Regulation of beta-globin gene expression: straightening out the locus.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Current Opinion in Genetics and Development

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 8791532
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Transcriptional enhancers act in cis to suppress position-effect variegation.

  1996cited by this paper
• Locus Control Region Function and Heterochromatin-Induced Position Effect Variegation

  1996cited by this paper
• Age-dependent silencing of globin transgenes in the mouse.

  1996cited by this paper
• Analysis of mice containing a targeted deletion of beta-globin locus control region 5' hypersensitive site 3

  1996cited by this paper
• Effect of deletion of 5'HS3 or 5'HS2 of the human beta-globin locus control region on the developmental regulation of globin gene expression in beta-globin locus yeast artificial chromosome transgenic mice.

  1996cited by this paper
• Enhancers increase the probability but not the level of gene expression.

  1995cited by this paper
• Synergistic regulation of human beta-globin gene switching by locus control region elements HS3 and HS4.

  1995cited by this paper
• Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.

  1995cited by this paper
• Chromatin complexes regulating gene expression in Drosophila.

  1995cited by this paper
• Regulation of globin gene expression in erythroid cells.

  1995cited by this paper
• Transcription complex stability and chromatin dynamics in vivo

  1995cited by this paper
• Position-dependent variegation of globin transgene expression in mice.

  1995cited by this paper
• Participation of the Human β-Globin Locus Control Region in Initiation of DNA Replication

  1995cited by this paper
• Established epigenetic modifications determine the expression of developmentally regulated globin genes in somatic cell hybrids

  1995cited by this paper
• Red cell dimorphism in a young man with a constitutional chromosomal translocation t(11;22)(p15.5;q11.21)

  1994cited by this paper
• Developmental regulation of human gamma- and beta-globin genes in the absence of the locus control region.

  1994cited by this paper
• Dynamic changes in the higher-level chromatin organization of specific sequences revealed by in situ hybridization to nuclear halos

  1994cited by this paper
• Analysis of the developmental and transcriptional potentiation functions of 5'HS2 of the murine beta-globin locus control region in transgenic mice.

  1994cited by this paper
• Local domains of supercoiling activate a eukaryotic promoter in vivo

  1993cited by this paper
• Each hypersensitive site of the human beta-globin locus control region confers a different developmental pattern of expression on the globin genes.

  1993cited by this paper
• Developmental regulation of human gamma-globin genes in transgenic mice

  1993cited by this paper
• Developmental regulation of human beta-globin gene transcription: a switch of loyalties?

  1993cited by this paper
• Identification of a stage selector element in the human gamma‐globin gene promoter that fosters preferential interaction with the 5′ HS2 enhancer when in competition with the beta‐promoter.

  1992cited by this paper
• Physical mapping of yeast artificial chromosomes containing sequences from the human beta-globin gene region.

  1991cited by this paper
• Importance of globin gene order for correct developmental expression.

  1991cited by this paper
• Functional properties of the beta-globin locus control region in K562 erythroleukemia cells.

  1991cited by this paper
• Definition of the minimal requirements within the human beta‐globin gene and the dominant control region for high level expression.

  1990cited by this paper
• Conservation of the primary structure, organization, and function of the human and mouse beta-globin locus-activating regions.

  1990cited by this paper
• Control of globin gene transcription.

  1990cited by this paper
• Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice

  1990cited by this paper
• A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus.

  1990cited by this paper
• Human gamma- to beta-globin gene switching in transgenic mice.

  1990cited by this paper
• DNaseI hypersensitive sites 1, 2 and 3 of the human beta-globin dominant control region direct position-independent expression.

  1990cited by this paper
• A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice.

  1989cited by this paper
• An erythroid-specific, developmental-stage-independent enhancer far upstream of the human "beta-like globin" genes.

  1989cited by this paper
• Molecular analysis of the human beta-globin locus activation region.

  1989cited by this paper
• Gamma delta beta-thalassemia due to a de novo mutation deleting the 5' beta-globin gene activation-region hypersensitive sites.

  1989cited by this paper
• An enhancer stimulates transcription in trans when attached to the promoter via a protein bridge.

  1989cited by this paper
• Formation of stable transcription complexes as assayed by analysis of individual templates.

  1988cited by this paper
• Developmental regulation of beta-globin gene switching.

  1988cited by this paper
• Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids.

  1987cited by this paper
• Position-independent, high-level expression of the human beta-globin gene in transgenic mice.

  1987cited by this paper
• Expression of transfected DNA depends on DNA topology.

  1986cited by this paper
• Gene regulation by proteins acting nearby and at a distance

  1986cited by this paper
• A developmentally stable chromatin structure in the human beta-globin gene cluster.

  1986cited by this paper
• The "beta-like-globin" gene domain in human erythroid cells.

  1985cited by this paper
• Developmental regulation of a cloned adult beta-globin gene in transgenic mice.

  1985cited by this paper
• Erythroid‐specific expression of human beta‐globin genes in transgenic mice.

  1985cited by this paper
• Effect of topological constraint on transcription of ribosomal DNA in Xenopus oocytes. Comparison of plasmid and endogenous genes.

  1984cited by this paper
• Human fetal to adult hemoglobin switching: changes in chromatin structure of the beta-globin gene locus.

  1983cited by this paper
• Actively transcribed genes are associated with the nuclear matrix

  1983cited by this paper
• The association of transcriptionally active genes with the nuclear matrix of the chicken oviduct.

  1983cited by this paper
• Beta-globin gene inactivation by DNA translocation in gamma beta-thalassaemia.

  1983cited by this paper
• Propagation of globin DNAase I-hypersensitive sites in absence of factors required for induction: a possible mechanism for determination.

  1982cited by this paper
• The SV40 72 base repair repeat has a striking effect on gene expression both in SV40 and other chimeric recombinants.

  1981cited by this paper
• Hb switching in chickens.

  1980cited by this paper
• The chemical heterogeneity of the fetal hemoglobin in normal newborn infants and in adults

  1977cited by this paper

• Co-Regulated Genes and Gene Clusters

  2021cites this paper
• Contribution of CTCF binding to transcriptional activity at the HOXA locus in NPM1-mutant AML cells

  2020cites this paper
• Activity-by-Contact model of enhancer-promoter regulation from thousands of CRISPR perturbations

  2019cites this paper
• Activity-by-Contact model of enhancer specificity from thousands of CRISPR perturbations

  2019cites this paper
• Methods to Record Transcription Factor Binding and Enhancer Activity throughout Cellular Differentiation

  2018cites this paper
• Transcriptional Enhancers: Bridging the Genome and Phenome.

  2015cites this paper
• Enhancers, enhancers – from their discovery to today’s universe of transcription enhancers

  2015cites this paper
• Looping back to leap forward: transcription enters a new era.

  2014cites this paper
• Étude de la collaboration entre les facteurs de transcription hématopoïétiques lors du développement et de la différenciation des cellules érythroïdes

  2012cites this paper
• The GATA1-HS2 Enhancer Allows Persistent and Position-Independent Expression of a β-globin Transgene

  2011cites this paper
• "Over-expression of AHSP in Bone Marrow - derived CD34+ cells is not effective in ameliorating the thalassemic phenotype"

  2010cites this paper
• Ikaros controls isotype selection during immunoglobulin class switch recombination

  2009cites this paper
• Chromatin loops in gene regulation.

  2009cites this paper
• Hemoglobin research and the origins of molecular medicine.

  2008cites this paper
• Ultraconserved coding regions outside the homeobox of mammalian Hox genes

  2008cites this paper
• FUNCTIONAL CHARACTERIZATION OF UPD3 IN DROSOPHILA DEVELOPMENT

  2008cites this paper
• An enhancer required for transcription of the Col6a1 gene in muscle connective tissue is induced by signals released from muscle cells.

  2008cites this paper
• Unique nucleotide polymorphism of ankyrin gene cluster in Arabidopsis

  2007cites this paper
• Physical characteristics of an individual: The identification of biomarkers for biological age determination

  2007cites this paper
• Transcriptional interference among the murine beta-like globin genes.

  2007cites this paper
• A Transcription-dependent Micrococcal Nuclease-resistant Fragment of the Urokinase-type Plasminogen Activator Promoter Interacts with the Enhancer*

  2007cites this paper
• The identification of newborns using messenger RNA profiling analysis.

  2006cites this paper
• Constricting restricted transcription: the (actively?) shrinking web.

  2006cites this paper
• Family Members p53 and p73 Act Together in Chromatin Modification and Direct Repression of α-Fetoprotein Transcription*

  2005cites this paper
• Regulation of Erythroid Gene Expression by the Transcription Factor EKLF

  2004cites this paper
• Nuclear topography of beta-like globin gene cluster in IL-3-stimulated human leukemic K-562 cells.

  2004cites this paper
• Regulation of human 5-aminolevulinate synthase 2 expression during erythroid differentiation and its role in x-linked sideroblastic anaemia.

  2003cites this paper
• CP2 binding to the promoter is essential for the enhanced transcription of globin genes in erythroid cells.

  2003cites this paper
• The impact of FISH on globin gene regulation research.

  2003cites this paper
• Formation of a Tissue-Specific Histone Acetylation Pattern by the Hematopoietic Transcription Factor GATA-1

  2003cites this paper
• Interaction of NF-E2 in the Human β-Globin Locus Control Region before Chromatin Remodeling*

  2003cites this paper
• Transcriptional targeting of lentiviral vectors to the erythroblastic progeny of hematopoietic stem cells

  2003cites this paper
• BP1, a Homeodomain-Containing Isoform of DLX4, Represses the β-Globin Gene

  2002influential citation
• Long-range chromatin regulatory interactions in vivo

  2002cites this paper
• Transcriptional Targeting of Lentiviral Vectors by Long Terminal Repeat Enhancer Replacement

  2002cites this paper
• NAPP2, a peroxisomal membrane protein, is also a transcriptional corepressor.

  2002cites this paper
• Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors.

  2002cites this paper
• GAGA can mediate enhancer function in trans by linking two separate DNA molecules

  2002cites this paper
• Dynamics of enhancer-promoter communication during differentiation-induced gene activation.

  2002cites this paper
• BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene.

  2002cites this paper
• Globin gene transfer for the treatment of severe hemoglobinopathies: a paradigm for stem cell‐based gene therapy

  2002cites this paper
• Activation, Regulation and Transcription of the Human and Murine Globin Loci.

  2002cites this paper
• Short interspersed transposable elements (SINEs) are excluded from imprinted regions in the human genome

  2001cites this paper
• Human apolipoprotein B gene intestinal control region.

  2001cites this paper
• Function and Factor Interactions of a Locus Control Region Element in the Mouse T Cell Receptor-α/Dad1 Gene Locus1

  2001cites this paper
• The role of the -50 region of the human gamma-globin gene in switching.

  2001cites this paper
• Localization of the 3' IgH locus elements that effect long-distance regulation of class switch recombination.

  2001cites this paper
• Locus control region activity by 5′HS3 requires a functional interaction with β-globin gene regulatory elements: expression of novel β/γ-globin hybrid transgenes

  2000cites this paper
• Gene conversion may aid adaptive peak shifts.

  2000cites this paper
• Locus control region activity by 5'HS3 requires a functional interaction with beta-globin gene regulatory elements: expression of novel beta/gamma-globin hybrid transgenes.

  2000cites this paper
• A large upstream region is not necessary for gene expression or hypersensitive site formation at the mouse beta -globin locus.

  2000cites this paper
• Reporter constructs showing proper globin gene switching in cultured erythroid cell lines.

  2000cites this paper
• Deletions within the mouse beta-globin locus control region preferentially reduce beta(min) globin gene expression.

  2000cites this paper
• A recombinogenic targeting method to modify large-inserts for cis-regulatory analysis in transgenic mice: construction and expression of a 100-kb, zebrafish Hoxa-11b-lacZ reporter gene

  2000cites this paper
• Developmentally distinct effects on human epsilon-, gamma- and delta-globin levels caused by the absence or altered position of the human beta-globin gene in YAC transgenic mice.

  2000cites this paper
• In Vitro and in vivo Studies of Murine Polytropic Retrovirus Infections: a Dissertation

  2000cites this paper
• Erythroid Kruppel-like factor is recruited to the CACCC box in the beta-globin promoter but not to the CACCC box in the gamma-globin promoter: the role of the neighboring promoter elements.

  2000cites this paper
• V delta repertoire during thymic ontogeny suggests three novel waves of gamma delta TCR expression.

  2000cites this paper
• In vivo modulation of human beta-globin gene switching.

  2000cites this paper
• The 3' IgH regulatory region: a complex structure in a search for a function.

  2000cites this paper
• Analysis of linked human epsilon and gamma transgenes: effect of locus control region hypersensitive sites 2 and 3 or a distal YY1 mutation on stage-specific expression patterns.

  1999cites this paper
• Targeting a SWI/SNF-related chromatin remodeling complex to the beta-globin promoter in erythroid cells.

  1999cites this paper
• Transcriptional targeting of retroviral vectors to the erythroblastic progeny of transduced hematopoietic stem cells.

  1999cites this paper
• The beta-globin promoter is important for recruitment of erythroid Krüppel-like factor to the locus control region in erythroid cells.

  1999cites this paper
• Enhancer-Dependent Transcriptional Oscillations in Mouse Erythroleukemia Cells

  1999cites this paper
• Activation by locus control regions?

  1999cites this paper
• Looping versus linking: toward a model for long-distance gene activation.

  1999cites this paper
• The regulation of CD4 and CD8 coreceptor gene expression during T cell development.

  1999cites this paper
• Dividing the empire: boundary chromatin elements delimit the territory of enhancers

  1999cites this paper
• Tissue-specific and developmental stage-specific DNA binding by a mammalian SWI/SNF complex associated with human fetal-to-adult globin gene switching.

  1999cites this paper
• Role of the Intronic Elements in the Endogenous Immunoglobulin Heavy Chain Locus

  1999cites this paper
• Sharp DNA bends as landmarks of protein-binding sites on straightened DNA.

  1999cites this paper
• Nuclear matrix attachment regions antagonize methylation-dependent repression of long-range enhancer-promoter interactions.

  1999cites this paper
• Effects of altered gene order or orientation of the locus control region on human β-globin gene expression in mice

  1999cites this paper
• A New Element within the T-Cell Receptor α Locus Required for Tissue-Specific Locus Control Region Activity

  1999cites this paper
• Structural and Functional Cross-Talk between a Distant Enhancer and the ɛ-Globin Gene Promoter Shows Interdependence of the Two Elements in Chromatin

  1999cites this paper
• Large-Scale Chromatin Unfolding and Remodeling Induced by VP16 Acidic Activation Domain

  1999cites this paper
• The gamma-Globin Promoter Has a Major Role in Competitive Inhibition of beta-Globin Gene Expression in Early Erythroid Development

  1999cites this paper
• Anti-beta s-ribozyme reduces beta s mRNA levels in transgenic mice: potential application to the gene therapy of sickle cell anemia.

  1999cites this paper
• A 3'-flanking NF-kappaB site mediates developmental silencing of the human zeta-globin gene.

  1999cites this paper
• Temporal expression of a V(H) promoter-Cmu transgene linked to the IgH HS1,2 enhancer.

  1999cites this paper
• The roles of 5'-HS2, 5'-HS3, and the gamma-globin TATA, CACCC, and stage selector elements in suppression of beta-globin expression in early development.

  1999cites this paper
• Cell Type-specific Transcription of the α1(VI) Collagen Gene

  1999cites this paper
• Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes.

  1999cites this paper
• Structural analysis and mapping of DNase I hypersensitivity of HS5 of the beta-globin locus control region.

  1999cites this paper
• Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.

  1999cites this paper
• Hypersensitive Site 2 Specifies a Unique Function within the Human β-Globin Locus Control Region To Stimulate Globin Gene Transcription

  1999cites this paper
• Mechanisms of transcriptional regulation.

  1999cites this paper
• Characterization of a kidney-specific pattern of chromatin structure in the rat phosphoenolpyruvate carboxykinase gene.

  1999cites this paper
• Model for the fetal recruitment of simian gamma-globin genes based on findings from two New World monkeys Cebus apella and Callithrix jacchus (Platyrrhini, Primates).

  1999cites this paper
• Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus.

  1999cites this paper
• The Locus Control Region Is Necessary for Gene Expression in the Human β-Globin Locus but Not the Maintenance of an Open Chromatin Structure in Erythroid Cells

  1998cites this paper
• Class Switching in B Cells Lacking 3′ Immunoglobulin Heavy Chain Enhancers

  1998cites this paper
• Regulation of Erythroid Krüppel-like Factor (EKLF) Transcriptional Activity by Phosphorylation of a Protein Kinase Casein Kinase II Site within Its Interaction Domain*

  1998cites this paper
• Coinduction of embryonic and adult-type globin mRNAs by sodium butyrate and trichostatin A in two murine interleukin-3-dependent bone marrow-derived cell lines.

  1998cites this paper
• The Dynamics of Globin Gene Expression and Gene Therapy Vectors

  1998cites this paper
• Substitution of the human beta-spectrin promoter for the human agamma-globin promoter prevents silencing of a linked human beta-globin gene in transgenic mice.

  1998cites this paper
• The beta-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse beta-globin locus.

  1998cites this paper
• Studying the recruitment of Sp1 to the beta-globin promoter with an in vivo method: protein position identification with nuclease tail (PIN*POINT).

  1998cites this paper
• Identification and Characterization of a Conserved Erythroid-specific Enhancer Located in Intron 8 of the Human 5-Aminolevulinate Synthase 2 Gene*

  1998cites this paper