The pathogenesis of Shigella flexneri infection: lessons from in vitro and in vivo studies.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Philosophical transactions of the Royal Society of London. Series B, Biological sciences

• Publication date

  2000-05-28

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1098/RSTB.2000.0599PMID 10874731PMCID PMC1692768
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Invasive Shigella flexneri Activates NF-κB Through a Lipopolysaccharide-Dependent Innate Intracellular Response and Leads to IL-8 Expression in Epithelial Cells1

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• Global burden of Shigella infections: implications for vaccine development and implementation of control strategies.

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• A functional role for ezrin during Shigella flexneri entry into epithelial cells.

  1999cited by this paper
• Adaptive Immune Response to Shigella flexneri 2acydC in Immunocompetent Mice and Mice Lacking Immunoglobulin A

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• M cells as ports of entry for enteroinvasive pathogens: mechanisms of interaction, consequences for the disease process.

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• Trafficking of Shigella Lipopolysaccharide in Polarized Intestinal Epithelial Cells

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• Interleukin-8 Controls Bacterial Transepithelial Translocation at the Cost of Epithelial Destruction in Experimental Shigellosis

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• Thymic Independence of Adaptive Immunity to the Intracellular Pathogen Shigella flexneri Serotype 2a

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• Binding of the Shigella protein IpaA to vinculin induces F‐actin depolymerization

  1999cited by this paper
• Shigella flexneri YSH6000 induces two types of cell death, apoptosis and oncosis, in the differentiated human monoblastic cell line U937.

  1999cited by this paper
• Rupture of the intestinal epithelial barrier and mucosal invasion by Shigella flexneri.

  1999cited by this paper
• Requirement of the Shigella flexneri Virulence Plasmid in the Ability To Induce Trafficking of Neutrophils across Polarized Monolayers of the Intestinal Epithelium

  1998cited by this paper
• Requirement of the Shigella flexneri virulence plasmid in the ability to induce trafficking of neutrophils across polarized monolayers of the intestinal epithelium.

  1998cited by this paper
• An Essential Role for Gamma Interferon in Innate Resistance to Shigella flexneri Infection

  1998cited by this paper
• Type III Protein Secretion Systems in Bacterial Pathogens of Animals and Plants

  1998cited by this paper
• Shigella-induced Apoptosis Is Dependent on Caspase-1 Which Binds to IpaB*

  1998cited by this paper
• Shigella flexneri is trapped in polymorphonuclear leukocyte vacuoles and efficiently killed

  1997cited by this paper
• Conversion by Peyer's patch lymphocytes of human enterocytes into M cells that transport bacteria.

  1997cited by this paper
• Role of lipopolysaccharide in signaling to subepithelial polymorphonuclear leukocytes

  1997cited by this paper
• rho, a Small GTP-Binding Protein, Is Essential for Shigella Invasion of Epithelial Cells

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• Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production

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• Direct Interaction of the Rho GDP Dissociation Inhibitor with Ezrin/Radixin/Moesin Initiates the Activation of the Rho Small G Protein*

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• The interleukin 1beta-converting enzyme, caspase 1, is activated during Shigella flexneri-induced apoptosis in human monocyte-derived macrophages

  1997cited by this paper
• Modulation of bacterial entry into epithelial cells by association between vinculin and the Shigella IpaA invasin

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• In situ characterization of inflammatory responses in the rectal mucosae of patients with shigellosis

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• Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production.

  1997cited by this paper
• Human monocyte-derived macrophages infected with virulent Shigella flexneri in vitro undergo a rapid cytolytic event similar to oncosis but not apoptosis

  1997cited by this paper
• A bacterial invasin induces macrophage apoptosis by binding directly to ICE.

  1996cited by this paper
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• Interaction of Ipa proteins of Shigella flexneri with alpha5beta1 integrin promotes entry of the bacteria into mammalian cells

  1996cited by this paper
• Changes in the peripheral blood T-Cell receptor V beta repertoire in vivo and in vitro during shigellosis

  1996cited by this paper
• In vivo apoptosis in Shigella flexneri infections

  1996cited by this paper
• Rho‐dependent membrane folding causes Shigella entry into epithelial cells.

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• Antigen sampling across epithelial barriers and induction of mucosal immune responses.

  1996cited by this paper
• Shigella infection induces cellular activation of T and B cells and distinct species-related changes in peripheral blood lymphocyte subsets during the course of the disease

  1995cited by this paper
• A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion.

  1995cited by this paper
• Monoclonal immunoglobulin A antibody directed against serotype-specific epitope of Shigella flexneri lipopolysaccharide protects against murine experimental shigellosis

  1995cited by this paper
• Role of interleukin-1 in the pathogenesis of experimental shigellosis.

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• Antibody and cytokine responses in a mouse pulmonary model of Shigella flexneri serotype 2a infection

  1995cited by this paper
• Simultaneous identification of bacterial virulence genes by negative selection.

  1995cited by this paper
• IpaB mediates macrophage apoptosis induced by Shigella flexneri

  1994cited by this paper
• Polymorphonuclear leukocyte transmigration promotes invasion of colonic epithelial monolayer by Shigella flexneri.

  1994cited by this paper
• Cadherin expression is required for the spread of Shigella flexneri between epithelial cells.

  1994cited by this paper
• Acute inflammation causes epithelial invasion and mucosal destruction in experimental shigellosis

  1994cited by this paper
• Pathology of shigellosis and its complications

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• Extracellular association and cytoplasmic partitioning of the IpaB and IpaC invasins of S. flexneri.

  1994cited by this paper
• Interleukin 1 is released by murine macrophages during apoptosis induced by Shigella flexneri.

  1994cited by this paper
• Regional differences in glycoconjugates of intestinal M cells in mice: potential targets for mucosal vaccines.

  1994cited by this paper
• The secretion of the Shigella flexneri Ipa invasins is activated by epithelial cells and controlled by IpaB and IpaD.

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• Evaluation of Shigella vaccine safety and efficacy in an intranasally challenged mouse model.

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• Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells

  1993cited by this paper
• Shigella flexneri induces apoptosis in infected macrophages

  1992cited by this paper
• IpaB of Shigella flexneri causes entry into epithelial cells and escape from the phagocytic vacuole.

  1992cited by this paper
• Movement along actin filaments of the perijunctional area and de novo polymerization of cellular actin are required for Shigella flexneri colonization of epithelial Caco-2 cell monolayers

  1992cited by this paper
• Shigella flexneri enters human colonic Caco-2 epithelial cells through the basolateral pole

  1992cited by this paper
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