Iron depletion increases manganese uptake and potentiates apoptosis through ER stress.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Neurotoxicology

• Publication date

  2013-09-01

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1016/j.neuro.2013.06.002PMID 23764342PMCID PMC3770814
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• High blood manganese in iron-deficient children in Karachi

  2013cited by this paper
• Manganese-induced oxidative DNA damage in neuronal SH-SY5Y cells: attenuation of thymine base lesions by glutathione and N-acetylcysteine.

  2013influential reference
• Role of astrocytes in manganese mediated neurotoxicity

  2013cited by this paper
• Iron-Responsive Olfactory Uptake of Manganese Improves Motor Function Deficits Associated with Iron Deficiency

  2012cited by this paper
• Olfactory dysfunction in Parkinson disease

  2012cited by this paper
• Involvement of the molecular chaperone Hspa5 in copper homeostasis in astrocytes.

  2012cited by this paper
• H(+)-coupled divalent metal-ion transporter-1: functional properties, physiological roles and therapeutics.

  2012cited by this paper
• Apoptosis Induced by Manganese on Neuronal SK-N-MC Cell Line: Endoplasmic Reticulum (ER) Stress and Mitochondria Dysfunction

  2011cited by this paper
• The effects of 3, 4 or 5 amino salicylic acids on manganese-induced neuronal death: ER stress and mitochondrial complexes.

  2011cited by this paper
• Leucine-Rich Repeat Kinase 2 Is Associated With the Endoplasmic Reticulum in Dopaminergic Neurons and Accumulates in the Core of Lewy Bodies in Parkinson Disease

  2010cited by this paper
• Zinc prevents the copper-induced damage of cultured astrocytes.

  2010cited by this paper
• Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumes

  2010influential reference
• Regulation of translation initiation in eukaryotes: mechanisms and biological targets.

  2009cited by this paper
• Interleukin 10 blocked endoplasmic reticulum stress in intestinal epithelial cells: impact on chronic inflammation

  2007cited by this paper
• Translational Control and the Unfolded Protein Response

  2007cited by this paper
• Manganese accumulates in iron-deficient rat brain regions in a heterogeneous fashion and is associated with neurochemical alterations

  2007cited by this paper
• San Francisco/Oakland Bay Bridge Welder Study

  2007cited by this paper
• ER stress and neurodegenerative diseases

  2006cited by this paper
• Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates.

  2006cited by this paper
• Increased manganese uptake by primary astrocyte cultures with altered iron status is mediated primarily by divalent metal transporter.

  2006cited by this paper
• Hair Manganese and Hyperactive Behaviors: Pilot Study of School-Age Children Exposed through Tap Water

  2006cited by this paper
• Protein Kinase Cδ Is a Key Downstream Mediator of Manganese-Induced Apoptosis in Dopaminergic Neuronal Cells

  2005cited by this paper
• Neurobehavioral evaluation of rhesus monkey infants fed cow's milk formula, soy formula, or soy formula with added manganese.

  2005cited by this paper
• Sepiapterin attenuates 1-methyl-4-phenylpyridinium-induced apoptosis in neuroblastoma cells transfected with neuronal NOS: role of tetrahydrobiopterin, nitric oxide, and proteasome activation.

  2005cited by this paper
• Parkin attenuates manganese‐induced dopaminergic cell death

  2004cited by this paper
• The unfolded protein response--a stress signaling pathway of the endoplasmic reticulum.

  2004cited by this paper
• Increased DMT1 but not IREG1 or HFE mRNA following iron depletion therapy in hereditary haemochromatosis

  2004cited by this paper
• Induction of neuronal death by ER stress in Alzheimer's disease.

  2004influential reference
• Manganese-induced cytotoxicity in dopamine-producing cells.

  2004cited by this paper
• Anti-apoptotic and pro-apoptotic effect of NEPP11 on manganese-induced apoptosis and JNK pathway activation in PC12 cells.

  2004cited by this paper
• Effect of manganese exposure on MPTP neurotoxicities.

  2003cited by this paper
• Iron interactions and other biological reactions mediating the physiological and toxic actions of manganese.

  2003cited by this paper
• Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol

  2003cited by this paper
• The endoplasmic reticulum: a multifunctional signaling organelle.

  2002cited by this paper
• Manganese-induced apoptosis in PC12 cells.

  2002influential reference
• Manganese(II) Induces Apoptotic Cell Death in NIH3T3 Cells via a Caspase-12-dependent Pathway*

  2002cited by this paper
• Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation.

  2002cited by this paper
• Caspase-3-Dependent Proteolytic Cleavage of Protein Kinase Cδ Is Essential for Oxidative Stress-Mediated Dopaminergic Cell Death after Exposure to Methylcyclopentadienyl Manganese Tricarbonyl

  2002cited by this paper
• An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin.

  2001cited by this paper
• Putative Transmembrane Polypeptide , which Can Lead to Endoplasmic Reticulum Stress , Is a Substrate of Parkin

  2001cited by this paper
• Zinc status affects p53, gadd45, and c-fos expression and caspase-3 activity in human bronchial epithelial cells.

  2001cited by this paper
• The glucose-regulated proteins: stress induction and clinical applications.

  2001cited by this paper
• Manganese induces endoplasmic reticulum (ER) stress and activates multiple caspases in nigral dopaminergic neuronal cells, SN4741.

  2001cited by this paper
• Activation of Caspase-12, an Endoplastic Reticulum (ER) Resident Caspase, through Tumor Necrosis Factor Receptor-associated Factor 2-dependent Mechanism in Response to the ER Stress*

  2001cited by this paper
• Chronic marginal iron intakes during early development in mice alter brain iron concentrations and behavior despite postnatal iron supplementation.

  2000cited by this paper
• Glutamine Deprivation Induces the Expression ofGADD45 and GADD153 Primarily by mRNA Stabilization*

  1999cited by this paper
• Manganese induces apoptosis of human B cells: caspase-dependent cell death blocked by Bcl-2

  1999cited by this paper
• Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron.

  1999cited by this paper
• The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents III: the effect of the ligands on molecular targets involved in proliferation.

  1999cited by this paper
• Long-term exposure to "low levels" of manganese oxides and neurofunctional changes in ferroalloy workers.

  1999cited by this paper
• Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls.

  1999cited by this paper
• Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport.

  1998cited by this paper
• Cloning and characterization of a mammalian proton-coupled metal-ion transporter

  1997influential reference
• Manganese in the U.S. gasoline supply.

  1997cited by this paper
• Effects of iron deficiency and iron overload on manganese uptake and deposition in the brain and other organs of the rat

  1996cited by this paper
• Manganese toxicity in children receiving long-term parenteral nutrition.

  1996cited by this paper
• Occupational and environmental exposure of garage workers and taxi drivers to airborne manganese arising from the use of methylcyclopentadienyl manganese tricarbonyl in unleaded gasoline.

  1994cited by this paper
• Manganese induces spreading and process outgrowth in rat pheochromocytoma (PC12) cells

  1993cited by this paper
• Regulation of the C/EBP-related gene gadd153 by glucose deprivation

  1993cited by this paper
• Gadd45 and Gadd153 messenger RNA levels are increased during hypoxia and after exposure of cells to agents which elevate the levels of the glucose-regulated proteins.

  1992cited by this paper
• The physiopathologic significance of manganese in brain: its relation to schizophrenia and neurodegenerative disorders.

  1987cited by this paper
• Functions of trace elements in brain metabolism.

  1987cited by this paper
• Manganese and extrapyramidal disorders (a critical review and tribute to Dr. George C. Cotzias).

  1984cited by this paper
• Manganese in infant formulas and learning disability.

  1983cited by this paper
• The regional distribution of manganese in the normal human brain

  1982cited by this paper
• Hair element content in learning disabled children.

  1977cited by this paper
• Determination of Na+, K+, Mg2+, Cu2+, Zn2+, and Mn2+ in Rat Brain Regions

  1973cited by this paper
• Determination of Na + , K + , Mg 2+ , Cu 2+ , Zn 2+ , and Mn 2+ in rat brain regions.

  1973cited by this paper
• The FASEB Journal • Research Communication Olfactory uptake of manganese requires DMT1 and is enhanced by anemia

  year unknowncited by this paper

• Iron deficiency aggravates hepatic inflammation in suckling piglets via endoplasmic reticulum stress-driven NF-κB pathway activation

  2026cites this paper
• Dietary manganese intake is positively associated with metabolic dysfunction-associated steatotic liver disease: a multicohort study

  2025cites this paper
• Role of manganese in brain health and disease: focus on oxidative stress.

  2025cites this paper
• Systematic analysis of naturally occurring missense mutations in human manganese transporters: prediction and structural insights

  2025cites this paper
• Hepatic Dysfunction and Neuropsychiatric Sequelae Through Manganese Toxicity

  2025cites this paper
• Chronic Manganese Neuro-Toxicity in a Patient With Cirrhosis and the Role of Iron-Deficiency Anaemia

  2024cites this paper
• Iron consumption strengthens anti-tumoral STING activation mediated by manganese-based nanoparticles

  2024cites this paper
• Using Machine Learning to Construct the Blood-Follicle Distribution Models of Various Trace Elements and Explore the Transport-Related Pathways with Multiomics Data.

  2024cites this paper
• Zinc and manganese homeostasis closely interact in mammalian cells

  2024cites this paper
• Signal Transduction Associated with Mn-induced Neurological Dysfunction

  2023cites this paper
• Integrated regulation of stress responses, autophagy and survival by altered intracellular iron stores

  2022cites this paper
• Autophagy-Based Intervention Strategy in the Management of Hepatotoxicity

  2022cites this paper
• A GATA-type transcription factor SreA affects manganese susceptibility by regulating the expression of iron uptake-related genes.

  2022cites this paper
• Evaluating the neuroprotective activities of vinpocetine, punicalagin, niacin and vitamin E against behavioural and motor disabilities of manganese-induced Parkinson's disease in Sprague Dawley rats.

  2022cites this paper
• Transcriptome and metabolome analyses reveal new insights into chlorophyll, photosynthesis, metal ion and phenylpropanoids related pathways during sugarcane ratoon chlorosis

  2022cites this paper
• Multi-Elemental Analysis of Human Optic Chiasm—A New Perspective to Reveal the Pathomechanism of Nerve Fibers’ Degeneration

  2022cites this paper
• Ageing-associated effects of a long-term dietary modulation of four trace elements in mice

  2021cites this paper
• Manganese-Induced Neurotoxicity through Impairment of Cross-Talk Pathways in Human Neuroblastoma Cell Line SH-SY5Y Differentiated with Retinoic Acid

  2021cites this paper
• Alteration of iron (Fe), copper (Cu), zinc (Zn), and manganese (Mn) tissue levels and speciation in rats with desferioxamine-induced iron deficiency

  2021cites this paper
• Advances in nutrient metabolism and emission of livestock and poultry dietary trace elements

  2021cites this paper
• Milk productivity of cows and the content of the metal-ligand forms of iron

  2021cites this paper
• Impaired ferritinophagy flux induced by high fat diet mediates hepatic insulin resistance via endoplasmic reticulum stress.

  2020cites this paper
• Bioavailability and Modes of Action of Novel Metal Based Phenanthroline Drugs

  2020cites this paper
• Manganese as the essential element in oxidative stress and metabolic diseases

  2020cites this paper
• Siderophores induce mitophagy-dependent apoptosis in platelets.

  2020cites this paper
• Heavy Metals Exposure and Alzheimer’s Disease and Related Dementias

  2020cites this paper
• PdpaMn inhibits fatty acid synthase-mediated glycolysis by down-regulating PI3K/Akt signaling pathway in breast cancer

  2020cites this paper
• Metal-induced neurotoxicity in a RAGE-expressing C. elegans model.

  2020cites this paper
• Brain and Kidney Crosstalk

  2020cites this paper
• Modification of the effects of prenatal manganese exposure on child neurodevelopment by maternal anemia and iron deficiency

  2020cites this paper
• Neurologic conditions and disorders of uremic syndrome of chronic kidney disease: presentations, causes, and treatment strategies

  2019cites this paper
• Metal bashing: iron deficiency and manganese overexposure impact on peripheral nerves

  2019cites this paper
• Prenatal manganese and cord blood mitochondrial DNA copy number: Effect modification by maternal anemic status.

  2019cites this paper
• Rutin abrogates manganese-Induced striatal and hippocampal toxicity via inhibition of iron depletion, oxidative stress, inflammation and suppressing the NF-κB signaling pathway.

  2019cites this paper
• Manganese-induced cellular disturbance in the baker’s yeast, Saccharomyces cerevisiae with putative implications in neuronal dysfunction

  2019cites this paper
• Effect of endoplasmic reticulum stress involved in manganese‑induced neurotoxicity in rats.

  2019cites this paper
• Neuroprotective effects of docosahexaenoic acid against sub-acute manganese intoxication induced dopaminergic and motor disorders in mice.

  2019cites this paper
• Manganese-Induced Disruption of Cross-Talking Pathways in Danio rerio (Zebrafish) is Potentially Linked to Toxicity and Neurodegeneration

  2019cites this paper
• Regulated Necrosis Orchestrates Microglial Cell Death in Manganese-Induced Toxicity.

  2018cites this paper
• Protective effect of vinpocetine against neurotoxicity of manganese in adult male rats

  2018cites this paper
• The research advances in the mechanism of manganese-induced neurotoxicity

  2018cites this paper
• Iron deficiency impairs contractility of human cardiomyocytes through decreased mitochondrial function

  2018cites this paper
• Ferroportin disease mutations influence manganese accumulation and cytotoxicity

  2018cites this paper
• Functional analysis of SLC39A8 mutations and their implications for manganese deficiency and mitochondrial disorders

  2018cites this paper
• Iron depletion participates in the suppression of cell proliferation induced by lipin1 overexpression.

  2018cites this paper
• Intestinal DMT1 Is Essential for Optimal Assimilation of Dietary Copper in Male and Female Mice with Iron-Deficiency Anemia.

  2018cites this paper
• The Essential Element Manganese, Oxidative Stress, and Metabolic Diseases: Links and Interactions

  2018cites this paper
• Manganese transport and toxicity in polarized WIF-B hepatocytes.

  2018cites this paper
• Multielement analysis of swiss mice brains with Alzheimer's disease induced by beta amyloid oligomers using a portable total reflection X- ray fluorescence system

  2017cites this paper
• Redox dynamics of manganese as a mitochondrial life-death switch.

  2017cites this paper
• Influence of iron metabolism on manganese transport and toxicity.

  2017cites this paper
• Switch of Mitochondrial Superoxide Dismutase into a Prooxidant Peroxidase in Manganese-Deficient Cells and Mice.

  2017cites this paper
• Hepatic ZIP14-mediated zinc transport is required for adaptation to endoplasmic reticulum stress

  2017cites this paper
• Metals and Neurodegeneration

  2016cites this paper
• Biomedical and Pharmaceutical Applications

  2016cites this paper
• Exposure, epidemiology, and mechanism of the environmental toxicant manganese

  2016influential citation
• A role for amyloid precursor protein translation to restore iron homeostasis and ameliorate lead (Pb) neurotoxicity

  2016cites this paper
• Endoplasmic reticulum stress-mediated neuronal apoptosis by acrylamide exposure.

  2016cites this paper
• Review about the manganese speciation project related to neurodegeneration: An analytical chemistry approach to increase the knowledge about manganese related parkinsonian symptoms.

  2016cites this paper
• ER Stress via CHOP Pathway is Involved in FK506-Induced Apoptosis in Rat Fibroblasts

  2016cites this paper
• KHSRP Participates in Manganese-Induced Neurotoxicity in Rat Striatum and PC12 Cells

  2015cites this paper
• ER stress and ER stress-mediated apoptosis are involved in manganese-induced neurotoxicity in the rat striatum in vivo.

  2015cites this paper
• Manganese Is Essential for Neuronal Health.

  2015cites this paper
• SLC30A10: A novel manganese transporter

  2015cites this paper
• Iron incorporation into MnSOD A (bacterial Mn-dependent superoxide dismutase) leads to the formation of a peroxidase/catalase implicated in oxidative damage to bacteria.

  2015cites this paper
• Effect of olfactory manganese dose on motor coordination in iron-deficient rats

  2014cites this paper
• Manganese disturbs metal and protein homeostasis in Caenorhabditis elegans.

  2014cites this paper
• Ferroportin deficiency impairs manganese metabolism in flatiron mice

  2014cites this paper
• Impact of manganese on primary hippocampal neurons from rodents

  2014cites this paper
• Metals and Neurodegeneration [version 1; peer review: 3 approved]

  year unknowncites this paper