1,4-Dihydropyridines as Calcium Channel Ligands and Privileged Structures

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Cellular and molecular neurobiology

• Publication date

  2003-06-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1023/A:1023632419813PMID 12825828PMCID PMC11530185
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The 1,4-dihydropyridine nucleus: a pharmacophoric template part 1. Actions at ion channels.

  2003influential reference
• 1,4‐dihydropyridine calcium channel ligands: Selectivity of action. The roles of pharmacokinetics, state‐dependent interactions, channel isoforms, and other factors

  2003influential reference
• The IUPHAR compendium of voltage-gated ion channels

  2002cited by this paper
• Dihydropyridine neuropeptide Y Y(1) receptor antagonists.

  2002cited by this paper
• Recent developments in the chemistry of dihydropyridines

  2002cited by this paper
• Dihydropyridine Neuropeptide Y Y1 Receptor Antagonists.

  2002cited by this paper
• Medicinal Chemistry: Challenges and Opportunities.

  2001cited by this paper
• CHAPTER 45 – Mechanisms of Action of Calcium Antagonists

  2001cited by this paper
• Calcium channel modulators of the dihydropyridine family are human pregnane X receptor activators and inducers of CYP3A, CYP2B, and CYP2C in human hepatocytes.

  2001cited by this paper
• Pharmacology of H 394/84, a dihydropyridine neuropeptide Y Y(1) receptor antagonist, in vivo.

  2001cited by this paper
• Target-oriented and diversity-oriented organic synthesis in drug discovery.

  2000cited by this paper
• Conopeptides: From deadly venoms to novel therapeutics.

  2000cited by this paper
• State- and isoform-dependent interaction of isradipine with the α1C L-type calcium channel

  2000cited by this paper
• Speciation of Cone Snails and Interspecific Hyperdivergence of Their Venom Peptides: Potential Evolutionary Significance of Introns a

  1999cited by this paper
• Chiral resolution and stereospecificity of 6-phenyl-4-phenylethynyl- 1,4-dihydropyridines as selective A(3) adenosine receptor antagonists.

  1999cited by this paper
• Isoform-specific inhibition of L-type calcium channels by dihydropyridines is independent of isoform-specific gating properties.

  1998cited by this paper
• The action of calcium channel blockers on recombinant L‐type calcium channel α1‐subunits

  1998cited by this paper
• Identification of a dihydropyridine as a potent alpha1a adrenoceptor-selective antagonist that inhibits phenylephrine-induced contraction of the human prostate.

  1998cited by this paper
• Design and synthesis of novel alpha1a adrenoceptor-selective dihydropyridine antagonists for the treatment of benign prostatic hyperplasia.

  1998cited by this paper
• Ca2+ channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human α1C subunit gene

  1998cited by this paper
• Thirty years of discovering arthropod alkaloids in amphibian skin.

  1998cited by this paper
• Structural basis of drug binding to L Ca2+ channels.

  1998cited by this paper
• Selectivity of the action of calcium channel blockers in recombinant L-type calcium channels

  1998cited by this paper
• Design and Synthesis of Novel α1a Adrenoceptor-Selective Dihydropyridine Antagonists for the Treatment of Benign Prostatic Hyperplasia

  1998cited by this paper
• Cardiovascular effects of YM430, a 1,4-dihydropyridine derivative with beta-adrenoceptor blocking activity, in dogs and rats.

  1997cited by this paper
• Structure-activity relationships of 4-(phenylethynyl)-6-phenyl-1,4-dihydropyridines as highly selective A3 adenosine receptor antagonists.

  1997cited by this paper
• Transfer of the high affinity dihydropyridine sensitivity from L-type To non-L-type calcium channel.

  1997cited by this paper
• Nine L-type Amino Acid Residues Confer Full 1,4-Dihydropyridine Sensitivity to the Neuronal Calcium Channel α1ASubunit

  1997cited by this paper
• Molecular determinants of drug binding and action on L-type calcium channels.

  1997cited by this paper
• The unusual binding properties of the endothelin receptor antagonist CGS 27830 distinguishes receptor/agonist interactions.

  1996cited by this paper
• Interaction of 1,4-dihydropyridine and pyridine derivatives with adenosine receptors: selectivity for A3 receptors.

  1996cited by this paper
• Phenylalanine in the second membrane-spanning domain of alpha 1A-adrenergic receptor determines subtype selectivity of dihydropyridine antagonists.

  1996cited by this paper
• 6-phenyl-1,4-dihydropyridine derivatives as potent and selective A3 adenosine receptor antagonists.

  1996cited by this paper
• Structure and function of voltage-gated ion channels.

  1995cited by this paper
• [Calcium antagonists].

  1995cited by this paper
• K-channel opening activity of dihydropyridine ZM244085: effect on 86Rb efflux and 3H-P1075 binding in urinary bladder smooth muscle.

  1995cited by this paper
• The dihydropyridine nitrendipine reduces N-methyl-D-aspartate (NMDA)-evoked currents of rodent cortical neurons through a direct interaction with the NMDA receptor-associated ion channel.

  1994cited by this paper
• Peptidomimetics derived from natural products

  1993cited by this paper
• The nicotinic acetylcholine receptor of the bovine chromaffin cell, a new target for dihydropyridines.

  1993cited by this paper
• The dihydropyridine nitrendipine modulates N-methyl-D-aspartate receptor channel function in mammalian neurons.

  1993cited by this paper
• Dihydropyridine KATP potassium channel openers

  1993cited by this paper
• Subunit-dependent modulation of recombinant L-type calcium channels. Molecular basis for dihydropyridine tissue selectivity.

  1993cited by this paper
• Selectivity Scale of Calcium Antagonists in the Human Cardiovascular System Based on In Vitro Studies

  1992cited by this paper
• Murder, Magic, and Medicine

  1992cited by this paper
• Calcium Antagonists in Clinical Medicine

  1992cited by this paper
• 1,4-Dihydropyridines as antagonists of platelet activating factor. 1. Synthesis and structure-activity relationships of 2-(4-heterocyclyl)phenyl derivatives.

  1992cited by this paper
• 1,4‐Dihydropyridines: Effects of Chirality and Conformation on the Calcium Antagonist and Calcium Agonist Activities

  1991cited by this paper
• Interactions of dihydropyridine Ca2+ channel agonists with the human platelet thromboxane A2/prostaglandin H2 receptor.

  1991cited by this paper
• Effects of Ca2+ channel ligands on [3H]QNB binding at m1 and m3 muscarinic receptors.

  1991cited by this paper
• Calcium antagonists. History and perspective.

  1990cited by this paper
• Synthesis and activity of 1,4-dihydropyridine analogues of histamine H2-receptor antagonists.

  1990cited by this paper
• 4-Alkyl-1,4-dihydropyridines derivatives as specific PAF-acether antagonists.

  1990cited by this paper
• Calcium Antagonists History and Perspective

  1990cited by this paper
• 1,4‐Dihydropyridines—a basis for developing new drugs

  1989cited by this paper
• Ca2+ channel ligands: Structure‐function relationships of the 1,4‐dihydropyridines

  1989influential reference
• Synthesis, platelet aggregation inhibitory activity, and in vivo antithrombotic activity of new 1,4-dihydropyridines.

  1988cited by this paper
• Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists.

  1988cited by this paper
• [Mechanism of action of calcium antagonists].

  1985influential reference
• Calcium antagonism in heart and smooth muscle

  1984influential reference
• A preliminary biochemical examination of micrencephalic rat brains.

  1973cited by this paper
• The coronary vasodilator action of khellin.

  1949cited by this paper

• Recent advances in metal-free catalysts for the synthesis of N-heterocyclic frameworks focusing on 5- and 6-membered rings: a review

  2025cites this paper
• Reaction of Ethyl 3-Aryl-2-cyanoacrylates with N,N-Disubstituted Malonamides: Synthesis and Properties of Stable Michael Adducts

  2025cites this paper
• Reaction of ethyl 2-(arylidene)acetoacetates, 3-methyl-1H-pyrazol-5(4H)-one, and ammonium acetate: Unexpected formation of bis(pyrazolyl)methanes versus fused pyrazolo-1,4-dihydropyridines

  2025cites this paper
• Repurposing 1,4-Dihydropyridine Scaffold: 4-Imidazo[2,1-b]thiazole-Derivatives from Calcium Entry Blockers to a New Approach for Gut Dysfunctional Motility

  2025cites this paper
• Advances in Mechanochemical Methods for One‐Pot Multistep Organic Synthesis

  2025cites this paper
• Blue LED photolytic method for the synthesis of 1,4-dihydropyridine derivatives from benzo [b]thiophene-2-carbaldehyde

  2025cites this paper
• Copper Catalyst-Promoted Regioselective Multicomponent Cascade Cyclization of 3-Aza-1,5-enynes with Sulfur Dioxide and Cycloketone Oxime Esters to Access Cyanoalkylsulfonylated 1,2-Dihydropyridines.

  2024cites this paper
• Acridinedione-phthalimide conjugates: Intramolecular electron transfer and singlet oxygen generation studies for optical and photodynamic therapy applications

  2024cites this paper
• Green synthesis of potent anticancer and antibacterial xanthene and chromene derivatives using agar as a catalyst: Molecular docking and in silico ADMET insights

  2024cites this paper
• Stereoselective synthesis of gem-dihalopiperidines via the halo-aza-Prins cyclization reaction: access to piperidin-4-ones and pyridines.

  2024cites this paper
• Sulfonated reduced graphene oxide (rGO-SO3H): a green, sustainable and efficient heterogeneous catalyst for synthesis of pyrazole containing 1,4 dihydropyridine derivatives

  2024cites this paper
• Oxidation Potential of 2,6-Dimethyl-1,4-dihydropyridine Derivatives Estimated by Structure Descriptors

  2024cites this paper
• Selective blockade of Cav1.2 (α1C) versus Cav1.3 (α1D) L-type calcium channels by the black mamba toxin calciseptine

  2024cites this paper
• Novel Far-Red Fluorescent 1,4-Dihydropyridines for L-Type Calcium Channel Imaging.

  2024cites this paper
• Reaction Optimization of Strontium Perchlorate Catalyzed Novel Protocol for Stereoselective Synthesis of Dihydropyrimidinones.

  2023cites this paper
• Fe-mediated oxidative cascade [1 + 2 + 3]-cyclization/esterification reaction: synthesis of 4-alkylated 1,4-dihydropyridines.

  2023cites this paper
• Tandem Protocol of Hexahydroquinoline Synthesis Using [H2-DABCO][HSO4]2 Ionic Liquid as a Green Catalyst at Room Temperature

  2023cites this paper
• Synthesis of 4-Alkylated 1,4-Dihydropyridines: Fe(II)-Mediated Oxidative Cascade Cyclization Reaction of Cyclic Ethers with Enaminones.

  2023cites this paper
• Synthesis of Dihydropyrimidines: Isosteres of Nifedipine and Evaluation of Their Calcium Channel Blocking Efficiency

  2023cites this paper
• Synthesis and cytotoxicity evaluation of novel 1,8-acridinedione derivatives bearing phthalimide moiety as potential antitumor agents

  2023cites this paper
• Design of 1,4-Dihydropyridine Hybrid Benzamide Derivatives: Synthesis and Evaluation of Analgesic Activity and Their Molecular Docking Studies

  2022cites this paper
• Pyrimidine-fused Dinitrogenous Penta-heterocycles as a Privileged Scaffold for Anti-Cancer Drug Discovery.

  2022cites this paper
• Role and mechanism of REG2 depletion in insulin secretion augmented by glutathione peroxidase-1 overproduction

  2022cites this paper
• Recent approaches for the synthesis of pyridines and (iso)quinolines using propargylic Alcohols.

  2022cites this paper
• Efficient and green synthesis of novel hexahydro-5H-thiazolo[2',3':2,3]pyrimido[4,5-b]quinoline derivatives

  2022cites this paper
• 4-Hydroxycoumarin: a versatile substrate for the transition-metal-free multicomponent synthesis of bioactive heterocycles

  2021cites this paper
• Evaluation of Physicochemical Properties of Amphiphilic 1,4-Dihydropyridines and Preparation of Magnetoliposomes

  2021cites this paper
• Microwave assisted organic syntheses (MAOS): The green synthetic method

  2021cites this paper
• Sulfonyl radical-induced regioselective cyclization of 3-aza-1,5-enynes with sulfonyl chlorides to produce 1,2-dihydropyridines by copper catalysis

  2021cites this paper
• Stereo‐ and Regioselective [3+3] Annulation Reaction Catalyzed by Ytterbium: Synthesis of Bicyclic 1,4‐Dihydropyridines

  2021cites this paper
• Genome-Edited Coincidence and PMP22-HiBiT Fusion Reporter Cell Lines Enable an Artifact-Suppressive Quantitative High-Throughput Screening Strategy for PMP22 Gene-Dosage Disorder Drug Discovery.

  2021cites this paper
• Ca2+ Channel Inhibitors

  2021cites this paper
• Exploring the therapeutic potential of mitochondrial uncouplers in cancer

  2021cites this paper
• Fatty Dihydropyridines With Anti-Hypertensive and Cardioprotective Potential During Ischemia and Reperfusion

  2021cites this paper
• Recent developments in the nanomaterial-catalyzed green synthesis of structurally diverse 1,4-dihydropyridines

  2021cites this paper
• New 4-(2-Furyl)-1,4-dihydronicotinonitriles and 1,4,5,6-Tetrahydronicotinonitriles: Synthesis, Structure, and Analgesic Activity

  2021cites this paper
• Sonochemical synthesis of 1,4-dihydropyridines using a bio-derived magnetic nanocomposite based on the pectin modified with the di-sulfonic acids under mild conditions

  2021cites this paper
• An unexpected Cu(II) complex of oxidized 1,4-dydropyridine derivative: Synthesis, characterization and DFT calculations

  2021cites this paper
• Synthesis of medicinally important heterocycles inside the nanoreactors built-in nonconventional reaction media

  2020cites this paper
• Reductive CO2 Fixation via the Selective Formation of C-C Bonds: Bridging Enaminones and Synthesis of 1,4-Dihydropyridines.

  2020cites this paper
• Study of Synthesis and Biological Importance of 1,4-Dihydropyridines Derivatives

  2020cites this paper
• Novel biomass-derived from Grape pomace waste as an efficient nanocatalyst for synthesis of dibenzoxanthene, tetraketone, bis(indolyl)alkane and chromene derivatives and antimicrobial evaluation.

  2020cites this paper
• Proline and its Derivatives as Organocatalysts for Multi‐ Component Reactions in Aqueous Media: Synergic Pathways to the Green Synthesis of Heterocycles

  2020cites this paper
• A Metal Free, Hantzsch Synthesis for Privileged Scaffold 1, 4-Dihydropyridines: A Glycerol Promoted Sustainable Protocol

  2020cites this paper
• Ordered mesoporous molecular sieves as active catalyts for the synthesis of 1,4-dihydropyridine derivatives

  2020cites this paper
• 6-Amino-4-Aryl-3-Carbamoyl-5-Cyano-1,4-Dihydropyridine-2-Thiolates: Synthesis, Reactions and Docking Studies

  2020cites this paper
• Anticancer activity of a 1,4-dihydropyridine in DMBA-induced mouse skin tumor model

  2020cites this paper
• Multicomponent and 1,3-dipolar cycloaddition synthesis of triazole- and isoxazole-acridinedione/xanthenedione heterocyclic hybrids: Cytotoxic effects on human cancer cells

  2020cites this paper
• Catalyst-Free Solid Phase Microwave-Assisted Synthesis of 1,4-Dihydropyridine Derivatives and Their Single Crystal Structure Determination

  2019cites this paper
• High-Voltage-Activated Calcium Channel in the Afferent Pain Pathway: An Important Target of Pain Therapies

  2019cites this paper
• Catalyst-free green synthesis of tetrahydro-benzo[b]pyrans in magnetized water: experimental aspects and molecular dynamics simulation

  2019cites this paper
• GABA‐containing compound gammapyrone protects against brain impairments in Alzheimer’s disease model male rats and prevents mitochondrial dysfunction in cell culture

  2019cites this paper
• Recent Synthetic Approaches and Biological Evaluations of Amino Hexahydroquinolines and Their Spirocyclic Structures.

  2019cites this paper
• The mitochondrial uncoupling as a promising pharmacological target against cancer

  2019cites this paper
• An efficient catalytic method for the synthesis of pyrido[2,3-d]pyrimidines as biologically drug candidates by using novel magnetic nanoparticles as a reusable catalyst

  2018cites this paper
• The mechanism of action of praziquantel: can new drugs exploit similar mechanisms?

  2018cites this paper
• Sulfonated Reduced Graphene Oxide (RGO-SO3H): As an Efficient Nanocatalyst for One-Pot Synthesis of 2-Amino-3-cyano-7-hydroxy-4H-chromenes Derivatives in Water

  2018cites this paper
• New chiral proline-based catalysts for silicon and zirconium oxides-promoted asymmetric Biginelli reaction

  2018cites this paper
• IR-Spectroscopic Study of Adsorption of Aminoazoles on Oxide Catalysts of Biginelli Reaction

  2018cites this paper
• Regio- and stereoselective reaction of 3-fluoropyridine, electron-deficient alkynes and bis(fluoroalkyl) phosphites: Catalyst- and solvent-free synthesis of polyfluoroalkylphosphonylated 3-fluoro-1,2-dihydropyridines

  2018cites this paper
• Design, synthesis and calcium channel blocking activity of novel tetrahydropyrimidine derivatives for potential benefit in angina pectoris

  2017cites this paper
• Trapping of Transient Zwitterionic Intermediates by N-Acylpyridinium Salts: A Palladium-Catalyzed Diastereoselective Three-Component Reaction.

  2017cites this paper
• The cytotoxic effects of VE-3N, a novel 1,4-dihydropyridine derivative, involve the mitochondrial bioenergetic disruption via uncoupling mechanisms.

  2017cites this paper
• Metal-Free Selective Synthesis of 1,4-Dihydropyridazines from Hydroxypyrrolines and Hydrazines

  2017cites this paper
• Murine Electrophysiological Models of Cardiac Arrhythmogenesis.

  2017cites this paper
• 3,6-Dioxaoctamethylenediamminium trifluoromethanesulfonate [3,6-DOMDA]OTf as a novel ionic liquid catalyst for the synthesis of functionalized 1,4-dihydropyridines

  2017cites this paper
• Cardiomyopathy development protection after myocardial infarction in rats: Successful competition for major dihydropyridines’ common metabolite against captopril

  2017cites this paper
• In search of the mutual relationship between the structure, solid-state spectroscopy and molecular dynamics in selected calcium channel blockers.

  2016cites this paper
• Expedient Protocols for the Installation of 1,5-benzodiazepine-based Privileged Templates on 2-position of α, β-enone Incorporated Derivatives of the 1,4-benzodiazepine Nucleus Linked Through a Phenoxyl Spacer

  2016cites this paper
• Chapter 19 – Antianginal Drugs

  2016cites this paper
• One-pot synthesis of polyfluoroalkylphosphonylated dihydropyridines with a carboxylate function from pyridines, alkyl propiolates, and bis(fluoroalkyl) phosphonates

  2016cites this paper
• Synthesis, Evaluation of Pharmacological Activity, and Molecular Docking of 1,4-Dihydropyridines as Calcium Antagonists.

  2016cites this paper
• Multi-Scale Cardiomyocyte Organisation as a Determinant of Cardiac Function

  2016cites this paper
• Novel tandem hydrogen migrations across five chemical bonds for 1,4-dihydropyridine using electrospray ionization FT-ICR mass spectrometry

  2016cites this paper
• 4-Dialkylaminopyridine modified magnetic nanoparticles: as an efficient nano-organocatalyst for one-pot synthesis of 2-amino-4H-chromene-3-carbonitrile derivatives in water

  2016cites this paper
• Atypical 1,4-dihydropyridine derivatives, an approach to neuroprotection and memory enhancement.

  2016cites this paper
• Natural Tetrahydrocurcumin in Multi‐Component Synthesis of 1,4‐Dihydropyridine Derivatives.

  2016cites this paper
• Pyridines and Imidazopyridines with Medicinal Significance.

  2016cites this paper
• Reaction of dithiocarbamates with malononitrile dimer; simple synthesis of new 1,4-dihydropyridine-2-thiols

  2016cites this paper
• 1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues—Model Compounds Targeting Oxidative Stress

  2016cites this paper
• Structure-Based Scaffold Repurposing for G Protein-Coupled Receptors: Transformation of Adenosine Derivatives into 5HT2B/5HT2C Serotonin Receptor Antagonists.

  2016cites this paper
• David J. Triggle: A personal and retrospective overview of an academic journey.

  2015cites this paper
• Evaluation of Antiradical Activity and Reducing Capacity of Synthesised Bispyridinium Dibromides Obtained by Quaternisation of 4-Pyridyl-1,4-dihydropyridines with Propargyl Bromide

  2015cites this paper
• Practical Radiosynthesis and Preclinical Neuroimaging of [11C]isradipine, a Calcium Channel Antagonist

  2015cites this paper
• Computational studies to predict or explain GPCR polypharmacology

  2015cites this paper
• On Becoming a Pharmacologist: Channeling David Triggle.

  2015cites this paper
• Hantzsch-Type dihydropyridines and Biginelli-type tetra-hydropyrimidines: a review of their chemotherapeutic activities.

  2015cites this paper
• A Novel 1,4-Dihydropyridine Derivative Improves Spatial Learning and Memory and Modifies Brain Protein Expression in Wild Type and Transgenic APPSweDI Mice

  2015cites this paper
• Effect of nanosized TiO2–SiO2 covalently modified by chiral molecules on the asymmetric Biginelli reaction

  2015cites this paper
• David J. Triggle: Medicinal chemistry, to pharmacology, calcium channels, and beyond.

  2015cites this paper
• Synthesis and in vitro dual calcium channel antagonist-agonist activity of some 1, 4-Dihydo-2,6-dimethyl-3-nitro and cyano-4-(1-methyl-5- nitro-1H-imidazol-2-yl)-5-pyridinecarboxylates

  2015cites this paper
• Novel synthesis of a series of spiro 1,3-indanedione-fused dihydropyridines through the condensation of a tetrone with N-aryl/alkylenamines in presence of solid support silica sulfuric acid

  2015cites this paper
• Dihydropyridines’ metabolites-induced early apoptosis after myocardial infarction in rats; new outlook on preclinical study with M-2 and M-3

  2015cites this paper
• Formation of magnetoliposomes using self-assembling 1,4-dihydropyridine derivative and maghemite γ-Fe2O3 nanoparticles

  2015cites this paper
• The Triggle effect.

  2015cites this paper
• Diethyl 4-(biphenyl-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

  2014cites this paper
• Structural Probing of Off-Target G Protein-Coupled Receptor Activities within a Series of Adenosine/Adenine Congeners

  2014cites this paper
• High frequency resonant waveguide grating imager for assessing drug-induced cardiotoxicity

  2014cites this paper
• Vascular L-type Ca²⁺ channel blocking activity of sulfur-containing indole alkaloids from Glycosmis petelotii.

  2014cites this paper
• Synthesis and studies of calcium channel blocking and antioxidant activities of novel 4-pyridinium and/or N-propargyl substituted 1,4-dihydropyridine derivatives

  2014cites this paper