Strategies in case of positive in vivo results in genotoxicity testing.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Mutation research

• Publication date

  2011-08-16

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1016/j.mrgentox.2010.09.002PMID 20854927
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Scientific Opinion on Flavouring Group Evaluation 220, Revision 2 (FGE.220Rev1): α,β‐Unsaturated ketones and precursors from chemical subgroup 4.4 of FGE.19: 3(2H)‐Furanones

  2013cited by this paper
• Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies.

  2010cited by this paper
• The use of PIG-A as a sentinel gene for the study of the somatic mutation rate and of mutagenic agents in vivo.

  2010cited by this paper
• Mechanisms mediating the vesicant actions of sulfur mustard after cutaneous exposure.

  2010cited by this paper
• Pig-a mutation: kinetics in rat erythrocytes following exposure to five prototypical mutagens.

  2010cited by this paper
• Somatic gene mutation and human disease other than cancer: an update.

  2010cited by this paper
• Spontaneous Mutagenesis in Rodents: Spontaneous Gene Mutations Identified by Neutral Reporter Genes in gpt Delta Transgenic Mice and Rats

  2009cited by this paper
• Considerations regarding a permitted daily exposure calculation for ethyl methanesulfonate.

  2009cited by this paper
• Ethyl methanesulfonate toxicity in Viracept--a comprehensive human risk assessment based on threshold data for genotoxicity.

  2009cited by this paper
• In vivo genotoxicity of EMS: statistical assessment of the dose response curves.

  2009cited by this paper
• Integration of In Vivo Genotoxicity and Short-term Carcinogenicity Assays Using F344 gpt Delta Transgenic Rats: In Vivo Mutagenicity of 2,4-Diaminotoluene and 2,6-Diaminotoluene Structural Isomers

  2009cited by this paper
• Flow cytometric detection of Pig‐A mutant red blood cells using an erythroid‐specific antibody: Application of the method for evaluating the in vivo genotoxicity of methylphenidate in adolescent rats

  2009cited by this paper
• The genetic toxicology of methylphenidate hydrochloride in non-human primates.

  2009cited by this paper
• Investigation of the low-dose response in the in vivo induction of micronuclei and adducts by acrylamide.

  2009cited by this paper
• Existence of a Threshold for the Genotoxic Carcinogens: Evidence from Mechanism-based Carcinogenicity Studies

  2009cited by this paper
• A functional genetic study identifies HAND1 mutations in septation defects of the human heart.

  2009cited by this paper
• In vivo studies in the mouse to define a threshold for the genotoxicity of EMS and ENU.

  2009cited by this paper
• The Viracept (nelfinavir)--ethyl methanesulfonate case: a threshold risk assessment for human exposure to a genotoxic drug contamination?

  2009cited by this paper
• Thresholds for genotoxins and their application in risk assessment.

  2009cited by this paper
• Statistical model to estimate a threshold dose and its confidence limits for the analysis of sublinear dose-response relationships, exemplified for mutagenicity data.

  2009cited by this paper
• Dose-response relationships for N7-(2-hydroxyethyl)guanine induced by low-dose [14C]ethylene oxide: evidence for a novel mechanism of endogenous adduct formation.

  2009cited by this paper
• Accumulation and persistence of Pig-A mutant peripheral red blood cells following treatment of rats with single and split doses of N-ethyl-N-nitrosourea.

  2009cited by this paper
• Modelling of patient EMS exposure: translating pharmacokinetics of EMS in vitro and in animals into patients.

  2009cited by this paper
• Dose-response and operational thresholds/NOAELs for in vitro mutagenic effects from DNA-reactive mutagens, MMS and MNU.

  2009cited by this paper
• Nonlinear cancer response at ultralow dose: a 40800-animal ED(001) tumor and biomarker study.

  2009cited by this paper
• Development of an in vivo gene mutation assay using the endogenous Pig‐A gene: II. Selection of Pig‐A mutant rat spleen T‐cells with proaerolysin and sequencing Pig‐A cDNA from the mutants

  2008cited by this paper
• 2nd International Symposium on Genotoxic and Carcinogenic Thresholds

  2008cited by this paper
• Extrapolation of the Animal Carcinogenesis Threshold to Humans

  2008cited by this paper
• Flow cytometric analysis of micronuclei in peripheral blood reticulocytes IV: an index of chromosomal damage in the rhesus monkey (Macaca mulatta).

  2008cited by this paper
• Biomarkers in toxicology and risk assessment: informing critical dose-response relationships.

  2008cited by this paper
• Thresholds in Genotoxicity and Carcinogenicity : Urinary Bladder Carcinogenesis

  2008cited by this paper
• Theoretical and Experimental Approaches to Address Possible Thresholds of Response in Carcinogenicity

  2008cited by this paper
• Analysis of in vivo mutation data can inform cancer risk assessment.

  2008cited by this paper
• In vivo mutation assay based on the endogenous Pig‐a locus

  2008cited by this paper
• Possible Mechanisms of Practical Thresholds for Genotoxicity

  2008cited by this paper
• Development of an in vivo gene mutation assay using the endogenous Pig‐A gene: I. Flow cytometric detection of CD59‐negative peripheral red blood cells and CD48‐negative spleen T‐cells from the rat

  2008cited by this paper
• Erythrocyte-based Pig-a gene mutation assay: demonstration of cross-species potential.

  2008cited by this paper
• Characterization of the genotoxicity of nitrilotriacetic acid

  2008cited by this paper
• Experimental Design and Statistical Analysis of Studies to Demonstrate a Threshold in Genetic Toxicology: A Mini-review

  2008cited by this paper
• Recent developments in frameworks to consider human relevance of hypothesized modes of action for tumours in animals

  2008cited by this paper
• The Concept of “Practical Thresholds” in the Derivation of Occupational Exposure Limits for Carcinogens by the Scientific Committee on Occupational Exposure Limits (SCOEL) of the European Union

  2008cited by this paper
• A Margin-of-Exposure Approach to Assessment of Noncancer Risks of Dioxins Based on Human Exposure and Response Data

  2008cited by this paper
• Mechanistic influences for mutation induction curves after exposure to DNA-reactive carcinogens.

  2007cited by this paper
• Flow cytometric analysis of micronuclei in peripheral blood reticulocytes III. An efficient method of monitoring chromosomal damage in the beagle dog.

  2007cited by this paper
• Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother‐to‐child transmission of HIV

  2007cited by this paper
• Strategy for genotoxicity testing: hazard identification and risk assessment in relation to in vitro testing.

  2007cited by this paper
• Automated human blood micronucleated reticulocyte measurements for rapid assessment of chromosomal damage.

  2007cited by this paper
• Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: II. An efficient method of monitoring chromosomal damage in the rat.

  2006cited by this paper
• Approaches to the risk assessment of genotoxic carcinogens in food: a critical appraisal.

  2006cited by this paper
• Bridging the gap between anatomy and molecular genetics for an improved understanding of congenital heart disease.

  2006cited by this paper
• Practical threshold for micronucleated reticulocyte induction observed for low doses of mitomycin C, Ara-C and colchicine.

  2006cited by this paper
• Molecular nature of intrachromosomal deletions and base substitutions induced by environmental mutagens

  2005cited by this paper
• Evaluation of the reticulocyte micronucleus assay in patients treated with radioiodine for thyroid cancer.

  2005cited by this paper
• A simple assay for frequency of chromosome breaks and loss (micronuclei) by flow cytometry of human reticulocytes

  2005cited by this paper
• Opinion of the Scientific Committee on "A Harmonised Approach for Risk Assessment of Compounds which are both Genotoxic and Carcinogenic". Comments from the Norwegian Scientific Committee for Food Safety

  2005cited by this paper
• Quantitative analysis of Howell-Jolly bodies in children with sickle cell disease.

  2004cited by this paper
• Somatic NKX2-5 mutations as a novel mechanism of disease in complex congenital heart disease

  2004cited by this paper
• Human UDP-glucuronosyltransferases show atypical metabolism of mycophenolic acid and inhibition by curcumin.

  2004cited by this paper
• Somatic gene mutation and human disease other than cancer.

  2003cited by this paper
• Tissue mRNA expression of the rat UDP-glucuronosyltransferase gene family.

  2003cited by this paper
• Indirect mechanisms of genotoxicity.

  2003cited by this paper
• In vivo transgenic mutation assays.

  2003cited by this paper
• Novel transgenic rat for in vivo genotoxicity assays using 6‐thioguanine and Spi− selection

  2003cited by this paper
• Mutagenic activity of ethylene oxide and propylene oxide under XPG proficient and deficient conditions in relation to N-7-(2-hydroxyalkyl)guanine levels in Drosophila.

  2003cited by this paper
• A Framework for Human Relevance Analysis of Information on Carcinogenic Modes of Action

  2003cited by this paper
• Micronucleated CD71-positive reticulocytes: a blood-based endpoint of cytogenetic damage in humans.

  2003cited by this paper
• Regulatory recognition of indirect genotoxicity mechanisms in the European Union.

  2003cited by this paper
• Strategy for genotoxicity testing and stratification of genotoxicity test results--report on initial activities of the IWGT Expert Group.

  2003cited by this paper
• Enumeration of micronucleated CD71-positive human reticulocytes with a single-laser flow cytometer.

  2002cited by this paper
• Evaluation of the rodent micronucleus assay by a 28‐day treatment protocol: Summary of the 13th Collaborative Study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Environmental Mutagen Society of Japan (JEMS)–Mammalian Mutagenicity Study Group (MMS)

  2001cited by this paper
• Human cytogenetic biomonitoring using flow‐cytometric analysis of micronuclei in transferrin‐positive immature peripheral blood reticulocytes

  2000cited by this paper
• Recent advances in the protocols of transgenic mouse mutation assays.

  2000cited by this paper
• Human biological relevance and the use of threshold-arguments in regulatory genotoxicity assessment: experience with pharmaceuticals.

  2000cited by this paper
• Effect of mitogenic or regenerative cell proliferation on lacz mutant frequency in the liver of MutaTMMice treated with 5, 9-dimethyldibenzo[c,g]carbazole.

  1999cited by this paper
• Kinetics of induction of DNA adducts, cell proliferation and gene mutations in the liver of MutaMice treated with 5,9-dimethyldibenzo[c,g]carbazole.

  1999cited by this paper
• 7H‐ジベンゾ[c,g]カルバゾール及び2つの誘導体のMutaマウス肝臓及び皮膚における比較変異原性

  1998cited by this paper
• Comparative mutagenicity of 7H-dibenzo[c,g]carbazole and two derivatives in MutaMouse liver and skin.

  1998cited by this paper
• 'Spontaneous' genetic damage in man: evaluation of interindividual variability, relationship among markers of damage, and influence of nutritional status.

  1997cited by this paper
• Other transgenic mutation assays: A new transgenic mouse mutagenesis test system using Spi− and 6‐thioguanine selections

  1996cited by this paper
• Workshop report on EPA (Environmental Protection Agency) guidelines for carcinogen risk assessment. Held in Virginia Beach, Virginia on January 11-13, 1989

  1989cited by this paper
• The Environment and Disease: Association or Causation?

  1965cited by this paper

• International workshops on genotoxicity testing (IWGT): Origins, achievements and ambitions.

  2023cites this paper
• Ocular Cell Lines and Genotoxicity Assessment

  2020cites this paper
• Application of the adverse outcome pathway framework to genotoxic modes of action

  2019cites this paper
• Mutagenicity Testing: Regulatory Guidelines and Current Needs

  2018cites this paper
• The various aspects of genetic and epigenetic toxicology: testing methods and clinical applications

  2017cites this paper
• Genotoxicity testing: progress and prospects for the next decade

  2017cites this paper
• International regulatory requirements for genotoxicity testing for pharmaceuticals used in human medicine, and their impurities and metabolites

  2017cites this paper
• Genetic toxicology at the crossroads-from qualitative hazard evaluation to quantitative risk assessment.

  2016cites this paper
• Dexrazoxane mitigates epirubicin-induced genotoxicity in mice bone marrow cells.

  2016cites this paper
• Impacts of 2,4‐dichlorophenoxyacetic acid aquatic herbicide formulations on reproduction and development of the fathead minnow (Pimephales promelas)

  2015cites this paper
• Chromosomal damage and micronucleus induction by MP-124, a novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor: Evidence for a non-DNA-reactive mode of action.

  2015cites this paper
• Guidance Document on Revisions to OECD Genetic Toxicology Test Guidelines

  2015cites this paper
• IWGT report on quantitative approaches to genotoxicity risk assessment I. Methods and metrics for defining exposure-response relationships and points of departure (PoDs).

  2015cites this paper
• Ensaios toxicológicos pré-clínicos na avaliação da segurança de novos fármacos

  2014cites this paper
• A critical appraisal of the process of regulatory implementation of novel in vivo and in vitro methods for chemical hazard and risk assessment

  2014cites this paper
• Developmental Study of Repeated-Dose Liver Micronucleus Assay Using Adult Rats

  2013cites this paper
• The Evolution, Scientific Reasoning and Use of ICH S2 Guidelines for Genotoxicity Testing of Pharmaceuticals

  2013cites this paper
• Progress in the Development, Validation and Regulatory Acceptance of In Vitro Methods for Toxicity Testing

  2013cites this paper
• Factors influencing mutagenic mode of action determinations of regulatory and advisory agencies.

  2012cites this paper
• Existe-t-il une dose seuil pour les effets génotoxiques ?

  2012cites this paper
• Cell Transformation Assays: Are we Barking up the Wrong Tree?

  2012cites this paper
• Micronucleus assays in rodent tissues other than bone marrow.

  2011cites this paper
• When pigs fly: immunomagnetic separation facilitates rapid determination of Pig-a mutant frequency by flow cytometric analysis.

  2011cites this paper
• Scientific opinion on genotoxicity testing strategies applicable to food and 3 feed safety assessment

  2011cites this paper