Downregulation of endothelial cell thrombospondin 1 enhances in vitro angiogenesis.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Journal of Vascular Research

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1159/000319585PMID 7511943
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characterization of mouse thrombospondin 2 sequence and expression during cell growth and development.

  1992cited by this paper
• Reorganization of basement membrane matrices by cellular traction promotes the formation of cellular networks in vitro.

  1992cited by this paper
• Thrombospondin II: partial cDNA sequence, chromosome location, and expression of a second member of the thrombospondin gene family in humans.

  1992cited by this paper
• Thrombospondin exerts an antiangiogenic effect on cord formation by endothelial cells in vitro.

  1991cited by this paper
• Extracellular matrix and cell shape: Potential control points for inhibition of angiogenesis

  1991cited by this paper
• Differential expression of extracellular proteins is correlated with angiogenesis in vitro.

  1991cited by this paper
• Extracellular proteins that modulate cell-matrix interactions. SPARC, tenascin, and thrombospondin.

  1991cited by this paper
• A second, expressed thrombospondin gene (Thbs2) exists in the mouse genome.

  1991cited by this paper
• A second thrombospondin gene in the mouse is similar in organization to thrombospondin 1 but does not respond to serum.

  1991cited by this paper
• Focal adhesion integrity is downregulated by the alternatively spliced domain of human tenascin [published erratum appears in J Cell Biol 1992 Feb;116(3):833]

  1991cited by this paper
• Characterization of the murine thrombospondin gene.

  1991cited by this paper
• A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

  1990cited by this paper
• Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro

  1990cited by this paper
• A simple method for subcloning DNA fragments from gel slices.

  1990cited by this paper
• Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: a potential angiogenesis regulatory factor

  1990cited by this paper
• Modulation of microvascular growth and morphogenesis by reconstituted basement membrane gel in three-dimensional cultures of rat aorta: A comparative study of angiogenesis in Matrigel, collagen, fibrin, and plasma clot

  1990cited by this paper
• Specific inhibition of endothelial cell proliferation by thrombospondin.

  1990cited by this paper
• Thrombospondin gene expression by endothelial cells in culture is modulated by cell proliferation, cell shape and the substratum.

  1990cited by this paper
• Thrombospondin modulates focal adhesions in endothelial cells

  1989cited by this paper
• Two different laminin domains mediate the differentiation of human endothelial cells into capillary-like structures in vitro.

  1989cited by this paper
• How does extracellular matrix control capillary morphogenesis?

  1989cited by this paper
• Regulation of the activity of a new inhibitor of angiogenesis by a cancer suppressor gene.

  1989cited by this paper
• SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix

  1989cited by this paper
• Complete thrombospondin mRNA sequence includes potential regulatory sites in the 3' untranslated region

  1989cited by this paper
• Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: role of extracellular matrix

  1989cited by this paper
• Changes in the vascular extracellular matrix during embryonic vasculogenesis and angiogenesis.

  1988cited by this paper
• Phenotypic modulation of endothelial cells by transforming growth factor-beta depends upon the composition and organization of the extracellular matrix

  1988cited by this paper
• Thrombospondin inhibits adhesion of endothelial cells.

  1988cited by this paper
• Interactions of Thrombospondin with Cells in Culture: Rapid Degradation of Both Soluble and Matrix Thrombospondin

  1987cited by this paper
• Phorbol ester induces cultured endothelial cells to invade a fibrin matrix in the presence of fibrinolytic inhibitors

  1987cited by this paper
• Thrombospondin promotes cell-substratum adhesion.

  1987cited by this paper
• Thrombospondin in early human wound tissue.

  1987cited by this paper
• Thrombospondin: a modular adhesive glycoprotein of platelets and nucleated cells

  1987cited by this paper
• Angiogenic factors.

  1987cited by this paper
• Basic fibroblast growth factor induces angiogenesis in vitro.

  1986cited by this paper
• Critical factors controlling angiogenesis: cell products, cell matrix, and growth factors.

  1986cited by this paper
• Endothelial cell proliferation during angiogenesis. In vitro modulation by basement membrane components.

  1986cited by this paper
• Endothelial cell-matrix interactions: in vitro models of angiogenesis.

  1986cited by this paper
• The structural and functional properties of thrombospondin.

  1986cited by this paper
• Vascular outgrowths from tissue explants embedded in fibrin or collagen gels: a simple in vitro model of angiogenesis.

  1985cited by this paper
• In vitro rapid organization of endothelial cells into capillary-like networks is promoted by collagen matrices

  1983cited by this paper
• A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

  1983cited by this paper
• Capillary endothelial cell cultures: phenotypic modulation by matrix components

  1983cited by this paper
• Angiogenesis in vitro

  1980cited by this paper
• Selection and characterization of bovine aortic endothelial cells

  1978cited by this paper

• Developments in Extracellular Matrix-Based Angiogenesis Therapy for Ischemic Heart Disease: A Review of Current Strategies, Methodologies and Future Directions

  2025cites this paper
• Current Status of Tissue Regenerative Engineering for the Treatment of Uterine Infertility

  2023cites this paper
• Pericardial Adipose Tissue Thrombospondin-1 Associates With Antiangiogenesis in Ischemic Heart Disease.

  2023cites this paper
• Adipokines in atherosclerosis: unraveling complex roles

  2023cites this paper
• Thrombospondins in human aortic aneurysms

  2022cites this paper
• Thrombospondin-1 Levels in Patients with Coronary Heart Disease

  2021cites this paper
• Extracellular matrices derived from different cell sources and their effect on macrophage behavior and wound healing.

  2020cites this paper
• H19/TET1 axis promotes TGF‐β signaling linked to endothelial‐to‐mesenchymal transition

  2020cites this paper
• Transplantation of Human Amnion Epithelial Cells Improves Endometrial Regeneration in Rat Model of Intrauterine Adhesions

  2020cites this paper
• Role of thrombospondin-1 and thrombospondin-2 in cardiovascular diseases (Review)

  2020cites this paper
• Regulation of cell behavior by extracellular proteins

  2020cites this paper
• Thrombospondin-4 (TSP4) gene-modified bone marrow stromal cells (BMSCs) promote the effect of therapeutic angiogenesis in critical limb ischemia (CLI) of diabetic rats.

  2019cites this paper
• Kaempferol targets estrogen-related receptor α and suppresses the angiogenesis of human retinal endothelial cells under high glucose conditions.

  2017cites this paper
• Transcriptional and Post-Transcriptional Regulation of Thrombospondin-1 Expression: A Computational Model

  2017cites this paper
• MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease

  2016cites this paper
• Asthma is not only an airway disease, but also a vascular disease.

  2015cites this paper
• Proangiogenic Properties of Thrombospondin-4

  2015cites this paper
• ADAMTS13 and Angiogenesis

  2015cites this paper
• ADAMTS-7 Inhibits Re-endothelialization of Injured Arteries and Promotes Vascular Remodeling Through Cleavage of Thrombospondin-1

  2015influential citation
• Macrophage heterogeneity in neovascularization

  2014cites this paper
• Adrenomedullin22-52 suppresses high-glucose-induced migration, proliferation, and tube formation of human retinal endothelial cells

  2014cites this paper
• Untersuchung neuartiger Substanzen auf antineoplastische und antiangiogene Eigenschaften beim testikulären Keimzelltumor

  2013cites this paper
• The unfolded protein response induces the angiogenic switch in human tumor cells through the PERK/ATF4 pathway.

  2012cites this paper
• The critical role of vascular endothelial growth factor in tumor angiogenesis.

  2012cites this paper
• ANGIOGENESIS AND TUMOR

  2011cites this paper
• Glucose and insulin modify thrombospondin 1 expression and secretion in primary adipocytes from diet-induced obese rats

  2011cites this paper
• ANGIOGENESIS AND THE MODELS TO STUDY ANGIOGENESIS

  2010cites this paper
• The role of keratinocyte alpha v beta6 integrin in the regulation of transforming growth factor beta during wound healing

  2010cites this paper
• PEDF – A Noninhibitory Serpin with Neurotrophic Activity

  2010cites this paper
• Expression of Integrin αvβ6 and TGF-β in Scarless vs Scar-forming Wound Healing

  2009cites this paper
• Untersuchungen zur antiangiogenen Aktivität des matrizellulären Proteins Thrombospondin-2

  2008cites this paper
• Capillary sprout endothelial cells exhibit a CD36 low phenotype: regulation by shear stress and vascular endothelial growth factor-induced mechanism for attenuating anti-proliferative thrombospondin-1 signaling.

  2008cites this paper
• Cell Type-specific Post-transcriptional Regulation of Production of the Potent Antiangiogenic and Proatherogenic Protein Thrombospondin-1 by High Glucose*

  2008cites this paper
• CCAAT box is required for the induction of human thrombospondin‐1 gene by trichostatin A

  2008cites this paper
• Chapter Thirteen – Regulation of Cell Behavior by Extracellular Proteins

  2007cites this paper
• Thrombospondin 1, thrombospondin 2 and the eye.

  2006cites this paper
• Angiogenesis and the inception of pregnancy

  2006cites this paper
• Angiogenic Factors and Angiogenesis Inhibitors in Exudative Pleural Effusions

  2005cites this paper
• Wound healing: findings of the 2005 AAOMS Research Summit.

  2005cites this paper
• Activation of Latent TGF-β1 by Thrombospondin-1 is a Major Component of Wound Repair.

  2005cites this paper
• Regulation of vascular genes by glucose.

  2005cites this paper
• Estudio de la angiogénesis en la patología pleural y su asociación con los marcadores de actividad neutrofílica, el sistema de la fibrinolisis y la matriz extracelular

  2005cites this paper
• The modulation of thrombospondin and other naturally occurring inhibitors of angiogenesis during tumor progression

  2004cites this paper
• Effects of levonorgestrel, medroxyprogesterone acetate, norethindrone, and 17beta-estradiol on vascular endothelial growth factor isomers 121 and 165 in Ishikawa cells.

  2004cites this paper
• RESEARCH REVIEW The Role of Thrombospondin-1 in Human Disease 1

  2004cites this paper
• Effect of tibolone and its metabolites on vascular endothelial growth factor isoforms 121 and 165 and thrombospondin-1 mRNA in Ishikawa cells

  2004cites this paper
• The role of thrombospondin-1 in human disease.

  2004cites this paper
• Effects of mifepristone on vascular endothelial growth factor and thrombospondin-1 mRNA in Ishikawa cells: implication for the endometrial effects of mifepristone.

  2004cites this paper
• Angiogenesis in arthritis: role in disease pathogenesis and as a potential therapeutic target

  2004cites this paper
• Effects of levonorgestrel, medroxyprogesterone acetate, norethindrone, progesterone, and 17beta-estradiol on thrombospondin-1 mRNA in Ishikawa cells.

  2004cites this paper
• Angiogenesis in rheumatoid arthritis: implications for future therapeutic strategies

  2004cites this paper
• Expression of the type-1 repeats of thrombospondin-1 inhibits tumor growth through activation of transforming growth factor-beta.

  2004cites this paper
• Role of endothelial cell survival and death signals in angiogenesis

  2004influential citation
• Reduced Expression of the TSP1 Gene and Its Association with Promoter Hypermethylation in Gastric Carcinoma

  2003cites this paper
• Thrombospondins 1 and 2 function as inhibitors of angiogenesis.

  2003cites this paper
• An N-terminal 80 kDa recombinant fragment of human thrombospondin-2 inhibits vascular endothelial growth factor induced endothelial cell migration in vitro and tumor growth and angiogenesis in vivo.

  2003cites this paper
• Temporal Profile of Angiogenesis and Expression of Related Genes in the Brain after Ischemia

  2003cites this paper
• Effect of raloxifene, 17beta-estradiol, and progesterone on mRNA for vascular endothelial growth factor isoforms 121 and 165 and thrombospondin-1 in Ishikawa cells.

  2003cites this paper
• Role of Vascular Endothelial Growth Factor in Bone Marrow Stromal Cell Modulation of Endothelial Cells

  2003cites this paper
• Differential angiogenic and proliferative activity of surgical and burn wound fluids.

  2003cites this paper
• Anti-angiogenic agents for the treatment of brain tumors.

  2002cites this paper
• Regulation of Vascular Morphogenesis by Extracellular Matrix Proteins

  2002cites this paper
• Reduced expression of thrombospondin-1 correlates with a poor prognosis in patients with non-small cell lung cancer.

  2002cites this paper
• Thrombospondin 2 Inhibits Microvascular Endothelial Cell Proliferation by a Caspase-independent Mechanism

  2002cites this paper
• Angiogenesis and metastasis.

  2002cites this paper
• In vivo mechanisms by which tumors producing thrombospondin 1 bypass its inhibitory effects.

  2001cites this paper
• Decorin inhibits endothelial migration and tube-like structure formation: role of thrombospondin-1.

  2001cites this paper
• Steroids and cytokines in endometrial angiogenesis.

  2001cites this paper
• In Vitro Models of Vasculogenesis and Angiogenesis

  2001cites this paper
• MINIREVIEW In Vitro Models of Vasculogenesis and Angiogenesis

  2001cites this paper
• Angiogenesis in head and neck squamous cell carcinoma.

  2000cites this paper
• Thrombospondin-1 Induces Endothelial Cell Apoptosis and Inhibits Angiogenesis by Activating the Caspase Death Pathway

  2000cites this paper
• Thrombospondins and Angiogenesis

  2000cites this paper
• CHAPTER 11 – REGULATION OF CELL BEHAVIOR BY MATRICELLULAR PROTEINS

  2000cites this paper
• Expression and characterization of novel thrombospondin 1 type I repeat fusion proteins.

  2000cites this paper
• Anti-angiogenic Treatment Strategies for Malignant Brain Tumors

  2000cites this paper
• Thrombospondin as an Inhibitor of Angiogenesis

  1999cites this paper
• Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression.

  1999cites this paper
• Tumor suppression in human skin carcinoma cells by chromosome 15 transfer or thrombospondin-1 overexpression through halted tumor vascularization.

  1999cites this paper
• Expression of thrombospondin-1 in ischemia-induced retinal neovascularization.

  1999influential citation
• Methylation and silencing of the Thrombospondin-1 promoter in human cancer

  1999cites this paper
• Role of thrombospondin-1-derived peptide, 4N1K, in FGF-2-induced angiogenesis.

  1999cites this paper
• The Wilms' tumor gene product represses the transcription of thrombospondin 1 in response to overexpression of c-Jun

  1999cites this paper
• Contribution of the Extracellular Matrix and Macrophages in Angiogenesis

  1999cites this paper
• Effects of thrombospondin-1 on disease course and angiogenesis in rat adjuvant-induced arthritis.

  1998cites this paper
• Exposure of the cryptic Arg-Gly-Asp sequence in thrombospondin-1 by protein disulfide isomerase.

  1998cites this paper
• Antiangiogenic agents in cancer therapy

  1998influential citation
• Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing.

  1998cites this paper
• Angiogenesis in Rheumatoid Arthritis: Pathogenic and Clinical Significance

  1998cites this paper
• Thrombospondin-1 suppresses tumorigenesis and angiogenesis in serum- and anchorage-independent NIH 3T3 cells.

  1997cites this paper
• Induction of activating transcription factor 1 by nickel and its role as a negative regulator of thrombospondin I gene expression.

  1997cites this paper
• Thrombospondin as a regulator of angiogenesis.

  1997cites this paper
• Role of the macrophage in angiogenesis-dependent diseases.

  1997cites this paper
• Angiogenesis inhibitor SR 25989 upregulates thrombospondin-1 expression in human vascular endothelial cells and foreskin fibroblasts.

  1997cites this paper
• Expression of interleukin‐1β in human breast carcinoma

  1997cites this paper
• Inhibition of malignant angiogenesis.

  1997cites this paper
• Angiogenesis inhibitor SR 25989 upregulates thrombospondin‐1 expression in human vascular endothelial cells and foreskin fibroblasts

  1997cites this paper
• The 140-kilodalton antiangiogenic fragment of thrombospondin-1 binds to basic fibroblast growth factor.

  1997cites this paper
• Thrombospondin-1 modulates angiogenesis in vitro by up-regulation of matrix metalloproteinase-9 in endothelial cells.

  1997cites this paper
• CD36 Mediates the In Vitro Inhibitory Effects of Thrombospondin-1 on Endothelial Cells

  1997cites this paper