Stress‐induced cellular responses in immunogenic cell death: Implications for cancer immunotherapy

&NA; Cancer is evading the host's defense mechanisms leading to avoidance of immune destruction. During tumor progression, immune‐evading cancer cells arise due to selective pressure from the hypoxic and nutrient‐deprived microenvironment. Thus, therapies aiming at re‐establishing immune destruction of pathological cells constitute innovating anti‐cancer strategies. Accumulating evidence suggests that selected conventional chemotherapeutic drugs increase the immunogenicity of stressed and dying cancer cells by triggering a form of cell death called immunogenic cell death (ICD), which is characterized by the release of danger‐associated molecular patterns (DAMPs). In this review, we summarize the effects of ICD inducers on DAMP signaling leading to adjuvanticity and antigenicity. We will discuss the associated stress response pathways that cause the release of DAMPs leading to improved immune recognition and their relevance in cancer immunotherapy. Our aim is to highlight the contribution of adaptive immunity to the long‐term clinical benefits of anticancer treatments and the properties of immune memory that can protect cancer patients against relapse. Graphical abstract Figure. No caption available.

• Publication year

  2018

• Venue

  Biochemical Pharmacology

• Publication date

  2018-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.bcp.2018.02.006PMID 29438676
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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