Mitochondrial dysfunction in Autism Spectrum Disorder: clinical features and perspectives.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Current Opinion in Neurobiology

• Publication date

  2017-08-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1016/j.conb.2017.05.018PMID 28628841
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Interplay of Axonal Energy Homeostasis and Mitochondrial Trafficking and Anchoring.

  2017cited by this paper
• Dendrite and spine modifications in autism and related neurodevelopmental disorders in patients and animal models

  2017cited by this paper
• Mitochondrial disease and endocrine dysfunction

  2017cited by this paper
• The neuroanatomy of autism spectrum disorder: An overview of structural neuroimaging findings and their translatability to the clinical setting

  2017cited by this paper
• Mitochondrial Cristae: Where Beauty Meets Functionality.

  2016cited by this paper
• Genetic Evidence for Elevated Pathogenicity of Mitochondrial DNA Heteroplasmy in Autism Spectrum Disorder

  2016cited by this paper
• Differential Mitochondrial Requirements for Radially and Non-radially Migrating Cortical Neurons: Implications for Mitochondrial Disorders.

  2016cited by this paper
• The functional brain connectome of the child and autism spectrum disorders

  2016cited by this paper
• Targeting Oxidative Stress in Central Nervous System Disorders.

  2016cited by this paper
• A cellular perspective on brain energy metabolism and functional imaging.

  2015cited by this paper
• Mitochondrial enzyme dysfunction in autism spectrum disorders; a novel biomarker revealed from buccal swab analysis.

  2015cited by this paper
• Elevated mitochondrial DNA copy number in peripheral blood cells is associated with childhood autism

  2015cited by this paper
• A systematic review of molecular imaging (PET and SPECT) in autism spectrum disorder: current state and future research opportunities.

  2015cited by this paper
• Autism Spectrum Disorders: Translating human deficits into mouse behavior

  2015cited by this paper
• Evidence That Dendritic Mitochondria Negatively Regulate Dendritic Branching in Pyramidal Neurons in the Neocortex

  2014cited by this paper
• Mitochondrial trafficking and anchoring in neurons: New insight and implications

  2014cited by this paper
• Copy number variation and autism: new insights and clinical implications.

  2014cited by this paper
• p53 and mitochondrial function in neurons.

  2014cited by this paper
• Brain-region–specific alterations of the trajectories of neuronal volume growth throughout the lifespan in autism

  2014cited by this paper
• The protein import machinery of mitochondria-a regulatory hub in metabolism, stress, and disease.

  2014cited by this paper
• Mitochondrial dysfunction as a neurobiological subtype of autism spectrum disorder: evidence from brain imaging.

  2014cited by this paper
• Creativity, brain, and art: biological and neurological considerations

  2014cited by this paper
• A higher mutational burden in females supports a "female protective model" in neurodevelopmental disorders.

  2014cited by this paper
• Metabolic pathology of autism in relation to redox metabolism.

  2014cited by this paper
• Downregulation of the Expression of Mitochondrial Electron Transport Complex Genes in Autism Brains

  2013cited by this paper
• OPA1 loss of function affects in vitro neuronal maturation.

  2013cited by this paper
• Mitochondrial dysfunction in autism.

  2013cited by this paper
• Diagnostic and Statistical Manual of Mental Disorders

  2013cited by this paper
• Mitochondrial abnormalities in temporal lobe of autistic brain.

  2013cited by this paper
• Decreased tryptophan metabolism in patients with autism spectrum disorders

  2013cited by this paper
• Alterations in mitochondrial DNA copy number and the activities of electron transport chain complexes and pyruvate dehydrogenase in the frontal cortex from subjects with autism

  2013cited by this paper
• Mitochondrial trafficking in neurons.

  2013cited by this paper
• Autism spectrum disorders associated to a deficiency of the enzymes of the mitochondrial respiratory chain

  2013cited by this paper
• Evaluating Mitochondrial DNA Variation in Autism Spectrum Disorders

  2013cited by this paper
• Brain region-specific altered expression and association of mitochondria-related genes in autism

  2012cited by this paper
• Brain Transcriptional and Epigenetic Associations with Autism

  2012cited by this paper
• Mitochondrial and ion channel gene alterations in autism.

  2012cited by this paper
• Proton Magnetic Resonance Spectroscopy and MRI Reveal No Evidence for Brain Mitochondrial Dysfunction in Children with Autism Spectrum Disorder

  2012cited by this paper
• The dendritic tree and brain disorders.

  2012cited by this paper
• The Energetics of CNS White Matter

  2012cited by this paper
• Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

  2012cited by this paper
• Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis

  2011cited by this paper
• Brain region‐specific deficit in mitochondrial electron transport chain complexes in children with autism

  2011cited by this paper
• Regulation of axonal trafficking of cytochrome c oxidase IV mRNA.

  2010cited by this paper
• Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization.

  2010cited by this paper
• Mitochondrial dysfunction in autism.

  2010cited by this paper
• Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1

  2010cited by this paper
• Fever Plus Mitochondrial Disease Could Be Risk Factors for Autistic Regression

  2010cited by this paper
• 5q14.3 Deletion Manifesting as Mitochondrial Disease and Autism: Case Report

  2010cited by this paper
• Mitochondrial trafficking and the provision of energy and calcium buffering at excitatory synapses

  2010cited by this paper
• How mitochondria produce reactive oxygen species

  2008cited by this paper
• Dopamine Inhibits Mitochondrial Motility in Hippocampal Neurons

  2008cited by this paper
• Mitochondrial Disease in Autism Spectrum Disorder Patients: A Cohort Analysis

  2008cited by this paper
• Autism spectrum disorders: developmental disconnection syndromes

  2007cited by this paper
• ADP regulates movements of mitochondria in neurons.

  2007cited by this paper
• Mitochondria and neuronal activity.

  2007cited by this paper
• Serotonin stimulates mitochondrial transport in hippocampal neurons.

  2007cited by this paper
• Epidemiology of autism spectrum disorder in Portugal: prevalence, clinical characterization, and medical conditions

  2007cited by this paper
• Developmental Regression and Mitochondrial Dysfunction in a Child With Autism

  2006cited by this paper
• BCL-xL regulates synaptic plasticity.

  2006cited by this paper
• DNA precursor asymmetries in mammalian tissue mitochondria and possible contribution to mutagenesis through reduced replication fidelity.

  2005cited by this paper
• Mitochondrial dysfunction in autism spectrum disorders: a population‐based study

  2005cited by this paper
• Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism.

  2004cited by this paper
• Regional brain chemical alterations in young children with autism spectrum disorder

  2003cited by this paper
• Mitochondrial dysfunction in autistic patients with 15q inverted duplication

  2003cited by this paper
• Mitochondrial Dysfunction in Patients With Hypotonia, Epilepsy, Autism, and Developmental Delay: HEADD Syndrome

  2002cited by this paper
• CNS energy metabolism as related to function.

  2000cited by this paper
• Review of oxidative stress in brain and spinal cord injury: suggestions for pharmacological and nutritional management strategies.

  1998cited by this paper
• In situ localization of mitochondrial DNA replication in intact mammalian cells

  1996cited by this paper
• Ratio of central nervous system to body metabolism in vertebrates: its constancy and functional basis.

  1981cited by this paper
• diagnostic and statistical manual of mental disorders,

  year unknowncited by this paper

• Mitochondrial dynamics in neurodevelopment and neurodevelopmental disorders.

  2026cites this paper
• Oxidative markers and SOD variant: predictors of autism severity and susceptibility

  2025cites this paper
• The Interplay of Oxidative Stress, Mitochondrial Dysfunction, and Neuroinflammation in Autism Spectrum Disorder: Behavioral Implications and Therapeutic Strategies

  2025cites this paper
• Fueling the Mind: Brain Metabolism in Health and Neurodevelopmental Disorders.

  2025cites this paper
• Metabolic Phenotyping of Synaptic Mitochondria Using MitoPlates™ and Synaptoneurosomes.

  2025cites this paper
• Redox System Dysfunction as a Key Mechanism in Autism Spectrum Disorder Pathogenesis

  2025cites this paper
• Targeting exercise triggered irisin for therapeutic intervention of autism-associated social anxiety.

  2025cites this paper
• Mitochondrial dysfunction reveals H2S-mediated synaptic sulfhydration as a potential mechanism for autism-associated social defects.

  2025cites this paper
• Mechanisms with network pharmacology approach of Ginsenosides in Alzheimer's disease

  2024cites this paper
• The Role of Parvalbumin Interneurons in Autism Spectrum Disorder

  2024cites this paper
• Investigation of cell metabolism dysfunction in autism spectrum disorders using genome-scale metabolic network analysis of neuronal development

  2024cites this paper
• Mutation in the mitochondrial chaperone TRAP1 leads to autism with more severe symptoms in males

  2024cites this paper
• Animal Model of Autism Induced by Valproic Acid Combined with Maternal Deprivation: Sex-Specific Effects on Inflammation and Oxidative Stress

  2024cites this paper
• Activation of the 5-HT1A Receptor by Eltoprazine Restores Mitochondrial and Motor Deficits in a Drosophila Model of Fragile X Syndrome

  2024cites this paper
• GPR50 regulates neuronal development as a mitophagy receptor

  2024cites this paper
• Neurons Specialize in Presynaptic Autophagy: A Perspective to Ameliorate Neurodegeneration

  2024cites this paper
• ADNP dysregulates methylation and mitochondrial gene expression in the cerebellum of a Helsmoortel–Van der Aa syndrome autopsy case

  2024cites this paper
• Metabolic dynamics in astrocytes and microglia during post-natal development and their implications for autism spectrum disorders

  2024cites this paper
• Crosstalk Between Mitochondrial DNA and Immune Response: Focus on Autism Spectrum Disorder

  2024cites this paper
• The Microbiome–Genetics Axis in Autism Spectrum Disorders: A Probiotic Perspective

  2024cites this paper
• Early dysregulation of GSK3β impairs mitochondrial activity in Fragile X Syndrome.

  2024cites this paper
• Metabolomic biomarkers in autism: identification of complex dysregulations of cellular bioenergetics

  2023cites this paper
• Species-specific FMRP regulation of RACK1 is critical for prenatal cortical development.

  2023cites this paper
• Effects of melatonin on dopaminergic neuron development via IP3-mediated mitochondrial Ca2+ regulation in autism spectrum disorder.

  2023cites this paper
• Activation of cell-free mtDNA-TLR9 signaling mediates chronic stress-induced social behavior deficits

  2023cites this paper
• Mutation in mitochondrial chaperone TRAP1 results in male-specific autism

  2023cites this paper
• High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways

  2023cites this paper
• Neuroinflammation and Oxidative Stress in the Pathogenesis of Autism Spectrum Disorder

  2023cites this paper
• LLLT applications may enhance ASD aspects related to disturbances in the gut microbiome, mitochondrial activity, and neural network function

  2023cites this paper
• The effect of nutritional interventions reducing oxidative stress on behavioural and gastrointestinal problems in autism spectrum disorder

  2023cites this paper
• Alterations of mitochondrial dynamics in serotonin transporter knockout rats: A possible role in the fear extinction recall mechanisms

  2022cites this paper
• Implications of the endocannabinoid system and the therapeutic action of cannabinoids in autism spectrum disorder: A literature review.

  2022cites this paper
• Construction of an immune-related ceRNA network to screen for potential diagnostic markers for autism spectrum disorder

  2022cites this paper
• Beneficial effects and neurobiological aspects of environmental enrichment associated to major depressive disorder and autism spectrum disorder.

  2022cites this paper
• Urine lactate concentration as a non-invasive screener for metabolic abnormalities: Findings in children with autism spectrum disorder and regression

  2022cites this paper
• Lower Availability of Mitochondrial Complex I in Anterior Cingulate Cortex in Autism: A Positron Emission Tomography Study.

  2022cites this paper
• TCHis mitigate oxidative stress and improve abnormal behavior in a prenatal valproic acid-exposed rat model of autism.

  2022cites this paper
• Slc6a20a Heterozygous and Homozygous Mutant Mice Display Differential Behavioral and Transcriptomic Changes

  2022cites this paper
• The serotonin reuptake transporter modulates mitochondrial copy number and mitochondrial respiratory complex gene expression in the frontal cortex and cerebellum in a sexually dimorphic manner

  2022cites this paper
• Associations Among Maternal Metabolic Conditions, Cord Serum Leptin Levels, and Autistic Symptoms in Children

  2022cites this paper
• Age, brain region, and gene dosage-differential transcriptomic changes in Shank3-mutant mice

  2022cites this paper
• Gene Dosage- and Age-Dependent Differential Transcriptomic Changes in the Prefrontal Cortex of Shank2-Mutant Mice

  2021cites this paper
• Meta鄄Analysis of Relationship between Vitamin D and Autism Spectrum Disorder in Children

  2021cites this paper
• Drug repositioning based on network-specific core genes identifies potential drugs for the treatment of autism spectrum disorder in children

  2021cites this paper
• Antioxidant activity of linear and star-shaped polypeptides modified with dopamine and glutathione

  2021cites this paper
• Folic Acid and Autism: A Systematic Review of the Current State of Knowledge

  2021cites this paper
• Early Chronic Memantine Treatment-Induced Transcriptomic Changes in Wild-Type and Shank2-Mutant Mice

  2021cites this paper
• Mitochondrial abnormalities in psychological disorders

  2021cites this paper
• Mitochondrial, exosomal miR137-COX6A2 and gamma synchrony as biomarkers of parvalbumin interneurons, psychopathology, and neurocognition in schizophrenia

  2021cites this paper
• Critical role of dysfunctional mitochondria and defective mitophagy in Autism Spectrum Disorders.

  2021cites this paper
• Oxidative stress marker aberrations in children with autism spectrum disorder: a systematic review and meta-analysis of 87 studies (N = 9109)

  2021cites this paper
• The Synaptic Dysregulation in Adolescent Rats Exposed to Maternal Immune Activation

  2021cites this paper
• The impact of glutathione metabolism in autism spectrum disorder.

  2021cites this paper
• Mental Health, Mitochondria, and the Battle of the Sexes

  2021cites this paper
• Metabolomics analysis of maternal serum exposed to high air pollution during pregnancy and risk of autism spectrum disorder in offspring.

  2021cites this paper
• Protein Biomarkers of Autism Spectrum Disorder Identified by Computational and Experimental Methods

  2021cites this paper
• Potential Role of L-Carnitine in Autism Spectrum Disorder

  2021cites this paper
• Powering the brain in health and disease

  2021cites this paper
• PTEN regulates mitochondrial biogenesis via the AKT/GSK-3β/PGC-1α pathway in autism.

  2021cites this paper
• Differential Metabolites in Chinese Autistic Children: A Multi-Center Study Based on Urinary 1H-NMR Metabolomics Analysis

  2021cites this paper
• FoxG1 regulates the formation of cortical GABAergic circuit during an early postnatal critical period resulting in autism spectrum disorder-like phenotypes

  2021cites this paper
• Autisms

  2020cites this paper
• Gut-Amygdala Interactions in Autism Spectrum Disorders: Developmental Roles via regulating Mitochondria, Exosomes, Immunity and microRNAs.

  2020cites this paper
• Molecular modelling, Synthesis and Evaluation of Flavone and Flavanone Scaffolds as Anti-inflammatory Agents.

  2020cites this paper
• Behavioural and brain ultrastructural changes following the systemic administration of propionic acid in adolescent male rats. Further development of a rodent model of autism

  2020cites this paper
• Aralar Sequesters GABA into Hyperactive Mitochondria, Causing Social Behavior Deficits.

  2020cites this paper
• Mitochondrial Function in Gilles de la Tourette Syndrome Patients With and Without Intragenic IMMP2L Deletions

  2020cites this paper
• Sulforaphane as an adjunctive treatment for irritability in children with autism spectrum disorder: A randomized, double‐blind, placebo‐controlled clinical trial

  2020cites this paper
• Anti-PDHA1 antibody is detected in a subset of patients with schizophrenia

  2020cites this paper
• Bioinformatics Analyses of the Transcriptome Reveal Ube3a-Dependent Effects on Mitochondrial-Related Pathways

  2020cites this paper
• A Metabolomics Approach to Screening for Autism Risk in the Children's Autism Metabolome Project

  2020cites this paper
• Mitochondrial protein biogenesis in the synapse is supported by local translation

  2020cites this paper
• Inflammation and Mitochondrial Dysfunction in Autism Spectrum Disorder.

  2020cites this paper
• Bridging the Gap Between Physical Health and Autism Spectrum Disorder

  2020cites this paper
• Neurodevelopmental impairment induced by prenatal valproic acid exposure shown with the human cortical organoid-on-a-chip model

  2020cites this paper
• VLDL-specific increases of fatty acids in autism spectrum disorder correlate with social interaction

  2020cites this paper
• The role of glutathione redox imbalance in autism spectrum disorder: A review.

  2020cites this paper
• Air Pollution-Related Brain Metal Dyshomeostasis as a Potential Risk Factor for Neurodevelopmental Disorders and Neurodegenerative Diseases

  2020influential citation
• Exploring the crosstalk of glycolysis and mitochondrial metabolism in psychiatric disorders and brain tumours

  2020cites this paper
• Simultaneous evaluation of antioxidative serum profiles facilitates the diagnostic screening of autism spectrum disorder in under-6-year-old children

  2020cites this paper
• The Pathophysiological Role of CoA

  2020cites this paper
• NDT_A_251394 1605..1618

  2020cites this paper
• Proteomic investigations of human HERC2 mutants: Insights into the pathobiology of a neurodevelopmental disorder.

  2019cites this paper
• Effects of sulforaphane in the central nervous system

  2019cites this paper
• Mitochondria, Metabolism, and Redox Mechanisms in Psychiatric Disorders

  2019cites this paper
• Mitochondrial function and abnormalities implicated in the pathogenesis of ASD

  2019cites this paper
• Effects of l-Carnitine in Patients with Autism Spectrum Disorders: Review of Clinical Studies

  2019cites this paper
• Ghrelin receptor signalling is not required for glucocorticoid induced obesity in male mice.

  2019cites this paper
• Gestational B-vitamin supplementation alleviates PM2.5-induced autism-like behavior and hippocampal neurodevelopmental impairment in mice offspring.

  2019cites this paper
• Proteomic Investigations of Autism Brain Identify Known and Novel Pathogenetic Processes

  2019cites this paper
• Untargeted Metabolomics for Autism Spectrum Disorders: Current Status and Future Directions

  2019cites this paper
• Cerium Oxide Nanoparticles and Gadolinium Integration : Synthesis, Characterization and Biomedical Applications

  2019cites this paper
• Advances in dermatology using DNA aptamer “Aptamin C” innovation: Oxidative stress prevention and effect maximization of vitamin C through antioxidation

  2019cites this paper
• Antigenic Targets of Patient and Maternal Autoantibodies in Autism Spectrum Disorder

  2019cites this paper
• Design, synthesis and identification of novel, orally bioavailable non-covalent Nrf2 activators.

  2019cites this paper
• Nutritional Epidemiology Research in the Field of Autism Spectrum Disorders A Review

  2019cites this paper
• The Association Between Somatic Health, Autism Spectrum Disorder, and Autistic Traits

  2019cites this paper
• Mitochondria biogenesis in the synapse is supported by local translation

  2019cites this paper
• Nuclear Peroxisome Proliferator-Activated Receptors (PPARs) as Therapeutic Targets of Resveratrol for Autism Spectrum Disorder

  2019cites this paper
• Phenotypic subgrouping and multi-omics analyses reveal reduced diazepam-binding inhibitor (DBI) protein levels in autism spectrum disorder with severe language impairment

  2019cites this paper