Mechanism of the Nrf2/Keap1/ARE signaling system

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Biochemistry (Moscow)

• Publication date

  2011-04-30

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1134/S0006297911040031PMID 21585316
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nuclear Redox Signaling

  2010cited by this paper
• Activation of NRF2 by Nitrosative Agents and H2O2 Involves KEAP1 Disulfide Formation*

  2010cited by this paper
• A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

  2010cited by this paper
• A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders.

  2010cited by this paper
• The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

  2010cited by this paper
• Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway*

  2010cited by this paper
• Nrf2 Expression Is Regulated by Epigenetic Mechanisms in Prostate Cancer of TRAMP Mice

  2010cited by this paper
• Role of Nrf1 in antioxidant response element-mediated gene expression and beyond.

  2010cited by this paper
• Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

  2010cited by this paper
• Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones.

  2010cited by this paper
• Electrophilic tuning of the chemoprotective natural product sulforaphane

  2010cited by this paper
• An Autoregulatory Loop between Nrf2 and Cul3-Rbx1 Controls Their Cellular Abundance*

  2010cited by this paper
• Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains

  2010cited by this paper
• Keap1‐Nrf2 activation in the presence and absence of DJ‐1

  2010cited by this paper
• Nrf2: friend or foe for chemoprevention?

  2010cited by this paper
• The Critical Role of Nitric Oxide Signaling, via Protein S-Guanylation and Nitrated Cyclic GMP, in the Antioxidant Adaptive Response*

  2010cited by this paper
• Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin

  2010cited by this paper
• CR6-interacting Factor 1 (CRIF1) Regulates NF-E2-related Factor 2 (NRF2) Protein Stability by Proteasome-mediated Degradation

  2010cited by this paper
• Critical Cysteine Residues of Kelch-Like ECH-Associated Protein 1 in Arsenic Sensing and Suppression of Nuclear Factor Erythroid 2-Related Factor 2

  2010cited by this paper
• Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds.

  2009cited by this paper
• Molecular mechanisms of Nrf2‐mediated antioxidant response

  2009cited by this paper
• Repression of classical nuclear export by S-nitrosylation of CRM1

  2009cited by this paper
• Catechol estrogens mediated activation of Nrf2 through covalent modification of its quinone metabolite to Keap1.

  2009cited by this paper
• Prothymosin-α Mediates Nuclear Import of the INrf2/Cul3·Rbx1 Complex to Degrade Nuclear Nrf2*

  2009cited by this paper
• Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response

  2009cited by this paper
• Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response.

  2009cited by this paper
• Synthetic triterpenoids attenuate cytotoxic retinal injury: cross-talk between Nrf2 and PI3K/AKT signaling through inhibition of the lipid phosphatase PTEN.

  2009cited by this paper
• Hydrogen peroxide is a second messenger in phase 2 enzyme induction by cancer chemopreventive dithiolethiones.

  2009cited by this paper
• An internal ribosomal entry site mediates redox-sensitive translation of Nrf2

  2009cited by this paper
• Antioxidant-induced Phosphorylation of Tyrosine 486 Leads to Rapid Nuclear Export of Bach1 That Allows Nrf2 to Bind to the Antioxidant Response Element and Activate Defensive Gene Expression*

  2009cited by this paper
• NRP/B mutations impair Nrf2-dependent NQO1 induction in human primary brain tumors

  2009cited by this paper
• NRF2 Cysteine Residues Are Critical for Oxidant/Electrophile-Sensing, Kelch-Like ECH-Associated Protein-1-Dependent Ubiquitination-Proteasomal Degradation, and Transcription Activation

  2009cited by this paper
• Phosphorylation of Nrf2 at Multiple Sites by MAP Kinases Has a Limited Contribution in Modulating the Nrf2-Dependent Antioxidant Response

  2009cited by this paper
• Structure activity relationship of carotenoid derivatives in activation of the electrophile/antioxidant response element transcription system.

  2009cited by this paper
• Extracellular redox status regulates Nrf2 activation through mitochondrial reactive oxygen species.

  2009cited by this paper
• Antioxidant-induced modification of INrf2 cysteine 151 and PKC-δ-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance

  2009cited by this paper
• Inhibition and Genetic Deficiency of p38 MAPK Up-Regulates Heme Oxygenase-1 Gene Expression via Nrf21

  2009cited by this paper
• Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1.

  2009cited by this paper
• Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction.

  2008cited by this paper
• Prospective type 1 and type 2 disulfides of Keap1 protein.

  2008cited by this paper
• Physiological Significance of Reactive Cysteine Residues of Keap1 in Determining Nrf2 Activity

  2008cited by this paper
• Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1.

  2008cited by this paper
• Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues.

  2008cited by this paper
• The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds

  2008cited by this paper
• 15-Deoxy-Delta(12,14)-prostaglandin J(2) rescues PC12 cells from H2O2-induced apoptosis through Nrf2-mediated upregulation of heme oxygenase-1: potential roles of Akt and ERK1/2.

  2008cited by this paper
• Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3.

  2008cited by this paper
• Heterodimerization with small Maf proteins enhances nuclear retention of Nrf2 via masking the NESzip motif.

  2008cited by this paper
• Role and regulation of ferritin H in rotenone-mediated mitochondrial oxidative stress.

  2008cited by this paper
• Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: quinone oxidoreductase 1 by alkylating Keap1.

  2008cited by this paper
• The hepatotoxic metabolite of acetaminophen directly activates the Keap1‐Nrf2 cell defense system

  2008cited by this paper
• PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria.

  2008cited by this paper
• Essential roles of the PI3 kinase/Akt pathway in regulating Nrf2-dependent antioxidant functions in the RPE.

  2008cited by this paper
• NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK.

  2008cited by this paper
• Activating transcription factor 3 is a novel repressor of the nuclear factor erythroid-derived 2-related factor 2 (Nrf2)-regulated stress pathway.

  2008cited by this paper
• Phosphorylation and Dephosphorylation of Tyrosine 141 Regulate Stability and Degradation of INrf2

  2008cited by this paper
• Activation of Nrf2 in defense against cadmium-induced oxidative stress.

  2008cited by this paper
• Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

  2008cited by this paper
• Histone acetyltransferase MOZ acts as a co-activator of Nrf2-MafK and induces tumour marker gene expression during hepatocarcinogenesis.

  2007cited by this paper
• Identification of the highly reactive cysteine 151 in the chemopreventive agent-sensor Keap1 protein is method-dependent.

  2007cited by this paper
• Curcumin induces heme oxygenase 1 through generation of reactive oxygen species, p38 activation and phosphatase inhibition.

  2007cited by this paper
• Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes.

  2007cited by this paper
• Paraquat induces dopaminergic dysfunction and proteasome impairment in DJ-1-deficient mice.

  2007cited by this paper
• Translational Control of Nrf2 Protein in Activation of Antioxidant Response by Oxidants

  2007cited by this paper
• An Auto-regulatory Loop between Stress Sensors INrf2 and Nrf2 Controls Their Cellular Abundance*

  2007cited by this paper
• Bach1 Repression of Ferritin and Thioredoxin Reductase1 Is Heme-sensitive in Cells and in Vitro and Coordinates Expression with Heme Oxygenase1, β-Globin, and NADP(H) Quinone (Oxido) Reductase1*

  2007cited by this paper
• Biomechanical Forces in Atherosclerosis-Resistant Vascular Regions Regulate Endothelial Redox Balance via Phosphoinositol 3-Kinase/Akt-Dependent Activation of Nrf2

  2007cited by this paper
• REDOX ACTIVATION OF REF‐1 POTENTIATES CELL SURVIVAL FOLLOWING MYOCARDIAL ISCHEMIA REPERFUSION INJURY

  2007cited by this paper
• Interaction with Keap1 does not lead to ubiquitination and degradation of prothymosin α

  2007cited by this paper
• The nuclear matrix protein, NRP/B, enhances Nrf2-mediated oxidative stress responses in breast cancer cells.

  2007cited by this paper
• Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

  2007cited by this paper
• Keap1 Controls Postinduction Repression of the Nrf2-Mediated Antioxidant Response by Escorting Nuclear Export of Nrf2

  2007cited by this paper
• A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity.

  2007cited by this paper
• ERRbeta: a potent inhibitor of Nrf2 transcriptional activity.

  2007cited by this paper
• GSK-3beta acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2.

  2007cited by this paper
• Up-regulation of aldose reductase expression mediated by phosphatidylinositol 3-kinase/Akt and Nrf2 is involved in the protective effect of curcumin against oxidative damage.

  2007cited by this paper
• ERRβ: A potent inhibitor of Nrf2 transcriptional activity

  2007cited by this paper
• Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2.

  2007cited by this paper
• Sequestosome 1/p62 – More than just a scaffold

  2007cited by this paper
• Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes.

  2007cited by this paper
• Heme Induces Ubiquitination and Degradation of the Transcription Factor Bach1

  2007cited by this paper
• Sites of alkylation of human Keap1 by natural chemoprevention agents

  2007cited by this paper
• DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

  2006cited by this paper
• Induction of Phase II Enzyme Activity by Various Selenium Compounds

  2006cited by this paper
• Oxidative and Electrophilic Stresses Activate Nrf2 through Inhibition of Ubiquitination Activity of Keap1

  2006cited by this paper
• Mechanistic Studies of the Nrf2-Keap1 Signaling Pathway

  2006cited by this paper
• Peroxynitrite induces HO-1 expression via PI3K/Akt-dependent activation of NF-E2-related factor 2 in PC12 cells.

  2006cited by this paper
• Arsenic Induces NAD(P)H-quinone Oxidoreductase I by Disrupting the Nrf2·Keap1·Cul3 Complex and Recruiting Nrf2·Maf to the Antioxidant Response Element Enhancer*

  2006cited by this paper
• Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells.

  2006cited by this paper
• Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2

  2006cited by this paper
• Role of transcription factor AP-1 in integration of cell signaling systems

  2006cited by this paper
• Keap1 Recruits Neh2 through Binding to ETGE and DLG Motifs: Characterization of the Two-Site Molecular Recognition Model

  2006cited by this paper
• Age affects ERK1/2 and NRF2 signaling in the regulation of GCLC expression

  2006cited by this paper
• A Dominant Function of IKK/NF-κB Signaling in Global Lipopolysaccharide-induced Gene Expression*

  2006cited by this paper
• [Role of transcription factor AP-1 in integration of cellular signalling systems].

  2006cited by this paper
• Active defense under oxidative stress. The antioxidant responsive element

  2006cited by this paper
• Transcription of TIMP3, DAPK1, and AKR1B10 in squamous-cell lung cancer

  2006cited by this paper
• Nrf2 Possesses a Redox-sensitive Nuclear Exporting Signal in the Neh5 Transactivation Domain*

  2006cited by this paper
• Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells.

  2005cited by this paper
• Gene expression profiling of NRF2-mediated protection against oxidative injury.

  2005cited by this paper
• Redox regulation of the transcriptional repressor Bach1.

  2005cited by this paper

• Effects of chitosan supplementation versus placebo on liver fat and metabolic parameters in patients with non-alcoholic fatty liver disease: a randomized controlled trial protocol.

  2026cites this paper
• Bioactive Nanomaterials: Comprehensive Monitoring and Regulation of Acute Pancreatitis Induced Acute Lung Injury

  2025cites this paper
• Tanshinone IIA + Osthole alleviates ferroptosis in LPS-induced acute lung injury by Keap1-Nrf2/HO-1 pathway.

  2025cites this paper
• 13-Decyl Berberine Derivative Is a Novel Mitochondria-Targeted Antioxidant and a Potent Inhibitor of Ferroptosis

  2025cites this paper
• Liangxue Huoxue decoction protects against sepsis-induced acute lung injury by restoring gut microbiota and inhibiting inflammation and oxidative stress via the SIRT1/NF-κB/Nrf2 signaling pathway.

  2025cites this paper
• MicroRNAs as Epigenetic Biomarkers of Pathogenetic Mechanisms of the Metabolic Syndrome Induced by Antiseizure Medications: Systematic Review

  2025cites this paper
• The Potential of Superoxide Dismutase-Rich Tetraselmis chuii as a Promoter of Cellular Health

  2025cites this paper
• Plant food-derived antioxidant nutrients in neuroprotection against chemotherapy-induced neurotoxicity: from molecular mechanisms to clinical applications

  2025cites this paper
• Structural insights for peptide and small molecules based drug discovery targeting the KEAP1 Kelch domain: A review.

  2025cites this paper
• The regulatory role of the nuclear scaffold protein Emerin on the migration of amniotic epithelial cells and oxidative stress in a pressure environment.

  2025cites this paper
• Role of the Nrf2/ARE Pathway in the mtDNA Reparation.

  2024cites this paper
• Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy

  2024cites this paper
• New perspectives on the therapeutic potential of quercetin in non-communicable diseases: Targeting Nrf2 to counteract oxidative stress and inflammation

  2024cites this paper
• Supplementation with L-theanine promotes intestinal antioxidant ability via Nrf2 signaling pathway in weaning piglets and H2O2-induced IPEC-J2 cells

  2024cites this paper
• Photosensitized Reactions of Oxidative Damage to Biomolecules: Role in Genotoxic and Cytotoxic Processes

  2024cites this paper
• Litchi Pericarp Extract Treats Type 2 Diabetes Mellitus by Regulating Oxidative Stress, Inflammatory Response, and Energy Metabolism

  2024cites this paper
• EGCG Alleviates Skeletal Muscle Oxidative Damage in Heat-Stressed Pigs via Keap1/PGAM5 Complex-Mediated Mitophagy.

  2024cites this paper
• Fucoxanthin alleviates renal fibrosis in experimental diabetic nephropathy by regulating p62/Keap1/Nrf2 signaling and improving mitochondrial damage

  2024cites this paper
• Influence of Redox-Active Chitosan-Polyaminoxyl Micelles Loaded with Daunorubicin on Activity of Nrf2 Transcription Factor

  2024cites this paper
• Macadamia oil alleviates dextran sulfate sodium-induced ulcerative colitis in mice via activating the Nrf2/Ho-1 pathway

  2024cites this paper
• Neuroprotective Effects of Phenolic Antioxidant Tert-butylhydroquinone (tBHQ) in Brain Diseases

  2023cites this paper
• Ginsenoside Rb1 alleviates chronic intermittent hypoxia-induced diabetic cardiomyopathy in db/db mice by regulating the adenosine monophosphate-activated protein kinase/Nrf2/heme oxygenase-1 signaling pathway.

  2023cites this paper
• Effects of Replacing Soybean Meal Protein with Chlorella vulgaris Powder on the Growth and Intestinal Health of Grass Carp (Ctenopharyngodon idella)

  2023cites this paper
• Optimization of the C2 substituents on the 1,4-bis(arylsulfonamido)naphthalene-N,N'-diacetic acid scaffold for better inhibition of Keap1-Nrf2 protein-protein interaction.

  2023cites this paper
• Nrf2 as a Potential Therapeutic Target for Treatment of Huntington’s Disease

  2023cites this paper
• Oridonin attenuates the progression of atherosclerosis by inhibiting NLRP3 and activating Nrf2 in apolipoprotein E-deficient mice

  2023cites this paper
• Efficacy of Artemisia annua Linné in improving cognitive impairment in a chronic cerebral hypoperfusion-induced vascular dementia animal model.

  2023cites this paper
• Maresin-1 inhibits high glucose induced ferroptosis in ARPE-19 cells by activating the Nrf2/HO-1/GPX4 pathway

  2023cites this paper
• Impact of Breaking up of Sitting Time on Anti-inflammatory Response Induced by Extracellular Vesicles.

  2023cites this paper
• Celastrol alleviates oxidative stress induced by multi-walled carbon nanotubes through the Keap1/Nrf2/HO-1 signaling pathway.

  2023cites this paper
• MG132, Attenuates the Retinal Vascular Injury Through the Upregulation of Nrf2 Expression

  2023cites this paper
• Targeting Protein–Protein Interfaces with Peptides: The Contribution of Chemical Combinatorial Peptide Library Approaches

  2023cites this paper
• C1q/tumor necrosis factor-related protein-6 exerts protective effects on myocardial ischemia-reperfusion injury through the modulation of the Akt-GSK-3β-Nrf2 signaling cascade.

  2023cites this paper
• Saponins of Tomato Extract Improve Non-Alcoholic Fatty Liver Disease by Regulating Oxidative Stress and Lipid Homeostasis

  2023cites this paper
• Oxidative Stress in Arterial Hypertension (HTN): The Nuclear Factor Erythroid Factor 2-Related Factor 2 (Nrf2) Pathway, Implications and Future Perspectives

  2022cites this paper
• Moringa Oleifera Lam. in Cardiometabolic Disorders: A Systematic Review of Recent Studies and Possible Mechanism of Actions

  2022cites this paper
• Chitosan Oligosaccharide Attenuates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction through Suppressing the Inflammatory Response and Oxidative Stress in Mice

  2022cites this paper
• Experimental Evaluation of the Effectiveness of Isobornylphenols in the Model of Pathospermia and Their Effect on the Antioxidant—Prooxidant Balance of Male Germ Cells

  2022cites this paper
• MitoQ alleviates triptolide-induced cardiotoxicity via activation of p62/Nrf2 axis in H9c2 cells.

  2022cites this paper
• ALCAM Deficiency Alleviates LPS-Induced Acute Lung Injury by Inhibiting Inflammatory Response

  2022cites this paper
• 1,2,3,4,6-O-Pentagalloylglucose Protects against Acute Lung Injury by Activating the AMPK/PI3K/Akt/Nrf2 Pathway

  2022cites this paper
• Protective effect of selenomethionine on kidney injury induced by ochratoxin A in rabbits

  2022cites this paper
• The role of AMPK-dependent pathways in cellular and molecular mechanisms of metformin: a new perspective for treatment and prevention of diseases

  2022cites this paper
• Modification of Ischemia/Reperfusion-Induced Alterations in Subcellular Organelles by Ischemic Preconditioning

  2022cites this paper
• The Cross-Talk between Polyphenols and the Target Enzymes Related to Oxidative Stress-Induced Thyroid Cancer

  2022cites this paper
• PLK-1 Interacting Checkpoint Helicase, PICH, Mediates Cellular Oxidative Stress Response

  2022cites this paper
• p-Chloro-diphenyl diselenide modulates Nrf2/Keap1 signaling and counteracts renal oxidative stress in mice exposed to dexamethasone repeated administrations.

  2022cites this paper
• Melatonin-related signaling pathways and their regulatory effects in aging organisms

  2022cites this paper
• Inhibitory Effects of Ethyl Acetate and Butanol Fractions from Morinda lucida Benth on Benzene-Induced Leukemia in Mice

  2022cites this paper
• The principal molecular mechanisms behind the activation of Keap1/Nrf2/ARE pathway leading to neuroprotective action in Parkinson's disease.

  2022cites this paper
• Arginine Enhances Ovarian Antioxidant Capability via Nrf2/Keap1 Pathway during the Luteal Phase in Ewes

  2022cites this paper
• Citrulline protects against LPS‑induced acute lung injury by inhibiting ROS/NLRP3‑dependent pyroptosis and apoptosis via the Nrf2 signaling pathway

  2022cites this paper
• Dietary Chitosan Supplementation Improved Egg Production and Antioxidative Function in Laying Breeders

  2022cites this paper
• Icariin protects podocytes from NLRP3 activation by Sesn2-induced mitophagy through the Keap1-Nrf2/HO-1 axis in diabetic nephropathy.

  2022cites this paper
• Antioxidant defense system in the prefrontal cortex of chronically stressed rats treated with lithium

  2022cites this paper
• Neuroprotective effect of targeted regulatory Nrf2 gene on rats with acute brain injury induced by carbon monoxide poisoning

  2021cites this paper
• Pharmacological Protection against Ischemia-Reperfusion Injury by Regulating the Nrf2-Keap1-ARE Signaling Pathway

  2021cites this paper
• Catalpol Protects ARPE-19 Cells against Oxidative Stress via Activation of the Keap1/Nrf2/ARE Pathway

  2021cites this paper
• Cadmium, an Environmental Contaminant, Exacerbates Alzheimer’s Pathology in the Aged Mice’s Brain

  2021cites this paper
• Bacterial Infections Affect Male Fertility: A Focus on the Oxidative Stress-Autophagy Axis

  2021cites this paper
• The Effect of Bu Shen Huo Xue Tang on Autoimmune Premature Ovarian Insufficiency via Modulation of the Nrf2/Keap1 Signaling Pathway in Mice.

  2021cites this paper
• Histone deacetylase 3 inhibition alleviates type 2 diabetes mellitus-induced endothelial dysfunction via Nrf2

  2021cites this paper
• Molecular dynamics, quantum mechanics and docking studies of some Keap1 inhibitors – An insight into the atomistic mechanisms of their antioxidant potential

  2021cites this paper
• Unveiling the structural properties of water-soluble lignin from gramineous biomass by autohydrolysis and its functionality as a bioactivator (anti-inflammatory and antioxidative).

  2021cites this paper
• Responses of JNK signaling pathway to the toxic dinoflagellate Prorocentrum lima in the mussel Perna viridis.

  2021cites this paper
• The ethanol extract of flower buds of Tussilago farfara L. attenuates cigarette smoke-induced lung inflammation through regulating NLRP3 inflammasome, Nrf2, and NF-κB.

  2021cites this paper
• Insights on the mechanisms of action of ozone in the medical therapy against COVID-19

  2021cites this paper
• Eletrophilic Chemistry of Tranilast Is Involved in Its Anti-Colitic Activity via Nrf2-HO-1 Pathway Activation

  2021cites this paper
• Lactobacillus plantarum Exhibits Antioxidant and Cytoprotective Activities in Porcine Intestinal Epithelial Cells Exposed to Hydrogen Peroxide

  2021cites this paper
• Signal Pathways and Markers Involved in Acute Lung Injury Induced by Acute Pancreatitis

  2021cites this paper
• Epigallocatechin-3-gallate Alleviates Vanadium-Induced Reduction of Antioxidant Capacity via Keap1-Nrf2-sMaf Pathway in the Liver, Kidney, and Ovary of Laying Hens

  2021cites this paper
• Fisetin, potential flavonoid with multifarious targets for treating neurological disorders: An updated review.

  2021cites this paper
• Identification of novel antioxidant peptide from porcine plasma hydrolysate and its effect in in vitro digestion/HepG2 cells model.

  2021cites this paper
• Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo

  2021cites this paper
• The Antimalaria Drug Artesunate Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication by Activating AMPK and Nrf2/HO-1 Signaling Pathways

  2021cites this paper
• Genetic and epigenetic regulation of the NRF2-KEAP1 pathway in human lung cancer

  2021cites this paper
• Role of microgliosis, oxidative stress and associated neuroinflammation in the pathogenesis of Parkinson's disease: The therapeutic role of Nrf2 activators.

  2021cites this paper
• Effects of Microglial Activation and Polarization on Brain Injury After Stroke

  2021cites this paper
• Natural product curcumin-based coordination nanoparticles for treating osteoarthritis via targeting Nrf2 and blocking NLRP3 inflammasome

  2021cites this paper
• Antioxidant Activity of Novel Casein-Derived Peptides with Microbial Proteases as Characterized via Keap1-Nrf2 Pathway in HepG2 Cells

  2021cites this paper
• Dry-Cured Ham-Derived Peptide (Asp–Leu–Glu–Glu) Exerts Cytoprotective Capacity in Human Intestinal Epithelial Caco-2 Cells

  2021cites this paper
• Evaluation of oxidative damage and Nrf2 activation by combined pollution exposure in lung epithelial cells

  2020cites this paper
• Targeted Isolation of Antioxidant Constituents from Plantago asiatica L. and In Vitro Activity Assay

  2020cites this paper
• Icariin Prevents Extracellular Matrix Accumulation and Ameliorates Experimental Diabetic Kidney Disease by Inhibiting Oxidative Stress via GPER Mediated p62-Dependent Keap1 Degradation and Nrf2 Activation

  2020cites this paper
• Nrf2 activation through the inhibition of Keap1–Nrf2 protein–protein interaction

  2020cites this paper
• Relationships among pancreatic beta cell function, the Nrf2 pathway, and IRS2: a cross-sectional study

  2020cites this paper
• Crosstalk between the mTOR and Nrf2/ARE signaling pathways as a target in the improvement of long-term potentiation.

  2020cites this paper
• Novel structured diacylglycerol (DAG) rich oleo formulations activate the Nrf2 pathway and impedes NF-κB translocation to mitigate pre-clinical conditions of hypertension

  2020cites this paper
• Rule of UA on Cardiac Myocytes Uric Acid Differently Influence the Oxidative Damage Induced by Acute Exposure of High Level of Glucose in Chicken Cardiac Myocytes

  2020cites this paper
• p62-Nrf2-p62 Mitophagy Regulatory Loop as a Target for Preventive Therapy of Neurodegenerative Diseases

  2020cites this paper
• Keap1/Nrf2/ARE signaling unfolds therapeutic targets for redox imbalanced-mediated diseases and diabetic nephropathy.

  2020cites this paper
• Gly-Pro-Ala peptide and FGSHF3 exert protective effects in DON-induced toxicity and intestinal damage via decreasing oxidative stress.

  2020cites this paper
• TetraSOD activates the antioxidant response pathway in human cells: An in vitro approach

  2020cites this paper
• New Plant Growth Stimulants Based on Water-Soluble Nanoparticles of N-Substituted Monoamino-Acid Derivatives of Fullerene C60 and the Study of their Mechanisms of Action

  2020cites this paper
• Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials

  2020cites this paper
• The Cutaneous Physiological Redox: Essential to Maintain but Difficult to Define

  2020cites this paper
• Pretreatment with dexmedetomidine alleviates lung injury in a rat model of intestinal ischemia reperfusion

  2020cites this paper
• Low-Dose Berberine Attenuates the Anti-Breast Cancer Activity of Chemotherapeutic Agents via Induction of Autophagy and Antioxidation

  2020influential citation
• Astaxanthin Protects OTA-Induced Lung Injury in Mice through the Nrf2/NF-κB Pathway

  2019cites this paper
• Study of the Prooxidant and Antioxidant Activity of Anti-Radiation Agents with LUX-Biosensors

  2019cites this paper