Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5'-methoxyhydnocarpin, a multidrug pump inhibitor.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2000-02-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1073/PNAS.030540597PMID 10677479PMCID PMC26451
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Interaction of chromosomal stains with DNA

  2004cited by this paper
• Multidrug resistance: Versatile drug sensors of bacterial cells.

  1999cited by this paper
• Multiple Novel Inhibitors of the NorA Multidrug Transporter of Staphylococcus aureus

  1999cited by this paper
• Transport of molecules across microbial membranes

  1999cited by this paper
• Flavonoid-related modulators of multidrug resistance: synthesis, pharmacological activity, and structure-activity relationships.

  1999cited by this paper
• A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene

  1998cited by this paper
• Unified inventory of established and putative transporters encoded within the complete genome of Saccharomyces cerevisiae

  1998cited by this paper
• Bacterial solute uptake and efflux systems.

  1998cited by this paper
• Bacteria lacking a multidrug pump: a sensitive tool for drug discovery.

  1998cited by this paper
• Multiple antibiotic resistance and efflux.

  1998cited by this paper
• Isolation and characterization of a putative multidrug resistance pump from Vibrio cholerae

  1998cited by this paper
• Microbial genome analyses: global comparisons of transport capabilities based on phylogenies, bioenergetics and substrate specificities.

  1998cited by this paper
• The challenge of antibiotic resistance.

  1998cited by this paper
• Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein.

  1997cited by this paper
• Proton-dependent multidrug efflux systems

  1996cited by this paper
• Quinolone resistance mediated by norA: physiologic characterization and relationship to flqB, a quinolone resistance locus on the Staphylococcus aureus chromosome

  1994cited by this paper
• Useful plants of dermatology. I. Hydnocarpus and chaulmoogra.

  1994cited by this paper
• Medicinal Plants of the Pacific West

  1993cited by this paper
• Biochemistry of multidrug resistance mediated by the multidrug transporter.

  1993cited by this paper
• Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter

  1993cited by this paper
• Emr, an Escherichia coli locus for multidrug resistance.

  1992cited by this paper
• Efflux-mediated multidrug resistance in Bacillus subtilis: similarities and dissimilarities with the mammalian system.

  1991cited by this paper
• Chapter 2 Protoberberine Alkaloids

  1986cited by this paper
• The alkaloids : chemistry and pharmacology

  1983cited by this paper
• Alkaloids of Mahonia repens With A Brief Review of Previous Work in the Genus Mahonia

  1981cited by this paper
• Phytochemical screening of some Rocky Mountain plants.

  1981cited by this paper
• 13C NMR of flavonolignans from Hydnocarpus wightiana

  1979cited by this paper
• Mechanism by Which Hydnocarpic Acid Inhibits Mycobacterial Multiplication

  1973cited by this paper
• Berberine sulfate: antimicrobial activity, bioassay, and mode of action.

  1969cited by this paper
• Mechanism of Coupling of Oxidative Phosphorylation and the Membrane Potential of Mitochondria

  1969cited by this paper

• Fungistatic effects of purified conifer tannins against five wood-decaying fungi

  2026cites this paper
• The in vitro evaluation of synergistic effects of ciprofloxacin and berberine hydrochloride against Pseudomonas aeruginosa

  2025cites this paper
• Mechanism, Efficacy, and Safety of Natural Antibiotics

  2025cites this paper
• The potential use of linalool and cuminaldehyde as efflux pump inhibitor for the modulation of drugs and disinfectant resistance in oral Staphylococcus aureus isolates harbored the NorB gene.

  2025cites this paper
• The Perspectives of Combining Antibiotics with Saponins—Herbal Excipients

  2025cites this paper
• Medicinal plants: bioactive compounds, biological activities, combating multidrug-resistant microorganisms, and human health benefits - a comprehensive review

  2025cites this paper
• Flavonoids from Pteris vittata L. Enhance Antibiotic Sensitivity to Multidrug‐Resistant Stenotrophomonas maltophilia

  2025cites this paper
• Phyto-molecules show potentials to combat drug-resistance in bacterial cell membranes.

  2025cites this paper
• Antioxidant and Antibacterial Activities of Pteris vittata L. Extracts from Metalliferous Soils: Correlations with Phenolic Compounds

  2025cites this paper
• Berberine and its nanoformulations and extracts: potential strategies and future perspectives against multi-drug resistant bacterial infections

  2025cites this paper
• Enhancing antibiotic potency with Adiantum venustum D. Don extracts and fractions: A phyto-antibiotic synergistic approach against microbial strains

  2025cites this paper
• Combining Plant Bioactives With Antibiotics for Enhanced Antibiofilm Activity Against Uropathogenic Staphylococcus spp. and Cytotoxicity Evaluation

  2025cites this paper
• UHPLC-MS/MS profiling and antibacterial activity of hydrolysed and native flavonoids from Crocus sativus stamens

  2025cites this paper
• Carum carvi and Ormenis multicaulis Extracts: Chemical Analysis and In Vivo Experiments to Evaluate the Synergistic Analgesic and Anti‐Inflammatory Effects

  2025cites this paper
• Inhibitory Action of Plant Extracts (Maidenhair, Cranberry, and Vitis vinifera) Against Gram-Negative Bacteria Isolated from Urinary Tract Infection

  2025cites this paper
• Comparative Evaluation of Antioxidant and Antibacterial Activities of Helichrysum plicatum Obtained by Different Extraction Methods, with Phenolic Profiling by LC-MS/MS

  2025cites this paper
• Suppression of the Rhizoma Coptidis-Mediated Antibiotic Cross-Resistance in Staphylococcus aureus Using Radix Paeoniae Rubra

  2025cites this paper
• Structural biology of plant-derived antibacterials: Opportunities for rational lead optimization.

  2025cites this paper
• Plant Metabolites as Potential Agents That Potentiate or Block Resistance Mechanisms Involving β-Lactamases and Efflux Pumps

  2025cites this paper
• Exploring the Role of Berberine as a Molecular Disruptor in Antimicrobial Strategies

  2025cites this paper
• Phytochemicals and bioenhancers: tackling antibiotic resistance in the era of emerging microbial threats

  2025cites this paper
• Harnessing L-asparaginase from Solanaceae plants: Purification and molecular dynamics studies for cancer targeting

  2025cites this paper
• A Comprehensive Review on the Role of Medicinal Plants as Antimicrobial Agents

  2024influential citation
• Designing combinational herbal drugs based on target space analysis

  2024cites this paper
• Computational mechanistic investigation of the kinetic resolution of α-methyl-phenylacetaldehyde by norcoclaurine synthase

  2024cites this paper
• Exploring the Benefits of Herbal Medicine Composite 5 (HRMC5) for Skin Health Enhancement

  2024cites this paper
• Botanical Study of Berberis vulgaris L of Family Berberidaceae: A Review

  2024cites this paper
• "Deciphering the Potential Therapeutic Effects of Hydnocarpus wightianus Seed Extracts using in vitro and in silico approaches".

  2024cites this paper
• Recognition of the inducible, secretory small protein OsSSP1 by the membrane receptor OsSSR1 and coreceptor OsBAK1 confers rice resistance to the blast fungus.

  2024cites this paper
• Synthesis of organic–inorganic hybrid nanocomposites modified by catalase-like catalytic sites for the controlling of kiwifruit bacterial canker

  2024cites this paper
• Bacterial Efflux Pump Inhibitors Reduce Antibiotic Resistance

  2024cites this paper
• Synergistic Antibacterial Activity of Gallic Acid Based Chalcone Indl 2 by Inhibiting Efflux Pump Transporters

  2024cites this paper
• Plant antibacterials: The challenges and opportunities

  2024cites this paper
• Capsicum chinense cell cultures: a biotechnological platform for the sustainable production of bioactive metabolites for the cosmetics market

  2024cites this paper
• Photosensitizer associated with efflux pump inhibitors as a strategy for photodynamic therapy against bacterial resistance.

  2024cites this paper
• Sophisticated natural products as antibiotics

  2024cites this paper
• Phytochemicals: potential alternative strategy to fight Salmonella enterica serovar Typhimurium

  2023cites this paper
• Role of bacterial efflux pumps in antibiotic resistance, virulence, and strategies to discover novel efflux pump inhibitors

  2023cites this paper
• Synergistic Interaction of Glycyrrhizin with Norfloxacin Displays ROS-Induced Bactericidal Activity against Multidrug-Resistant Staphylococcus aureus

  2023cites this paper
• Plant-Derived Products with Therapeutic Potential against Gastrointestinal Bacteria

  2023cites this paper
• Prenylated isoflavonoids from Fabaceae against the NorA efflux pump in Staphylococcus aureus

  2023cites this paper
• Superior Performance of Iron-Coated Silver Nanoparticles and Cefoxitin as an Antibiotic Composite Against Methicillin-Resistant  Staphylococcus aureus (MRSA): A Population Study

  2023cites this paper
• Design, Synthesis and Evaluation of Catechol-Based Amyloid Beta Aggregation Inhibitors

  2023cites this paper
• Bibliometric insights into the most influential papers on antibiotic adjuvants: a comprehensive analysis

  2023cites this paper
• Immunomodulatory Properties of Natural Extracts and Compounds Derived from Bidens pilosa L.: Literature Review

  2023cites this paper
• Comparative Study on the Phytometabolites, in vitro Antiplasmodial Activity and Cytotoxicity of Stem Bark Extracts of Annickia affinis (Exell) Versteegh & Sosef and Annickia chlorantha (Oliv.) Setten & PJ. Mass

  2023cites this paper
• The Art of War with Pseudomonas aeruginosa: Targeting Mex Efflux Pumps Directly to Strategically Enhance Antipseudomonal Drug Efficacy

  2023cites this paper
• Interaction Metabolomics to Discover Synergists in Natural Product Mixtures

  2023cites this paper
• Tackling multidrug-resistant Staphylococcus aureus by natural products and their analogues acting as NorA efflux pump inhibitors.

  2023cites this paper
• Recent advances in anti-inflammatory active components and action mechanisms of natural medicines

  2023cites this paper
• Antibacterial sensitizers from natural plants: A powerful weapon against methicillin-resistant Staphylococcus aureus

  2023cites this paper
• Antibiotic Adjuvants: A Versatile Approach to Combat Antibiotic Resistance

  2023cites this paper
• Efflux Pump Inhibitors in Controlling Antibiotic Resistance: Outlook under a Heavy Metal Contamination Context

  2023cites this paper
• Insights into the preventive actions of natural compounds against Klebsiella pneumoniae infections and drug resistance.

  2023cites this paper
• Singlet oxygen production analysis of reduced berberine analogs via NMR spectroscopy

  2023cites this paper
• Fish Epidermal Mucus as a Source of Diverse Therapeutical Compounds

  2023cites this paper
• Antibiotic Potentiation Through Phytochemical-Based Efflux Pump Inhibitors to Combat Multidrug Resistance Bacteria.

  2023cites this paper
• Lethal and Sublethal Toxicity of Beta-Carboline Alkaloids from Peganum harmala (L.) against Aedes albopictus Larvae (Diptera: Culicidae)

  2023cites this paper
• Inhibitory Activity of Quaternary Isoquinoline Alkaloids on Soluble Epoxide Hydrolase

  2022cites this paper
• Nghiên cứu tác dụng điều trị vết thương thực nghiệm của gel nano Berberin trên lâm sàng.

  2022influential citation
• What Approaches to Thwart Bacterial Efflux Pumps-Mediated Resistance?

  2022cites this paper
• Herbal Products and Their Active Constituents Used Alone and in Combination with Antibiotics against Multidrug-Resistant Bacteria

  2022cites this paper
• Interactions between Medical Plant-Derived Bioactive Compounds: Focus on Antimicrobial Combination Effects

  2022cites this paper
• Antimicrobial activity of natural products against MDR bacteria: A scientometric visualization analysis

  2022cites this paper
• Modulation of Drug Resistance by Furanochromones in NorA Overexpressing Staphylococcus Aureus

  2022cites this paper
• Antibiotic Potentiators Against Multidrug-Resistant Bacteria: Discovery, Development, and Clinical Relevance

  2022cites this paper
• Herbal Extracts: Importance, Classification, Quality Characteristics, and Control

  2022cites this paper
• Research Progress of Traditional Chinese Medicine Inhibiting Staphylococcus aureus

  2022cites this paper
• Identification of molecular mechanisms underlying the therapeutic effects of Xintong granule in coronary artery disease by a network pharmacology and molecular docking approach

  2022cites this paper
• A Possible Synergistic Herbal Solution for COVID-19.

  2022cites this paper
• Mechanisms of Antimicrobial Resistance: Highlights on Current Advance Methods for Detection of Drug Resistance and Current Pipeline Antitubercular Agents.

  2022cites this paper
• Isolation of bioactive constituents from the ethylacetate leaf extract portion of Gmelina arborea (Verbenaceae)

  2022cites this paper
• Medicinal Chemistry of Inhibitors Targeting Resistant Bacteria.

  2022cites this paper
• pH-Responsive On-Demand Alkaloids Release from Core-Shell ZnO@ZIF-8 Nanosphere for Synergistic Control of Bacterial Wilt Disease.

  2022cites this paper
• Efflux pump and its inhibitors: Cause and cure for multidrug resistance

  2022cites this paper
• Polylactide-Based Films Incorporated with Berberine—Physicochemical and Antibacterial Properties

  2022cites this paper
• Conjugates of Chloramphenicol Amine and Berberine as Antimicrobial Agents

  2022cites this paper
• Pomelo seed oil: Natural insecticide against cowpea aphid

  2022cites this paper
• Recent advances to combat ESKAPE pathogens with special reference to essential oils

  2022cites this paper
• Deciphering the Role of β-Lactamase Inhibitors, Membrane Permeabilizers and Efflux Pump Inhibitors as Emerging Targets in Antibiotic Resistance

  2022cites this paper
• Multidrug Efflux Pumps in Bacteria and Efflux Pump Inhibitors

  2022cites this paper
• Biosynthesis Investigations of Terpenoid, Alkaloid, and Flavonoid Antimicrobial Agents Derived from Medicinal Plants

  2022cites this paper
• Bioactive Components in Traditional Foods Aimed at Health Promotion: A Route to Novel Mechanistic Insights and Lead Molecules?

  2022cites this paper
• Evaluation of the Antibacterial and Anti-Inflammatory Effects of a Natural Products-Containing Toothpaste

  2022cites this paper
• Impeding efflux-mediated resistance in Staphylococcus aureus

  2022cites this paper
• Preliminary Phytochemical Screening and Antimicrobial Activity of the Methanol Fractions of the Leaf of Gmelina arborea (Verbenaceae)

  2022cites this paper
• Multidrug Efflux Pumps in Bacteria and Efflux Pump Inhibitors

  2022cites this paper
• Targeting Bacterial Membrane Proteins to Explore the Beneficial Effects of Natural Products: New Antibiotics against Drug Resistance.

  2021cites this paper
• Antimicrobial Potential of Naturally Occurring Bioactive Secondary Metabolites

  2021cites this paper
• Chemically Mediated Multi-trophic Interactions

  2021cites this paper
• Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids

  2021cites this paper
• Synthesis, Characterization and Fluorescence Properties of Novel Porous Fe/ZnO Nano-Hybrid Assemblies by Using Berberis thunbergii Extract

  2021cites this paper
• Multivariate analysis of herbal drugs with diverse pharmacological activities: metabolomics study

  2021cites this paper
• A Comprehensive Review on Pharmacology of Efflux Pumps and their Inhibitors in Antibiotic Resistance.

  2021cites this paper
• Multiple Molecular Mechanisms to Overcome Multidrug Resistance in Cancer by Natural Secondary Metabolites

  2021cites this paper
• Comparative screening of dose-dependent and strain-specific antimicrobial efficacy of berberine against a representative library of broad-spectrum antibiotics

  2021cites this paper
• Plant defense synergies and antagonisms affect performance of specialist herbivores of common milkweed

  2021cites this paper
• The Effects of Natural Products and Environmental Conditions on Antimicrobial Resistance

  2021cites this paper
• Berberine ameliorates the LPS-induced imbalance of osteogenic and adipogenic differentiation in rat bone marrow-derived mesenchymal stem cells

  2021cites this paper
• A Potential Combination Therapy of Berberine Hydrochloride With Antibiotics Against Multidrug-Resistant Acinetobacter baumannii

  2021cites this paper