How plausible is the use of dietary n-3 PUFA in the adjuvant therapy of cancer?

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Nutrition research reviews

• Publication date

  2016-05-13

• Fields of study

  Medicine

• Identifiers
  DOI 10.1017/S0954422416000044PMID 27172872
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Long-chain n-3 PUFA against breast and prostate cancer: Which are the appropriate doses for intervention studies in animals and humans?

  2017influential reference
• High-Dose Eicosapentaenoic Acid and Docosahexaenoic Acid Supplementation Reduces Bone Resorption in Postmenopausal Breast Cancer Survivors on Aromatase Inhibitors: A Pilot Study

  2014cited by this paper
• Randomized Study of Antiinflammatory and Immune-Modulatory Effects of Enteral Immunonutrition During Concurrent Chemoradiotherapy for Esophageal Cancer

  2014cited by this paper
• Molecular mechanisms of hyperthermia-induced apoptosis enhanced by docosahexaenoic acid: implication for cancer therapy.

  2014influential reference
• Omega-3 fatty acids, EPA and DHA induce apoptosis and enhance drug sensitivity in multiple myeloma cells but not in normal peripheral mononuclear cells.

  2014influential reference
• TRAIL combinations: The new ‘trail’ for cancer therapy (Review)

  2014cited by this paper
• Breaking the cycle: the role of omega-3 polyunsaturated fatty acids in inflammation-driven cancers.

  2014cited by this paper
• Omega-3 Fatty Acid Is a Potential Preventive Agent for Recurrent Colon Cancer

  2014cited by this paper
• DHA-mediated enhancement of TRAIL-induced apoptosis in colon cancer cells is associated with engagement of mitochondria and specific alterations in sphingolipid metabolism.

  2014cited by this paper
• Characterization of lovastatin-docosahexaenoate anticancer properties against breast cancer cells.

  2014cited by this paper
• Interaction of ω-3 polyunsaturated fatty acids with radiation therapy in two different colorectal cancer cell lines.

  2014cited by this paper
• Omega 3 fatty acids increase the chemo-sensitivity of B-CLL-derived cell lines EHEB and MEC-2 and of B-PLL-derived cell line JVM-2 to anti-cancer drugs doxorubicin, vincristine and fludarabine

  2013cited by this paper
• Experimental Evidence of ω-3 Polyunsaturated Fatty Acid Modulation of Inflammatory Cytokines and Bioactive Lipid Mediators: Their Potential Role in Inflammatory, Neurodegenerative, and Neoplastic Diseases

  2013cited by this paper
• A disease‐specific enteral nutrition formula improves nutritional status and functional performance in patients with head and neck and esophageal cancer undergoing chemoradiotherapy: Results of a randomized, controlled, multicenter trial

  2013cited by this paper
• Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by down-regulating cholesterol synthesis and altering detergent resistant membranes composition

  2013cited by this paper
• Fish Oil Decreases C-Reactive Protein/Albumin Ratio Improving Nutritional Prognosis and Plasma Fatty Acid Profile in Colorectal Cancer Patients

  2013cited by this paper
• Omega-3 Poly-Unsaturated Fatty Acids for the Prevention of Severe Neutropenic Enterocolitis in Patients with Acute Myeloid Leukemia

  2013cited by this paper
• Reduction in circulating pro-angiogenic and pro-inflammatory factors is related to improved outcomes in patients with advanced pancreatic cancer treated with gemcitabine and intravenous omega-3 fish oil.

  2013cited by this paper
• Omega-3 Eicosapentaenoic Acid Decreases CD133 Colon Cancer Stem-Like Cell Marker Expression While Increasing Sensitivity to Chemotherapy

  2013influential reference
• Tumor and non-tumor tissues differential oxidative stress response to supplemental DHA and chemotherapy in rats

  2012cited by this paper
• Colon cancer cell chemosensitisation by fish oil emulsion involves apoptotic mitochondria pathway

  2012cited by this paper
• Docosahexanoic Acid Improves Chemotherapy Efficacy by Inducing CD95 Translocation to Lipid Rafts in ER− Breast Cancer Cells

  2012cited by this paper
• Docosahexaenoic acid sensitizes colon cancer cells to sulindac sulfide-induced apoptosis.

  2012cited by this paper
• Involvement of oxidative stress in taxol-induced apoptosis in chronic myelogenous leukemia K562 cells.

  2012cited by this paper
• Omega-3 fatty acids are protective against paclitaxel-induced peripheral neuropathy: A randomized double-blind placebo controlled trial

  2012cited by this paper
• In Vivo Anti-Tumor Activity of a New Doxorubicin Conjugate via α-Linolenic Acid

  2012cited by this paper
• Application of polyunsaturated fatty acids in internal medicine: beyond the established cardiovascular effects

  2012cited by this paper
• The omega-3 fatty acid nutritional landscape: health benefits and sources.

  2012cited by this paper
• Update on taxane development: new analogs and new formulations

  2012cited by this paper
• DHA induces apoptosis and differentiation in human melanoma cells in vitro: involvement of HuR-mediated COX-2 mRNA stabilization and β-catenin nuclear translocation.

  2012cited by this paper
• Imaging features of bowel toxicities in the setting of molecular targeted therapies in cancer patients.

  2012cited by this paper
• DHA induces apoptosis by altering the expression and cellular location of GRP78 in colon cancer cell lines.

  2012cited by this paper
• Fish Oil Supplementation Improves Neutrophil Function During Cancer Chemotherapy

  2012influential reference
• DHA Effect on Chemotherapy-Induced Body Weight Loss: An Exploratory Study in a Rodent Model of Mammary Tumors

  2012cited by this paper
• Inhibition of neuroblastoma cell proliferation with omega-3 fatty acids and treatment of a murine model of human neuroblastoma using a diet enriched with omega-3 fatty acids in combination with sunitinib

  2012cited by this paper
• Cardiac side effects of molecular targeted therapies: towards a better dialogue between oncologists and cardiologists.

  2011cited by this paper
• Phase 3 study of docosahexaenoic acid-paclitaxel versus dacarbazine in patients with metastatic malignant melanoma.

  2011cited by this paper
• Omega-3 Fatty Acid Supplementation in Cancer Therapy

  2011cited by this paper
• Clinical review: Effect of endocrine therapies on bone in breast cancer patients.

  2011cited by this paper
• Nutritional intervention with fish oil provides a benefit over standard of care for weight and skeletal muscle mass in patients with nonsmall cell lung cancer receiving chemotherapy

  2011cited by this paper
• Supplementation with fish oil increases first‐line chemotherapy efficacy in patients with advanced nonsmall cell lung cancer

  2011cited by this paper
• Effect of n-3 fatty acids on patients with advanced lung cancer: a double-blind, placebo-controlled study

  2011cited by this paper
• Docosahexaenoic acid (DHA) sensitizes brain tumor cells to etoposide-induced apoptosis.

  2011cited by this paper
• Omega-3 fatty acids induce apoptosis in human breast cancer cells and mouse mammary tissue through syndecan-1 inhibition of the MEK-Erk pathway.

  2011cited by this paper
• Dietary n-3 polyunsaturated fatty acids and the paradox of their health benefits and potential harmful effects.

  2011cited by this paper
• Correlation of Circulating Angiogenic Factors with Circulating Tumor Cells and Disease Recurrence in Patients Undergoing Curative Resection for Colorectal Liver Metastases

  2011cited by this paper
• Effects of fish oil and Tamoxifen on preneoplastic lesion development and biomarkers of oxidative stress in the early stages of N-methyl-N-nitrosourea-induced rat mammary carcinogenesis.

  2011cited by this paper
• Polyunsaturated fatty acids reduce Fatty Acid Synthase and Hydroxy-Methyl-Glutaryl CoA-Reductase gene expression and promote apoptosis in HepG2 cell line

  2011cited by this paper
• Long-Chain Polyunsaturated Fatty Acids Promote Paclitaxel Cytotoxicity via Inhibition of the MDR1 Gene in the Human Colon Cancer Caco-2 Cell Line

  2011cited by this paper
• Bortezomib-resistant myeloma cell lines: a role for mutated PSMB5 in preventing the accumulation of unfolded proteins and fatal ER stress

  2010cited by this paper
• Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma

  2010influential reference
• The Impact of Fish Oil on the Chemopreventive Efficacy of Tamoxifen against Development of N-Methyl-N-Nitrosourea–Induced Rat Mammary Carcinogenesis

  2010cited by this paper
• Enhancement of human cancer cell radiosensitivity by conjugated eicosapentaenoic acid - a mammalian DNA polymerase inhibitor.

  2010cited by this paper
• Effects of lovastatin on breast cancer cells: a proteo-metabonomic study

  2010cited by this paper
• Docosahexaenoic acid metabolome in neural tumors: identification of cytotoxic intermediates

  2010cited by this paper
• Potential usefulness of an EPA-enriched nutritional supplement on chemotherapy tolerability in cancer patients without overt malnutrition.

  2010cited by this paper
• Syndecan-1-dependent suppression of PDK1/Akt/bad signaling by docosahexaenoic acid induces apoptosis in prostate cancer.

  2010cited by this paper
• Oral nutritional supplements containing (n-3) polyunsaturated fatty acids affect the nutritional status of patients with stage III non-small cell lung cancer during multimodality treatment.

  2010cited by this paper
• PUFAs enhance oxidative stress and apoptosis in tumour cells exposed to hypericin-mediated PDT

  2010cited by this paper
• Dissemination and publication of research findings: an updated review of related biases.

  2010cited by this paper
• A systematic review of positron emission tomography (PET) and positron emission tomography/computed tomography (PET/CT) for the diagnosis of breast cancer recurrence.

  2010cited by this paper
• Phase 2 open-label study of weekly docosahexaenoic acid–paclitaxel in patients with metastatic uveal melanoma

  2010cited by this paper
• The effects of omega-3 polyunsaturated fatty acids against cancer

  2010cited by this paper
• Dietary omega-3 polyunsaturated fatty acids and cancer

  2010cited by this paper
• Vitamins in the prevention of human diseases

  2010cited by this paper
• ω-3 PUFAs, why are we speaking of them?

  2010cited by this paper
• Improving outcome of chemotherapy of metastatic breast cancer by docosahexaenoic acid: a phase II trial

  2009cited by this paper
• Dietary polyunsaturated fatty acids as inducers of apoptosis: implications for cancer

  2009cited by this paper
• Sulindac Sulfide Differentially Induces Apoptosis in Smac-Proficient and -Deficient Human Colon Cancer Cells.

  2009cited by this paper
• Chronic inflammation, the tumor microenvironment and carcinogenesis.

  2009cited by this paper
• Single and combined supplementation of glutamine and n-3 polyunsaturated fatty acids on host tolerance and tumour response to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin (CPT-11)/5-fluorouracil chemotherapy in rats bearing Ward colon tumour

  2009cited by this paper
• Phase 1 and pharmacokinetic study of weekly docosahexaenoic acid-paclitaxel, Taxoprexin®, in resistant solid tumor malignancies

  2009cited by this paper
• Anticancer actions of omega-3 fatty acids--current state and future perspectives.

  2009cited by this paper
• Simvastatin and lovastatin inhibit breast cell invasion induced by H-Ras.

  2009cited by this paper
• Phase 2 open-label study of weekly docosahexaenoic acid-paclitaxel in cutaneous and mucosal metastatic melanoma patients

  2009cited by this paper
• Omega-3 and omega-6 polyunsaturated fatty acids enhance arsenic trioxide efficacy in arsenic trioxide-resistant leukemic and solid tumor cells.

  2009influential reference
• Antineoplastic Effects of N-3 Polyunsaturated Fatty Acids in Combination With Drugs and Radiotherapy: Preventive and Therapeutic Strategies

  2009cited by this paper
• Proinflammatory cytokines and IL-10 in inflammatory bowel disease and colorectal cancer patients

  2009cited by this paper
• Bortezomib-Resistant Nuclear Factor-κB Activity in Multiple Myeloma Cells

  2008cited by this paper
• The effect of combination treatment with docosahexaenoic acid and 5-fluorouracil on the mRNA expression of apoptosis-related genes, including the novel gene BCL2L12, in gastric cancer cells

  2008cited by this paper
• A phase II open-label study of DHA-paclitaxel (Taxoprexin) by 2-h intravenous infusion in previously untreated patients with locally advanced or metastatic gastric or oesophageal adenocarcinoma

  2008cited by this paper
• Docosahexaenoic acid induces apoptosis in lung cancer cells by increasing MKP-1 and down-regulating p-ERK1/2 and p-p38 expression

  2008cited by this paper
• Cancer multidrug resistance (MDR): a major impediment to effective chemotherapy.

  2008cited by this paper
• Sensitization by docosahexaenoic acid (DHA) of breast cancer cells to anthracyclines through loss of glutathione peroxidase (GPx1) response.

  2008cited by this paper
• Docosahexaenoic acid enhances the efficacy of docetaxel in prostate cancer cells by modulation of apoptosis: The role of genes associated with the NF‐κB pathway

  2008cited by this paper
• Dietary n-3 polyunsaturated fatty acids and oxidants increase rat mammary tumor sensitivity to epirubicin without change in cardiac toxicity

  2007cited by this paper
• Docosahexaenoic acid induces proteasome-dependent degradation of beta-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2.

  2007cited by this paper
• Localization of the Human Breast Cancer Resistance Protein (BCRP/ABCG2) in Lipid Rafts/Caveolae and Modulation of Its Activity by Cholesterol in Vitro

  2007cited by this paper
• Emodin and DHA potently increase arsenic trioxide interferon-alpha-induced cell death of HTLV-I-transformed cells by generation of reactive oxygen species and inhibition of Akt and AP-1.

  2007cited by this paper
• Docosahexaenoic acid enhances the toxic effect of imatinib on Bcr-Abl expressing HL-60 cells.

  2007cited by this paper
• n-3 polyunsaturated fatty acids and the prevention of colorectal cancer: molecular mechanisms involved.

  2007cited by this paper
• Sensitization by Dietary Docosahexaenoic Acid of Rat Mammary Carcinoma to Anthracycline: A Role for Tumor Vascularization

  2006cited by this paper
• n-3 Polyunsaturated Fatty Acids as Signal Transduction Modulators and Therapeutical Agents in Cancer

  2006cited by this paper
• DHA-Paclitaxel (Taxoprexin) as First-Line Treatment in Patients with Stage IIIB or IV Non-small Cell Lung Cancer: Report of a Phase II Open-Label Multicenter Trial

  2006cited by this paper
• Influences of Lovastatin on membrane ion flow and intracellular signaling in breast cancer cells

  2006cited by this paper
• Docosahexaenoic acid in combination with celecoxib modulates HSP70 and p53 proteins in prostate cancer cells

  2006cited by this paper
• Nitroreductase-based therapy of prostate cancer, enhanced by raising expression of heat shock protein 70, acts through increased anti-tumour immunity

  2006cited by this paper
• Targeting multidrug resistance in cancer

  2006cited by this paper
• Phase 1 and pharmacokinetic study of weekly docosahexaenoic acid-paclitaxel (Taxoprexin) in resistant solid tumor malignancies.

  2006cited by this paper
• A systematic review of the effectiveness of docetaxel and mitoxantrone for the treatment of metastatic hormone-refractory prostate cancer

  2006cited by this paper

• Omega-3 fatty acids and chemotherapy-induced toxicities: mechanisms and emerging evidence with a pediatric focus

  2025cites this paper
• Effects of omega-3 fatty acid supplementation on nutritional status and inflammatory response in patients with stage II-III NSCLC undergoing postoperative chemotherapy: a double-blind randomized controlled trial

  2023cites this paper
• Dysregulated lipid metabolism blunts the sensitivity of cancer cells to EZH2 inhibitor

  2022cites this paper
• Nutraceutical-Based Nanoformulations for Breast and Ovarian Cancer Treatment

  2022cites this paper
• Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects.

  2021cites this paper
• New Insights on the Effects of Dietary Omega-3 Fatty Acids on Impaired Skin Healing in Diabetes and Chronic Venous Leg Ulcers

  2021cites this paper
• Anti-obesity Medications in Cancer Therapy: A Comprehensive Insight.

  2021cites this paper
• Cancer diets for cancer patients: Lessons from mouse studies and new insights from the study of fatty acid metabolism in tumors.

  2020cites this paper
• Zinc, ω-3 polyunsaturated fatty acids and vitamin D: An essential combination for prevention and treatment of cancers.

  2020cites this paper
• Nutriments et cancer : alliés ou ennemis ?

  2020cites this paper
• Oxidative Stress, Nutrition and Cancer: Friends or Foes?

  2020cites this paper
• Comparing the In Vitro Antitumor, Antioxidant and Anti-Inflammatory Activities between Two New Very Long Chain Polyunsaturated Fatty Acids, Docosadienoic Acid (DDA) and Docosatrienoic Acid (DTA), and Docosahexaenoic Acid (DHA)

  2020cites this paper
• Impact of 17β-HSD12, the 3-ketoacyl-CoA reductase of long-chain fatty acid synthesis, on breast cancer cell proliferation and migration

  2019cites this paper
• Combination of &ohgr;-3 fatty acids and cisplatin as a potential alternative strategy for personalized therapy of metastatic melanoma: an in-vitro study

  2019cites this paper
• Xanthan gum-based materials for omega-3 PUFA delivery: Preparation, characterization and antineoplastic activity evaluation.

  2019cites this paper
• Fatty acids: Adiposity and breast cancer chemotherapy, a bad synergy?

  2019cites this paper
• Nanomedicine-based formulations containing ω-3 polyunsaturated fatty acids: potential application in cardiovascular and neoplastic diseases

  2019cites this paper
• Engineered nanoparticles for imaging and drug delivery in colorectal cancer.

  2019cites this paper
• PUFA protection against 60 Co γ-ray-induced abnormal expression of DNA damage-related genes in C . elegans

  2019cites this paper
• DHA Abolishes the Detrimental Effect of Docetaxel on Downregulation of the MICA via Decreasing the Expression Level of MicroRNA-20a in Gastric Cancer

  2019cites this paper
• Omega-3 PUFA Loaded in Resveratrol-Based Solid Lipid Nanoparticles: Physicochemical Properties and Antineoplastic Activities in Human Colorectal Cancer Cells In Vitro

  2018cites this paper
• Role of omega-3 polyunsaturated fatty acids in preventing gastrointestinal cancers: current status and future perspectives

  2018cites this paper
• Long-chain omega-3 fatty acids and cancer: any cause for concern?

  2017cites this paper
• Modulation of Ras/ERK and Phosphoinositide Signaling by Long-Chain n-3 PUFA in Breast Cancer and Their Potential Complementary Role in Combination with Targeted Drugs

  2017cites this paper
• The effects of EPA and DHA enriched fish oil on nutritional and immunological markers of treatment naïve breast cancer patients: a randomized double-blind controlled trial

  2017cites this paper
• Lipidomics Insights in Health and Nutritional Intervention Studies.

  2017cites this paper
• Protective Effects of ω-3 PUFA in Anthracycline-Induced Cardiotoxicity: A Critical Review

  2017cites this paper
• Interaction between omega 3 PUFA and UVB radiation: Photoprotective effect in normal and tumoral murine melanocytes?

  2016cites this paper
• ω3 Polyunsaturated Fatty Acids as Immunomodulators in Colorectal Cancer: New Potential Role in Adjuvant Therapies

  2016cites this paper
• World Journal of Gastroenterology

  year unknowncites this paper