Synthetic model proteins: the relative contribution of leucine residues at the nonequivalent positions of the 3-4 hydrophobic repeat to the stability of the two-stranded alpha-helical coiled-coil.

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Biochemistry

• Publication date

  1992-06-30

• Fields of study

  Biology, Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.1021/BI00140A008PMID 1610823
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The two‐stranded α‐helical coiled‐coil is an ideal model for studying protein stability and subunit interactions

  1992cited by this paper
• Synthetic model proteins. Positional effects of interchain hydrophobic interactions on stability of two-stranded alpha-helical coiled-coils.

  1992cited by this paper
• Predicting coiled coils from protein sequences

  1991cited by this paper
• Molecular analysis of protein assembly in muscle development.

  1991cited by this paper
• Consider the coiled coil

  1991cited by this paper
• 1H NMR and circular dichroism studies of the N-terminal domain of cyclic GMP dependent protein kinase: a leucine/isoleucine zipper.

  1991cited by this paper
• X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil.

  1991cited by this paper
• Designed coiled-coil proteins: synthesis and spectroscopy of two 78-residue alpha-helical dimers.

  1991cited by this paper
• Colon cancer. Consider the coiled coil....

  1991cited by this paper
• Energetics of repacking a protein interior.

  1991cited by this paper
• Solution structure of the basic region from the transcriptional activator GCN4.

  1991cited by this paper
• Contributions of the large hydrophobic amino acids to the stability of staphylococcal nuclease.

  1990cited by this paper
• Secondary structure of a leucine zipper determined by nuclear magnetic resonance spectroscopy.

  1990cited by this paper
• α‐Helical coiled coils and bundles: How to design an α‐helical protein

  1990cited by this paper
• Sequence requirements for coiled-coils: analysis with lambda repressor-GCN4 leucine zipper fusions.

  1990cited by this paper
• Glycine to alanine substitutions in helices of glyceraldehyde-3-phosphate dehydrogenase: effects on stability.

  1990cited by this paper
• A thermodynamic scale for the helix-forming tendencies of the commonly occurring amino acids.

  1990cited by this paper
• Synthetic model proteins: contribution of hydrophobic residues and disulfide bonds to protein stability.

  1990cited by this paper
• Effect of preferred binding domains on peptide retention behavior in reversed-phase chromatography: amphipathic alpha-helices.

  1990cited by this paper
• Evidence for coiled-coil dimer formation by an Epstein-Barr virus transactivator that lacks a heptad repeat of leucine residues.

  1990cited by this paper
• Alpha-helical coiled coils and bundles: how to design an alpha-helical protein.

  1990cited by this paper
• Use of site-directed mutagenesis to destabilize native apomyoglobin relative to folding intermediates.

  1989cited by this paper
• Probing the determinants of protein folding and stability with amino acid substitutions.

  1989cited by this paper
• Preferential heterodimer formation by isolated leucine zippers from fos and jun.

  1989cited by this paper
• Evidence that the leucine zipper is a coiled coil.

  1989cited by this paper
• Parallel association of Fos and Jun leucine zippers juxtaposes DNA binding domains.

  1989cited by this paper
• Energetics of complementary side-chain packing in a protein hydrophobic core.

  1989cited by this paper
• Protein design using model synthetic peptides.

  1988cited by this paper
• Contribution of hydrophobic interactions to protein stability

  1988cited by this paper
• Folding of immunogenic peptide fragments of proteins in water solution. II. The nascent helix.

  1988cited by this paper
• The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins.

  1988cited by this paper
• The role of protein structure in chromatographic behavior.

  1987cited by this paper
• Temperature-sensitive mutations of bacteriophage T4 lysozyme occur at sites with low mobility and low solvent accessibility in the folded protein.

  1987cited by this paper
• Determination and analysis of urea and guanidine hydrochloride denaturation curves.

  1986cited by this paper
• Tropomyosin crystal structure and muscle regulation.

  1986cited by this paper
• α-Helical coiled coils — a widespread motif in proteins

  1986cited by this paper
• A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

  1986cited by this paper
• A New Standard Substance for Calibration of Circular Dichroism: Ammonium d-10-Camphorsulfonate

  1985cited by this paper
• Synthesis of a model protein of defined secondary and quaternary structure. Effect of chain length on the stabilization and formation of two-stranded alpha-helical coiled-coils.

  1984cited by this paper
• Solvent-accessible surfaces of proteins and nucleic acids.

  1983cited by this paper
• Tropomyosin: a model protein for studying coiled-coil and .alpha.-helix stabilization

  1982cited by this paper
• Periodic charge distributions in the myosin rod amino acid sequence match cross-bridge spacings in muscle

  1982cited by this paper
• Synthetic model for two-stranded alpha-helical coiled-coils. Design, synthesis, and characterization of an 86-residue analog of tropomyosin.

  1981cited by this paper
• Tropomyosin coiled-coil interactions: evidence for an unstaggered structure.

  1975cited by this paper
• Tropomyosin: Amino Acid Sequence and Coiled-Coil Structure

  1973cited by this paper
• Amino-acid sequence of rabbit skeletal tropomyosin and its coiled-coil structure.

  1972cited by this paper

• A Self-Cross-Linked Dual-Enzyme Assembly for Safe and Efficient Hyperuricemia Therapy.

  2026cites this paper
• Secondary Structures of Human Calcitonin at Different Temperatures and in Different Membrane-Mimicking Environments, Characterized by Circular Dichroism (CD) Spectroscopy

  2025cites this paper
• Effect of osmolytes on the conformational stability of Aβ(25-35): A circular dichroism analysis.

  2025cites this paper
• Binding of Hg(I) and Hg(II) Ions to Amyloid‐Beta (Aβ) Peptide Variants Affect their Structure and Aggregation

  2025cites this paper
• Molecular interactions between gelatin-derived carbon quantum dots and Apo-myoglobin: Implications for carbon nanomaterial frameworks.

  2024cites this paper
• Ionic displacement of Ca2+ by Pb2+ in calmodulin is affected by arrhythmia-associated mutations.

  2023cites this paper
• Thermo-reversible gelation of myofibrillar protein: Relationship between coiled-coil and thermal reversibility

  2023influential citation
• Heme-Aβ in SDS micellar environment: Active site environment and reactivity.

  2023cites this paper
• Structural and biological characterization of shortened derivatives of the cathelicidin PMAP-36

  2023cites this paper
• Modulation of Ferrocene–Ferrocene Interactions by Varying Their Reciprocal Positions in L-Dap/Aib Helical Peptides

  2023cites this paper
• Natural and Engineered Isoforms of the Inflammasome Adaptor ASC Form Noncovalent, pH-Responsive Hydrogels.

  2023cites this paper
• Residue-specific binding of Ni(II) ions influences the structure and aggregation of amyloid beta (Aβ) peptides

  2023cites this paper
• Amino acid substitutions in human growth hormone affect secondary structure and receptor binding

  2023cites this paper
• Myofibrillar protein can form a thermo-reversible gel through elaborate deamidation using protein-glutaminase.

  2022cites this paper
• Mercury Ion Binding to Apolipoprotein E Variants ApoE2, ApoE3, and ApoE4: Similar Binding Affinities but Different Structure Induction Effects

  2022cites this paper
• Dilute phase oligomerization can oppose phase separation and modulate material properties of a ribonucleoprotein condensate

  2021cites this paper
• Stability of HA2 Prefusion Structure and pH-Induced Conformational Changes in the HA2 Domain of H3N2 Hemagglutinin.

  2021cites this paper
• Protein fibrils formed by rationally designed α-helical peptides.

  2020cites this paper
• Coiled-coil inspired functional inclusion bodies

  2020cites this paper
• Intra-helical Interactions in α-Helical Coiled-Coil Determine the Structural Stability of Tropomyosin.

  2020cites this paper
• Binding mechanism of a de novo coiled coil complex elucidated from surface forces measurements.

  2020cites this paper
• Bioinspired Histidine–Zn2+ Coordination for Tuning the Mechanical Properties of Self-Healing Coiled Coil Cross-Linked Hydrogels

  2019cites this paper
• High efficiency liposome fusion induced by reducing undesired membrane peptides interaction

  2019cites this paper
• Controlling the Self-Assembly of Synthetic Metal-Coordinating Coiled-Coil Peptides: Orthorhombic Lattice from a Trimeric Coiled Coil

  2019cites this paper
• Self-assembly and soluble aggregate behavior of computationally designed coiled-coil peptide bundles.

  2018cites this paper
• Combinatorial use of disulfide bridges and native sulfur-SAD phasing for rapid structure determination of coiled-coils

  2018cites this paper
• ACTIVITY AGAINST BACTERIA AND INTRACELLULAR PATHOGENS

  2017cites this paper
• Vectofusin-1, a potent peptidic enhancer of viral gene transfer forms pH-dependent α-helical nanofibrils, concentrating viral particles.

  2017cites this paper
• ACCORD: an assessment tool to determine the orientation of homodimeric coiled-coils

  2017cites this paper
• Specific Binding of Cu(II) Ions to Amyloid-Beta Peptides Bound to Aggregation-Inhibiting Molecules or SDS Micelles Creates Complexes that Generate Radical Oxygen Species

  2016cites this paper
• Platform technology to generate broadly cross‐reactive antibodies to α‐helical epitopes in hemagglutinin proteins from influenza A viruses

  2016cites this paper
• Structural investigations into functional aspects of the centriolar key proteins CEP135/Bld10p and SAS-6/Bld12p

  2016cites this paper
• The Human Centriolar Protein CEP135 Contains a Two-Stranded Coiled-Coil Domain Critical for Microtubule Binding.

  2016cites this paper
• Probing coiled-coil assembly by paramagnetic NMR spectroscopy.

  2015cites this paper
• The Role of the C-terminal Coiled-coil in the Cellular Localization and in the Osmotic Stress Response of Transporter ProP

  2015cites this paper
• Increasing the affinity of selective bZIP‐binding peptides through surface residue redesign

  2014cites this paper
• Concentration effects on peptide elution from pendant PEO layers.

  2014cites this paper
• Optical Control of Protein–Protein Interactions via Blue Light-Induced Domain Swapping

  2014cites this paper
• Acidic pH triggers conformational changes at the NH2-terminal propeptide of the precursor of pulmonary surfactant protein B to form a coiled coil structure.

  2014cites this paper
• Modular design of coiled coils to target bZIP transcription factors

  2014cites this paper
• Transmission of Stability Information through the N-domain of Tropomyosin Is Interrupted by a Stabilizing Mutation (A109L) in the Hydrophobic Core of the Stability Control Region (Residues 97–118)

  2013cites this paper
• Structural and Biophysical Characterization of the Cytoplasmic Domains of Human BAP29 and BAP31

  2013cites this paper
• Structural Basis for the Oligomerization-State Switch from a Dimer to a Trimer of an Engineered Cortexillin-1 Coiled-Coil Variant

  2013cites this paper
• Coiled-coil formation on lipid bilayers--implications for docking and fusion efficiency.

  2012cites this paper
• Tunable energy transfer rates via control of primary, secondary, and tertiary structure of a coiled coil peptide scaffold.

  2012cites this paper
• Caractérisation structurale et fonctionnelle d'une lectine de type-C des cellules de Langerhans : La Langérine

  2012cites this paper
• Engineered Synthetic Virus‐Like Particles and Their Use in Vaccine Delivery

  2011cites this paper
• Coiled coils: attractive protein folding motifs for the fabrication of self-assembled, responsive and bioactive materials.

  2010cites this paper
• Interaction studies of novel cell selective antimicrobial peptides with model membranes and E. coli ATCC 11775.

  2010cites this paper
• Critical interactions in the stability control region of tropomyosin.

  2010cites this paper
• Metal clips that induce unstructured pentapeptides to be alpha-helical in water.

  2009cites this paper
• Engineering of five 88-residue receptor-adhesive modular proteins containing a parallel alpha-helical coiled coil and two RGD ligand sites.

  2009cites this paper
• Stability and specificity of heterodimer formation for the coiled-coil neck regions of the motor proteins Kif3A and Kif3B: the role of unstructured oppositely charged regions.

  2008cites this paper
• Enzyme-inorganic nanoporous materials: Stabilization of proteins intercalated in α-zirconium(IV) phosphate by a denaturant

  2008cites this paper
• Hyperactive antifreeze protein from fish contains multiple ice-binding sites.

  2008cites this paper
• pH-sensitivity of the E3/K3 heterodimeric coiled coil.

  2008cites this paper
• The role of position a in determining the stability and oligomerization state of α‐helical coiled coils: 20 amino acid stability coefficients in the hydrophobic core of proteins

  2008cites this paper
• Multiple Intrinsically Disordered Sequences Alter DNA Binding by the Homeodomain of the Drosophila Hox Protein Ultrabithorax*

  2008cites this paper
• Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 ORF50/Rta Lytic Switch Protein Functions as a Tetramer

  2007cites this paper
• Four-helix bundle cavitein reveals middle leucine as linchpin.

  2007cites this paper
• Reversible and irreversible coiled coils in the stalk domain of ncd motor protein.

  2007cites this paper
• Kinking the coiled coil--negatively charged residues at the coiled-coil interface.

  2007cites this paper
• Structure and topology of the non‐amyloid‐β component fragment of human α‐synuclein bound to micelles: Implications for the aggregation process

  2006cites this paper
• Structure and topology of the non-amyloid-beta component fragment of human alpha-synuclein bound to micelles: implications for the aggregation process.

  2006cites this paper
• Design of a heterospecific, tetrameric, 21-residue miniprotein with mixed alpha/beta structure.

  2005cites this paper
• Design of a Heterospecific, Tetrameric, 21-Residue Miniprotein with Mixed α/β Structure

  2005cites this paper
• Effect of chain length on coiled‐coil stability: Decreasing stability with increasing chain length

  2004cites this paper
• Defining the minimum size of a hydrophobic cluster in two‐stranded α‐helical coiled‐coils: Effects on protein stability

  2004cites this paper
• Alpha-turn mimetics: short peptide alpha-helices composed of cyclic metallopentapeptide modules.

  2004cites this paper
• Metal clips induce folding of a short unstructured peptide into an alpha-helix via turn conformations in water. Kinetic versus thermodynamic products.

  2004cites this paper
• Temperature profiling of polypeptides in reversed-phase liquid chromatography. I. Monitoring of dimerization and unfolding of amphipathic alpha-helical peptides.

  2003cites this paper
• The FAR Protein Family of the Nematode Caenorhabditis elegans

  2003cites this paper
• Real-time monitoring of the interactions of two-stranded de novo designed coiled-coils: effect of chain length on the kinetic and thermodynamic constants of binding.

  2003cites this paper
• Temperature profiling of polypeptides in reversed-phase liquid chromatography. II. Monitoring of folding and stability of two-stranded alpha-helical coiled-coils.

  2003cites this paper
• Designing heterodimeric two-stranded alpha-helical coiled-coils. Effects of hydrophobicity and alpha-helical propensity on protein folding, stability, and specificity.

  2002cites this paper
• Specific Sequences Determine the Stability and Cooperativity of Folding of the C-terminal Half of Tropomyosin*

  2002cites this paper
• Streptococcal Antigen I / II the Alanine-Rich Repetitive Domain of Structural and Functional Variation within

  2002cites this paper
• Designing Heterodimeric Two-stranded α-Helical Coiled-coils

  2002cites this paper
• The role of unstructured highly charged regions on the stability and specificity of dimerization of two-stranded alpha-helical coiled-coils: analysis of the neck-hinge region of the kinesin-like motor protein Kif3A.

  2002cites this paper
• The C-terminal portion of the fibrinogen-binding protein of Streptococcus equi subsp. equi contains extensive alpha-helical coiled-coil structure and contributes to thermal stability.

  2002cites this paper
• Structural and Functional Variation within the Alanine-Rich Repetitive Domain of Streptococcal Antigen I/II

  2002cites this paper
• Amino Acids, Peptides, and Proteins

  2001cites this paper
• De novo design of fibrils made of short α-helical coiled coil peptides

  2001cites this paper
• De novo design of fibrils made of short alpha-helical coiled coil peptides.

  2001cites this paper
• Helix-loop-helix peptides as scaffolds for the construction of bridged metal assemblies in proteins: the spectroscopic A-cluster structure in carbon monoxide dehydrogenase.

  2001cites this paper
• Thermodynamics of trimer-of-hairpins formation by the SIV gp41 envelope protein.

  2001cites this paper
• A de novo designed peptide ligase: a mechanistic investigation.

  2001cites this paper
• Designing heterodimeric two-stranded alpha-helical coiled-coils: the effect of chain length on protein folding, stability and specificity.

  2001cites this paper
• Effect of the reaction field electrostatic term on the molecular dynamics simulation of the activation domain of procarboxypeptidase B.

  2000cites this paper
• A designed four-alpha-helix bundle that binds the volatile general anesthetic halothane with high affinity.

  2000cites this paper
• Synthesis and NMR solution structure of an α‐helical hairpin stapled with two disulfide bridges

  2000cites this paper
• Engineering novel bioactive mini-proteins from small size natural and de novo designed scaffolds.

  2000cites this paper
• Effects of side-chain characteristics on stability and oligomerization state of a de novo-designed model coiled-coil: 20 amino acid substitutions in position "d".

  2000cites this paper
• Interhelical ion pairing in coiled coils: solution structure of a heterodimeric leucine zipper and determination of pKa values of Glu side chains.

  2000cites this paper
• The Putative Coiled Coil Domain of the φ29 Terminal Protein Is a Major Determinant Involved in Recognition of the Origin of Replication*

  2000cites this paper
• Electrostatic Interactions in Leucine Zippers: Effects on Stability and Specificity of Interaction

  2000cites this paper
• The Conformation of de Novo Designed Amphiphilic Peptides with Six or Nine L-2-(2,2,2-Trifluoroethyl)glycines as the Hydrophobic Amino Acid

  2000cites this paper
• Covalent control of polypeptide folding. Induction of helix-loop-helix motifs by bridging

  2000cites this paper
• De novo design of a model peptide sequence to examine the effects of single amino acid substitutions in the hydrophobic core on both stability and oligomerization state of coiled-coils.

  1999cites this paper
• Characterization of MB‐1

  1999cites this paper