The repair of DNA damages/modifications during the maturation of the immune system: lessons from human primary immunodeficiency disorders and animal models.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Advances in Immunology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0065-2776(05)87007-5PMID 16102576
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints.

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• 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination

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• De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination.

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• H2AX May Function as an Anchor to Hold Broken Chromosomal DNA Ends in Close Proximity

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• A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex

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• Activation-induced Cytosine Deaminase (AID) Is Actively Exported out of the Nucleus but Retained by the Induction of DNA Breaks*

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• RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination.

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• Uracil DNA Glycosylase Activity Is Dispensable for Immunoglobulin Class Switch

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• Analysis of DNA ligase IV mutations found in LIG4 syndrome patients: the impact of two linked polymorphisms.

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• A Role for Msh6 But Not Msh3 in Somatic Hypermutation and Class Switch Recombination

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• Chromosomal Translocations and Non-B DNA Structures in the Human Genome

  2004cited by this paper
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  2004cited by this paper
• Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1

  2004cited by this paper
• Replication protein A interacts with AID to promote deamination of somatic hypermutation targets

  2004cited by this paper
• Phosphorylation of Artemis following irradiation‐induced DNA damage

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• Recombinant human zona pellucida proteins ZP1, ZP2 and ZP3 co-expressed in a human cell line.

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• Somatic Hypermutation Is Limited by CRM1-dependent Nuclear Export of Activation-induced Deaminase

  2004cited by this paper
• 53BP1 is required for class switch recombination

  2004cited by this paper
• AID is required for c-myc/IgH chromosome translocations in vivo.

  2004cited by this paper
• Absence of DNA Polymerase η Reveals Targeting of C Mutations on the Nontranscribed Strand in Immunoglobulin Switch Regions

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• Evidence that polyadenylation factor CPSF-73 is the mRNA 3' processing endonuclease.

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• Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex

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• AID: how does it aid antibody diversity?

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• DNA Polymerase η Is Involved in Hypermutation Occurring during Immunoglobulin Class Switch Recombination

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• Clinical, immunologic and genetic analysis of 29 patients with autosomal recessive hyper-IgM syndrome due to Activation-Induced Cytidine Deaminase deficiency.

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• Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to S mu in Ig class switch recombination.

  2004cited by this paper
• Ataxia-telangiectasia, an evolving phenotype.

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• Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation

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• Functional and biochemical dissection of the structure‐specific nuclease ARTEMIS

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• Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire.

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• Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1–mutant mice

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• The DNA double-strand break response in the nervous system.

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• Delineation of the Role of the Mre11 Complex in Class Switch Recombination*

  2004cited by this paper
• Examination of Msh6- and Msh3-deficient Mice in Class Switching Reveals Overlapping and Distinct Roles of MutS Homologues in Antibody Diversification

  2004cited by this paper
• Requirement of the MRN complex for ATM activation by DNA damage

  2003cited by this paper
• DNA-PK is activated by nucleosomes and phosphorylates H2AX within the nucleosomes in an acetylation-dependent manner.

  2003cited by this paper
• H2AX Is Required for Recombination Between Immunoglobulin Switch Regions but Not for Intra-Switch Region Recombination or Somatic Hypermutation

  2003cited by this paper
• 129-derived Strains of Mice Are Deficient in DNA Polymerase ι and Have Normal Immunoglobulin Hypermutation

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• Somatic hypermutation does not require Rad54 and Rad54B‐mediated homologous recombination

  2003cited by this paper
• Ig gene somatic hypermutation in mice defective for DNA polymerase δ proofreading

  2003cited by this paper
• Hyper-IgM syndrome type 4 with a B lymphocyte-intrinsic selective deficiency in Ig class-switch recombination.

  2003cited by this paper
• In Situ Studies of the Primary Immune Response to ( 4-hydroxy-3-nitrophenyl ) acetyl . II . A Common Clonal Origin for Periarteriolar Lymphoid Sheath-associated Foci and Germinal Centers

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• MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

  2003cited by this paper
• Reduced Switching in SCID B Cells Is Associated with Altered Somatic Mutation of Recombined S Regions 1

  2003cited by this paper
• Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance.

  2003cited by this paper
• Chk1 Mediates S and G2 Arrests through Cdc25A Degradation in Response to DNA-damaging Agents*

  2003cited by this paper
• MDC1 is a mediator of the mammalian DNA damage checkpoint

  2003cited by this paper
• AID mutant analyses indicate requirement for class-switch-specific cofactors

  2003cited by this paper
• Defective DNA Repair and Increased Genomic Instability in Artemis-deficient Murine Cells

  2003cited by this paper
• AID-dependent generation of resected double-strand DNA breaks and recruitment of Rad52/Rad51 in somatic hypermutation.

  2003cited by this paper
• DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

  2003cited by this paper
• Phosphorylation of Histone H2AX and Activation of Mre11, Rad50, and Nbs1 in Response to Replication-dependent DNA Double-strand Breaks Induced by Mammalian DNA Topoisomerase I Cleavage Complexes*

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• Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

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• Genetic heterogeneity for a Nijmegen breakage‐like syndrome

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• NFBD1, a Novel Nuclear Protein with Signature Motifs of FHA and BRCT, and an Internal 41-Amino Acid Repeat Sequence, Is an Early Participant in DNA Damage Response*

  2003cited by this paper
• Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

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• Msh2 ATPase Activity Is Essential for Somatic Hypermutation at A-T Basepairs and for Efficient Class Switch Recombination

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• Outcome of hematopoietic stem cell transplantation in hyper-IgM syndrome caused by CD40 deficiency.

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• Radiosensitive SCID patients with Artemis gene mutations show a complete B-cell differentiation arrest at the pre-B-cell receptor checkpoint in bone marrow.

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• Constitutive Expression of AID Leads to Tumorigenesis

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• Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding

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• De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination

  2003cited by this paper
• The Block in Immunoglobulin Class Switch Recombination Caused by Activation-Induced Cytidine Deaminase Deficiency Occurs Prior to the Generation of DNA Double Strand Breaks in Switch μ Region 1

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• R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells

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• Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations.

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• AID Mediates Hypermutation by Deaminating Single Stranded DNA

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• Transcription-targeted DNA deamination by the AID antibody diversification enzyme

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• Impact of DNA ligase IV on the fidelity of end joining in human cells.

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• Transcription-Coupled Events Associating with Immunoglobulin Switch Region Chromatin

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• Nonhomologous end joining and V(D)J recombination require an additional factor

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• NFBD1, Like 53BP1, Is an Early and Redundant Transducer Mediating Chk2 Phosphorylation in Response to DNA Damage*

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• Human uracil–DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

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• Type two hyper-IgM syndrome caused by mutation in activation-induced cytidine deaminase.

  2003cited by this paper
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  2003cited by this paper
• Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis.

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• The mechanism and regulation of chromosomal V(D)J recombination.

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• Sensing of intermediates in V(D)J recombination by ATM.

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• Genomic Instability in Mice Lacking Histone H2AX

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• [Paralogy and redundancy: maintaining genome integrity during V(D)J recombination].

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• Paralogie et redondance : maintenir l’intégrité du génome au cours de la recombinaison V(D)J

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• RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair

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• Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model

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• Role of DNA repair in host immune response and inflammation.

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  2006cites this paper
• [Cernunnos, a novel DNA repair factor essential for the immune system].

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• Cernunnos Interacts with the XRCC4·DNA-ligase IV Complex and Is Homologous to the Yeast Nonhomologous End-joining Factor Nej1*

  2006cites this paper