1400W, a highly selective inducible nitric oxide synthase inhibitor is a potential disease modifier in the rat kainate model of temporal lobe epilepsy.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Neurobiology of Disease

• Publication date

  2016-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.nbd.2016.05.013PMID 27208748
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Immediate epileptogenesis: Impact on brain in C57BL/6J mouse kainate model.

  2016cited by this paper
• Interleukin-4 Is Essential for Microglia/Macrophage M2 Polarization and Long-Term Recovery After Cerebral Ischemia

  2016cited by this paper
• Blood-brain barrier, bulk flow, and interstitial clearance in epilepsy.

  2016cited by this paper
• Conditional Deletion of the Glutamate Transporter GLT-1 Reveals That Astrocytic GLT-1 Protects against Fatal Epilepsy While Neuronal GLT-1 Contributes Significantly to Glutamate Uptake into Synaptosomes

  2015cited by this paper
• Epilepsy: new advances.

  2015cited by this paper
• Microglia/Macrophage Polarization After Experimental Intracerebral Hemorrhage

  2015cited by this paper
• Alternatively activated microglia and macrophages in the central nervous system.

  2015cited by this paper
• Candidate drug targets for prevention or modification of epilepsy.

  2015cited by this paper
• Immediate Epileptogenesis after Kainate-Induced Status Epilepticus in C57BL/6J Mice: Evidence from Long Term Continuous Video-EEG Telemetry

  2015cited by this paper
• Seizure-Induced Oxidative Stress in Temporal Lobe Epilepsy

  2015cited by this paper
• Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

  2015cited by this paper
• Redox regulation of NF‐κB p50 and M1 polarization in microglia

  2015cited by this paper
• Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood-brain barrier dysfunction.

  2015cited by this paper
• Advantages of Repeated Low Dose against Single High Dose of Kainate in C57BL/6J Mouse Model of Status Epilepticus: Behavioral and Electroencephalographic Studies

  2014cited by this paper
• The dual role of astrocyte activation and reactive gliosis.

  2014cited by this paper
• Temporal and spatial increase of reactive nitrogen species in the kainate model of temporal lobe epilepsy.

  2014cited by this paper
• Epilepsy and Inflammation in the Brain: Overview and Pathophysiology

  2014cited by this paper
• Does mossy fiber sprouting give rise to the epileptic state?

  2014cited by this paper
• Progressive neurodegeneration after experimental brain trauma: association with chronic microglial activation.

  2014cited by this paper
• Widespread activation of microglial cells in the hippocampus of chronic epileptic rats correlates only partially with neurodegeneration

  2014cited by this paper
• Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

  2014cited by this paper
• Epilepsy therapy development: Technical and methodologic issues in studies with animal models

  2013cited by this paper
• Glial cells as primary therapeutic targets for epilepsy.

  2013cited by this paper
• The Prevalence and Phenotype of Activated Microglia/Macrophages within the Spinal Cord of the Hyperostotic Mouse (twy/twy) Changes in Response to Chronic Progressive Spinal Cord Compression: Implications for Human Cervical Compressive Myelopathy

  2013cited by this paper
• High‐dose rapamycin blocks mossy fiber sprouting but not seizures in a mouse model of temporal lobe epilepsy

  2013cited by this paper
• Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy.

  2013cited by this paper
• On the selectivity of neuronal NOS inhibitors

  2013cited by this paper
• Interleukin‐1β orchestrates underlying inflammatory responses in microglia via Krüppel‐like factor 4

  2013cited by this paper
• Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro

  2013cited by this paper
• Cerebrovascular Remodeling and Epilepsy

  2013cited by this paper
• Hemoglobin-Induced Nitric Oxide Synthase Overexpression and Nitric Oxide Production Contribute to Blood–Brain Barrier Disruption in the Rat

  2013cited by this paper
• Invasive EEG studies in tumor‐related epilepsy: When are they indicated and with what kind of electrodes?

  2013cited by this paper
• Epilepsy biomarkers

  2013cited by this paper
• Development, maintenance and disruption of the blood-brain barrier

  2013cited by this paper
• Blood‐brain barrier dysfunction, TGFβ signaling, and astrocyte dysfunction in epilepsy

  2012cited by this paper
• Peripheral inflammation increases the deleterious effect of CNS inflammation on the nigrostriatal dopaminergic system.

  2012cited by this paper
• Genomic Analysis of Reactive Astrogliosis

  2012cited by this paper
• Characterization of status epilepticus induced by two organophosphates in rats.

  2012cited by this paper
• Glia-neuronal interactions in ictogenesis and epileptogenesis: role of inflammatory mediators

  2012cited by this paper
• NIH Image to ImageJ: 25 years of image analysis

  2012cited by this paper
• L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: the ‘collusion’ hypothesis for increased extracellular L-glutamate concentration in neuroinflammation

  2012cited by this paper
• N w‐Propyl‐l‐arginine (L‐NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses

  2012cited by this paper
• Seizure‐induced brain‐borne inflammation sustains seizure recurrence and blood–brain barrier damage

  2012cited by this paper
• Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

  2012cited by this paper
• Sequel of spontaneous seizures after kainic acid-induced status epilepticus and associated neuropathological changes in the subiculum and entorhinal cortex

  2012cited by this paper
• Rapamycin Suppresses Mossy Fiber Sprouting But Not Seizure Frequency in a Mouse Model of Temporal Lobe Epilepsy

  2011cited by this paper
• Molecular targets for antiepileptic drug development

  2011cited by this paper
• Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs.

  2011cited by this paper
• Blood-Brain Barrier Breakdown Following Traumatic Brain Injury: A Possible Role in Posttraumatic Epilepsy

  2011cited by this paper
• Drug-resistant epilepsy.

  2011cited by this paper
• Epileptiform Activity Induces Vascular Remodeling and Zonula Occludens 1 Downregulation in Organotypic Hippocampal Cultures: Role of VEGF Signaling Pathways

  2011cited by this paper
• Kainic Acid-Induced Neurotoxicity: Targeting Glial Responses and Glia-Derived Cytokines

  2011cited by this paper
• Is there a critical period for mossy fiber sprouting in a mouse model of temporal lobe epilepsy?

  2011cited by this paper
• Mossy fiber sprouting in the dentate gyrus

  2010cited by this paper
• Convulsive status epilepticus duration as determinant for epileptogenesis and interictal discharge generation in the rat limbic system.

  2010cited by this paper
• EEG spike activity precedes epilepsy after kainate‐induced status epilepticus

  2010cited by this paper
• The effects of nitric oxide inhibition prior to kainic acid treatment on neuro- and gliogenesis in the rat dentate gyrus in vivo and in vitro.

  2010cited by this paper
• Kainate and temporal lobe epilepsies: Three decades of progress

  2010cited by this paper
• Microglial activation and chronic neurodegeneration

  2010cited by this paper
• The myeloid cells of the central nervous system parenchyma

  2010cited by this paper
• Mitochondria, oxidative stress, and temporal lobe epilepsy.

  2010cited by this paper
• Management of refractory complex partial seizures: current state of the art

  2010cited by this paper
• Endogenous Nitric Oxide Is a Key Promoting Factor for Initiation of Seizure-Like Events in Hippocampal and Entorhinal Cortex Slices

  2009cited by this paper
• Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

  2009cited by this paper
• Development of Spontaneous Recurrent Seizures after Kainate-Induced Status Epilepticus

  2009cited by this paper
• Nitric Oxide Regulates Activity-Dependent Neuroprotective Protein (ADNP) in the Dentate Gyrus of the Rodent Model of Kainic Acid-Induced Seizure

  2009cited by this paper
• Astrocytic Dysfunction in Epileptogenesis: Consequence of Altered Potassium and Glutamate Homeostasis?

  2009cited by this paper
• Transcriptome Profiling Reveals TGF-β Signaling Involvement in Epileptogenesis

  2009cited by this paper
• The role of cytokines in the pathophysiology of epilepsy.

  2008cited by this paper
• Regulation of activity-dependent neuroprotective protein (ADNP) by the NO-cGMP pathway in the hippocampus during kainic acid-induced seizure.

  2008cited by this paper
• Epileptiform activities in slices of hippocampus from mice after intra‐hippocampal injection of kainic acid

  2008cited by this paper
• Glia as a source of cytokines: Implications for neuronal excitability and survival

  2008cited by this paper
• Modeling CNS microglia: the quest to identify predictive models.

  2008cited by this paper
• Development of Spontaneous Seizures after Experimental Status Epilepticus: Implications for Understanding Epileptogenesis

  2007cited by this paper
• Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy.

  2007cited by this paper
• Unmasking recurrent excitation generated by mossy fiber sprouting in the epileptic dentate gyrus: an emergent property of a complex system.

  2007cited by this paper
• TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis.

  2007cited by this paper
• Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy.

  2007cited by this paper
• New Roles for Interleukin-1 Beta in the Mechanisms of Epilepsy

  2007cited by this paper
• Nitric Oxide-NGF Mediated PPTA/SP, ADNP, and VIP Expression in the Peripheral Nervous System

  2007cited by this paper
• Treatment of Experimental Status Epilepticus in Immature Rats: Dissociation Between Anticonvulsant and Antiepileptogenic Effects

  2006cited by this paper
• Nitric oxide, a biological double-faced janus--is this good or bad?

  2006cited by this paper
• IL-1beta, an immediate early protein secreted by activated microglia, induces iNOS/NO in C6 astrocytoma cells through p38 MAPK and NF-kappaB pathways.

  2006cited by this paper
• IL‐1β, an immediate early protein secreted by activated microglia, induces iNOS/NO in C6 astrocytoma cells through p38 MAPK and NF‐κB pathways

  2006cited by this paper
• Regional neuropathology following kainic acid intoxication in adult and aged C57BL/6J mice.

  2006cited by this paper
• Hippocampal neurodegeneration, spontaneous seizures, and mossy fiber sprouting in the F344 rat model of temporal lobe epilepsy

  2006cited by this paper
• Astrocyte–endothelial interactions at the blood–brain barrier

  2006cited by this paper
• Inhibition of iNOS activity by 1400W decreases glutamate release and ameliorates stroke outcome after experimental ischemia.

  2005cited by this paper
• ATP mediates rapid microglial response to local brain injury in vivo

  2005cited by this paper
• Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo

  2005cited by this paper
• Inflammatory Response and Glia Activation in Developing Rat Hippocampus after Status Epilepticus

  2005cited by this paper
• Repair of the Injured Adult Hippocampus through Graft-Mediated Modulation of the Plasticity of the Dentate Gyrus in a Rat Model of Temporal Lobe Epilepsy

  2005cited by this paper
• Epileptogenesis and chronic seizures in a mouse model of temporal lobe epilepsy are associated with distinct EEG patterns and selective neurochemical alterations in the contralateral hippocampus.

  2005cited by this paper
• Nitric oxide, S-nitrosylation and neurodegeneration.

  2005cited by this paper
• Sequential changes of nitric oxide levels in the temporal lobes of kainic acid-treated mice following application of nitric oxide synthase inhibitors and phenobarbital.

  2005cited by this paper
• Effects of 7-nitroindazole and N-nitro-l-arginine methyl ester on changes in cerebral blood flow and nitric oxide production preceding development of hyperbaric oxygen-induced seizures in rats.

  2005cited by this paper
• 1400W, a potent selective inducible NOS inhibitor, improves histopathological outcome following traumatic brain injury in rats.

  2005cited by this paper
• Brain Inflammation in Epilepsy: Experimental and Clinical Evidence

  2005cited by this paper
• Mossy Fiber Sprouting and Recurrent Excitation: Direct Electrophysiologic Evidence and Potential Implications

  2004cited by this paper
• The neurobiology of antiepileptic drugs

  2004cited by this paper

• Chidamide Is Screened to Suppress Epileptogenesis in Mice Models via Blocking Histone Deacetylase 1

  2026cites this paper
• Dual targeting of iNOS and Src tyrosine kinase as a superior therapeutic strategy against soman-induced long-term neurotoxicity: multimodal biomarker, imaging, and neurobehavioral outcome analyses

  2026influential citation
• Potential for Therapeutic Alteration of the Underlying Biology of Epilepsy

  2025cites this paper
• Synergistic Integration of Immune Regulation and Bioactive Guidance Cues in Multi-Channel Nanofibrous Nerve Guidance Conduits for Accelerated Peripheral Nerve Regeneration

  2025cites this paper
• Proinflammatory cytokines, oxidative stress, and organ function as biomarkers of soman (GD) chronic neurotoxicity

  2025cites this paper
• iNOS in Macrophage Polarization: Pharmacological and Regulatory Insights

  2025cites this paper
• A review on oxidative stress in organophosphate-induced neurotoxicity.

  2025cites this paper
• Toll-Like Receptor 1/2 Postconditioning by the Ligand Pam3cys Tempers Posttraumatic Hyperexcitability, Neuroinflammation, and Microglial Response: A Potential Candidate for Posttraumatic Epilepsy

  2024cites this paper
• Valproic acid attenuates the severity of astrogliosis in the hippocampus of animal models of temporal lobe epilepsy

  2024cites this paper
• Enhanced Fyn-tau and NR2B-PSD95 interactions in epileptic foci in experimental models and human epilepsy

  2024cites this paper
• Neuroprotective effects of naltrexone in a mouse model of post-traumatic seizures

  2024cites this paper
• 1400 W, a selective inducible nitric oxide synthase inhibitor, mitigates early neuroinflammation and nitrooxidative stress in diisopropylfluorophosphate-induced short-term neurotoxicity rat model

  2023influential citation
• Inhibiting Inducible Nitric Oxide Synthase with 1400W Reduces Soman (GD)-Induced Ferroptosis in Long-Term Epilepsy-Associated Neuropathology: Structural and Functional Magnetic Resonance Imaging Correlations with Neurobehavior and Brain Pathology

  2023cites this paper
• The effects of Src tyrosine kinase inhibitor, saracatinib, on the markers of epileptogenesis in a mixed-sex cohort of adult rats in the kainic acid model of epilepsy

  2023cites this paper
• Neuroprotective Effects of Naltrexone in a Mouse Model of Post-Traumatic Epilepsy

  2023cites this paper
• Disease-modifying effects of a glial-targeted inducible nitric oxide synthase inhibitor (1400W) in mixed-sex cohorts of a rat soman (GD) model of epilepsy

  2023cites this paper
• Disease-Modifying Effects of a Glial-targeted Inducible Nitric Oxide Synthase Inhibitor (1400W) in Mixed-sex Cohorts of a Rat Soman (GD) Model of Epilepsy

  2023influential citation
• Beneficial Effects of Probiotic Bifidobacterium longum in a Lithium–Pilocarpine Model of Temporal Lobe Epilepsy in Rats

  2023cites this paper
• Scoping review of disease-modifying effect of drugs in experimental epilepsy

  2023cites this paper
• Soman (GD) Rat Model to Mimic Civilian Exposure to Nerve Agent: Mortality, Video-EEG Based Status Epilepticus Severity, Sex Differences, Spontaneously Recurring Seizures, and Brain Pathology

  2022cites this paper
• Gut dysbiosis following organophosphate, diisopropylfluorophosphate (DFP), intoxication and saracatinib oral administration

  2022influential citation
• Cholesterol 24-hydroxylase is a novel pharmacological target for anti-ictogenic and disease modification effects in epilepsy.

  2022cites this paper
• DFP-Induced Status Epilepticus Severity in Mixed-Sex Cohorts of Adult Rats Housed in the Same Room: Behavioral and EEG Comparisons

  2022cites this paper
• Electrophysiological, histopathological, and biochemical evaluation of the protective effect of probiotic supplementation against pentylenetetrazole‐induced seizures in rats

  2022cites this paper
• Characterization of Cortical Glial Scars in the Diisopropylfluorophosphate (DFP) Rat Model of Epilepsy

  2022cites this paper
• The Beneficial Effect of Probiotics Supplementation on Penicillin-Induced Focal Seizure in Rats

  2022cites this paper
• Diazepam Monotherapy or Diazepam-Ketamine Dual Therapy at Different Time Points Terminates Seizures and Reduces Mortality in a Status Epilepticus Animal Model

  2021cites this paper
• Inhibitors of Src Family Kinases, Inducible Nitric Oxide Synthase, and NADPH Oxidase as Potential CNS Drug Targets for Neurological Diseases

  2021cites this paper
• Neuropathophysiological Mechanisms and Treatment Strategies for Post-traumatic Epilepsy

  2021cites this paper
• Female mice lacking ERβ display excitatory/inhibitory synaptic imbalance to drive the pathogenesis of temporal lobe epilepsy

  2021cites this paper
• On the origin of paroxysmal depolarization shifts: the contribution of Cav1.x channels as the common denominator of a polymorphous neuronal discharge pattern.

  2021cites this paper
• The Role of Neuroinflammation in Post-traumatic Epilepsy

  2021cites this paper
• Mechanisms of disease-modifying effect of saracatinib (AZD0530), a Src/Fyn tyrosine kinase inhibitor, in the rat kainate model of temporal lobe epilepsy

  2021cites this paper
• The Impacts of Surgery and Intracerebral Electrodes in C57BL/6J Mouse Kainate Model of Epileptogenesis: Seizure Threshold, Proteomics, and Cytokine Profiles

  2021cites this paper
• Emerging Molecular Mechanisms of Neuroinflammation in Seizure Disorders

  2021cites this paper
• Fyn-tau Ablation Modifies PTZ-Induced Seizures and Post-seizure Hallmarks of Early Epileptogenesis

  2020cites this paper
• Inflammation and reactive oxygen species as disease modifiers in epilepsy.

  2020cites this paper
• Inducible nitric oxide synthase: Regulation, structure, and inhibition

  2020cites this paper
• Inducible nitric oxide synthase inhibitor, 1400W, mitigates DFP-induced long-term neurotoxicity in the rat model.

  2020cites this paper
• Diapocynin, an NADPH oxidase inhibitor, counteracts diisopropylfluorophosphate‐induced long‐term neurotoxicity in the rat model

  2020cites this paper
• Sex as a biological variable in the rat model of diisopropylfluorophosphate‐induced long‐term neurotoxicity

  2020cites this paper
• Downregulation of Nitric Oxide Collaborated with Radiotherapy to Promote Anti-Tumor Immune Response via Inducing CD8+ T Cell Infiltration

  2020cites this paper
• Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy?

  2020cites this paper
• The role of nitric oxide in glutaric acid‐induced convulsive behavior in pup rats

  2020cites this paper
• Seizure-Induced Oxidative Stress in Status Epilepticus: Is Antioxidant Beneficial?

  2020cites this paper
• Astrocytes as Guardians of Neuronal Excitability: Mechanisms Underlying Epileptogenesis

  2020cites this paper
• Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy

  2019cites this paper
• Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy

  2019cites this paper
• Glial source of nitric oxide in epileptogenesis: A target for disease modification in epilepsy

  2019cites this paper
• Inflammation and reactive oxygen species in status epilepticus: Biomarkers and implications for therapy.

  2019cites this paper
• The impact of postsynaptic density 95 blocking peptide (Tat‐NR2B9c) and an iNOS inhibitor (1400W) on proteomic profile of the hippocampus in C57BL/6J mouse model of kainate‐induced epileptogenesis

  2019cites this paper
• In Focus: Disease promoters during epileptogenesis

  2019cites this paper
• New Directions in the Management of Status Epilepticus

  2019cites this paper
• The role of NO-cGMP pathway inhibition in vascular endothelial-dependent smooth muscle relaxation disorder of AT1-AA positive rats: protective effects of adiponectin.

  2019cites this paper
• Dysregulation of stress systems and nitric oxide signaling underlies neuronal dysfunction in Alzheimer's disease.

  2019cites this paper
• The Paroxysmal Depolarization Shift: Reconsidering Its Role in Epilepsy, Epileptogenesis and Beyond

  2019cites this paper
• Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy.

  2019cites this paper
• Oxidative stress and inflammation in a spectrum of epileptogenic cortical malformations: molecular insights into their interdependence

  2018cites this paper
• Role of the Fyn-PKCδ signaling in SE-induced neuroinflammation and epileptogenesis in experimental models of temporal lobe epilepsy.

  2018cites this paper
• Pharmacological targeting of brain inflammation in epilepsy: Therapeutic perspectives from experimental and clinical studies

  2018cites this paper
• Astroglial role in the pathophysiology of status epilepticus: an overview

  2018cites this paper
• Inducible nitric oxide synthase inhibitor 1400W increases Na+,K+‐ATPase levels and activity and ameliorates mitochondrial dysfunction in Ctns null kidney proximal tubular epithelial cells

  2018cites this paper
• Development of a reactive oxygen species‐sensitive nitric oxide synthase inhibitor for the treatment of ischemic stroke

  2018cites this paper
• Status Epilepticus: Behavioral and Electroencephalography Seizure Correlates in Kainate Experimental Models

  2018influential citation
• Inducible nitric oxide synthase inhibition by 1400W limits pain hypersensitivity in a neuropathic pain rat model

  2018influential citation
• 1400 W ameliorates acute hypobaric hypoxia/reoxygenation‐induced cognitive deficits by suppressing the induction of inducible nitric oxide synthase in rat cerebral cortex microglia

  2017cites this paper
• Breaking Bad: the Structure and Function of the Blood-Brain Barrier in Epilepsy

  2017cites this paper
• Faster flux of neurotransmitter glutamate during seizure — Evidence from 13C-enrichment of extracellular glutamate in kainate rat model

  2017cites this paper
• The roles of fyn and tau in the early phase of epileptogenesis: Studies from transgenic mouse models

  2017cites this paper
• La réponse antitumorale des macrophages dirigée contre les cellules de mésothéliome pleural malin

  2017cites this paper
• Mechanisms of Excessive Extracellular Glutamate Accumulation in Temporal Lobe Epilepsy

  2017cites this paper
• Nitric Oxide: Exploring the Contextual Link with Alzheimer's Disease

  2016influential citation
• Pathophysiology of status epilepticus.

  2016cites this paper