Evolutionary and Functional Conservation of the DNA Non-homologous End-joining Protein, XLF/Cernunnos*

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Journal of Biological Chemistry

• Publication date

  2006-12-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1074/jbc.M608727200PMID 17038309
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Highly Variable Rates of Genome Rearrangements between Hemiascomycetous Yeast Lineages

  2006cited by this paper
• XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining.

  2006cited by this paper
• Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair.

  2006cited by this paper
• Cernunnos Interacts with the XRCC4·DNA-ligase IV Complex and Is Homologous to the Yeast Nonhomologous End-joining Factor Nej1*

  2006cited by this paper
• Interplay between Ku, Artemis, and the DNA-dependent Protein Kinase Catalytic Subunit at DNA Ends*

  2006cited by this paper
• Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode.

  2006cited by this paper
• Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly.

  2006cited by this paper
• Hemiascomycetous yeasts at the forefront of comparative genomics.

  2005cited by this paper
• Biochemistry of V(D)J recombination.

  2005cited by this paper
• Three novel antibiotic marker cassettes for gene disruption and marker switching in Schizosaccharomyces pombe

  2005cited by this paper
• Sequence Finishing and Gene Mapping for Candida albicans Chromosome 7 and Syntenic Analysis Against the Saccharomyces cerevisiae Genome The entire chromosome 7 sequence has been deposited at DDBJ/EMBL/GenBank under the project accession no. AP006852.

  2005cited by this paper
• DNA Joint Dependence of Pol X Family Polymerase Action in Nonhomologous End Joining*

  2005cited by this paper
• Three-dimensional structure and regulation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs).

  2005cited by this paper
• Repair of Double-Strand DNA Breaks by the Human Nonhomologous DNA End Joining Pathway: The Iterative Processing Model

  2005cited by this paper
• Mechanism of DNA double-strand break repair by non-homologous end joining.

  2005cited by this paper
• The repair of DNA damages/modifications during the maturation of the immune system: lessons from human primary immunodeficiency disorders and animal models.

  2005cited by this paper
• A biochemically defined system for mammalian nonhomologous DNA end joining.

  2004cited by this paper
• Identification of DNA-PKcs phosphorylation sites in XRCC4 and effects of mutations at these sites on DNA end joining in a cell-free system.

  2004cited by this paper
• MUSCLE: multiple sequence alignment with high accuracy and high throughput.

  2004cited by this paper
• Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV

  2004cited by this paper
• Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints.

  2004cited by this paper
• Two modes of DNA double-strand break repair are reciprocally regulated through the fission yeast cell cycle.

  2004cited by this paper
• Nonhomologous end joining and V(D)J recombination require an additional factor

  2003cited by this paper
• Ku Stimulation of DNA Ligase IV-dependent Ligation Requires Inward Movement along the DNA Molecule*

  2003cited by this paper
• The role of DNA dependent protein kinase in synapsis of DNA ends

  2003cited by this paper
• NEJ1 prevents NHEJ-dependent telomere fusions in yeast without telomerase.

  2003cited by this paper
• Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment.

  2003cited by this paper
• DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination.

  2003cited by this paper
• Tetramerization and DNA ligase IV interaction of the DNA double-strand break repair protein XRCC4 are mutually exclusive.

  2003cited by this paper
• Synapsis of DNA ends by DNA‐dependent protein kinase

  2002cited by this paper
• Involvement of human polynucleotide kinase in double‐strand break repair by non‐homologous end joining

  2002cited by this paper
• Association of DNA Polymerase μ (pol μ) with Ku and Ligase IV: Role for pol μ in End-Joining Double-Strand Break Repair

  2002cited by this paper
• V(D)J recombination: RAG proteins, repair factors, and regulation.

  2002cited by this paper
• Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair.

  2002cited by this paper
• A DNA Microarray-Based Genetic Screen for Nonhomologous End-Joining Mutants in Saccharomyces cerevisiae

  2001cited by this paper
• Crystal structure of an Xrcc4–DNA ligase IV complex

  2001cited by this paper
• NHEJ regulation by mating type is exercised through a novel protein, Lif2p, essential to the ligase IV pathway.

  2001cited by this paper
• Nej1p, a cell type-specific regulator of nonhomologous end joining in yeast.

  2001cited by this paper
• Novel functional requirements for non‐homologous DNA end joining in Schizosaccharomyces pombe

  2001cited by this paper
• Chromosomal stability and the DNA double-stranded break connection

  2001cited by this paper
• NEJ1 controls non-homologous end joining in Saccharomyces cerevisiae

  2001cited by this paper
• Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

  2001cited by this paper
• FUGUE: sequence-structure homology recognition using environment-specific substitution tables and structure-dependent gap penalties.

  2001cited by this paper
• Crystal structure of the Xrcc4 DNA repair protein and implications for end joining

  2000cited by this paper
• DNA Ligase IV and XRCC4 Form a Stable Mixed Tetramer That Functions Synergistically with Other Repair Factors in a Cell-free End-joining System*

  2000cited by this paper
• Lif1p targets the DNA ligase Lig4p to sites of DNA double-strand breaks.

  2000cited by this paper
• Enhanced genome annotation using structural profiles in the program 3D-PSSM.

  2000cited by this paper
• Interactions of the DNA Ligase IV-XRCC4 Complex with DNA Ends and the DNA-dependent Protein Kinase*

  2000cited by this paper
• The DNA-dependent Protein Kinase Catalytic Activity Regulates DNA End Processing by Means of Ku Entry into DNA*

  1999cited by this paper
• Absence of DNA ligase IV protein in XR-1 cells: evidence for stabilization by XRCC4.

  1999cited by this paper
• DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity

  1999cited by this paper
• The XRCC4 Gene Product Is a Target for and Interacts with the DNA-dependent Protein Kinase*

  1998cited by this paper
• DNA ligase IV binds to XRCC4 via a motif located between rather than within its BRCT domains.

  1998cited by this paper
• Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage.

  1998cited by this paper
• Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.

  1997cited by this paper
• Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

  1997cited by this paper
• Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV.

  1997cited by this paper
• Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double‐strand break repair and serves as a barrier to error‐prone DNA repair pathways.

  1996cited by this paper
• Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination.

  1994cited by this paper
• The Cell Cycle

  1994cited by this paper
• Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks.

  1993cited by this paper
• Molecular genetic analysis of fission yeast Schizosaccharomyces pombe.

  1991cited by this paper
• Genetics

  1981cited by this paper

• Lactylation of XLF promotes non-homologous end-joining repair and chemoresistance in cancer.

  2025cites this paper
• Plant PAXX has an XLF-like function and stimulates DNA end-joining by the Ku-DNA ligase IV-XRCC4 complex

  2023cites this paper
• DNA damage and repair: underlying mechanisms leading to microcephaly

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• Schizosaccharomyces pombe Assays to Study Mitotic Recombination Outcomes

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• Regulation of non-homologous end joining via post-translational modifications of components of the ligation step

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• XLF/Cernunnos: An important but puzzling participant in the nonhomologous end joining DNA repair pathway.

  2017cites this paper
• Structural and Functional Characterization of Non-Homologous End Joining Factors

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• Investigating Role of Tyrosyl-DNA Phosphodiesterase 1 (TDP1) In Non-Homologous End Joining (NHEJ)

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• Single-Molecule Imaging of DNA Organization and Repair

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• Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining

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• The democratization of gene editing: Insights from site-specific cleavage and double-strand break repair.

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• A Life Investigating Pathways That Repair Broken Chromosomes.

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• TOLERANCE OF THYMINE GLYCOL AT THE BLUNT DNA DOUBLE STRAND BREAK FOR NONHOMOLOGUS END JOINING REPAIR AND INTERFERENCE BY BASE EXCISION REPAIR

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• Construction and Analysis of a Genome-Wide Insertion Library in Schizosaccharomyces pombe Reveals Novel Aspects of DNA Repair

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• CHARACTERIZATION OF A PLEIOTROPIC PROTEIN PROMOTING DNA REPAIR

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• Genome-wide Screens for Sensitivity to Ionizing Radiation Identify the Fission Yeast Nonhomologous End Joining Factor Xrc4

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• Emerging models for DNA repair: Dictyostelium discoideum as a model for nonhomologous end-joining.

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• The spatial organization of non-homologous end joining: From bridging to end joining

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• Cdk1 Restrains NHEJ through Phosphorylation of XRCC4-like Factor Xlf1

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• A role for XLF in DNA repair and recombination in human somatic cells.

  2014cites this paper
• Severe Combined Immunodeficiencies

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• Effects of chemopreventive natural products on non-homologous end-joining DNA double-strand break repair.

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  2011cites this paper
• Non-homologous end-joining partners in a helical dance: structural studies of XLF-XRCC4 interactions.

  2011cites this paper
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  2010cites this paper
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