The Ly‐6A (Sca‐1) GFP Transgene is Expressed in all Adult Mouse Hematopoietic Stem Cells

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Stem Cells

• Publication date

  2002-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1634/stemcells.20-6-514PMID 12456959
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Studies of the mouse Ly-6 alloantigen system

  2005cited by this paper
• Isolation and analysis of hematopoietic stem cells from mouse embryos.

  2002cited by this paper
• Expression of the Ly‐6A (Sca‐1) lacZ transgene in mouse haematopoietic stem cells and embryos

  2002cited by this paper
• Hematopoietic stem cells localize to the endothelial cell layer in the midgestation mouse aorta.

  2002cited by this paper
• Cloning of the Ly‐6A (Sca‐1) gene locus and identification of a 3′ distal fragment responsible for high‐level γ‐interferon‐induced expression in vitro

  2001cited by this paper
• Identification of a lineage of multipotent hematopoietic progenitors.

  1997cited by this paper
• Expression of the Ly-6E.1 (Sca-1) transgene in adult hematopoietic stem cells and the developing mouse embryo.

  1997cited by this paper
• The Ly-6E.1 (Sca-1) gene requires a 3' chromatin-dependent region for high-level gamma-interferon-induced hematopoietic cell expression.

  1996cited by this paper
• Definitive hematopoiesis is autonomously initiated by the AGM region.

  1996cited by this paper
• Long-range physical map of the Ly-6 complex : mapping the Ly-6 multigene family by field-inversion and two-dimensional gel electrophoresis

  1994cited by this paper
• Development of hematopoietic stem cell activity in the mouse embryo.

  1994cited by this paper
• Rapid and sustained hematopoietic recovery in lethally irradiated mice transplanted with purified Thy-1.1lo Lin-Sca-1+ hematopoietic stem cells.

  1994cited by this paper
• Cloning of the complete Ly-6E.1 gene and identification of DNase I hypersensitive sites corresponding to expression in hematopoietic cells.

  1993cited by this paper
• Induction of the Ly-6A/E gene by interferon alpha/beta and gamma requires a DNA element to which a tyrosine-phosphorylated 91-kDa protein binds.

  1993cited by this paper
• Mouse strain variability in the expression of the hematopoietic stem cell antigen Ly-6A/E by bone marrow cells.

  1993cited by this paper
• Identification and characterization of hematopoietic stem cells from the yolk sac of the early mouse embryo.

  1993cited by this paper
• In vivo and in vitro stem cell function of c-kit- and Sca-1-positive murine hematopoietic cells.

  1992cited by this paper
• Long-range physical map of the Ly-6 complex: mapping the Ly-6 multigene family by field-inversion and two-dimensional gel electrophoresis.

  1992cited by this paper
• Clonal, in vivo behavior of the totipotent hematopoietic stem cell.

  1991cited by this paper
• Mouse hematopoietic stem cells.

  1991cited by this paper
• Isolation, expression, and sequence of the TAP/Ly-6A.2 chromosomal gene.

  1991cited by this paper
• Clonal, in vivo behavior of the totipotent hematopoietic stem cell.

  1991cited by this paper
• DNaseI hypersensitive sites 1, 2 and 3 of the human beta-globin dominant control region direct position-independent expression.

  1990cited by this paper
• Characterization of promoter elements of an interferon-inducible Ly-6E/A differentiation antigen, which is expressed on activated T cells and hematopoietic stem cells

  1990cited by this paper
• Regulation and selective expression of Ly-6A/E, a lymphocyte activation molecule, in the central nervous system.

  1990cited by this paper
• Mouse hematopoietic stem-cell antigen Sca-1 is a member of the Ly-6 antigen family.

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  1988cited by this paper
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  1988cited by this paper
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  1988cited by this paper
• Purification and characterization of mouse hematopoietic stem cells.

  1988cited by this paper
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  1986cited by this paper
• Isolation of a murine Ly‐6 cDNA reveals a new multigene family.

  1986cited by this paper
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