Deformation and failure of protein materials in physiologically extreme conditions and disease.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Nature Materials

• Publication date

  2009-03-01

• Fields of study

  Biology, Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.1038/nmat2387PMID 19229265
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• What is Systems Biology?

  2010cited by this paper
• Deformation rate controls elasticity and unfolding pathway of single tropocollagen molecules.

  2009cited by this paper
• The Amyloid Hypothesis of Alzheimer ’ s Disease : Progress and Problems on the Road to Therapeutics

  2009cited by this paper
• Cell and biomolecular mechanics in silico.

  2008cited by this paper
• Natural protective amyloids.

  2008cited by this paper
• Molecular basis of fibrin clot elasticity.

  2008cited by this paper
• Assembly mechanism of recombinant spider silk proteins

  2008cited by this paper
• Hierarchical Coexistence of Universality and Diversity Controls Robustness and Multi-Functionality in Protein Materials

  2008cited by this paper
• Elastic bond network model for protein unfolding mechanics.

  2008cited by this paper
• Theoretical and computational hierarchical nanomechanics of protein materials: Deformation and fracture

  2008cited by this paper
• Towards an integrated understanding of the structure and mechanics of the cell nucleus

  2008cited by this paper
• Single molecule effects of osteogenesis imperfecta mutations in tropocollagen protein domains

  2008cited by this paper
• Measuring molecular rupture forces between single actin filaments and actin-binding proteins

  2008cited by this paper
• Enigmas of Blood Clot Elasticity

  2008cited by this paper
• Strength limit of entropic elasticity in beta-sheet protein domains.

  2008cited by this paper
• Nanomechanical analysis of cells from cancer patients.

  2007cited by this paper
• Morphology and mechanical stability of amyloid-like peptide fibrils

  2007cited by this paper
• Simplicity in biology

  2007cited by this paper
• Biomechanical properties of intermediate filaments: from tissues to single filaments and back

  2007cited by this paper
• Mechanics and deformation of the nucleus in micropipette aspiration experiment.

  2007cited by this paper
• Single-Molecule Experiments in Vitro and in Silico

  2007cited by this paper
• Reverse Engineering of Biological Complexity

  2007cited by this paper
• Nature’s hierarchical materials

  2007cited by this paper
• Forced Unfolding of Proteins Within Cells

  2007cited by this paper
• Nanoscale heterogeneity promotes energy dissipation in bone.

  2007cited by this paper
• Hierarchies, multiple energy barriers, and robustness govern the fracture mechanics of α-helical and β-sheet protein domains

  2007cited by this paper
• Entropic elasticity controls nanomechanics of single tropocollagen molecules.

  2007cited by this paper
• Intermediate filament scaffolds fulfill mechanical, organizational, and signaling functions in the cytoplasm.

  2007cited by this paper
• Forced unfolding of coiled-coils in fibrinogen by single-molecule AFM.

  2007cited by this paper
• Abnormal Mineral-Matrix Interactions Are a Significant Contributor to Fragility in oim/oim Bone

  2007cited by this paper
• Mechanical properties of hydrated collagen fibrils measured by MEMS device

  2007cited by this paper
• Hierarchies, multiple energy barriers, and robustness govern the fracture mechanics of alpha-helical and beta-sheet protein domains.

  2007cited by this paper
• Intermediate filaments: from cell architecture to nanomechanics

  2007cited by this paper
• Forced Unfolding of Proteins Within Cells

  2007cited by this paper
• Role of Intermolecular Forces in Defining Material Properties of Protein Nanofibrils

  2007cited by this paper
• Living with cracks: damage and repair in human bone.

  2007cited by this paper
• Insights into material and structural basis of bone fragility from diseases associated with fractures: how determinants of the biomechanical properties of bone are compromised by disease.

  2007cited by this paper
• Cellular mechanotransduction: putting all the pieces together again

  2006cited by this paper
• Fibrin Fibers Have Extraordinary Extensibility and Elasticity

  2006cited by this paper
• Experimental techniques for single cell and single molecule biomechanics

  2006cited by this paper
• Mutations in vimentin disrupt the cytoskeleton in fibroblasts and delay execution of apoptosis.

  2006cited by this paper
• Intrinsic rates and activation free energies from single-molecule pulling experiments.

  2006cited by this paper
• Nature designs tough collagen: Explaining the nanostructure of collagen fibrils

  2006cited by this paper
• Nanoscale Mechanical Characterisation of Amyloid Fibrils Discovered in a Natural Adhesive

  2006cited by this paper
• Evidence for an elementary process in bone plasticity with an activation enthalpy of 1 eV

  2006cited by this paper
• Distinct structural and mechanical properties of the nuclear lamina in Hutchinson–Gilford progeria syndrome

  2006cited by this paper
• Monitoring intermediate filament assembly by small-angle x-ray scattering reveals the molecular architecture of assembly intermediates

  2006cited by this paper
• New Tools Provide New Insights in NMR Studies of Protein Dynamics

  2006cited by this paper
• Microfibrillar structure of type I collagen in situ.

  2006cited by this paper
• Intersex Management: What Is Achieved and What Is Needed

  2006cited by this paper
• Anisotropic deformation response of single protein molecules

  2006cited by this paper
• Characterization of the nanoscale properties of individual amyloid fibrils

  2006cited by this paper
• Cooperative deformation of mineral and collagen in bone at the nanoscale

  2006cited by this paper
• Protein misfolding, functional amyloid, and human disease.

  2006cited by this paper
• Molecular designer self-assembling peptides.

  2006cited by this paper
• Matrix elasticity directs stem cell lineage specification.

  2006cited by this paper
• Nano measurements with micro-devices: mechanical properties of hydrated collagen fibrils

  2006cited by this paper
• β-Sheet mediated self-assembly of dipeptides of ω-amino acids and remarkable fibrillation in the solid state

  2005cited by this paper
• beta-Sheet mediated self-assembly of dipeptides of omega-amino acids and remarkable fibrillation in the solid state.

  2005cited by this paper
• Sacrificial bonds and hidden length dissipate energy as mineralized fibrils separate during bone fracture

  2005cited by this paper
• The nuclear lamina comes of age

  2005cited by this paper
• X-ray tomography of whole cells.

  2005cited by this paper
• Optical deformability as an inherent cell marker for testing malignant transformation and metastatic competence.

  2005cited by this paper
• Controlled assembly of macromolecular beta-sheet fibrils.

  2005cited by this paper
• A classic assembly of nanobiomaterials

  2005cited by this paper
• How well can simulation predict protein folding kinetics and thermodynamics?

  2005cited by this paper
• Controlled Assembly of Macromolecular β-Sheet Fibrils

  2005cited by this paper
• Osteogenesis imperfecta.

  2004cited by this paper
• Large deformation of living cells using laser traps

  2004cited by this paper
• Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction.

  2004cited by this paper
• Kinetic control of dimer structure formation in amyloid fibrillogenesis.

  2004cited by this paper
• Stability of adhesion clusters under constant force.

  2004cited by this paper
• Molecular dynamics simulations of spontaneous fibril formation by random-coil peptides.

  2004cited by this paper
• The nuclear envelope and human disease.

  2004cited by this paper
• Mapping domain structures in silks from insects and spiders related to protein assembly.

  2004cited by this paper
• Mechanics of vimentin intermediate filaments

  2004cited by this paper
• High-resolution AFM imaging of intact and fractured trabecular bone.

  2004cited by this paper
• Crystal structure of the human lamin A coil 2B dimer: implications for the head-to-tail association of nuclear lamins.

  2004cited by this paper
• Measurement of hardness and elastic modulus by instrumented indentation: Advances in understanding and refinements to methodology

  2004cited by this paper
• Stretching type II collagen with optical tweezers.

  2004cited by this paper
• Molecular mechanisms underlying the assembly of intermediate filaments.

  2004cited by this paper
• Designing materials for biology and medicine

  2004cited by this paper
• Intermediate filament proteins and their associated diseases.

  2004cited by this paper
• Empirical force fields for biological macromolecules: Overview and issues

  2004cited by this paper
• Synchrotron diffraction study of deformation mechanisms in mineralized tendon.

  2004cited by this paper
• Mechanics of the human red blood cell deformed by optical tweezers

  2003cited by this paper
• Conducting nanowires built by controlled self-assembly of amyloid fibers and selective metal deposition

  2003cited by this paper
• Properties of Collagen in OIM Mouse Tissues

  2003cited by this paper
• INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL 232

  2003cited by this paper
• Protein folding and misfolding

  2003cited by this paper
• Intermediate filaments: molecular structure, assembly mechanism, and integration into functionally distinct intracellular Scaffolds.

  2003cited by this paper
• Molecular architecture of intermediate filaments

  2003cited by this paper
• Kinetics from nonequilibrium single-molecule pulling experiments.

  2003cited by this paper
• Materials become insensitive to flaws at nanoscale: Lessons from nature

  2003cited by this paper
• Assembly and structure of neurofilaments

  2003cited by this paper
• Alport's syndrome, Goodpasture's syndrome, and type IV collagen.

  2003cited by this paper
• Mechanistic fracture criteria for the failure of human cortical bone

  2003cited by this paper
• Collagens--structure, function, and biosynthesis.

  2003cited by this paper
• Reverse Engineering of Biological Complexity

  2002cited by this paper
• Molecular dynamics simulations of biomolecules

  2002cited by this paper

• Design and sustainability of polypeptide material systems

  2025cites this paper
• The feather’s multi-functional structure across nano to macro scales inspires hierarchical design

  2025cites this paper
• Visual β-Sheet-to-β-Turn Transition in Luminescent Polymeric Vesicles for Color-Reporting Drug Delivery.

  2025cites this paper
• Ultrastructural viscoelasticity of fibrillar collagen identified by AFM Nano-Rheometry and direct indentation.

  2025cites this paper
• 3D full-field lacunar morphology and deformation of calcified fibrocartilage in the loaded Achilles enthesis of a mouse

  2025cites this paper
• Protein Catalysis Through Structural Dynamics: A Comprehensive Analysis of Energy Conversion in Enzymatic Systems and Its Computational Limitations

  2025cites this paper
• Mechanistic Understanding of Protein–MOF Integration through Surfactant-Driven Interfacial Design

  2025cites this paper
• Animal-skin-pattern-inspired multifunctional composites by generative AI

  2025cites this paper
• Selective Imperfection as a Generative Framework for Analysis, Creativity and Discovery

  2025cites this paper
• A Bio‐Inspired Perspective on Materials Sustainability

  2025cites this paper
• Compositional, Structural, and Biomechanical Properties of Three Different Soft Tissue-Hard Tissue Insertions: A Comparative Review.

  2024cites this paper
• Understanding the effects of mineralization and structure on the mechanical properties of tendon-bone insertion using mesoscale computational modeling.

  2024cites this paper
• Injectable tissue-engineered human cartilage matrix composite fibrin glue for regeneration of articular cartilage defects.

  2024cites this paper
• Poroviscoelasto-plasticity of agarose-based hydrogels.

  2023cites this paper
• Review paper: The importance of consideration of collagen cross-links in computational models of collagen-based tissues.

  2023cites this paper
• Sensing Dynamically Evolved Short‐Range Nanomechanical Forces in Fast‐Mutating Single Viral Spike Proteins

  2023cites this paper
• Building block aspect ratio controls assembly, architecture, and mechanics of synthetic and natural protein networks

  2023cites this paper
• Mineralization of Bone Extracellular Matrix-like Scaffolds Fabricated as Silk Sericin-Functionalized Dense Collagen–Fibrin Hybrid Hydrogels

  2023cites this paper
• High-performance artificially reeled silkworm silk via a multi-task and high-efficiency centrifugal reeling technique and its application in soft actuators.

  2023cites this paper
• Alteration of extracellular matrix proteins in atrophic periodontal ligament of hypofunctional rat molars

  2023cites this paper
• A synergistic investigation of azo-thiazole derivatives incorporating thiazole moieties: a comprehensive exploration of their synthesis, characterization, computational insights, solvatochromism, and multimodal biological activity assessment

  2023cites this paper
• A highly carboxylated sponge-like material: preparation, characterization and protein adsorption

  2023cites this paper
• Generative design of de novo proteins based on secondary structure constraints using an attention-based diffusion model.

  2023cites this paper
• End-to-End Deep Learning Model to Predict and Design Secondary Structure Content of Structural Proteins.

  2022cites this paper
• MIT Open

  2022cites this paper
• Quantum, molecular and continuum modeling in nonlinear mechanics of viruses

  2022cites this paper
• Design, manufacture, and testing of customized sterilizable respirator

  2022cites this paper
• Finite element modeling of α-helices and tropocollagen molecules referring to spike of SARS-CoV-2

  2022cites this paper
• CollagenTransformer: End-to-End Transformer Model to Predict Thermal Stability of Collagen Triple Helices Using an NLP Approach.

  2022cites this paper
• Natural Silk Spinning‐Inspired Meso‐Assembly‐Processing Engineering Strategy for Fabricating Soft Tissue‐Mimicking Biomaterials

  2022cites this paper
• Double - Network Hydrogel Based on Exopolysaccharides as a Biomimetic Extracellular Matrix to Augment Articular Cartilage Regeneration.

  2022cites this paper
• Molecular investigations of the prenucleation mechanism of bone-like apatite assisted by type I collagen nanofibrils: insights into intrafibrillar mineralization.

  2022cites this paper
• Multiscale mechanical design of the lightweight, stiff, and damage-tolerant cuttlebone: a computational study.

  2022cites this paper
• Biodegradable and bioactive polymer/inorganic phase composites

  2022cites this paper
• Peculiar Tensile and Fracture Behaviors of Natural Silk Fiber in the Presence of an Artificial Notch

  2022cites this paper
• A Genetically Engineered, Chain Mail-Like Nanostructured Protein Material with Increased Fatigue Resistance and Enhanced Self-Healing.

  2022cites this paper
• Nano-biofertilizers as bio-emerging strategies for sustainable agriculture development: Potentiality and their limitations.

  2022cites this paper
• Selective Adsorption and Separation of Proteins by Ligand-Modified Nanofiber Fabric

  2021cites this paper
• A coarse-grained mechanical model for folding and unfolding of tropoelastin with possible mutations.

  2021cites this paper
• Insights into the hydrogen-bond cross-linking effects of small multiamine molecules on physical and mechanical properties of poly(vinly alcohol) by molecular dynamics simulations

  2021cites this paper
• Multiscale Modeling and Applications of Bioinspired Materials with Gyroid Structures

  2021cites this paper
• Stem cell therapies in tendon-bone healing

  2021cites this paper
• Synthesis, Characterization, and Simulation of Four-Armed Megamolecules.

  2021cites this paper
• Effect of receptors on the resonant and transient harmonic vibrations of Coronavirus

  2021cites this paper
• Automated biofabrication of anisotropic dense fibrin gels accelerate osteoblastic differentiation of seeded mesenchymal stem cells

  2021cites this paper
• Porous Biphasic Calcium Phosphate for Biomedical Application

  2021cites this paper
• Protein Assembly by Design.

  2021cites this paper
• Dimensional analysis of structural response in complex biological structures

  2020cites this paper
• Failure simulation and design optimization of bioinspired heterogeneous interfaces by Floquet-based bar-spring model

  2020cites this paper
• Comparative Analysis of Nanomechanical Features of Coronavirus Spike Proteins and Correlation with Lethality and Infection Rate

  2020cites this paper
• Side-Chain Length Dependence of Young’s Modulus and Strength in Crystalline Poly(3-alkylthiophene) Nanofibers

  2020cites this paper
• A perspective on musical representations of folded protein nanostructures

  2020cites this paper
• MAHDI PAHLEVAN: Silk-inspired molecular design of bacterial nanocellulose biomaterials

  2020cites this paper
• Tailoring extracellular matrix mechanics

  2020cites this paper
• Anisotropic Dynamics and Mechanics of Macromolecular Crystals Containing Lattice-Patterned Polymer Networks.

  2020cites this paper
• Nanomechanical sonification of the 2019-nCoV coronavirus spike protein through a materiomusical approach

  2020cites this paper
• Tunable and Cooperative Thermomechanical Properties of Protein-Metal-Organic Frameworks.

  2020cites this paper
• Silk-Based Hierarchical Materials for High Mechanical Performance at the Interface of Modeling, Synthesis, and Characterization

  2020cites this paper
• Connectivity and plasticity determine collagen network fracture

  2020cites this paper
• Achieving coalesced breathability, mechanical and shape memory properties of collagen fibrous matrix through complexing with chromium (III)

  2020cites this paper
• Rapunzel! Rapunzel! How Strong Is Your Hair?

  2020cites this paper
• Wave Propagation and Energy Dissipation in Collagen Molecules.

  2020cites this paper
• Single molecule protein stabilisation translates to macromolecular mechanics of a protein network.

  2020cites this paper
• Sonification based de novo protein design using artificial intelligence, structure prediction, and analysis using molecular modeling

  2020cites this paper
• Disorder protects collagen networks from fracture

  2019cites this paper
• Nonlinear mechanics of lamin filaments and the meshwork topology build an emergent nuclear lamina

  2019cites this paper
• Patterned Amyloid Materials Integrating Robustness and Genetically Programmable Functionality.

  2019cites this paper
• Desenvolvimento de ferramentas de análise da dinâmica de forças de tração durante o ciclo de contração de cardiomiócitos isolados in vitro

  2019cites this paper
• Evaluation of Biodegradability Characteristics of Cellulose-based Film as per IS/ISO 14855-1

  2019cites this paper
• Biomimetic Pulsating Vesicles with both pH-Tunable Membrane Permeability and Light-Triggered Disassembly-Reassembly Behaviors Prepared by Supra-Amphiphilic Helices.

  2019cites this paper
• 3D Printing of Silk Protein Structures by Aqueous Solvent-Directed Molecular Assembly.

  2019cites this paper
• Modulating conformational stability of human serum albumin and implications for surface passivation applications.

  2019cites this paper
• Revealing the assembly of filamentous proteins with scanning transmission electron microscopy

  2019cites this paper
• Atomistic study of interfacial creep behavior in epoxy-silica bilayer system

  2018cites this paper
• Multicomponent self-assembly as a tool to harness new properties from peptides and proteins in material design.

  2018cites this paper
• Rationally designed synthetic protein hydrogels with predictable mechanical properties

  2018cites this paper
• D nanomaterials assembled from sequence-defined molecules

  2018cites this paper
• The Rise of Hierarchical Nanostructured Materials from Renewable Sources: Learning from Nature.

  2018cites this paper
• The quest for mechanically and biologically functional soft biomaterials via soft network composites☆

  2018cites this paper
• Study on the oxidation of fibrinogen using Fe3O4 magnetic nanoparticles and its influence to the formation of fibrin.

  2018cites this paper
• De Novo Design of Recombinant Spider Silk Proteins for Material Applications

  2018cites this paper
• Interchain Overlap Affects Formation of Silk Fibroin Secondary Structures on Hydrophobic Polystyrene Surface Detected via Achiral/Chiral Sum Frequency Generation.

  2018cites this paper
• Nanofibrils in nature and materials engineering.

  2018cites this paper
• Nonamphiphilic Assembly of Metal Carbonyl Complexes: Chemical Structure, Kinetics, and Hydrophobic Effect

  2018cites this paper
• 1 Soft Composites with Tunable Optical and Electrical Properties

  2018cites this paper
• Soft Composites with Tunable Optical and Electrical Properties

  2018cites this paper
• Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment.

  2017cites this paper
• Micromechanical model for protein materials: From macromolecules to macroscopic fibers.

  2017cites this paper
• Universal structure motifs in biominerals: a lesson from nature for the efficient design of bioinspired functional materials

  2017influential citation
• Recent Advances and Future Prospects of Aggregation-induced Emission Carbohydrate Polymers.

  2017cites this paper
• Measuring the flexural rigidity of actin filaments and microtubules from their thermal fluctuating shapes: A new perspective

  2017cites this paper
• Staggered Fibrils and Damageable Interfaces Lead Concurrently and Independently to Hysteretic Energy Absorption and Inhomogeneous Strain Fields in Cyclically Loaded Antler Bone.

  2017cites this paper
• The processing and heterostructuring of silk with light.

  2017cites this paper
• Toughening of fibrous scaffolds by mobile mineral deposits.

  2017cites this paper
• Structural analysis of oligomeric and protofibrillar Aβ amyloid pair structures considering F20L mutation effects using molecular dynamics simulations

  2017cites this paper
• Mechanical and vibrational characterization of amyloid-like HET-s nanosheets based on the skewed plate theory.

  2017cites this paper
• The micromechanical and microstructural characterization of the structural interface at the tendon-bone attachment

  2017cites this paper
• 2D nanomaterials assembled from sequence-defined molecules

  2017cites this paper
• The microstructure and micromechanics of the tendon-bone insertion.

  2017cites this paper
• Recent developments of first‐principles force fields

  2017cites this paper