Hypoxia, melanocytes and melanoma – survival and tumor development in the permissive microenvironment of the skin

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Pigment Cell & Melanoma Research

• Publication date

  2009-04-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1111/j.1755-148X.2009.00553.xPMID 19222803PMCID PMC3038250
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells.

  2009cited by this paper
• Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche.

  2009cited by this paper
• Notch signaling regulates tumor angiogenesis by diverse mechanisms

  2008cited by this paper
• Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

  2008cited by this paper
• Understanding Signaling Cascades in Melanoma †

  2008influential reference
• Prognostic biomarkers in uveal melanoma: evidence for a stem cell-like phenotype associated with metastasis

  2008cited by this paper
• Notch1 is an effector of Akt and hypoxia in melanoma development.

  2008cited by this paper
• Hypoxia-inducible factor 1alpha mediates anoikis resistance via suppression of alpha5 integrin.

  2008cited by this paper
• TWIST activation by hypoxia inducible factor-1 (HIF-1): Implications in metastasis and development

  2008cited by this paper
• Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7.

  2008cited by this paper
• Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development.

  2008cited by this paper
• IGFBPs contribute to survival of pancreatic cancer cells under severely hypoxic conditions.

  2008cited by this paper
• The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways

  2008cited by this paper
• Oxygen sensing and the DNA-damage response.

  2007influential reference
• Mutant V600E BRAF increases hypoxia inducible factor-1alpha expression in melanoma.

  2007cited by this paper
• Hypoxia in cancer: significance and impact on clinical outcome

  2007cited by this paper
• Mutant V600E BRAF Increases Hypoxia Inducible Factor-1α Expression in Melanoma

  2007cited by this paper
• Two faces of p53: aging and tumor suppression

  2007cited by this paper
• HIF gene expression in cancer therapy.

  2007cited by this paper
• Mechanism of UV-related carcinogenesis and its contribution to nevi/melanoma.

  2007cited by this paper
• Hypoxia Inducible Factor-2α in Cancer

  2007cited by this paper
• [Hypoxia inducible factor 1a is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells].

  2006cited by this paper
• HIF1alpha delays premature senescence through the activation of MIF.

  2006cited by this paper
• Oxygen levels in normal and previously irradiated human skin as assessed by EF5 binding.

  2006cited by this paper
• Involvement of HIF-1 in Invasion of Mum2B Uveal Melanoma Cells

  2006cited by this paper
• HIF1α delays premature senescence through the activation of MIF

  2006cited by this paper
• Glucose metabolism and cancer.

  2006cited by this paper
• Lysyl oxidase is essential for hypoxia-induced metastasis

  2006cited by this paper
• Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/phosphatidylinositol 3-kinase-Akt pathways and up-regulating N-cadherin expression.

  2006cited by this paper
• Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells

  2006cited by this paper
• Regulation of angiogenesis by hypoxia-inducible factor 1.

  2006cited by this paper
• Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice.

  2006cited by this paper
• Spontaneous and UVR-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice

  2006cited by this paper
• Reactive Oxygen Species as Mediators of Cellular Senescence

  2005cited by this paper
• Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

  2005influential reference
• BRAFE600-associated senescence-like cell cycle arrest of human naevi

  2005cited by this paper
• Oncogene-induced senescence as an initial barrier in lymphoma development

  2005cited by this paper
• Senescence comes of age

  2005cited by this paper
• Immortalization of primary human prostate epithelial cells by c-Myc.

  2005cited by this paper
• Hypoxia-inducible factor 1α is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells

  2005cited by this paper
• Hypoxia requires notch signaling to maintain the undifferentiated cell state.

  2005cited by this paper
• Glycolytic enzymes can modulate cellular life span.

  2005cited by this paper
• [Cutaneous photobiology].

  2005cited by this paper
• Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27Kip1 degradation

  2005cited by this paper
• Insulin-like growth factor-binding protein-1 (IGFBP-1) mediates hypoxia-induced embryonic growth and developmental retardation.

  2005cited by this paper
• The hypoxic microenvironment of the skin contributes to Akt-mediated melanocyte transformation.

  2005cited by this paper
• Akt Stimulates Aerobic Glycolysis in Cancer Cells

  2004cited by this paper
• Uncontrolled Expression of Vascular Endothelial Growth Factor and Its Receptors Leads to Insufficient Skin Angiogenesis in Patients With Systemic Sclerosis

  2004cited by this paper
• Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia.

  2004cited by this paper
• Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

  2003cited by this paper
• Targeting HIF-1 for cancer therapy

  2003cited by this paper
• Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model

  2003cited by this paper
• Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin.

  2003cited by this paper
• Nuclear factor-kappaB mediates angiogenesis and metastasis of human bladder cancer through the regulation of interleukin-8.

  2003cited by this paper
• Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy

  2003cited by this paper
• Cutaneous photobiology. The melanocyte vs. the sun: who will win the final round?

  2003cited by this paper
• Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1.

  2003cited by this paper
• Inhibition of phosphoinositide 3-kinase β

  2003cited by this paper
• Induction of Cyclin D1 Transcription and CDK2 Activity by Notchic: Implication for Cell Cycle Disruption in Transformation by Notchic

  2001cited by this paper
• Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

  2001cited by this paper
• HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing

  2001influential reference
• Hypoxia Extends the Life Span of Vascular Smooth Muscle Cells through Telomerase Activation

  2001cited by this paper
• HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation.

  2001influential reference
• HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation

  2001cited by this paper
• Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation

  2001cited by this paper
• Enhanced Proliferation, Survival, and Dopaminergic Differentiation of CNS Precursors in Lowered Oxygen

  2000cited by this paper
• Atmospheric oxygen accelerates the induction of a post-mitotic phenotype in human dermal fibroblasts: the key protective role of glutathione.

  2000cited by this paper
• Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1 *

  2000cited by this paper
• Role of Interleukin-8 in Tumor Growth and Metastasis of Human Melanoma

  1999cited by this paper
• Ras Proteins Induce Senescence by Altering the Intracellular Levels of Reactive Oxygen Species*

  1999cited by this paper
• Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: a possible model for IGFBP-1 expression in fetal hypoxia.

  1998cited by this paper
• Myc activates telomerase.

  1998cited by this paper
• Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

  1997cited by this paper
• Intratumoral oxygen tension in metastatic melanoma

  1997cited by this paper
• Regulation of Angiogenesis

  1996cited by this paper
• Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

  1996influential reference
• Why is grass green?

  1994cited by this paper
• of Insulin-Like Growth

  1993cited by this paper
• Effects of oxygen tension on the growth and pigmentation of normal human melanocytes.

  1990cited by this paper
• Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

  1989cited by this paper
• Skin sensitization by misonidazole: a demonstration of uniform mild hypoxia.

  1982cited by this paper
• Extension of the lifespan of cultured normal human diploid cells by vitamin E: a reevaluation.

  1977cited by this paper
• The systemic oxygen supply to the surface of human skin.

  1967cited by this paper

• Non-optimal apparent temperatures can increase the risk of acne: a multi-center time-series study

  2026cites this paper
• Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

  2025cites this paper
• Impact of oxygen deprivation on the FLASH effect for skin toxicity in a murine model.

  2025cites this paper
• Patient-specific prediction of glioblastoma growth via reduced order modeling and neural networks.

  2024cites this paper
• Environmentally Controlled Microfluidic System Enabling Immune Cell Flow and Activation in an Endothelialised Skin‐On‐Chip

  2024cites this paper
• Physiological skin oxygen levels: An important criterion for skin cell functionality and therapeutic approaches.

  2024cites this paper
• 3D Artificial Skin Platform for Investigating Pregnancy-Related Skin Pigmentation

  2024cites this paper
• Femtosecond pulsed laser photodynamic therapy activates melanin and eradicates malignant melanoma

  2024cites this paper
• Interpreting cancer incidence rates and trends: A review of control factors and worldwide statistics

  2024cites this paper
• Ranolazine: a potential anti-metastatic drug targeting voltage-gated sodium channels

  2024cites this paper
• Deciphering oxygen distribution and hypoxia profiles in the tumor microenvironment: a data-driven mechanistic modeling approach

  2024cites this paper
• Hypoxic transcriptomes predict survival and tumor-infiltrating immune cell composition in cutaneous melanoma

  2024cites this paper
• Different Effects of Berberine Delivery to Mitochondria on Cells Derived from the Neural Crest.

  2024cites this paper
• Differential Impact of Intermittent vs. Sustained Hypoxia on HIF-1, VEGF and Proliferation of HepG2 Cells

  2023cites this paper
• Hypoxia in Skin Cancer: Molecular Basis and Clinical Implications

  2023cites this paper
• Melanomas and mast cells: an ambiguous relationship.

  2023cites this paper
• Treatment with the PPARα agonist fenofibrate improves the efficacy of CD8+ T cell therapy for melanoma

  2023cites this paper
• Hypoxia-Induced Changes in L-Cysteine Metabolism and Antioxidative Processes in Melanoma Cells

  2023cites this paper
• A Light sheet fluorescence microscopy and machine learning-based approach to investigate drug and biomarker distribution in whole organs and tumors

  2023cites this paper
• Long-term severe hypoxia adaptation induces non-canonical EMT and a novel Wilms Tumor 1 (WT1) isoform

  2023cites this paper
• On the Treatment of Melanoma: A Mathematical Model of Oncolytic Virotherapy.

  2023influential citation
• Hypoxia activation attenuates progesterone synthesis in goat trophoblast cells via NR1D1 inhibition of StAR expression

  2023cites this paper
• Global trends of cancer: The role of diet, lifestyle, and environmental factors

  2023cites this paper
• CA-IX-Expressing Small Extracellular Vesicles (sEVs) Are Released by Melanoma Cells under Hypoxia and in the Blood of Advanced Melanoma Patients

  2023cites this paper
• Association between hypertension and cutaneous melanoma, and the effect of aspirin: extended follow-up of a large randomised controlled trial.

  2022cites this paper
• Towards an In Vitro 3D Model for Photosynthetic Cancer Treatment: A Study of Microalgae and Tumor Cell Interactions

  2022cites this paper
• A cis-regulatory lexicon of DNA motif combinations mediating cell-type-specific gene regulation

  2022cites this paper
• Multiphoton imaging of melanoma 3D models with plasmonic nanocapsules.

  2022cites this paper
• ODOS MELANOMA. DIAGNOSTIKA IR GYDYMAS

  2022cites this paper
• The Impact of Hyaluronan on Tumor Progression in Cutaneous Melanoma

  2022cites this paper
• Expression of Alternative Splice Variants of 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase-4 in Normoxic and Hypoxic Melanoma Cells

  2021cites this paper
• HIF-1 inhibitors: differential effects of Acriflavine and Echinomycin on tumor associated CA-IX enzyme and VEGF in melanoma

  2021cites this paper
• Combinatorial Therapies to Overcome BRAF/MEK Inhibitors Resistance in Melanoma Cells: An in vitro Study

  2021cites this paper
• A reliable set of reference genes to normalize oxygen-dependent cytoglobin gene expression levels in melanoma

  2021cites this paper
• Hypoxia-dependent drivers of melanoma progression

  2021cites this paper
• Integrated Bioinformatics Analysis Exhibits Pivotal Exercise-Induced Genes and Corresponding Pathways in Malignant Melanoma

  2021cites this paper
• HSP70iQ435A to subdue autoimmunity and support anti-tumor responses

  2021cites this paper
• COL2A1 Is a Novel Biomarker of Melanoma Tumor Repopulating Cells

  2020cites this paper
• Dual-Agent Photodynamic Therapy with Optical Clearing Eradicates Pigmented Melanoma in Preclinical Tumor Models

  2020cites this paper
• Hypoxia: A Double-Edged Sword During Fungal Pathogenesis?

  2020cites this paper
• Targeting Melanoma Hypoxia with the Food-Grade Lactic Acid Bacterium Lactococcus Lactis

  2020cites this paper
• Current Therapies and New Targets to Fight Melanoma: A Promising Role for the β3-Adrenoreceptor

  2020cites this paper
• Modelling cancer cell budding in-vitro as a self-organised, non-equilibrium growth process.

  2020cites this paper
• Tumour Microenvironment in Skin Carcinogenesis.

  2020cites this paper
• Acriflavine, a Potent Inhibitor of HIF-1α, Disturbs Glucose Metabolism and Suppresses ATF4-Protective Pathways in Melanoma under Non-hypoxic Conditions

  2020cites this paper
• Learning epistatic polygenic phenotypes with Boolean interactions

  2020cites this paper
• OxyChip Implantation and Subsequent Electron Paramagnetic Resonance Oximetry in Human Tumors Is Safe and Feasible: First Experience in 24 Patients

  2020cites this paper
• Inhibition of Melanoma Cell Migration and Invasion Targeting the Hypoxic Tumor Associated CAXII

  2020cites this paper
• On the relationship between VDR, RORα and RORγ receptors expression and HIF1‐α levels in human melanomas

  2019cites this paper
• Composition, antioxidant capacity and cytotoxic activity of Eugenia uniflora L. chemotype-oils from the Amazon.

  2019cites this paper
• Melanoma Metabolism

  2019cites this paper
• The self-organised, non-equilibrium dynamics of spontaneous cancerous buds

  2019cites this paper
• Learning patient‐specific parameters for a diffuse interface glioblastoma model from neuroimaging data

  2019cites this paper
• Modifiable Host Factors in Melanoma: Emerging Evidence for Obesity, Diet, Exercise, and the Microbiome

  2019cites this paper
• A novel versatile animal-free 3D tool for rapid low-cost assessment of immunodiagnostic microneedles

  2019cites this paper
• Physiologically Relevant Oxygen Concentration (6% O2) as an Important Component of the Microenvironment Impacting Melanoma Phenotype and Melanoma Response to Targeted Therapeutics In Vitro

  2019cites this paper
• Metabolism: The Sweet Spot in Melanoma Precision Medicine?

  2018cites this paper
• Macrophages in skin melanoma-the key element in melanomagenesis.

  2018cites this paper
• Role of Vitamin C in Skin Diseases

  2018cites this paper
• Mitochondrial dynamic alterations regulate melanoma cell progression

  2018cites this paper
• Analysis of Malignant Melanoma Cell Lines Exposed to Hypoxia Reveals the Importance of PFKFB4 Overexpression for Disease Progression

  2018cites this paper
• Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis

  2018cites this paper
• Understanding the Microenvironment of Melanoma Cells for the Development of Target Drug Delivery Systems

  2017cites this paper
• An immunohistochemical study of NFE2L2, KEAP1 and 8-hydroxy-2'-deoxyguanosine and the EMT markers SNAI2, ZEB1 and TWIST1 in metastatic melanoma.

  2017cites this paper
• Employing the enzyme cofactor function of ascorbic acid to affect oncogenic pathways in human melanoma: modulating Hypoxia Inducible Factor-1α and DNA demethylation to reduce malignant potential

  2017cites this paper
• Hypoxia‐induced HIF1α targets in melanocytes reveal a molecular profile associated with poor melanoma prognosis

  2017cites this paper
• Synthetic lethality: emerging targets and opportunities in melanoma

  2017cites this paper
• Structural studies of two cancer targets involved in protein-protein interactions

  2017cites this paper
• Oscillations in microvascular flow : their relationship to tissue oxygenation, cellular metabolic function and their diagnostic potential for detecting skin melanoma - clinical, experimental and theoretical investigations

  2016cites this paper
• An immunohistochemical study of NFE 2 L 2 , KEAP 1 and 8-hydroxy-2 '-deoxyguanosine and the EMT markers SNAI 2 , ZEB 1 and TWIST 1 in metastatic melanoma

  2016cites this paper
• The Biology of Melanoma

  2016cites this paper
• Hypoxia and MITF regulate KIT oncogenic properties in melanocytes

  2016cites this paper
• Acidic tumor microenvironment in human melanoma

  2016cites this paper
• A gene expression signature identifying transient DNMT1 depletion as a causal factor of cancer-germline gene activation in melanoma

  2015cites this paper
• The clinicopathological and gene expression patterns associated with ulceration of primary melanoma

  2015cites this paper
• Notch1 Autoactivation via Transcriptional Regulation of Furin, Which Sustains Notch1 Signaling by Processing Notch1-Activating Proteases ADAM10 and Membrane Type 1 Matrix Metalloproteinase

  2015cites this paper
• Furin is a direct transcription target of Notch1

  2015cites this paper
• DW-F5: A novel formulation against malignant melanoma from Wrightia tinctoria

  2015cites this paper
• Ascorbic acid and ascorbate-2-phosphate decrease HIF activity and malignant properties of human melanoma cells

  2015cites this paper
• Vitamins and Melanoma

  2015cites this paper
• Senescence Escape in Melanoma: Role of Spleen Tyrosine Kinase SYK

  2014cites this paper
• Tumor Dormancy, Quiescence, and Senescence, Volume 2

  2014cites this paper
• Metabolism under hypoxia in Tm1 murine melanoma cells is affected by the presence of galectin-3, a metabolomics approach

  2014cites this paper
• CTGF is a therapeutic target for metastatic melanoma

  2014cites this paper
• Morphology of melanocytic lesions in situ

  2014cites this paper
• Proopiomelanocortin gene delivery induces apoptosis in melanoma through NADPH oxidase 4-mediated ROS generation.

  2014cites this paper
• Patterns in melanocytic lesions: impact of the geometry on growth and transport inside the epidermis

  2014cites this paper
• Functional involvement of β3-adrenergic receptors in melanoma growth and vascularization

  2013cites this paper
• Abnormalities of Pigmentation

  2013cites this paper
• [Role of tumor microenvironment in the formation and progression of skin melanoma].

  2013cites this paper
• Structure-based design of covalent Siah inhibitors.

  2013cites this paper
• Hypoxia-induced senescence contributes to the regulation of microenvironment in melanomas.

  2013cites this paper
• Melanoma: From Melanocyte to Genetic Alterations and Clinical Options

  2013cites this paper
• Therapeutic improvement of a stroma-targeted CRAd by incorporating motives responsive to the melanoma microenvironment.

  2013cites this paper
• Identification of the Hypoxia-inducible Factor 2α Nuclear Interactome in Melanoma Cells Reveals Master Proteins Involved in Melanoma Development*

  2012cites this paper
• Evaluation of protein expression pattern of stanniocalcin 2, insulin-like growth factor-binding protein 7, inhibin beta A and four and a half LIM domains 1 in esophageal squamous cell carcinoma

  2012cites this paper
• Hypoxia‐induced response of cell cycle and apoptosis regulators in melanoma

  2012cites this paper
• CCR7-expressing B16 melanoma cells downregulate interferon-γ-mediated inflammation and increase lymphangiogenesis in the tumor microenvironment

  2012cites this paper
• Subcutaneous phaeohyphomycosis in immunocompetent child caused by Exophiala jeanselmei

  2012cites this paper
• Post-transcriptional regulation in cancer progression

  2012cites this paper