Transfer of the high affinity dihydropyridine sensitivity from L-type To non-L-type calcium channel.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Molecular Pharmacology

• Publication date

  1997-10-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1124/MOL.52.4.735PMID 9380037
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Motif III S5 of L-type Calcium Channels Is Involved in the Dihydropyridine Binding Site

  1997cited by this paper
• Two Amino Acid Residues in the IIIS5 Segment of L-Type Calcium Channels Differentially Contribute to 1,4-Dihydropyridine Sensitivity*

  1996cited by this paper
• Molecular Determinants of High Affinity Dihydropyridine Binding in L-type Calcium Channels (*)

  1996influential reference
• Molecular pharmacology of voltage-dependent calcium channels.

  1996cited by this paper
• Transfer of 1,4-dihydropyridine sensitivity from L-type to class A (BI) calcium channels.

  1996cited by this paper
• The IVS6 segment of the L‐type calcium channel is critical for the action of dihydropyridines and phenylalkylamines.

  1996cited by this paper
• Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967).

  1995cited by this paper
• Structure and function of voltage-gated ion channels.

  1995cited by this paper
• Molecular basis for Ca2+ channel diversity.

  1994cited by this paper
• Molecular analysis and functional expression of the human type E neuronal Ca2+ channel alpha 1 subunit.

  1994cited by this paper
• Identification of 1,4‐dihydropyridine binding domains within the primary structure of the α1 subunit of the skeletal muscle L‐type calcium channel

  1993cited by this paper
• Molecular localization of regions in the L-type calcium channel critical for dihydropyridine action.

  1993cited by this paper
• Structure and function of voltage-gated ion channels.

  1993influential reference
• Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS neurons.

  1993cited by this paper
• Dihydropyridine receptor of L-type Ca2+ channels: identification of binding domains for [3H](+)-PN200-110 and [3H]azidopine within the alpha 1 subunit.

  1991cited by this paper
• Identification of 1,4-dihydropyridine binding regions within the alpha 1 subunit of skeletal muscle Ca2+ channels by photoaffinity labeling with diazipine.

  1991cited by this paper
• Identification of the site of interaction of the dihydropyridine channel blockers nitrendipine and azidopine with the calcium‐channel alpha 1 subunit.

  1991cited by this paper
• Primary structure and functional expression of a high voltage activated calcium channel from rabbit lung

  1990cited by this paper
• Voltage‐Dependent Modulation of Cardiac Calcium Channel Current by Optical Isomers of Bay K 8644: Implications for Channel Gating

  1987cited by this paper
• The optical isomers of the 1,4-dihydropyridine BAY K 8644 show opposite effects on Ca channels.

  1985cited by this paper
• Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state.

  1984cited by this paper
• Voltage‐Dependent Block of Calcium Channel Current in the Calf Cardiac Purkinje Fiber by Dihydropyridine Calcium Channel Antagonists

  1984cited by this paper

• Voltage gated sodium and calcium channels: Discovery, structure, function, and Pharmacology

  2023cites this paper
• Calcium‐activated SK potassium channels are key modulators of the pacemaker frequency in locus coeruleus neurons

  2018cites this paper
• L-Type Calcium Channels Modulation by Estradiol

  2016cites this paper
• Structural Basis for Pharmacology of Voltage-Gated Sodium and Calcium Channels

  2015cites this paper
• A concerted action of L- and T-type Ca(2+) channels regulates locus coeruleus pacemaking.

  2015cites this paper
• International Union of Basic and Clinical Pharmacology. XC. Multisite Pharmacology: Recommendations for the Nomenclature of Receptor Allosterism and Allosteric Ligands

  2014cites this paper
• 1,4-Dihydropyridine Calcium Channel Blockers: Homology Modeling of the Receptor and Assessment of Structure Activity Relationship

  2014influential citation
• The Characterization of Nemadipine and Migrazole as Small Molecule Tools for Use in the Nematode Caenorhabditis elegans

  2013influential citation
• Ca²⁺ channels and praziquantel: a view from the free world.

  2013cites this paper
• Chapter 29 – Ion Channels as Targets for Drugs

  2012cites this paper
• Interaction between Ca2+ channel blockers and isoproterenol on L‐type Ca2+ current in canine ventricular cardiomyocytes

  2012cites this paper
• Cardiac Channelopathies: Applications of Genomics and Proteomics in Diagnosis and Therapy

  2011cites this paper
• 1,4-Dihydropyridine scaffold in medicinal chemistry, the story so far and perspectives (part 1): action in ion channels and GPCRs.

  2011cites this paper
• Distinct properties of amlodipine and nicardipine block of the voltage-dependent Ca2+ channels Cav1.2 and Cav2.1 and the mutant channels Cav1.2/dihydropyridine insensitive and Cav2.1/dihydropyridine sensitive.

  2011cites this paper
• A region of N-type Ca(2+) channel critical for blockade by the dihydropyridine amlodipine.

  2010cites this paper
• Differential sensitivities of CaV1.2 IIS5-S6 mutants to 1,4-dihydropyridine analogs.

  2009cites this paper
• Correction: A Genetic Screen for Dihydropyridine (DHP)-Resistant Worms Reveals New Residues Required for DHP-Blockage of Mammalian Calcium Channels

  2009cites this paper
• Structural Model for Dihydropyridine Binding to L-type Calcium Channels*

  2009cites this paper
• A Genetic Screen for Dihydropyridine (DHP)-Resistant Worms Reveals New Residues Required for DHP-Blockage of Mammalian Calcium Channels

  2008influential citation
• Voltage‐Gated Ion Channels

  2007cites this paper
• Competitive and Cooperative Effects of Bay K8644 on the L-Type Calcium Channel Current Inhibition by Calcium Channel Antagonists

  2007cites this paper
• Stereoisomer specific blocking action of two dihydropyridine calcium antagonists (amlodipine, benidipine) on cloned calcium channel subtypes

  2007cites this paper
• Allosteric Interactions Required for High-Affinity Binding of Dihydropyridine Antagonists to CaV1.1 Channels Are Modulated by Calcium in the Pore

  2006cites this paper
• Ca2+ currents in cardiac myocytes: Old story, new insights.

  2006cites this paper
• Pharmacology and drug discovery for T-type calcium channels.

  2006cites this paper
• Biochemical Studies of Voltage-Gated Ca2+ Channels

  2005cites this paper
• Contrasting the effects of nifedipine on subtypes of endogenous and recombinant T-type Ca2+ channels.

  2005cites this paper
• Voltage-dependent calcium channels.

  2005influential citation
• The Molecular Basis of Ca2+ Antagonist Drug Action-Recent Developments

  2005cites this paper
• Calcium channel blockers and calcium channels

  2004cites this paper
• Molecular and functional insights into voltage-gated calcium channels

  2004cites this paper
• Potassium, sodium, calcium and glutamate‐gated channels: pore architecture and ligand action

  2004cites this paper
• Pharmacology of Cav1 (L-Type) Channels

  2004cites this paper
• Calcium Channel Blockers

  2004cites this paper
• Molecular Pharmacology of High Voltage-Activated Calcium Channels

  2003cites this paper
• 1,4-Dihydropyridines as Calcium Channel Ligands and Privileged Structures

  2003cites this paper
• Synthesis and evaluation of a new class of nifedipine analogs with T-type calcium channel blocking activity.

  2002cites this paper
• Mechanism of Dihydropyridine Interaction with Critical Binding Residues of L-type Ca2+ Channel α1 Subunits*

  2001cites this paper
• Potentiation of the Cardiac L-Type Ca2+ Channel (α1C) by Dihydropyridine Agonist and Strong Depolarization Occur via Distinct Mechanisms

  2001cites this paper
• Ion Channels as Targets for Drugs

  2001cites this paper
• State-dependent inhibition of L-type Ca2+ channels in A7r5 cells by cilnidipine and its derivatives.

  2001cites this paper
• Potentiation of the Cardiac L-Type Ca 2 (cid:2) Channel ( (cid:3) 1C ) by Dihydropyridine Agonist and Strong Depolarization Occur via Distinct Mechanisms

  2001cites this paper
• Voltage‐dependent acceleration of Cav1.2 channel current decay by (+)‐ and (−)‐isradipine

  2001cites this paper
• Multiple structural elements contribute to voltage-dependent facilitation of neuronal alpha 1C (CaV1.2) L-type calcium channels.

  2001cites this paper
• Ca2+ channel antagonists and agonists

  2000cites this paper
• State- and isoform-dependent interaction of isradipine with the α1C L-type calcium channel

  2000cites this paper
• Molecular Mechanism of Calcium Channel Block by Isradipine

  2000cites this paper
• Molecular determinants of diltiazem block in domains IIIS6 and IVS6 of L-type Ca(2+) channels.

  2000cites this paper
• Conserved Ca2+-antagonist-binding properties and putative folding structure of a recombinant high-affinity dihydropyridine-binding domain.

  2000cites this paper
• Structure of the Voltage-Dependent L-Type Calcium Channel

  2000cites this paper
• Sequence differences between alpha1C and alpha1S Ca2+ channel subunits reveal structural determinants of a guarded and modulated benzothiazepine receptor.

  1999cites this paper
• Selectivities of Dihydropyridine Derivatives in Blocking Ca 2 1 Channel Subtypes Expressed in Xenopus Oocytes 1

  1999cites this paper
• Reconstruction of the dihydropyridine site in a non‐L‐type calcium channel: the role of the IS6 segment

  1999cites this paper
• Sequence Differences between α1C and α1S Ca2+ Channel Subunits Reveal Structural Determinants of a Guarded and Modulated Benzothiazepine Receptor*

  1999cites this paper
• Distinctions in the molecular determinants of charged and neutral dihydropyridine block of L-type calcium channels.

  1999influential citation
• Dihydropyridine enantiomers block recombinant L‐type Ca2+ channels by two different mechanisms

  1999cites this paper
• Structure and function of the cardiac sodium channels.

  1999cites this paper
• Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes.

  1999cites this paper
• Voltage-dependent calcium channels: from structure to function.

  1999cites this paper
• Structural basis of drug binding to L Ca2+ channels.

  1998cites this paper
• Ca2+ channel block and inactivation: common molecular determinants.

  1998cites this paper
• Cloning and Functional Expression of a Voltage-gated Calcium Channel α1 Subunit from Jellyfish*

  1998cites this paper
• Ca2+ channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human α1C subunit gene

  1998cites this paper
• Molecular Basis of Drug Interaction with L-Type Ca2+ Channels

  1998cites this paper
• Isradipine interacts with the open state of the L-type calcium channel at high concentrations.

  1998cites this paper
• Alternatively spliced IS6 segments of the alpha 1C gene determine the tissue-specific dihydropyridine sensitivity of cardiac and vascular smooth muscle L-type Ca2+ channels.

  1997cites this paper
• Antagonist binding sites of voltage‐dependent calcium channels

  1997cites this paper