Role of Melatonin, Galanin, and RFamide Neuropeptides QRFP26 and QRFP43 in the Neuroendocrine Control of Pancreatic β-Cell Function

Glucose homeostasis is finely regulated by a number of hormones and peptides released mainly from the brain, gastrointestinal tract, and muscle, regulating pancreatic secretion through cellular receptors and their signal transduction cascades. The endocrine function of the pancreas is controlled by islets within the exocrine pancreatic tissue that release hormones like insulin, glucagon, somatostatin, pancreatic polypeptide, and ghrelin. Moreover, both exocrine and endocrine pancreatic functions are regulated by a variety of hormonal and neural mechanisms, such as ghrelin, glucagon-like peptide, glucose-dependent insulinotropic polypeptide, or the inhibitory peptide somatostatin. In this review, we describe the role of neurohormones that have been less characterized compared to others, on the regulation of insulin secretion. In particular, we will focus on melatonin, galanin, and RFamide neuropeptides QRFP26 and QRFP43, which display either insulinotropic or insulinostatic effects. In fact, in addition to other hormones, amino acids, cytokines, and a variety of proteins, brain-derived hormones are now considered as key regulators of glucose homeostasis, representing potential therapeutic targets for the treatment of diabetes and obesity.

• Publication year

  2017

• Venue

  Frontiers in Endocrinology

• Publication date

  2017-07-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3389/fendo.2017.00143PMID 28729853PMCID 5499649
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Chronomedicine and type 2 diabetes: shining some light on melatonin

  2017cited by this paper
• Melatonin: Protection against age-related cardiac pathology

  2017cited by this paper
• The Neuropeptide 26RFa (QRFP) and Its Role in the Regulation of Energy Homeostasis: A Mini-Review

  2016cited by this paper
• Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes.

  2016influential reference
• Advances in β cell replacement and regeneration strategies for treating diabetes.

  2016cited by this paper
• Anti-obesity effect of intranasal administration of galanin-like peptide (GALP) in obese mice

  2016cited by this paper
• Inter-organ communication and regulation of beta cell function

  2016cited by this paper
• QRFP-43 inhibits lipolysis by preventing ligand-induced complex formation between perilipin A, caveolin-1, the catalytic subunit of protein kinase and hormone-sensitive lipase in 3T3-L1 adipocytes.

  2015cited by this paper
• Experimental and clinical aspects of melatonin and clock genes in diabetes

  2015cited by this paper
• Regulation of glucose and insulin release following acute and repeated treatment with the synthetic galanin analog NAX-5055.

  2015cited by this paper
• Physiology, Signaling, and Pharmacology of Galanin Peptides and Receptors: Three Decades of Emerging Diversity

  2015cited by this paper
• Melatonin regulates somatotrope and lactotrope function through common and distinct signaling pathways in cultured primary pituitary cells from female primates.

  2015cited by this paper
• Hypothalamic Neuropeptide 26RFa Acts as an Incretin to Regulate Glucose Homeostasis

  2015influential reference
• RFamide Peptides in Early Vertebrate Development

  2014cited by this paper
• Extrapineal melatonin: sources, regulation, and potential functions

  2014cited by this paper
• Recent advances in the regulation of pancreatic secretion

  2014cited by this paper
• RFamide Peptides 43RFa and 26RFa Both Promote Survival of Pancreatic β-Cells and Human Pancreatic Islets but Exert Opposite Effects on Insulin Secretion

  2014cited by this paper
• Pyroglutamylated RF-amide peptide (QRFP) gene is regulated by metabolic endotoxemia.

  2014cited by this paper
• Molecular evolution of GPCRs: 26Rfa/GPR103.

  2014cited by this paper
• The potential antidepressant and antidiabetic effects of galanin system.

  2014cited by this paper
• Targeting the pancreatic β-cell to treat diabetes

  2014cited by this paper
• Melatonin receptor activation suppresses adrenocorticotropin production via BMP-4 action by pituitary AtT20 cells.

  2013cited by this paper
• Melatonin and Pancreatic Islets: Interrelationships between Melatonin, Insulin and Glucagon

  2013cited by this paper
• Galanin gene expression and effects of its knock‐down on the development of the nervous system in larval zebrafish

  2012cited by this paper
• Altered gene expression profiles in the hippocampus and prefrontal cortex of type 2 diabetic rats

  2012cited by this paper
• Melatonin influences insulin secretion primarily via MT(1) receptors in rat insulinoma cells (INS-1) and mouse pancreatic islets.

  2012cited by this paper
• Go2 G protein mediates galanin inhibitory effects on insulin release from pancreatic β cells

  2012cited by this paper
• Melatonin influences insulin secretion primarily via MT1 receptors in rat insulinoma cells (INS‐1) and mouse pancreatic islets

  2011cited by this paper
• Melatonin stimulates glucagon secretion in vitro and in vivo

  2011cited by this paper
• Melatonin inhibits insulin secretion in rat insulinoma β‐cells (INS‐1) heterologously expressing the human melatonin receptor isoform MT2

  2011cited by this paper
• Identification, localization, and function of a novel avian hypothalamic neuropeptide, 26RFa, and its cognate receptor, G protein-coupled receptor-103.

  2010cited by this paper
• Galanin acts as a trophic factor to the central and peripheral nervous systems.

  2010cited by this paper
• Galanin and epilepsy.

  2010cited by this paper
• GPR103b functions in the peripheral regulation of adipogenesis.

  2010cited by this paper
• Aspartimide modified galanin analogue antagonizes galanin action on insulin secretion.

  2010cited by this paper
• Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

  2009cited by this paper
• A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

  2009cited by this paper
• Variants in MTNR1B influence fasting glucose levels

  2009cited by this paper
• Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene

  2009cited by this paper
• Chronic increase of circulating galanin levels induces obesity and marked alterations in lipid metabolism similar to metabolic syndrome

  2009cited by this paper
• Molecular cloning and functional characterization of the first non-mammalian 26RFa/QRFP orthologue in Goldfish, Carassius auratus

  2009cited by this paper
• Galanin – 25 years with a multitalented neuropeptide

  2008cited by this paper
• Function and expression of melatonin receptors on human pancreatic islets

  2008cited by this paper
• Galanin – 25 years with a multitalented neuropeptide

  2008cited by this paper
• Biochemical Evaluation of Patients with Active Acromegaly and Type 2 Diabetes Mellitus: Efficacy and Safety of the Galanin Test

  2008cited by this paper
• Galanin – 25 years with a multitalented neuropeptide

  2008cited by this paper
• Pyroglutamylated RFamide peptide 43 stimulates the hypothalamic-pituitary-gonadal axis via gonadotropin-releasing hormone in rats.

  2008cited by this paper
• New galanin(1-15) analogues modified in positions 9, 10 and 11 act as galanin antagonists on glucose-induced insulin secretion.

  2007cited by this paper
• Evidence for the expression of both the MT1‐ and in addition, the MT2‐melatonin receptor, in the rat pancreas, islet and β‐cell

  2007cited by this paper
• Distribution of 26RFa binding sites and GPR103 mRNA in the central nervous system of the rat

  2007cited by this paper
• 26RFa, a novel orexigenic neuropeptide, inhibits insulin secretion in the rat pancreas.

  2007cited by this paper
• Effect of central administration of QRFP(26) peptide on energy balance and characterization of a second QRFP receptor in rat

  2006cited by this paper
• Novel role of 26RFa, a hypothalamic RFamide orexigenic peptide, as putative regulator of the gonadotropic axis

  2006cited by this paper
• The G-Protein-Coupled Receptor GPR103 Regulates Bone Formation

  2006cited by this paper
• RFamide peptide QRFP43 causes obesity with hyperphagia and reduced thermogenesis in mice.

  2006cited by this paper
• Behavioral effects of 26RFamide and related peptides.

  2006cited by this paper
• A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice.

  2006influential reference
• Parallel signaling pathways of melatonin in the pancreatic β‐cell

  2006cited by this paper
• Pineal effects on metabolism and glucose homeostasis: Evidence for lines of humoral mediation of pineal influences on tumor growth

  2005cited by this paper
• Mini review

  2004cited by this paper
• The expanding family of ‐RFamide peptides and their effects on feeding behaviour

  2004cited by this paper
• Loss-of-function mutation of the galanin gene is associated with perturbed islet function in mice.

  2004cited by this paper
• Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity

  2003cited by this paper
• Differential patterns of Fos induction in the hypothalamus of the rat following central injections of galanin-like peptide and galanin.

  2003influential reference
• Effect of Galanin on Plasma Glucose, Insulin and Pancreatic Glucagon in Dogs

  2003cited by this paper
• A New Peptidic Ligand and Its Receptor Regulating Adrenal Function in Rats*

  2003cited by this paper
• Calreticulin-melatonin. An unexpected relationship.

  2003cited by this paper
• Identification and Characterization of a Novel RF-amide Peptide Ligand for Orphan G-protein-coupled Receptor SP9155*

  2003cited by this paper
• A role for galanin-like peptide in the integration of feeding, body weight regulation, and reproduction in the mouse.

  2003influential reference
• Mammalian melatonin receptors: molecular biology and signal transduction

  2002cited by this paper
• Identification and functional characterization of melatonin Mel 1a receptors in pancreatic β cells: potential role in incretin-mediated cell function by sensitization of cAMP signaling

  2002cited by this paper
• Melatonin inhibits insulin secretion and decreases PKA levels without interfering with glucose metabolism in rat pancreatic islets

  2002cited by this paper
• Large Reduction in the Number of Galanin‐Immunoreactive Cells in Pancreatic Islets of Diabetic Rats

  2001cited by this paper
• Aging‐dependent changes in the effect of daily melatonin supplementation on rat metabolic and behavioral responses

  2001cited by this paper
• Discovery and mapping of ten novel G protein-coupled receptor genes.

  2001cited by this paper
• Influence of melatonin administration on glucose tolerance and insulin sensitivity of postmenopausal women

  2001cited by this paper
• Modulation of Hippocampal Excitability and Seizures by Galanin

  2000cited by this paper
• Plasma insulin, cholecystokinin, galanin, neuropeptide Y and leptin levels in obese women with and without type 2 diabetes mellitus

  2000cited by this paper
• Galanin receptor subtypes.

  2000cited by this paper
• Galanin‐like immunoreactive endocrine cells in bovine pancreas

  2000cited by this paper
• Daily melatonin administration at middle age suppresses male rat visceral fat, plasma leptin, and plasma insulin to youthful levels.

  1999cited by this paper
• The effect of melatonin administration on pituitary hormone secretion in man

  1999cited by this paper
• Melatonin administration and pituitary hormone secretion

  1998cited by this paper
• Galanin receptor subtypes.

  1998cited by this paper
• The Potential Role of the Transcription Factor RZR/ROR as a Mediator of Nuclear Melatonin Signaling

  1998cited by this paper
• Intraventricular galanin modulates a 5‐HT1A receptor‐mediated behavioural response in the rat

  1998cited by this paper
• Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily.

  1997cited by this paper
• Influence of melatonin and serotonin on glucose‐stimulated insulin release from perifused rat pancreatic islets in vitro

  1997cited by this paper
• Evidence for a circadian rhythm of insulin secretion.

  1996cited by this paper
• Characterization of high‐affinity melatonin binding sites in purified cell nuclei of rat liver

  1994cited by this paper
• Canine, human, and rat plasma insulin responses to galanin administration: species response differences.

  1994cited by this paper
• Binding of 3H-melatonin to calmodulin.

  1993cited by this paper
• Galanin reduces release of endogenous excitatory amino acids in the rat hippocampus.

  1993cited by this paper
• Evening administration of melatonin enhances the pulsatile secretion of prolactin but not of LH and TSH in normally cycling women

  1993cited by this paper
• On the effects of human galanin in man

  1993cited by this paper
• Immunohistochemical demonstration of galaninlike immunoreactive nerves in the human pancreas.

  1992cited by this paper
• Pancreatic Galanin: Molecular Forms and Anatomical Locations

  1992cited by this paper
• Reduced Pancreatic Content of the Inhibitory Neurotransmitter Galanin in Genetically Obese, Hyperinsulinemic Mice

  1992cited by this paper
• Insulin release from isolated mouse islets in vitro: No effect of physiological levels of melatonin or arginine vasotocin

  1991cited by this paper
• Galanin-induced inhibition of insulin secretion from rat islets: effects of rat and pig galanin and galanin fragments and analogues.

  1991cited by this paper

• EFFECT OF MELATONIN ON PLASMA PYRUVATE LEVELS IN ALLOXAN-INDUCED DIABETIC RATS UNDER DIFFERENT PHOTOPERIODS

  2024cites this paper
• Downregulation of the expression of galanin impairs erectile function in hypoandrogenic rats

  2023cites this paper
• Diabetes and diabesity in the view of proteomics, drug, and plant-derived remedies

  2023cites this paper
• An update on Galanin and Spexin and their potential for the treatment of type 2 diabetes and related metabolic disorders.

  2023cites this paper
• A Mini-Review on Potential of Neuropeptides as Future Therapeutics

  2022cites this paper
• Galanin family peptides: Molecular structure, expression and roles in the neuroendocrine axis and in the spinal cord

  2022cites this paper
• A Mini-Review on Potential of Neuropeptides as Future Therapeutics

  2022cites this paper
• INFLUENCE OF MELATONIN ON AGE-RELATED CHANGES IN CARBOHYDRATE METABOLISM AND ANTIOXIDANT CAPACITY IN THE BLOOD OF ALLOXAN DIABETIC RATS

  2021cites this paper
• Neuropeptide galanin and its effects on metabolic and reproductive disturbances in female rats with estradiol valerate (EV) - Induced polycystic ovary syndrome (PCOS).

  2020cites this paper
• AGE-RELATED CHANGES OF GLYCOLYTIC ACTIVITY AND ANTIOXIDANT CAPACITY IN THE BLOOD OF ALLOXAN DIABETIC RATS

  2020cites this paper
• The influence of melatonin on carbohydrate metabolism in muscles of alloxan diabetic rats

  2019cites this paper
• THE EFFECT OF MELATONIN ON THE ENERGY METABOLISM IN HEART OF DIABETIC RATS

  2019cites this paper
• Changes in thyroid hormones, leptin, ghrelin and, galanin following oral melatonin administration in intact and castrated dogs: a preliminary study

  2019cites this paper
• Etude pharmacochimique du système 26RFa/QRFPR : synthèse d'analogues peptidiques, activité biologique in vitro et in vivo et interactions moléculaires

  2018cites this paper