiquitination and SUMOylation of annexin A1 and helicase activity.

  2010cites this paper
• PCNA monoubiquitylation and DNA polymerase η ubiquitin-binding domain are required to prevent 8-oxoguanine-induced mutagenesis in Saccharomyces cerevisiae

  2009influential citation
• Control of histone methylation and genome stability by PTIP

  2009cites this paper
• Biochemical characterisation of the SWI/SNF family member HLTF.

  2009cites this paper
• The Fanconi anemia protein interaction network: casting a wide net.

  2009cites this paper
• Two proteolytic pathways regulate DNA repair by cotargeting the Mgt1 alkylguanine transferase

  2009cites this paper
• The Probability to Initiate X Chromosome Inactivation Is Determined by the X to Autosomal Ratio and X Chromosome Specific Allelic Properties

  2009cites this paper
• RAD6–RAD18–RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light

  2009cites this paper
• The Saccharomyces cerevisiae Rad6 Postreplication Repair and Siz1/Srs2 Homologous Recombination-Inhibiting Pathways Process DNA Damage That Arises in asf1 Mutants

  2009cites this paper
• Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

  2009cites this paper
• PCNA on the crossroad of cancer.

  2009cites this paper
• Ubiquitin recognition by ubiquitin-binding domains in Y-family DNA polymerases

  2009cites this paper
• Control of genome stability by SLX protein complexes.

  2009cites this paper
• Regulating post-translational modifications of the eukaryotic replication clamp PCNA.

  2009cites this paper
• X chromosome inactivation: Activation of Silencing

  2009cites this paper
• Dynamic localization of human RAD18 during the cell cycle and a functional connection with DNA double-strand break repair.

  2009cites this paper
• Ubiquitylation of proliferating cell nuclear antigen and recruitment of human DNA polymerase eta.

  2008cites this paper
• Snf2 proteins in plants: gene silencing and beyond.

  2008cites this paper
• Rad53 regulates replication fork restart after DNA damage in Saccharomyces cerevisiae.

  2008cites this paper
• hMMS2 serves a redundant role in human PCNA polyubiquitination

  2008cites this paper
• Activation of Ubiquitin-Dependent DNA Damage Bypass Is Mediated by Replication Protein A

  2008cites this paper
• Role of Dot1 in the Response to Alkylating DNA Damage in Saccharomyces cerevisiae: Regulation of DNA Damage Tolerance by the Error-Prone Polymerases Polζ/Rev1

  2008cites this paper
• Rapid unwinding of triplet repeat hairpins by Srs2 helicase of Saccharomyces cerevisiae

  2008cites this paper
• Saccharomyces cerevisiae Rad 53 regulates replication fork restart after DNA damage in data

  2008cites this paper
• SUMO modification of PCNA is controlled by DNA

  2008cites this paper
• Regulation of double-stranded DNA gap repair by the RAD6 pathway.

  2008cites this paper
• Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks

  2008cites this paper
• Cooperation of replication Protein A with the ubiquitin ligase Rad18 in DNA damage bypass

  2008cites this paper
• A Homolog of ScRAD5 Is Involved in DNA Repair and Homologous Recombination in Arabidopsis1[W]

  2008cites this paper
• DNA damage tolerance : from error free UV-damage bypass to mutagenesis of immunoglobulin genes

  2008cites this paper
• Human REV3L: Expression and protein interaction studies

  2007cites this paper
• A mutation in EXO1 defines separable roles in DNA mismatch repair and post-replication repair.

  2007cites this paper
• Meiosis and small ubiquitin‐related modifier (SUMO)‐conjugating enzyme, Ubc9

  2007cites this paper
• Analysis of the role of Rad5 for the regulation of repair of DSB, small deletions and oxidative damage

  2007cites this paper
• PCNASUMO and Srs2: a model SUMO substrate-effector pair.

  2007cites this paper
• The mammalian N-end rule pathway: new insights into its components and physiological roles.

  2007cites this paper
• Phosphorylation of Slx4 by Mec1 and Tel1 Regulates the Single-Strand Annealing Mode of DNA Repair in Budding Yeast

  2007influential citation
• Conservation of DNA damage tolerance pathways from yeast to humans.

  2007cites this paper
• Gam1-associated alterations of drug responsiveness through activation of apoptosis

  2007cites this paper
• A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification

  2007cites this paper
• Funções da proteína Pso9/Mec3 no controle do ciclo celular e reparação de DNA em Saccharomyces cerevisiae

  2006cites this paper
• Mms2–Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation

  2006cites this paper
• Postreplication repair and PCNA modification in Schizosaccharomyces pombe.

  2006cites this paper
• Postreplication Repair Inhibits CAG · CTG Repeat Expansions in Saccharomyces cerevisiae

  2006cites this paper
• Role of SUMO/Ubc9 in DNA Damage Repair and Tumorigenesis

  2006cites this paper
• Mgs1 and Rad18/Rad5/Mms2 are required for survival of Saccharomyces cerevisiae mutants with novel temperature/cold sensitive alleles of the DNA polymerase delta subunit, Pol31.

  2006cites this paper
• Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination

  2006cites this paper
• ADAPTIVE MUTAGENESIS IN THE YEAST SACCHAROMYCES CEREVISIAE

  2006cites this paper
• False Moves for Survival: Error-Prone DNA Repair in Adaptive Immunity

  2006cites this paper
• Saccharomyces cerevisiae DNA helicases Mph1, Srs2 and Sgs1 collaborate for the reinitiation of stalled or collapsed replication forks

  2006cites this paper
• Roles of DNA polymerases in replication, repair, and recombination in eukaryotes.

  2006cites this paper
• Involvement of Rad18 in somatic hypermutation

  2006cites this paper