The Fat and Warts signaling pathways: new insights into their regulation, mechanism and conservation

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Development

• Publication date

  2008-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/dev.020974PMID 18697904
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Tumor Suppressor LATS1 Is a Negative Regulator of Oncogene YAP*

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• The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway.

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• Morphogen control of wing growth through the Fat signaling pathway.

  2008influential reference
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  2007influential reference
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  2007influential reference
• The salvador-warts-hippo pathway is required for epithelial proliferation and axis specification in Drosophila.

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• Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila

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• Fat and Expanded act in parallel to regulate growth through Warts

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• Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control.

  2007influential reference
• The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance

  2006cited by this paper
• Comparative integromics on FAT1, FAT2, FAT3 and FAT4.

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• The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway.

  2006influential reference
• Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity

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• The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling.

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• Delineation of a Fat tumor suppressor pathway

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• Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C‐terminal coiled‐coil domains, leads to its stabilization and phosphorylation

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• Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins

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• The bantam microRNA is a target of the hippo tumor-suppressor pathway.

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• The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

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• The transcriptional co-activator TAZ interacts differentially with transcriptional enhancer factor-1 (TEF-1) family members.

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• Control of cell proliferation and apoptosis by mob as tumor suppressor, mats.

  2005influential reference
• The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP.

  2005cited by this paper
• Expression of mouse dchs1, fjx1, and fat‐j suggests conservation of the planar cell polarity pathway identified in drosophila

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• Planar cell polarization: an emerging model points in the right direction.

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• The orientation of cell divisions determines the shape of Drosophila organs.

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• Membrane organization and tumorigenesis--the NF2 tumor suppressor, Merlin.

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• The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors.

  2005cited by this paper
• The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1

  2005cited by this paper
• Human LATS1 is a mitotic exit network kinase.

  2005cited by this paper
• Tyrosine phosphorylation controls Runx2‐mediated subnuclear targeting of YAP to repress transcription

  2004cited by this paper
• Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling

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• Planar cell polarity in the Drosophila eye is directed by graded Four-jointed and Dachsous expression

  2004influential reference
• Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes.

  2004cited by this paper
• Cleavage and secretion is not required for Four-jointed function in Drosophila patterning

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• Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing

  2004influential reference
• The centrosomal protein Lats2 is a phosphorylation target of Aurora‐A kinase

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• Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity

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• LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1

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• Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras.

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• The fat-like Gene of Drosophila Is the True Orthologue of Vertebrate Fat Cadherins and Is Involved in the Formation of Tubular Organs*

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• Fidelity in planar cell polarity signalling

  2003cited by this paper
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• The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis.

  2003cited by this paper
• Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis.

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• WW Domain-containing Protein YAP Associates with ErbB-4 and Acts as a Co-transcriptional Activator for the Carboxyl-terminal Fragment of ErbB-4 That Translocates to the Nucleus*

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• Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye.

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• Physical interaction with Yes-associated protein enhances p73 transcriptional activity.

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• The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44.

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• Merlin, the Drosophila homologue of neurofibromatosis-2, is specifically required in posterior follicle cells for axis formation in the oocyte.

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• Multiple roles for four-jointed in planar polarity and limb patterning.

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• Roles for scalloped and vestigial in regulating cell affinity and interactions between the wing blade and the wing hinge.

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• Zyxin, a Regulator of Actin Filament Assembly, Targets the Mitotic Apparatus by Interacting with H-Warts/Lats1 Tumor Suppressor

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• The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation.

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• A WW domain‐containing Yes‐associated protein (YAP) is a novel transcriptional co‐activator

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• Integration of Hippo-YAP Signaling with Metabolism.

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