Regulation of PCP by the Fat signaling pathway

Planar cell polarity (PCP) in epithelia is essential for numerous developmental events and physiological functions. One distinct signaling module involving the atypical cadherins Fat and Dachsous and the ectokinase Four-jointed appears to link the direction of cell polarization to the tissue axes. This review by Matis and Axelrod discusses the existing models for the function of this signaling module and points out the remaining mysteries.

• Publication year

  2013

• Venue

  Genes & Development

• Publication date

  2013-10-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/gad.228098.113PMID 24142873PMCID 3814641
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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