Iron deficiency impairs contractility of human cardiomyocytes through decreased mitochondrial function

M. Hoes,N. Grote Beverborg,J. D. Kijlstra,J. Kuipers,D. Swinkels,B. Giepmans,R. Rodenburg,D. V. van Veldhuisen,R. D. de Boer,P. van der Meer

Published 2018 in European Journal of Heart Failure

ABSTRACT

Iron deficiency is common in patients with heart failure and associated with a poor cardiac function and higher mortality. How iron deficiency impairs cardiac function on a cellular level in the human setting is unknown. This study aims to determine the direct effects of iron deficiency and iron repletion on human cardiomyocytes.

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