Experimental Evidence of ω-3 Polyunsaturated Fatty Acid Modulation of Inflammatory Cytokines and Bioactive Lipid Mediators: Their Potential Role in Inflammatory, Neurodegenerative, and Neoplastic Diseases

A large body of evidence has emerged over the past years to show the critical role played by inflammation in the pathogenesis of several diseases including some cardiovascular, neoplastic, and neurodegenerative diseases, previously not considered inflammation-related. The anti-inflammatory action of ω-3 polyunsaturated fatty acids (PUFAs), as well as their potential healthy effects against the development and progression of the same diseases, has been widely studied by our and others' laboratories. As a result, a rethinking is taking place on the possible mechanisms underlying the beneficial effects of ω-3 PUFAs against these disorders, and, in particular, on the influence that they may exert on the molecular pathways involved in inflammatory process, including the production of inflammatory cytokines and lipid mediators active in the resolving phase of inflammation. In the present review we will summarize and discuss the current knowledge regarding the modulating effects of ω-3 PUFAs on the production of inflammatory cytokines and proresolving or protective lipid mediators in the context of inflammatory, metabolic, neurodegenerative, and neoplastic diseases.

• Publication year

  2013

• Venue

  BioMed Research International

• Publication date

  2013-04-17

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1155/2013/743171PMID 23691510PMCID 3652138
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?

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  2012cited by this paper
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  2012influential reference
• Fish Oil Improves the Lipid Profile and Reduces Inflammatory Cytokines in Wistar Rats With Precancerous Colon Lesions

  2012cited by this paper
• Inflammation and coronary artery disease: insights from genetic studies.

  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
• Mitochondrial Alterations, Oxidative Stress and Neuroinflammation in Alzheimer's Disease

  2012cited by this paper
• Multifaceted link between cancer and inflammation.

  2012cited by this paper
• Carcinoma origin dictates differential skewing of monocyte function

  2012influential reference
• Consumption of n-3 fatty acids and fish reduces risk of hepatocellular carcinoma.

  2012cited by this paper
• Long chain omega-3 fatty acids and cardiovascular disease: a systematic review

  2012cited by this paper
• Fatty acids in cardiovascular health and disease: a comprehensive update.

  2012cited by this paper
• N-3 Poly-Unsaturated Fatty Acids Shift Estrogen Signaling to Inhibit Human Breast Cancer Cell Growth

  2012cited by this paper
• BENEFICIAL EFFECTS OF DAILY DIETARY OMEGA-3 POLYUNSATURATED FATTY ACID SUPPLEMENTATION ON AGE- RELATED COGNITIVE DECLINE IN ELDERLY JAPANESE WITH VERY MILD DEMENTIA: A 2-YEAR RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL

  2012cited by this paper
• Omega-6 docosapentaenoic acid-derived resolvins and 17-hydroxydocosahexaenoic acid modulate macrophage function and alleviate experimental colitis

  2012cited by this paper
• Evaluation of risk equations for prediction of short-term coronary heart disease events in patients with long-standing type 2 diabetes: the Translating Research into Action for Diabetes (TRIAD) study

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• Correction: Hepatic Lipid Accumulation Alters Global Histone H3 Lysine 9 and 4 Trimethylation in the Peroxisome Proliferator-Activated Receptor Alpha Network

  2012cited by this paper
• Influence of marine n-3 polyunsaturated fatty acids on immune function and a systematic review of their effects on clinical outcomes in rheumatoid arthritis

  2012cited by this paper
• DHA induces apoptosis by altering the expression and cellular location of GRP78 in colon cancer cell lines.

  2012cited by this paper
• Docosahexaenoic acid reverts resistance to UV-induced apoptosis in human keratinocytes: involvement of COX-2 and HuR.

  2011cited by this paper
• Chronic inflammation and cancer: the role of the mitochondria.

  2011cited by this paper
• Effect of n-3 fatty acids on patients with advanced lung cancer: a double-blind, placebo-controlled study

  2011cited by this paper
• Anti-inflammatory and anti-angiogenic effect of long chain n-3 polyunsaturated fatty acids in intestinal microvascular endothelium.

  2011cited by this paper
• Parenteral fish-oil-based lipid emulsion improves fatty acid profiles and lipids in parenteral nutrition-dependent children.

  2011cited by this paper
• Effects of high-fat diets rich in either omega-3 or omega-6 fatty acids on UVB-induced skin carcinogenesis in SKH-1 mice.

  2011cited by this paper
• Analysis of omega-3 and omega-6 fatty acid-derived lipid metabolite formation in human and mouse blood samples.

  2011cited by this paper
• Role of lipoxins, resolvins, and other bioactive lipids in colon and pancreatic cancer

  2011cited by this paper
• Differential anti-cancer effects of purified EPA and DHA and possible mechanisms involved.

  2011cited by this paper
• Cox-2 expression, PGE(2) and cytokines production are inhibited by endogenously synthesized n-3 PUFAs in inflamed colon of fat-1 mice.

  2011cited by this paper
• Suppressed liver tumorigenesis in fat-1 mice with elevated omega-3 fatty acids is associated with increased omega-3 derived lipid mediators and reduced TNF-α.

  2011cited by this paper
• Docosahexaenoic Acid-Derived Neuroprotectin D1 Induces Neuronal Survival via Secretase- and PPARγ-Mediated Mechanisms in Alzheimer's Disease Models

  2011cited by this paper
• Reduced prostaglandin F2α release from blood mononuclear leukocytes after oral supplementation of ω3 fatty acids: the OmegAD study

  2010cited by this paper
• Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposis

  2010cited by this paper
• Docosahexaenoic acid alters epidermal growth factor receptor-related signaling by disrupting its lipid raft association.

  2010cited by this paper
• ω-3 PUFAs, why are we speaking of them?

  2010cited by this paper
• ω-3 PUFAs and Colon Cancer: Experimental Studies and Human Interventional Trials

  2010cited by this paper
• Dietary omega-3 polyunsaturated fatty acids and cancer

  2010cited by this paper
• Inflammation-mediated promotion of invasion and metastasis

  2010cited by this paper
• Mechanisms of n-3 fatty acid-mediated development and maintenance of learning memory performance.

  2010cited by this paper
• Synergistic anti-inflammatory effects of low doses of curcumin in combination with polyunsaturated fatty acids: docosahexaenoic acid or eicosapentaenoic acid.

  2010cited by this paper
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  2010cited by this paper
• Chemoprevention of lung pathologies by dietary n-3 polyunsaturated fatty acids.

  2010cited by this paper
• Non-mammalian fat-1 gene prevents neoplasia when introduced to a mouse hepatocarcinogenesis model: Omega-3 fatty acids prevent liver neoplasia.

  2010cited by this paper
• Inhibitory Mechanism of Omega‐3 Fatty Acids in Pancreatic Inflammation and Apoptosis

  2009cited by this paper
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  2009cited by this paper
• Antineoplastic Effects of N-3 Polyunsaturated Fatty Acids in Combination With Drugs and Radiotherapy: Preventive and Therapeutic Strategies

  2009cited by this paper
• The Epidermal Growth Factor Receptor: A Link Between Inflammation and Liver Cancer

  2009cited by this paper
• The protective effect of dietary eicosapentaenoic acid against impairment of spatial cognition learning ability in rats infused with amyloid beta(1-40).

  2009cited by this paper
• Effects of Omega-3 Fatty Acids on Inflammatory Markers in Cerebrospinal Fluid and Plasma in Alzheimer’s Disease: The OmegAD Study

  2009cited by this paper
• Mechanism of docosahexaenoic acid‐induced inhibition of in vitro Aβ1–42 fibrillation and Aβ1–42‐induced toxicity in SH‐S5Y5 cells

  2009cited by this paper
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  2009cited by this paper
• Cellular and molecular pathways linking inflammation and cancer.

  2009cited by this paper
• alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans.

  2009cited by this paper
• Experimental models and mechanisms underlying the protective effects of n-3 polyunsaturated fatty acids in Alzheimer's disease.

  2009cited by this paper
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  2008cited by this paper
• Eicosapentaenoic acid inhibits TNF-alpha-induced matrix metalloproteinase-9 expression in human keratinocytes, HaCaT cells.

  2008cited by this paper
• Cancer-related inflammation

  2008cited by this paper
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  2008cited by this paper
• Effects of docosahexaenoic acid-rich n-3 fatty acid supplementation on cytokine release from blood mononuclear leukocytes: the OmegAD study.

  2008cited by this paper
• Macrophage polarization in tumour progression.

  2008influential reference
• Reduction of inflammation and chronic tissue damage by omega-3 fatty acids in fat-1 transgenic mice with pancreatitis.

  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2007cited by this paper
• Plasma n-3 fatty acids and the risk of cognitive decline in older adults: the Atherosclerosis Risk in Communities Study.

  2007cited by this paper
• A lipidomic analysis of nonalcoholic fatty liver disease

  2007cited by this paper
• Eicosapentaenoic acid confers neuroprotection in the amyloid-beta challenged aged hippocampus.

  2007cited by this paper
• Docosahexaenoic acid induces proteasome-dependent degradation of beta-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2.

  2007cited by this paper
• Photoreceptor outer segment phagocytosis attenuates oxidative stress-induced apoptosis with concomitant neuroprotectin D1 synthesis

  2007cited by this paper
• Omega 3 fatty acids (fish oil) for maintenance of remission in ulcerative colitis.

  2007cited by this paper
• Dietary Docosahexaenoic Acid and Docosapentaenoic Acid Ameliorate Amyloid-β and Tau Pathology via a Mechanism Involving Presenilin 1 Levels

  2007cited by this paper
• Nutrition intervention using an eicosapentaenoic acid (EPA)-containing supplement in patients with advanced colorectal cancer. Effects on nutritional and inflammatory status: a phase II trial

  2007cited by this paper
• Colitis-associated colon tumorigenesis is suppressed in transgenic mice rich in endogenous n-3 fatty acids.

  2007cited by this paper
• Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling

  2007cited by this paper
• n-3 fatty acids decrease colonic epithelial cell proliferation in high-risk bowel mucosa

  2007cited by this paper
• Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis.

  2006cited by this paper
• p50 nuclear factor-kappaB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance.

  2006cited by this paper
• n-3 Polyunsaturated Fatty Acids as Signal Transduction Modulators and Therapeutical Agents in Cancer

  2006influential reference
• Long-chain n−3 PUFA: plant v. marine sources

  2006cited by this paper
• - 3 Fatty Acid Treatment in 174 Patients With Mild to Moderate Alzheimer Disease : OmegAD Study A Randomized Double-blind Trial

  2006cited by this paper
• Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: protectin D1 and 17S‐hydroxy‐DHA

  2006cited by this paper
• Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial.

  2006cited by this paper
• A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease.

  2005influential reference

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  2017cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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• [Polyunsaturated omega-3 fatty acids and systemic lupus erythematosus: what do we know?].

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