Pluripotent stem cell differentiation into vascular cells: a novel technology with promises for vascular re(generation).

Several types of stem and progenitor cells are currently under investigation for their potential to accomplish vascular regeneration. This review focuses on embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). We will discuss the technologies allowing for their derivation, culture expansion and maintenance in a pluripotent status. Moreover, both ESCs and iPSCs can be differentiated in endothelial cells (ECs) and mural cell, including vascular smooth muscle cells (VSMCs). Here, we will describe the involvements of growth factors (vascular endothelial growth factors-VEGFs-, platet-derived growth factors-PDGFs-), Wnt and Notch signal pathways, reactive oxygen species (ROS), histone deacetylases (HDACs), and microRNAs (miRNAs) in vascular cell differentiation from pluripotent stem cells. We will additionally describe the therapeutic potential of stem cells for vascular medicine.

• Publication year

  2011

• Venue

  Pharmacology and Therapeutics

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.pharmthera.2010.10.004PMID 20965210
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hypoxia Influences the Vascular Expansion and Differentiation of Embryonic Stem Cell Cultures Through the Temporal Expression of Vascular Endothelial Growth Factor Receptors in an ARNT‐Dependent Manner

  2010cited by this paper
• Cardiospheres and tissue engineering for myocardial regeneration: potential for clinical application

  2010cited by this paper
• Induction of pluripotent stem cells from adult somatic cells by protein-based reprogramming without genetic manipulation.

  2010cited by this paper
• Regulation of bone marrow-derived vascular progenitor cell mobilization and maintenance.

  2010cited by this paper
• The bioethics of stem cell research and therapy.

  2010cited by this paper
• Crucial Role of Nrf3 in Smooth Muscle Cell Differentiation From Stem Cells

  2010cited by this paper
• miR-10a Contributes to Retinoid Acid-induced Smooth Muscle Cell Differentiation*

  2010cited by this paper
• Hypoxia Promotes Efficient Differentiation of Human Embryonic Stem Cells to Functional Endothelium

  2010cited by this paper
• Pre-vascularization of in vitro three-dimensional tissues created by cell sheet engineering.

  2010cited by this paper
• Expansion and maintenance of human embryonic stem cell–derived endothelial cells by TGFβ inhibition is Id1 dependent

  2010cited by this paper
• Perivascular Ancestors of Adult Multipotent Stem Cells

  2010cited by this paper
• VEGF Induces Differentiation of Functional Endothelium From Human Embryonic Stem Cells: Implications for Tissue Engineering

  2010cited by this paper
• Human embryonic stem cell-derived vascular progenitor cells capable of endothelial and smooth muscle cell function.

  2010cited by this paper
• Design of prevascularized three-dimensional cell-dense tissues using a cell sheet stacking manipulation technology.

  2010cited by this paper
• Stem cells: roadmap to the clinic.

  2010cited by this paper
• Progress toward the clinical application of patient-specific pluripotent stem cells.

  2010cited by this paper
• A role for Egfl7 during endothelial organization in the embryoid body model system

  2010cited by this paper
• Clinical Potential of Adult Vascular Progenitor Cells

  2010cited by this paper
• Cell therapy for the treatment of coronary heart disease: a critical appraisal

  2010cited by this paper
• Vascular Precursors : Origin , Regulation and Function Series

  2010cited by this paper
• Derivation of Endothelial Cells From Human Embryonic Stem Cells by Directed Differentiation: Analysis of MicroRNA and Angiogenesis In Vitro and In Vivo

  2010cited by this paper
• Transforming Growth Factor‐β and Notch Signaling Mediate Stem Cell Differentiation into Smooth Muscle Cells

  2010cited by this paper
• Sirt1 plays an important role in mediating greater functionality of human ES/iPS-derived vascular endothelial cells.

  2010cited by this paper
• Convergence of Notch and β-catenin signaling induces arterial fate in vascular progenitors

  2010cited by this paper
• Human Adult Vena Saphena Contains Perivascular Progenitor Cells Endowed With Clonogenic and Proangiogenic Potential

  2010cited by this paper
• Convergence of Notch and β-catenin signaling induces arterial fate in vascular progenitors

  2010cited by this paper
• Hemangioblastic Derivatives from Human Induced Pluripotent Stem Cells Exhibit Limited Expansion and Early Senescence

  2010cited by this paper
• Towards an integrated view of Wnt signaling in development

  2009cited by this paper
• Signaling Hierarchy Regulating Human Endothelial Cell Development

  2009cited by this paper
• 17-P022 Virus-free induction of pluripotency and subsequentexcision of reprogramming factors

  2009cited by this paper
• ERG is required for the differentiation of embryonic stem cells along the endothelial lineage

  2009cited by this paper
• miR-145 and miR-143 Regulate Smooth Muscle Cell Fate Decisions

  2009cited by this paper
• Oct4-induced pluripotency in adult neural stem cells.

  2009cited by this paper
• A Regulatory Pathway Involving Notch1/β-Catenin/Isl1 Determines Cardiac Progenitor Cell Fate

  2009cited by this paper
• Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells.

  2009cited by this paper
• HDAC family: What are the cancer relevant targets?

  2009cited by this paper
• Functional Characterization and Transcriptome Analysis of Embryonic Stem Cell–Derived Contractile Smooth Muscle Cells

  2009cited by this paper
• Generation of induced pluripotent stem cells from neural stem cells

  2009cited by this paper
• Endothelial progenitor cells – hype or hope?

  2009cited by this paper
• nAChRs Mediate Human Embryonic Stem Cell-Derived Endothelial Cells: Proliferation, Apoptosis, and Angiogenesis

  2009cited by this paper
• Shear Stress Increases Expression of the Arterial Endothelial Marker EphrinB2 in Murine ES Cells via the VEGF-Notch Signaling Pathways

  2009cited by this paper
• Role of specific microRNAs for endothelial function and angiogenesis.

  2009cited by this paper
• Derivation of contractile smooth muscle cells from embryonic stem cells.

  2009cited by this paper
• Polycistronic Lentiviral Vector for “Hit and Run” Reprogramming of Adult Skin Fibroblasts to Induced Pluripotent Stem Cells

  2009cited by this paper
• Embryonic stem cell differentiation into smooth muscle cells is mediated by Nox4-produced H2O2.

  2009cited by this paper
• MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells.

  2009cited by this paper
• Hematopoietic and Endothelial Differentiation of Human Induced Pluripotent Stem Cells

  2009cited by this paper
• Neuropilin-1 Identifies Endothelial Precursors in Human and Murine Embryonic Stem Cells Before CD34 Expression

  2009cited by this paper
• Dysregulation of Hedgehog, Wnt and Notch signalling pathways in breast cancer.

  2009cited by this paper
• VEGFR2-PLCγ1 axis is essential for endothelial specification of VEGFR2+ vascular progenitor cells

  2009cited by this paper
• piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells

  2009cited by this paper
• Faculty Opinions recommendation of Human induced pluripotent stem cells free of vector and transgene sequences.

  2009cited by this paper
• Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors.

  2009cited by this paper
• Roles of TGF-β family signaling in stem cell renewal and differentiation

  2009cited by this paper
• Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences

  2009cited by this paper
• Functional and Transcriptional Characterization of Human Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Myocardial Infarction

  2009cited by this paper
• Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells

  2009cited by this paper
• Splicing of HDAC7 modulates the SRF-myocardin complex during stem-cell differentiation towards smooth muscle cells

  2009cited by this paper
• Abstract 5804: Embryonic Stem Cell-Derived Endothelial Cells Engraft Into the Ischemic Hindlimb and Restore Perfusion

  2009cited by this paper
• Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin

  2009cited by this paper
• High-Efficiency Production of Subculturable Vascular Endothelial Cells from Feeder-Free Human Embryonic Stem Cells Without Cell-Sorting Technique

  2009cited by this paper
• Stem cells: Bone marrow cell therapy for MI—goal achieved?

  2009cited by this paper
• Induction and Isolation of Vascular Cells From Human Induced Pluripotent Stem Cells—Brief Report

  2009cited by this paper
• Endogenous transforming growth factor (TGF) beta1 promotes differentiation of smooth muscle cells from embryonic stem cells: stable plasmid-based siRNA silencing of TGF beta1 gene expression

  2009cited by this paper
• miR-126 regulates angiogenic signaling and vascular integrity.

  2008cited by this paper
• VEGF-A splicing: the key to anti-angiogenic therapeutics?

  2008cited by this paper
• Cyclic strain induces mouse embryonic stem cell differentiation into vascular smooth muscle cells by activating PDGF receptor beta.

  2008cited by this paper
• Regulation of Self‐Renewal and Pluripotency by Sox2 in Human Embryonic Stem Cells

  2008cited by this paper
• Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells.

  2008cited by this paper
• Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling.

  2008cited by this paper
• Ras signaling directs endothelial specification of VEGFR2+ vascular progenitor cells

  2008cited by this paper
• Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts

  2008cited by this paper
• Control of protein synthesis and mRNA degradation by microRNAs.

  2008cited by this paper
• A high-efficiency system for the generation and study of human induced pluripotent stem cells.

  2008cited by this paper
• Reprogramming of human somatic cells to pluripotency with defined factors

  2008cited by this paper
• Wnt signaling mediates self-organization and axis formation in embryoid bodies.

  2008cited by this paper
• Endothelial Cell Coculture Within Tissue-Engineered Cardiomyocyte Sheets Enhances Neovascularization and Improves Cardiac Function of Ischemic Hearts

  2008cited by this paper
• Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells

  2008cited by this paper
• Wnt-mediated self-renewal of neural stem/progenitor cells

  2008cited by this paper
• MicroRNA Discovery and Profiling in Human Embryonic Stem Cells by Deep Sequencing of Small RNA Libraries

  2008cited by this paper
• Generation of human induced pluripotent stem cells from dermal fibroblasts

  2008cited by this paper
• Rapid Endothelial Turnover in Atherosclerosis-Prone Areas Coincides With Stem Cell Repair in Apolipoprotein E–Deficient Mice

  2008cited by this paper
• Generation of transducible versions of transcription factors Oct4 and Sox2

  2008cited by this paper
• Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse.

  2008cited by this paper
• Aging of signal transduction pathways, and pathology.

  2008cited by this paper
• Disease-specific induced pluripotent stem cells.

  2008cited by this paper
• Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells.

  2008cited by this paper
• Differential expression of the Wnt and Frizzled genes in Flk1+ cells derived from mouse ES cells

  2008cited by this paper
• Augmentation of Neovascularizaiton in Hindlimb Ischemia by Combined Transplantation of Human Embryonic Stem Cells-Derived Endothelial and Mural Cells

  2008cited by this paper
• Snail is required for TGFβ-induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells

  2008cited by this paper
• Wnt signaling promotes hematoendothelial cell development from human embryonic stem cells.

  2008cited by this paper
• Assessing identity, phenotype, and fate of endothelial progenitor cells.

  2008cited by this paper
• Wnt signaling and stem cell control

  2008cited by this paper
• Comparison of Reporter Gene and Iron Particle Labeling for Tracking Fate of Human Embryonic Stem Cells and Differentiated Endothelial Cells in Living Subjects

  2008cited by this paper
• Efficient differentiation of hESCs into endothelial cells in vitro is secured by epigenetic changes

  2008cited by this paper
• Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors

  2008cited by this paper
• Induced Pluripotent Stem Cells Generated Without Viral Integration

  2008cited by this paper
• Pluripotency and nuclear reprogramming

  2008cited by this paper
• Paracrine Mechanisms in Adult Stem Cell Signaling and Therapy

  2008cited by this paper
• Notch and vascular smooth muscle cell phenotype.

  2008cited by this paper

• Blood vessels in a dish: the evolution, challenges, and potential of vascularized tissues and organoids

  2024cites this paper
• Applications, challenges, and prospects of induced pluripotent stem cells for vascular disease

  2024cites this paper
• The discovery of promising candidate biomarkers in kidney renal clear cell carcinoma: evidence from the in-depth analysis of high-throughput data.

  2023cites this paper
• Expanding the Targets of Therapeutic Electrophysical Stimulation - For the Advancement of Peripheral Nerve Regenerative Rehabilitation

  2023cites this paper
• CPSF4 promotes tumor-initiating phenotype by enhancing VEGF/NRP2/TAZ signaling in lung cancer

  2022cites this paper
• Photodegradable avidin-biotinylated polymer conjugate hydrogels for cell manipulation.

  2021cites this paper
• Selection of different endothelialization modes and different seed cells for tissue-engineered vascular graft

  2021cites this paper
• Induced pluripotent stem cells from spermatogonial stem cells

  2021cites this paper
• Fabrication of vascularized tissue constructs under chemically defined culture conditions

  2020cites this paper
• Embryonic stem cells as a cell source for tissue engineering

  2020cites this paper
• The dual role of mir-146a in metastasis and disease progression.

  2020cites this paper
• Updated Perspectives On Vascular Cell Specification And Pluripotent Stem Cell-Derived Vascular Organoids For Studying Vasculopathies.

  2020cites this paper
• High gene expression levels of VEGFA and CXCL8 in the peritumoral brain zone are associated with the recurrence of glioblastoma: A bioinformatics analysis

  2019cites this paper
• Induced Pluripotent Stem Cells as Vasculature Forming Entities

  2019cites this paper
• Developing an induced pluripotent stem cell model of pulmonary arterial hypertension to understand the contribution of BMPR2 mutations to disease-associated phenotypes in smooth muscle cells

  2019cites this paper
• Characterisation of a novel nested encoding Laf4ir gene in the cardiovascular system

  2019cites this paper
• Cartilage oligomeric matrix protein is a novel notch ligand driving embryonic stem cell differentiation towards the smooth muscle lineage.

  2018cites this paper
• BDNF (Brain-Derived Neurotrophic Factor) Promotes Embryonic Stem Cells Differentiation to Endothelial Cells Via a Molecular Pathway, Including MicroRNA-214, EZH2 (Enhancer of Zeste Homolog 2), and eNOS (Endothelial Nitric Oxide Synthase)

  2018cites this paper
• Temporal Dynamics of Gene Expression During Endothelial Cell Differentiation From Human iPS Cells: A Comparison Study of Signalling Factors and Small Molecules

  2018cites this paper
• Effect of Electrospun Fibrous Scaffolds with Different Fiber Orientations on the Alignment of Microvessel-Like Structures

  2018cites this paper
• Challenges on the road to a multicellular bioartificial liver

  2018cites this paper
• Role of the Receptor-Mediated Signaling Pathways on the Proliferation and Differentiation of Pluripotent Stem Cells

  2018cites this paper
• Self-Condensation Culture Enables Vascularization of Tissue Fragments for Efficient Therapeutic Transplantation.

  2018cites this paper
• iPSCs-based generation of vascular cells: reprogramming approaches and applications

  2017cites this paper
• Exploring Mechanisms Linking Signal Transduction and Cancer Stem Cell Expansion

  2017cites this paper
• Chapter 19 Angiogenesis — The Key to Regeneration

  2017cites this paper
• VEGFA activates an epigenetic pathway upregulating ovarian cancer‐initiating cells

  2017cites this paper
• Effect of Electrospun Fibrous Scaffolds with Different Fiber Orientations on the Alignment of Microvessel-Like Structures

  2017cites this paper
• MicroRNA-214 regulates smooth muscle cell differentiation from stem cells by targeting RNA-binding protein QKI

  2017cites this paper
• Characterisation of human induced pluripotent stem cell-derived endothelial cells under shear stress using an easy-to-use microfluidic cell culture system

  2017cites this paper
• Exposure of Induced Pluripotent Stem Cell‐Derived Vascular Endothelial and Smooth Muscle Cells in Coculture to Hemodynamics Induces Primary Vascular Cell‐Like Phenotypes

  2017cites this paper
• Role of circulating endothelial progenitor cells in the reparative mechanisms of stable ischemic myocardium.

  2017cites this paper
• The Microvascular Gap Junction Channel: A Route to Deliver MicroRNAs for Neurological Disease Treatment

  2017cites this paper
• Generation of functional endothelial cells with progenitor-like features from murine induced pluripotent stem cells.

  2016cites this paper
• Efficient generation of endothelial cells from human pluripotent stem cells and characterization of their functional properties.

  2016cites this paper
• Characteristics of resistin in rheumatoid arthritis angiogenesis.

  2016cites this paper
• In Vivo Vascularization of Endothelial Cells Derived from Bone Marrow Mesenchymal Stem Cells in SCID Mouse Model

  2016cites this paper
• Vascular disease modeling using induced pluripotent stem cells: Focus in Hutchinson-Gilford Progeria Syndrome.

  2016influential citation
• pulmonary hypertensive rats and stimulates their accumulation in the lungs of progenitor cells self-renewal + in hypoxia-induced CD133 Glucose-6-phosphate dehydrogenase plays a critical role

  2016cites this paper
• Ambient particulate matter exposure and cardiovascular diseases: a focus on progenitor and stem cells

  2016cites this paper
• Nox2 contributes to the arterial endothelial specification of mouse induced pluripotent stem cells by upregulating Notch signaling

  2016cites this paper
• Biomolecular Regulation of Elastic Matrix Regeneration and Repair

  2016cites this paper
• Are Endothelial Progenitor Cells the Real Solution for Cardiovascular Diseases? Focus on Controversies and Perspectives

  2015influential citation
• In vivo repair of rat transected sciatic nerve by low-intensity pulsed ultrasound and induced pluripotent stem cells-derived neural crest stem cells

  2015cites this paper
• Bridging Basic Science with Cardiac Surgery: The Bristol Heart Institute Experience

  2015cites this paper
• Efficient differentiation of human embryonic stem cells to arterial and venous endothelial cells under feeder- and serum-free conditions

  2015influential citation
• Origin and differentiation of vascular smooth muscle cells

  2015cites this paper
• Murine coagulation factor VIII is synthesized in endothelial cells.

  2014cites this paper
• Stem/Progenitor cells in vascular regeneration.

  2014cites this paper
• Epigenetics in vascular disease - therapeutic potential of new agents.

  2014cites this paper
• VEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate Myc and Sox2

  2014cites this paper
• Direct Conversion of Adult Skin Fibroblasts to Endothelial Cells by Defined Factors

  2014cites this paper
• Microwell arrays for uniform-sized embryoid body-mediated endothelial cell differentiation

  2014cites this paper
• Embryonic origins of human vascular smooth muscle cells: implications for in vitro modeling and clinical application

  2014cites this paper
• Macrophages Control Vascular Stem/Progenitor Cell Plasticity Through Tumor Necrosis Factor-&agr;–Mediated Nuclear Factor-&kgr;B Activation

  2014cites this paper
• Embryonic rat vascular smooth muscle cells revisited - a model for neonatal, neointimal SMC or differentiated vascular stem cells?

  2014cites this paper
• Human Vascular Tissue Models Formed from Human Induced Pluripotent Stem Cell Derived Endothelial Cells

  2014cites this paper
• Antioxidants Maintain E-Cadherin Levels to Limit Drosophila Prohemocyte Differentiation

  2014cites this paper
• Adult vascular smooth muscle cells in culture express neural stem cell markers typical of resident multipotent vascular stem cells

  2014cites this paper
• MicroRNA-22 Regulates Smooth Muscle Cell Differentiation From Stem Cells by Targeting Methyl CpG–Binding Protein 2

  2014cites this paper
• Hyperbaric Oxygen, Vasculogenic Stem Cells, and Wound Healing

  2014cites this paper
• Vascular Stem Cell Therapy

  2014cites this paper
• Intramyocardial Bone Marrow Cell Injection : Clinical and Functional Effects in Ischemic Heart Disease

  2014cites this paper
• Development of Stem Cell Therapy for Medical Uses

  2014cites this paper
• ПОДХОДЫ К МОДИФИКАЦИИ ИСКУССТВЕННЫХ МАТРИКСОВ БИОЛОГИЧЕСКИ АКТИВНЫМИ МОЛЕКУЛАМИ ДЛЯ ПРИМЕНЕНИЯ В ТКАНЕВОЙ ИНЖЕНЕРИИ КРОВЕНОСНЫХ СОСУДОВ

  2014cites this paper
• Embryonic Stem Cells as a Cell Source for Tissue

  2014cites this paper
• NADPH Oxidase in Tissue Repair and Regeneration 110

  2014cites this paper
• Design of large-scale manufacturing of induced pluripotent stem cell derived cardiomyocytes

  2014cites this paper
• Glucose-6-phosphate dehydrogenase plays a critical role in hypoxia-induced CD133+ progenitor cells self-renewal and stimulates their accumulation in the lungs of pulmonary hypertensive rats.

  2014cites this paper
• Exploring the Oncogenic Role of p27 in Regulating Tumor Progression

  2013cites this paper
• Limited Gene Expression Variation in Human Embryonic Stem Cell and Induced Pluripotent Stem Cell‐Derived Endothelial Cells

  2013cites this paper
• Emerging Trends in Cell and Gene Therapy

  2013cites this paper
• Small-diameter vascular tissue engineering

  2013cites this paper
• Potential for pharmacological manipulation of human embryonic stem cells

  2013cites this paper
• Engineering the human pluripotent stem cell microenvironment to direct cell fate.

  2013cites this paper
• Perspectives on Stem Cell‐Based Elastic Matrix Regenerative Therapies for Abdominal Aortic Aneurysms

  2013cites this paper
• Differentiation of neuronal cells using a murine embryonic stem cell-based method

  2013cites this paper
• Angiogenesis — The Key to Regeneration

  2013cites this paper
• CHAPTER 32 Embryonic Stem Cells as a Cell Source for Tissue Engineering 609

  2013cites this paper
• Molecular Pathways Governing Development of Vascular Endothelial Cells from ES/iPS Cells

  2013cites this paper
• [Paroxysmal nocturnal hemoglobinuria].

  2012cites this paper
• Advances in Stem Cell Research

  2012influential citation
• Organ repair and regeneration: an overview.

  2012cites this paper
• EMBRYONIC STEM CELLS / INDUCED PLURIPOTENT STEM CELLS Role of MicroRNAs 99 b , 181 a , and 181 b in the Differentiation of Human Embryonic Stem Cells to Vascular Endothelial Cells

  2012cites this paper
• Vascular Differentiation of Human Pluripotent Stem Cells

  2012cites this paper
• Smooth Muscle Cell Differentiation from Embryonic Stem Cells: Role of HDAC7 and PDGF-BB

  2012cites this paper
• Towards the therapeutic use of vascular smooth muscle progenitor cells.

  2012cites this paper
• Amniotic fluid stem cells: a promising therapeutic resource for cell-based regenerative therapy.

  2012cites this paper
• Smooth Muscle Progenitor Cells

  2012cites this paper
• Role of MicroRNAs 99b, 181a, and 181b in the Differentiation of Human Embryonic Stem Cells to Vascular Endothelial Cells

  2012cites this paper
• Stem cells and calcium signaling.

  2012cites this paper
• An updated view on stem cell differentiation into smooth muscle cells.

  2012cites this paper
• Stem Cell Therapy for Endothelial Dysfunction in the Coronary Circulation

  2012influential citation
• Tissue Engineering and Regenerative Strategies to Replicate Biocomplexity of Vascular Elastic Matrix Assembly

  2012cites this paper
• Inducible pluripotent stem cells for the treatment of ischemic stroke: current status and problems

  2012cites this paper
• Using Stem Cells in Skin Regeneration: Possibilities and Reality

  2012cites this paper
• Vascular differentiation from embryonic stem cells: novel technologies and therapeutic promises.

  2012cites this paper
• Cell therapy in critical limb ischemia: current developments and future progress.

  2012cites this paper
• Cell therapy for the treatment of chronic ischemic heart disease.

  2011cites this paper
• Synergy of microRNA and stem cell: a novel therapeutic approach for diabetes mellitus and cardiovascular diseases.

  2011cites this paper