Cell stiffening in response to external stress is correlated to actin recruitment.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Biophysical Journal

• Publication date

  2008-04-01

• Fields of study

  Biology, Materials Science, Physics, Engineering, Medicine

• Identifiers
  DOI 10.1529/biophysj.107.118265PMID 18178644PMCID PMC2267136
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Rigidity-driven growth and migration of epithelial cells on microstructured anisotropic substrates

  2007cited by this paper
• The consensus mechanics of cultured mammalian cells

  2006cited by this paper
• Endothelial actin cytoskeleton remodeling during mechanostimulation with fluid shear stress.

  2006cited by this paper
• Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels

  2006cited by this paper
• Power laws in microrheology experiments on living cells: Comparative analysis and modeling.

  2006cited by this paper
• Ballistic intracellular nanorheology reveals ROCK-hard cytoplasmic stiffening response to fluid flow

  2006cited by this paper
• Limitation of cell adhesion by the elasticity of the extracellular matrix.

  2006cited by this paper
• The dissipative contribution of myosin II in the cytoskeleton dynamics of myoblasts

  2005cited by this paper
• Probing the viscoelastic behavior of cultured airway smooth muscle cells with atomic force microscopy: stiffening induced by contractile agonist.

  2005cited by this paper
• Creep function of a single living cell.

  2005cited by this paper
• Thrombin and histamine induce stiffening of alveolar epithelial cells.

  2005cited by this paper
• Force mapping in epithelial cell migration.

  2005cited by this paper
• Visualizing the mechanical activation of Src

  2005cited by this paper
• Is the mechanical activity of epithelial cells controlled by deformations or forces?

  2005cited by this paper
• Intracellular mechanics of migrating fibroblasts.

  2004cited by this paper
• Substrate compliance versus ligand density in cell on gel responses.

  2004cited by this paper
• Linearity and time-scale invariance of the creep function in living cells

  2004cited by this paper
• Membrane and acto-myosin tension promote clustering of adhesion proteins.

  2004cited by this paper
• Simultaneous mapping of filamentous actin flow and turnover in migrating cells by quantitative fluorescent speckle microscopy.

  2004cited by this paper
• Localized mechanical stress induces time-dependent actin cytoskeletal remodeling and stiffening in cultured airway smooth muscle cells.

  2004cited by this paper
• A three-dimensional viscoelastic model for cell deformation with experimental verification.

  2003cited by this paper
• Assessment of mechanical properties of adherent living cells by bead micromanipulation: comparison of magnetic twisting cytometry vs optical tweezers.

  2002cited by this paper
• The relationship between force and focal complex development

  2002cited by this paper
• Focal Contacts as Mechanosensors Externally Applied Local Mechanical Force Induces Growth of Focal Contacts by an Mdia1-Dependent and Rock-Independent Mechanism

  2001influential reference
• Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk.

  2001cited by this paper
• TRANSMEMBRANE EXTRACELLULAR MATRIX – CYTOSKELETON CROSSTALK

  2001cited by this paper
• Transmembrane crosstalk between the extracellular matrix and the cytoskeleton

  2001cited by this paper
• Molecular complexity and dynamics of cell-matrix adhesions.

  2001cited by this paper
• Scaling the microrheology of living cells.

  2001cited by this paper
• Focal Contacts as Mechanosensors

  2001cited by this paper
• Selected contribution: time course and heterogeneity of contractile responses in cultured human airway smooth muscle cells.

  2001cited by this paper
• Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates

  2001cited by this paper
• Physical state of the extracellular matrix regulates the structure and molecular composition of cell-matrix adhesions.

  2000cited by this paper
• Cell movement is guided by the rigidity of the substrate.

  2000cited by this paper
• Substrate flexibility regulates growth and apoptosis of normal but not transformed cells.

  2000cited by this paper
• Molecular diversity of cell-matrix adhesions.

  1999cited by this paper
• Selective regulation of integrin–cytoskeleton interactions by the tyrosine kinase Src

  1999cited by this paper
• Integrin signaling.

  1999cited by this paper
• Local measurements of viscoelastic parameters of adherent cell surfaces by magnetic bead microrheometry.

  1998cited by this paper
• Extracellular matrix rigidity causes strengthening of integrin-cytoskeleton linkages.

  1997cited by this paper
• Cell locomotion and focal adhesions are regulated by substrate flexibility.

  1997cited by this paper
• Quantitative measurements of force and displacement using an optical trap.

  1996cited by this paper
• Rho-stimulated contractility drives the formation of stress fibers and focal adhesions

  1996cited by this paper
• Ligand binding regulates the directed movement of β1 integrins on fibroblasts

  1996cited by this paper
• Control of cytoskeletal mechanics by extracellular matrix, cell shape, and mechanical tension.

  1994cited by this paper
• Mechanotransduction across the cell surface and through the cytoskeleton.

  1993cited by this paper

• Cell shape and maturation impacts α-actinin-2 tension in iPSC-derived cardiomyocytes

  2026cites this paper
• Cell–matrix feedback controls stretch-induced cellular memory and fibroblast activation

  2025cites this paper
• Viscoelastic mechanics of living cells.

  2025cites this paper
• A transition of dynamic rheological responses of single cells: from fluid-like to solid-like.

  2025cites this paper
• Characteristic frequencies of localized stress relaxation in scaling-law rheology of living cells.

  2024cites this paper
• Scaling-law variance and invariance of cell plasticity

  2024cites this paper
• Vimentin is a key regulator of cell mechanosensing through opposite actions on actomyosin and microtubule networks

  2024cites this paper
• PAI-1 Regulates the Cytoskeleton and Intrinsic Stiffness of Vascular Smooth Muscle Cells

  2024cites this paper
• Matrix Softening Controls Stretch-Induced Cellular Memory and Fibroblast Activation

  2023cites this paper
• Acoustic Wave‐Induced Stroboscopic Optical Mechanotyping of Adherent Cells

  2023cites this paper
• Extracellular matrix rigidity modulates physical properties of subcapsular sinus macrophage-B cell immune synapses

  2023cites this paper
• Spectral characterization of cell surface motion for mechanistic investigations of cellular mechanobiology.

  2022cites this paper
• Stiffening and softening in the power-law rheological behaviors of cells

  2022cites this paper
• Vimentin Intermediate Filaments Can Enhance or Abate Active Cellular Forces in a Microenvironmental Stiffness-Dependent Manner

  2022cites this paper
• Tension anisotropy drives phenotypic transitions of cells via two-way cell-ECM feedback

  2022cites this paper
• Mechanobiology of Fibroblast Activation in Skin Grafting

  2022cites this paper
• Biophysical interactions between components of the tumor microenvironment promote metastasis

  2021cites this paper
• Protocol to measure the membrane tension and bending modulus of cells using optical tweezers and scanning electron microscopy

  2021cites this paper
• Cytoskeleton-mediated alterations of nuclear mechanics by extracellular mechanical signals.

  2021cites this paper
• A hierarchical cellular structural model to unravel the universal power-law rheological behavior of living cells

  2021cites this paper
• Nonlinear Elastic and Inelastic Properties of Cells.

  2020cites this paper
• Nuclear Mechanics within Intact Cells Is Regulated by Cytoskeletal Network and Internal Nanostructures.

  2020cites this paper
• The impact of cell geometry and the cytoskeleton on the nucleo-cytoplasmic localisation of the SMYD3 methyltransferase suggests that the epigenetic machinery is mechanosensitive

  2020cites this paper
• Shear Stress Increases V-H + -ATPase and Acidic Vesicle Number Density, and p-mTORC2 Activation in Prostate Cancer Cells.

  2020cites this paper
• Cell geometry and the cytoskeleton impact the nucleo-cytoplasmic localisation of the SMYD3 methyltransferase

  2020cites this paper
• Environmentally controlled magnetic nano-tweezer for living cells and extracellular matrices

  2020cites this paper
• An Active Biomechanical Model of Cell Adhesion Actuated by Intracellular Tensioning-Taxis.

  2020cites this paper
• Vimentin Plays a Crucial Role in Fibroblast Ageing by Regulating Biophysical Properties and Cell Migration

  2019cites this paper
• Distribution of active forces in the cell cortex.

  2019cites this paper
• Finite element analysis reveals an important role for cell morphology in response to mechanical compression

  2019cites this paper
• Mechanical Point Loading Induces Cortex Stiffening and Actin Reorganization.

  2019cites this paper
• Regulation of nuclear architecture, mechanics, and nucleocytoplasmic shuttling of epigenetic factors by cell geometric constraints

  2019cites this paper
• Epidermal growth factor receptor and integrins control force-dependent vinculin recruitment to E-cadherin junctions

  2018cites this paper
• The desmin network is a determinant of the cytoplasmic stiffness of myoblasts

  2018cites this paper
• Integrated Mathematical and Experimental Study of Cell Migration and Shape

  2018cites this paper
• Enhanced blebbing as a marker for metastatic prostate cancer.

  2018cites this paper
• The nature and intensity of mechanical stimulation drive different dynamics of MRTF-A nuclear redistribution after actin remodeling in myoblasts

  2018cites this paper
• Microenvironment Influences Cancer Cell Mechanics from Tumor Growth to Metastasis.

  2018cites this paper
• Surface charges promote nonspecific nanoparticle adhesion to stiffer membranes

  2018cites this paper
• Cell membrane biophysics with optical tweezers

  2018cites this paper
• Tensile Loads on Tethered Actin Filaments Induce Accumulation of Cell Adhesion-Associated Proteins in Vitro.

  2018cites this paper
• Rheological Properties of Biological Structures, Scaffolds and Their Biomedical Applications

  2018cites this paper
• Microfluidic Iterative Mechanical Characteristics (iMECH) Analyzer for Single-Cell Metastatic Identification.

  2017cites this paper
• Beyond mice: Emerging and transdisciplinary models for the study of early-onset myopathies.

  2017cites this paper
• Quantitative Deformability Cytometry: Rapid, Calibrated Measurements of Cell Mechanical Properties.

  2017cites this paper
• Cell-ECM Interactions in Tumor Invasion.

  2016cites this paper
• Tumour-suppressor microRNAs regulate ovarian cancer cell physical properties and invasive behaviour

  2016cites this paper
• The dynamic mechanical properties of cellularised aggregates.

  2016cites this paper
• Desmin Mutation in the C-Terminal Domain Impairs Traction Force Generation in Myoblasts.

  2016cites this paper
• Systems Biology of Tumor Microenvironment

  2016cites this paper
• Cancer Cell Mechanics

  2016cites this paper
• Two-bubble acoustic tweezing cytometry for biomechanical probing and stimulation of cells.

  2015cites this paper
• Lamins at the crossroads of mechanosignaling

  2015cites this paper
• Arteriosclerosis, Thrombosis, and Vascular Biology.

  2015cites this paper
• Mechanical Sensing of Living Systems — From Statics to Dynamics

  2015cites this paper
• Inhibition of FSS-induced actin cytoskeleton reorganization by silencing LIMK2 gene increases the mechanosensitivity of primary osteoblasts.

  2015cites this paper
• The Mechanobiology of Aging.

  2015cites this paper
• Single cell metastatic phenotyping using pulsed nanomechanical indentations

  2015cites this paper
• Mechanobiology of Collective Cell Migration

  2015cites this paper
• Mechanical coupling of cytoskeletal elasticity and force generation is crucial for understanding the migrating nature of keloid fibroblasts

  2015cites this paper
• The Mechanobiology of Aging Jude

  2015cites this paper
• Molecular mechanisms underlying the force-dependent regulation of actin-to-ECM linkage at the focal adhesions.

  2014cites this paper
• &agr;-Catenin cytomechanics – role in cadherin-dependent adhesion and mechanotransduction

  2014cites this paper
• Physical biology in cancer. 5. The rocky road of metastasis: the role of cytoskeletal mechanics in cell migratory response to 3D matrix topography.

  2014cites this paper
• Plasticity of the actin cytoskeleton in response to extracellular matrix nanostructure and dimensionality.

  2014cites this paper
• Mechanotransduction of fluid stresses governs 3D cell migration

  2014cites this paper
• The rocky road of metastasis : the role of cytoskeletal mechanics in cell migratory response to 3 D matrix topography

  2013influential citation
• Optical traps for single cell analysis

  2013cites this paper
• Active contractions in single suspended epithelial cells

  2013cites this paper
• Experimental Investigation of the Response of Osteoblasts to Static and Dynamic Loading using a Modified Atomic Force Microscope

  2013cites this paper
• Force Mapping during the Formation and Maturation of Cell Adhesion Sites with Multiple Optical Tweezers

  2013cites this paper
• Multicellular aggregates: a model system for tissue rheology

  2013cites this paper
• Mechanical fluidity of fully suspended biological cells.

  2013cites this paper
• Single-molecule force spectroscopy studies of integrin-mediated cell signaling

  2012cites this paper
• Chemomechanics of attached and suspended cells

  2012cites this paper
• Microscopic origin of the rheological and surface properties of embryonic cell aggregates

  2012cites this paper
• Relation entre forme, tension, et adhésion au cours de l'étalement d'une cellule animale

  2012cites this paper
• Etude du comportement hors-équilibre du cortex cellulaire

  2012influential citation
• Physically based principles of cell adhesion mechanosensitivity in tissues

  2012cites this paper
• Mechanism of a flow-gated angiogenesis switch: early signaling events at cell-matrix and cell-cell junctions.

  2012cites this paper
• Calcium imaging in the optical stretcher.

  2011cites this paper
• Atomic force microscopy in mechanobiology: measuring microelastic heterogeneity of living cells.

  2011cites this paper
• Effects of shear stress cultivation on cell membrane disruption and intracellular calcium concentration in sonoporation of endothelial cells.

  2011cites this paper
• Cell cytoskeleton and tether extraction.

  2011cites this paper
• Multiple Trap Optical Tweezers for Live Cell Force Measurements

  2011cites this paper
• Advances in Experiments and Modeling in Micro- and Nano-Biomechanics: A Mini Review

  2011cites this paper
• An Analysis of the Cooperative Mechano-Sensitive Feedback Between Intracellular Signaling, Focal Adhesion Development, and Stress Fiber Contractility

  2011cites this paper
• Rigidity sensing explained by active matter theory.

  2011cites this paper
• Stress transmission within the cell.

  2011cites this paper
• Mesenchymal stem cell mechanics from the attached to the suspended state.

  2010cites this paper
• Cyclic Force Applied to FAs Induces Actin Recruitment Depending on the Dynamic Loading Pattern

  2010cites this paper
• Laser microbeams and optical tweezers in ageing research.

  2009cites this paper
• Impact of external stimuli and cell micro-architecture on intracellular transport states.

  2009cites this paper
• Prestress and adhesion site dynamics control cell sensitivity to extracellular stiffness.

  2009cites this paper
• Spatiotemporal analysis of cell response to a rigidity gradient: a quantitative study using multiple optical tweezers.

  2009cites this paper
• Characterization of Cell Mechanical Properties by Computational Modeling of Parallel Plate Compression

  2009cites this paper
• Power spectrum of out-of-equilibrium forces in living cells: amplitude and frequency dependence

  2009cites this paper
• Keratin contribution to cellular mechanical stress response at focal adhesions as assayed by laser tweezers.

  2008cites this paper
• Influence des propriétés mécaniques du substrat sur l'adhésion et la migration cellulaire

  2008cites this paper
• Limb bud and flank mesoderm have distinct "physical phenotypes" that may contribute to limb budding.

  2008cites this paper