G. Douglas

Error-corrected Next Generation Sequencing - Promises and Challenges for Genotoxicity and Cancer Risk Assessment.
202340 citationsauthor #4
Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing
202334 citationsauthor #4
Assessing the Quality and Making Appropriate Use of Historical Negative Control Data: A Report of the International Workshop on Genotoxicity Testing (IWGT).
202317 citationsauthor #4
Impact of sampling time on the detection of mutations in rapidly proliferating tissues using transgenic rodent gene mutation models: A review
20223 citationsauthor #1
The 28 + 28 day design is an effective sampling time for analyzing mutant frequencies in rapidly proliferating tissues of MutaMouse animals
202114 citationsauthor #7
Analysis of Biomarkers of DNA Damage and Mutagenicity in Mice Exposed to Acrylonitrile.
202013 citationsauthor #4
A Return to the Origin of the EMGS: Rejuvenating the Quest for Human Germ Cell Mutagens and Determining the Risk to Future Generations
202021 citationsauthor #2
Analysis of DNA Adducts and Mutagenic Potency and Specificity in Rats Exposed to Acrylonitrile.
20208 citationsauthor #6
A comparison of transgenic rodent mutation and in vivo comet assay responses for 91 chemicals.
201945 citationsauthor #7
In vivo genotoxicity testing strategies: Report from the 7th International workshop on genotoxicity testing (IWGT).
201942 citationsauthor #8
Mutation as a Toxicological Endpoint for Regulatory Decision‐Making
201954 citationsauthor #5
Corrigendum to "Simulation of mouse and rat spermatogenesis to inform genotoxicity testing using OECD test guideline 488" [Mutat. Res. 832-833 (2018) 19-28].
20191 citationsauthor #5
Corrigendum to "Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell Gene mutation assays) and integration with somatic cell testing." [Mutat. Res. 832-833 (2018) 7-18].
20190 citationsauthor #9
In utero Exposure to Genotoxicants Leading to Genetic Mosaicism: An Overlooked Window of Susceptibility in Genetic Toxicology Testing?
201915 citationsauthor #4
Adverse Outcome Pathway on Alkylation of DNA in Male Pre-Meiotic Germ Cells Leading to Heritable Mutations
201812 citationsauthor #4
Simulation of mouse and rat spermatogenesis to inform genotoxicity testing using OECD test guideline 488.
201822 citationsauthor #5
Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing.
201822 citationsauthor #9
Quantitative relationships between lacZ mutant frequency and DNA adduct frequency in Muta™Mouse tissues and cultured cells exposed to 3-nitrobenzanthrone
201713 citationsauthor #2
Main issues addressed in the 2014–2015 revisions to the OECD Genetic Toxicology Test Guidelines
201734 citationsauthor #5
Next generation testing strategy for assessment of genomic damage: A conceptual framework and considerations
201780 citationsauthor #5
Mutagenic Activity of Drinking Water Extracts in Salmonella and Chinese Hamster Ovary Cells
20160 citationsauthor #1
Development of the adverse outcome pathway “alkylation of DNA in male premeiotic germ cells leading to heritable mutations” using the OECD's users' handbook supplement
201532 citationsauthor #4
Approaches for identifying germ cell mutagens: Report of the 2013 IWGT workshop on germ cell assays(☆).
201578 citationsauthor #15
Sublinear response in lacZ mutant frequency of Muta™Mouse spermatogonial stem cells after low dose subchronic exposure to N‐ethyl‐N‐nitrosourea
201518 citationsauthor #4
Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency
201425 citationsauthor #5
Transgenic Rodent Gene Mutation Assay in Somatic Tissues
201424 citationsauthor #5
Harnessing genomics to identify environmental determinants of heritable disease.
201329 citationsauthor #7
The development of adverse outcome pathways for mutagenic effects for the organization for economic co‐operation and development
201316 citationsauthor #4
No evidence for transgenerational genomic instability in the F1 or F2 descendants of Muta™Mouse males exposed to N-ethyl-N-nitrosourea.
201310 citationsauthor #4
Mutation spectrum in FE1‐MUTATMMouse lung epithelial cells exposed to nanoparticulate carbon black
201171 citationsauthor #6
Assessment of subclinical, toxicant-induced hepatic gene expression profiles after low-dose, short-term exposures in mice.
201115 citationsauthor #6
Session V-4 : Replacement and Reduction in the use of genetically-engineered animals Session V-4 : Oral presentations
20110 citationsauthor #2
New and emerging technologies for genetic toxicity testing
201174 citationsauthor #11
Strategies in case of positive in vivo results in genotoxicity testing.
201124 citationsauthor #6
Suitable top concentration for tests with mammalian cells: mouse lymphoma assay workgroup.
201117 citationsauthor #5
Characterisation of Muta™Mouse λgt10-lacZ transgene: evidence for in vivo rearrangements
201034 citationsauthor #3
Transgenic Rodent Gene Mutation Assays : Current State of Validation
20102 citationsauthor #1
Transgenic Rodent Gene Mutation Assays
20100 citationsauthor #1
Toxicogenomic analysis of mainstream tobacco smoke-exposed mice reveals repression of plasminogen activator inhibitor-1 gene in heart.
20097 citationsauthor #5
The genotoxicity of mainstream and sidestream marijuana and tobacco smoke condensates.
200944 citationsauthor #5
Mutagenicity testing for chemical risk assessment: update of the WHO/IPCS Harmonized Scheme.
2009200 citationsauthor #7
Global transcriptional characterization of a mouse pulmonary epithelial cell line for use in genetic toxicology.
200926 citationsauthor #5
IS II-2 The Utility Transgenic Rodent Gene Mutation Assays(Session II: In Vivo Tests) :
20080 citationsauthor #1
Tissue‐specific metabolic activation and mutagenicity of 3‐nitrobenzanthrone in Muta™Mouse
200816 citationsauthor #4
Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location
2008309 citationsauthor #11
Genotoxicity of 3-nitrobenzanthrone and 3-aminobenzanthrone in Muta (cid:1) Mouse and lung epithelial cells derived from Muta (cid:1) Mouse
20080 citationsauthor #5
Toxicogenomic Analysis of Mainstream Tobacco Smoke-Exposed Mice Reveals Repression of Plasminogen Activator Inhibitor-1 Gene in Heart
20086 citationsauthor #5
P-122 Validation of Transgenic Rodent Gene Mutation Assays using DNA Sequence Data(Poster Session)
20080 citationsauthor #1
Mutagenic and carcinogenic hazards of settled house dust. I: Polycyclic aromatic hydrocarbon content and excess lifetime cancer risk from preschool exposure.
2008156 citationsauthor #5
Genotoxicity of 3-nitrobenzanthrone and 3-aminobenzanthrone in MutaMouse and lung epithelial cells derived from MutaMouse.
200836 citationsauthor #5
Mutagenic and carcinogenic hazards of settled house dust. II: Salmonella mutagenicity.
200835 citationsauthor #3
Increased mutant frequency by carbon black, but not quartz, in the lacZ and cII transgenes of muta™mouse lung epithelial cells
2007131 citationsauthor #10
Mainstream tobacco smoke causes paternal germ-line DNA mutation.
2007107 citationsauthor #5
Hepatic gene expression changes in hypothyroid juvenile mice: characterization of a novel negative thyroid-responsive element.
200724 citationsauthor #5
Analysis of gene expression in two human‐derived cell lines exposed in vitro to a 1.9 GHz pulse‐modulated radiofrequency field
200728 citationsauthor #7
Follow-up testing of rodent carcinogens not positive in the standard genotoxicity testing battery: IWGT workgroup report.
200729 citationsauthor #5
A single-molecule PCR approach to the measurement of induced expanded simple tandem repeat instability in vitro.
20068 citationsauthor #4
Instability of expanded simple tandem repeats is induced in cell culture by a variety of agents: N-Nitroso-N-ethylurea, benzo(a)pyrene, etoposide and okadaic acid.
20067 citationsauthor #4
Novel design and controls for focused DNA microarrays: applications in quality assurance/control and normalization for the Health Canada ToxArray™
200613 citationsauthor #10
Environmental health criteria for transgenic animal mutagenicity assays
20062 citationsauthor #3
Detection of induced male germline mutation: correlations and comparisons between traditional germline mutation assays, transgenic rodent assays and expanded simple tandem repeat instability assays.
200655 citationsauthor #4
The mutagenic hazards of complex mixtures of polycyclic aromatic hydrocarbons in soil
20060 citationsauthor #6
A lacZ transgenic mouse assay for the detection of mutations in follicular granulosa cells.
20058 citationsauthor #6
Global Issues in Genetic Toxicology and Environmental Mutagenesis
20050 citationsauthor #6
Meeting Report: Validation of Toxicogenomics-Based Test Systems: ECVAM–ICCVAM/NICEATM Considerations for Regulatory Use
200575 citationsauthor #7
Detailed review of transgenic rodent mutation assays.
2005354 citationsauthor #4
Assessment of 3-nitrobenzanthrone reductase activity in mammalian tissues by normal-phase HPLC with fluorescence detection.
20057 citationsauthor #3
Molecular insight into the effects of hypothyroidism on the developing cerebellum.
200575 citationsauthor #5
Automation of cDNA microarray hybridization and washing yields improved data quality.
20055 citationsauthor #4
S2-1 Tandem Repeat DNA : applications in germline mutation analysis
20041 citationsauthor #5
Comprehensive comparison of six microarray technologies.
2004248 citationsauthor #4
Treatment and sampling protocols for transgenic mutation assays
200346 citationsauthor #3
Development and characterization of a stable epithelial cell line from Muta™Mouse lung
200359 citationsauthor #2
Mutagenicity of the oral carcinogen 4-nitroquinoline-1-oxide in cultured BigBlue rat tongue epithelial cells and fibroblasts.
200311 citationsauthor #2
In vivo transgenic mutation assays.
2003168 citationsauthor #5
2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP)–induced mutagenesis in cultured Big Blue™ rat mammary epithelial and fibroblast cells
200217 citationsauthor #2
Epithelial and fibroblast cell lines cultured from the transgenic BigBlue rat: an in vitro mutagenesis assay.
200118 citationsauthor #2
IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans. International Programme on Chemical Safety.
2000784 citationsauthor #3
In vivo transgenic mutation assays
200088 citationsauthor #6
Comparative Performance of Conventional and Molecular Dosimetry Methods in Environmental Biomonitoring
20005 citationsauthor #2
Evidence for the lack of base‐change and small‐deletion mutation induction by trichloroethylene in lacZ transgenic mice
199912 citationsauthor #1
Evidence for the lack of base-change and small-deletion mutation induction by trichloroethylene in lacZ transgenic mice.
19999 citationsauthor #1
Databases and software for the analysis of mutations in the human p53 gene, human hprt gene and both the lacI and lacZ gene in transgenic rodents
199865 citationsauthor #2
Statistical analysis of lacZ mutant frequency data from MutaMouse mutagenicity assays.
199811 citationsauthor #2
Sources of variability in data from a positive selection lacZ transgenic mouse mutation assay: an interlaboratory study.
199730 citationsauthor #6
O XII.2 Prospects for the use of transgenic mouse models to assess germ line risk from chemicals
19970 citationsauthor #1
Analysis of tissue-specific lacZ mutations induced by N-nitrosodibenzylamine in transgenic mice.
199724 citationsauthor #2
Databases and software for the analysis of mutations in the human p53 gene, the human hprt gene and both the lacI and lacZ gene in transgenic rodents
199717 citationsauthor #2
Toward an understanding of the use of transgenic mice for the detection of gene mutations in germ cells.
199718 citationsauthor #1
Bacteriophage Lambda and Plasmid lacZ Transgenic Mice for Studying Mutations in Vivo
199671 citationsauthor #2
System issues: Temporal and molecular characteristics of lacZ mutations in somatic tissues of transgenic mice
199661 citationsauthor #1
Database and software for the analysis of mutations at the lacZ locus in transgenic rodents
19963 citationsauthor #2
Comparison of the molecular characteristics of lacZ transgenic mouse mutations detected by visual and positive selection.
199610 citationsauthor #2
Databases and software for the analysis of mutations in the human p53 gene, the human hprt gene and the lacZ gene in transgenic rodents
199610 citationsauthor #2
IPCS harmonization of methods for the prediction and quantification of human carcinogenic/mutagenic hazard, and for indicating the probable mechanism of action of carcinogens.
199641 citationsauthor #5
Temporal and molecular characteristics of mutations induced by ethylnitrosourea in germ cells isolated from seminiferous tubules and in spermatozoa of lacZ transgenic mice.
199589 citationsauthor #1
Cytogenetic mapping of λgt10 lacZ sequences in the transgenic mouse strain 40.6 (MutaTMMouse)
199527 citationsauthor #2
International Commission for Protection Against Environmental Mutagens and Carcinogens. Genetic risk extrapolation from animal data to human disease. A Taskgroup Report. No. 00105.
19956 citationsauthor #6
Evidence for in vivo non-mutagenicity of the carcinogen hydrazine sulfate in target tissues of lacZ transgenic mice.
199519 citationsauthor #1
Acrylamide: a review of its genotoxicity and an assessment of heritable genetic risk.
1995301 citationsauthor #2

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