Mechanical Force-Triggered Drug Delivery.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Chemical Reviews

• Publication date

  2016-09-29

• Fields of study

  Medicine, Chemistry, Engineering

• Identifiers
  DOI 10.1021/ACS.CHEMREV.6B00369PMID 27680291
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Impact of particle elasticity on particle‐based drug delivery systems☆

  2017cited by this paper
• Emerging Frontiers in Drug Delivery.

  2016cited by this paper
• Bioresorbable silicon electronic sensors for the brain

  2016cited by this paper
• Emerging Frontiers in Drug Delivery

  2016cited by this paper
• Stretch-Induced Drug Delivery from Superhydrophobic Polymer Composites: Use of Crack Propagation Failure Modes for Controlling Release Rates.

  2016cited by this paper
• Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems.

  2016cited by this paper
• Co-Assembly of Heparin and Polypeptide Hybrid Nanoparticles for Biomimetic Delivery and Anti-Thrombus Therapy.

  2016cited by this paper
• Hypoxia-Sensitive Materials for Biomedical Applications

  2016cited by this paper
• Nano-biomaterials for cardiovascular applications: Clinical perspective.

  2016cited by this paper
• ATP-Responsive Drug Delivery Systems

  2016cited by this paper
• A Strain‐Regulated, Refillable Elastic Patch for Controlled Release

  2016cited by this paper
• Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis

  2016cited by this paper
• Recent advances of cocktail chemotherapy by combination drug delivery systems.

  2016cited by this paper
• Analysis of nanoparticle delivery to tumours

  2016cited by this paper
• Adenosine Triphosphate-Triggered Release of Macromolecular and Nanoparticle Loads from Aptamer/DNA-Cross-Linked Microcapsules.

  2015cited by this paper
• Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery

  2015cited by this paper
• pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices

  2015cited by this paper
• Targeted tumor theranostics using folate-conjugated and camptothecin-loaded acoustic nanodroplets in a mouse xenograft model.

  2015cited by this paper
• Novel pH sensitive ferrogels as new approach in cancer treatment: Effect of the magnetic field on swelling and drug delivery.

  2015cited by this paper
• Ultrasound-mediated destruction of paclitaxel and oxygen loaded lipid microbubbles for combination therapy in ovarian cancer xenografts.

  2015cited by this paper
• Ultrasound-guided delivery of microRNA loaded nanoparticles into cancer.

  2015cited by this paper
• Flow shear stress differentially regulates endothelial uptake of nanocarriers targeted to distinct epitopes of PECAM-1.

  2015cited by this paper
• Spatiotemporal drug delivery using laser-generated-focused ultrasound system.

  2015cited by this paper
• Engineering precision

  2015cited by this paper
• Ultrasound-mediated gastrointestinal drug delivery

  2015cited by this paper
• Engineering synthetically modified insulin for glucose-responsive diabetes therapy

  2015cited by this paper
• A Force to Be Reckoned With: A Review of Synthetic Microswimmers Powered by Ultrasound.

  2015cited by this paper
• On-demand drug delivery from local depots.

  2015cited by this paper
• Stretch-Triggered Drug Delivery from Wearable Elastomer Films Containing Therapeutic Depots.

  2015cited by this paper
• A skin-inspired organic digital mechanoreceptor

  2015cited by this paper
• Real-Time Monitoring of ATP-Responsive Drug Release Using Mesoporous-Silica-Coated Multicolor Upconversion Nanoparticles.

  2015cited by this paper
• Interaction between drug delivery vehicles and cells under the effect of shear stress.

  2015cited by this paper
• Stimuli-responsive nanomaterials for therapeutic protein delivery.

  2014cited by this paper
• Managing diabetes with nanomedicine: challenges and opportunities

  2014cited by this paper
• pH-sensitive nano-systems for drug delivery in cancer therapy.

  2014cited by this paper
• Ultrasound induced cancer immunotherapy.

  2014cited by this paper
• Enzyme-responsive nanomaterials for controlled drug delivery.

  2014cited by this paper
• ATP-triggered anticancer drug delivery

  2014cited by this paper
• State-of-the-art materials for ultrasound-triggered drug delivery.

  2014cited by this paper
• Platelet-like Nanoparticles: Mimicking Shape, Flexibility, and Surface Biology of Platelets To Target Vascular Injuries

  2014cited by this paper
• Physical energy for drug delivery; poration, concentration and activation.

  2014cited by this paper
• Ultrasound-enhanced drug delivery in prostate cancer xenografts by nanoparticles stabilizing microbubbles.

  2014cited by this paper
• Acoustic behavior of microbubbles and implications for drug delivery.

  2014cited by this paper
• Echogenic nanoparticles for ultrasound technologies: Evolution from diagnostic imaging modality to multimodal theranostic agent

  2014cited by this paper
• Controlled drug delivery systems: past forward and future back.

  2014cited by this paper
• Multifunctional Theranostic Red Blood Cells For Magnetic‐Field‐Enhanced in vivo Combination Therapy of Cancer

  2014cited by this paper
• Controlled release from a mechanically-stimulated thermosensitive self-heating composite hydrogel.

  2014cited by this paper
• Ultrasound sensitive eLiposomes containing doxorubicin for drug targeting therapy.

  2014cited by this paper
• Ultrasound-mediated blood-brain barrier disruption for targeted drug delivery in the central nervous system

  2014cited by this paper
• Acoustic propulsion of nanorod motors inside living cells.

  2014cited by this paper
• Magnetic Targeting Enhanced Theranostic Strategy Based on Multimodal Imaging for Selective Ablation of Cancer

  2014cited by this paper
• Recent advances in molecular, multimodal and theranostic ultrasound imaging.

  2014cited by this paper
• Nucleic acid delivery with microbubbles and ultrasound.

  2014cited by this paper
• Hypoxia-targeted siRNA delivery.

  2014cited by this paper
• Perspective and potential of oral lipid-based delivery to optimize pharmacological therapies against cardiovascular diseases.

  2014cited by this paper
• Cocoon-Like Self-Degradable DNA Nanoclew for Anticancer Drug Delivery

  2014cited by this paper
• Ultrasound mediated transdermal drug delivery.

  2014cited by this paper
• Turning erythrocytes into functional micromotors.

  2014cited by this paper
• Reactive oxygen species-responsive protein modification and its intracellular delivery for targeted cancer therapy.

  2014cited by this paper
• Nano/micromotors in (bio)chemical science applications.

  2014cited by this paper
• Engineering and evaluating drug delivery particles in microfluidic devices.

  2014cited by this paper
• Cardiovascular drug delivery with ultrasound and microbubbles.

  2014cited by this paper
• Ultrasound‐Triggered Regulation of Blood Glucose Levels Using Injectable Nano‐Network

  2014cited by this paper
• Ultrasound-mediated gene delivery of naked plasmid DNA in skeletal muscles: a case for bolus injections.

  2014cited by this paper
• Mesoporous silica nanoparticles as a breast-cancer targeting ultrasound contrast agent.

  2014cited by this paper
• Successive mechanochemical activation and small molecule release in an elastomeric material.

  2014cited by this paper
• Emerging micro- and nanotechnology based synthetic approaches for insulin delivery.

  2014cited by this paper
• Prolonged survival upon ultrasound-enhanced doxorubicin delivery in two syngenic glioblastoma mouse models.

  2014cited by this paper
• Redox-Sensitive Materials for Drug Delivery: Targeting the Correct Intracellular Environment, Tuning Release Rates, and Appropriate Predictive Systems

  2014cited by this paper
• Ultrasound-propelled nanoporous gold wire for efficient drug loading and release.

  2014cited by this paper
• Ultrasound-triggered disruption and self-healing of reversibly cross-linked hydrogels for drug delivery and enhanced chemotherapy

  2014cited by this paper
• Understanding ultrasound induced sonoporation: definitions and underlying mechanisms.

  2014cited by this paper
• Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery

  2014cited by this paper
• Hyaluronic acid-based hydrogels containing covalently integrated drug depots: implication for controlling inflammation in mechanically stressed tissues.

  2013cited by this paper
• Ultrasound-aided microbubbles facilitate the delivery of drugs to the inner ear via the round window membrane.

  2013cited by this paper
• Magnetic responsive polymer composite materials.

  2013cited by this paper
• Shear stress and its effect on the interaction of myoblast cells with nanosized drug delivery vehicles.

  2013cited by this paper
• Doxorubicin loaded superparamagnetic PLGA-iron oxide multifunctional microbubbles for dual-mode US/MR imaging and therapy of metastasis in lymph nodes.

  2013cited by this paper
• Redox signaling in cardiovascular health and disease.

  2013cited by this paper
• Self-propelled polymer-based multilayer nanorockets for transportation and drug release.

  2013cited by this paper
• Ultrasound-mediated drug delivery for cardiovascular disease

  2013cited by this paper
• Methods for activating and characterizing mechanically responsive polymers.

  2013cited by this paper
• PEG-functionalized iron oxide nanoclusters loaded with chlorin e6 for targeted, NIR light induced, photodynamic therapy.

  2013cited by this paper
• Targeted liposome-loaded microbubbles for cell-specific ultrasound-triggered drug delivery.

  2013cited by this paper
• Investigating the acoustic release of doxorubicin from targeted micelles.

  2013cited by this paper
• Triggered Drug Release from Superhydrophobic Meshes using High‐Intensity Focused Ultrasound

  2013cited by this paper
• Stimuli-responsive nanocarriers for drug delivery.

  2013cited by this paper
• Glucose-responsive microgels integrated with enzyme nanocapsules for closed-loop insulin delivery.

  2013cited by this paper
• Chain-shattering polymeric therapeutics with on-demand drug-release capability.

  2013cited by this paper
• Controlled pH stability and adjustable cellular uptake of mixed-charge nanoparticles.

  2013cited by this paper
• SPIO-conjugated, doxorubicin-loaded microbubbles for concurrent MRI and focused-ultrasound enhanced brain-tumor drug delivery.

  2013cited by this paper
• Controversies in cardiovascular medicine Why are we failing to implement effective therapies in cardiovascular disease ?

  2013cited by this paper
• Devices for overcoming biological barriers: the use of physical forces to disrupt the barriers.

  2013cited by this paper
• Superparamagnetic iron oxide and drug complex-embedded acoustic droplets for ultrasound targeted theranosis.

  2013cited by this paper
• Antiangiogenic-targeting drug-loaded microbubbles combined with focused ultrasound for glioma treatment.

  2013cited by this paper
• Mechanobiochemistry: harnessing biomacromolecules for force-responsive materials

  2013cited by this paper
• A vector-free microfluidic platform for intracellular delivery

  2013cited by this paper
• Targeted drug delivery with focus ultrasound-induced blood-brain barrier opening Using acoustically-activated nanodroplets

  2013cited by this paper
• Dynamic flow behaviour of surfactant vesicles under shear flow: role of a multilamellar microstructure

  2013cited by this paper
• Ultrasonic gene and drug delivery using eLiposomes.

  2013cited by this paper

• Remote Molecule Activation in Living Mice Triggered by Therapeutic Ultrasound.

  2026cites this paper
• Electric, pH, and Mechanical Stimuli-Responsive Hydrogels from Methacrylated Pullulan and Carboxymethylated-Methacrylated Xanthan Gum as Drug Carriers

  2026cites this paper
• Mechanomedicine

  2026cites this paper
• Advances in stimuli-responsive polymers for biomedical and environmental applications

  2026cites this paper
• Effective Approaches to Cancer Therapies Based on Biomechanics and Pathology: Review Study

  2025cites this paper
• Advanced Design of Next-Generation Piezoresistive Sensors with Tailored Microstructures for Digital Healthcare.

  2025cites this paper
• Theranostic Applications of Tailored Lipid-based Nanoparticles as Drug Delivery Systems for Cancer Treatment

  2025cites this paper
• Single- and multi-modal molecular probes with second near-infrared activatable optical signals for disease diagnosis and theranostics.

  2025cites this paper
• 3D printing of scaffolds for articular cartilage/osteochondral regeneration: Design, performance, and applications

  2025cites this paper
• Measurement of Residual Stress in the Brain.

  2025cites this paper
• Mechanics Mediated Semi‐Convertible Hydrogel Enabled Sustained Drug Release

  2025cites this paper
• 肿瘤微环境的多维特征及其靶向递送策略研究进展

  2025cites this paper
• Ternary composite material based on copper-metal organic frameworks, Mxene and carbon nanotubes as a sensitive electrochemical platform for determination of dopamine in aquatic environments.

  2025cites this paper
• Advanced microneedle arrays for transdermal antibiotic delivery.

  2025cites this paper
• Drug Delivery Systems for Enhancing Cancer Chemotherapy

  2025cites this paper
• Wearable and implantable microfluidic technologies for future digital therapeutics.

  2025cites this paper
• Untethered miniature robots for minimally invasive thrombus treatment: From bench to clinical trials

  2025cites this paper
• Multiphysics modelling enhanced by imaging and artificial intelligence for personalised cancer nanomedicine: Foundations for clinical digital twins.

  2025cites this paper
• Mechanochemistry for On-Demand Polymer Network Materials

  2025cites this paper
• Leveraging Instabilities in Multifunctional Soft Materials: A Cutting Edge Review

  2025cites this paper
• Recent advances in smart responsive hydrogel microspheres for tissue regeneration: preparation, characteristics and applications.

  2025cites this paper
• Dissipative Particle Dynamics Models of Encapsulated Microbubbles and Nanoscale Gas Vesicles for Biomedical Ultrasound Simulations

  2025cites this paper
• Measurement of residual stress in the brain

  2025cites this paper
• Decaying Oscillating Pulsed Magnetic Field Induces Lysosome-Dependent Cell Death in A375 Melanoma via Magneto-Mechanical Force

  2025cites this paper
• Advanced Biologics and Smart Delivery Systems for Cardiovascular Diseases: A Comprehensive Review

  2025cites this paper
• Biodegradable drug-eluting PLGA nanofiber scaffolds for long-term inhibition of colon cancer progression

  2025cites this paper
• Numerical simulation of the effects of subcutaneous injection in conjunction with periodic compression on tissue pressure and drug diffusion.

  2025cites this paper
• Gold Nanostar‐Decorated Electrospun Nanofibers Enable On‐Demand Drug Delivery

  2025cites this paper
• Activatable Enzymatic Nanoplatform Incorporated into Microneedle Patch for Relieving Tumor Hypoxia Augmented Photodynamic Therapy

  2025cites this paper
• Enhancing cancer therapy via acoustics: chemotherapy-enhanced tunable acoustofluidic permeabilization (ChemoTAP)

  2025cites this paper
• Recent advances in stimuli-responsive microrobots for biomedical applications

  2025cites this paper
• External stimuli-responsive drug delivery to the posterior segment of the eye

  2025cites this paper
• Organic Fluorescent Molecules Based on Coumarin Acylhydrazone with Acidochromic Luminescence and Their Application as Anti-counterfeiting Materials

  2025cites this paper
• Tailoring Design of Microneedles for Drug Delivery and Biosensing.

  2025cites this paper
• Wirelessly controlled drug delivery systems for translational medicine

  2025cites this paper
• Mucoadhesive Boronated‐Chitosan Nanoparticles for Cisplatin Delivery: A Novel Approach for Localized Cervical Cancer Therapy

  2025cites this paper
• Force-Responsive Delivery of Anticancer Drugs via a DNA Mechanical Nanovehicle.

  2024cites this paper
• Mechano-Triggered Release of Biomolecules from Supramolecular Hyaluronic Acid Hydrogels

  2024cites this paper
• Acoustofluidics-Based Intracellular Nanoparticle Delivery

  2024cites this paper
• Mechano‐Responsive Biomaterials for Bone Organoid Construction

  2024cites this paper
• A single molecule carrier for ocular posterior segment diseases.

  2024cites this paper
• Advancements in microneedle technology: current status and next-generation innovations

  2024cites this paper
• Targeted gold nanoparticles for ovarian cancer (Review)

  2024cites this paper
• A stimulus responsive microneedle-based drug delivery system for cancer therapy.

  2024cites this paper
• Strain-Engineered Particle Diffusion in Uniaxially Deformed Polymer Networks

  2024cites this paper
• Current advance of nanotechnology in diagnosis and treatment for malignant tumors

  2024cites this paper
• Recent advances with erythrocytes as therapeutics carriers.

  2024cites this paper
• Designing intelligent bioorthogonal nanozymes: Recent advances of stimuli-responsive catalytic systems for biomedical applications.

  2024cites this paper
• Advances in stimulus-responsive nanomedicine for treatment and diagnosis of atherosclerosis.

  2024cites this paper
• A comprehensive review of advanced focused ultrasound (FUS) microbubbles-mediated treatment of Alzheimer's disease

  2024cites this paper
• Mechano-assisted strategies to improve cancer chemotherapy.

  2024cites this paper
• Expanding the arsenal against diabetes mellitus via transdermal application of drug-loaded nanoparticles and microneedles: Recent advances and future perspectives

  2024cites this paper
• Propulsion mechanisms of micro/nanorobots: a review.

  2024cites this paper
• Dynamic Covalent Boronic-Acid-Functionalized Alginate/PVA Hydrogels for pH and Shear-Responsive Drug Delivery

  2024cites this paper
• Labeling a Polydiene Elastomer with a π-Extended Mechanophore with a Facile and Low Temperature Synthetic Route

  2024cites this paper
• Echogenic Gold Nanorod Incorporated Hybrid Poly(2-oxazoline) Nanocapsules for Real-Time Ultrasound/Fluorescent Imaging and Targeted Cancer Theranostics.

  2024cites this paper
• Fibrinogen binding to activated platelets and its biomimetic thrombus-targeted thrombolytic strategies.

  2024cites this paper
• From lab to wearables: Innovations in multifunctional hydrogel chemistry for next-generation bioelectronic devices.

  2024cites this paper
• An Ultrasound‐Responsive and In Situ Gelling Hydrogel Nanocomposite for Boosting Anti PD‐L1 Immunotherapy via Remodeling Aberrant ECM of Post‐Surgical Residual Cancer

  2024cites this paper
• Dynamic Monitoring of Biomolecular Hydrodynamic Dimensions by Magnetization Motion on Quartz Crystal Microbalance.

  2024cites this paper
• Numerical modeling of ultrasound-triggered microneedle-mediated delivery of drug particles into bacterial biofilms.

  2024cites this paper
• The Dilemma of Insulin Delivery into the Brain: A Comprehensive Review.

  2024cites this paper
• Structural and energetic properties of lecithin liposomes encapsulating coenzyme Q10 from coarse-grained simulations

  2024cites this paper
• Controlling spatiotemporal mechanics of globular protein-polymer hydrogel via metal-coordination interactions

  2024cites this paper
• Mechanical force-mediated interactions between cancer cells and fibroblasts and their role in the progression of hepatocellular carcinoma

  2024cites this paper
• A comprehensive review on the biomedical frontiers of nanowire applications

  2024cites this paper
• Biomechanical forces and force-triggered drug delivery in tumor neovascularization.

  2024cites this paper
• Ultrasound-nanovesicles interplay for theranostics.

  2024cites this paper
• Combination of Focused Ultra Sound and MnO2/GOD Loaded Microbubble Nanoparticles in Targeted Tumor Therapy of Breast Cancer

  2024cites this paper
• Mechanically Active Supramolecular Systems

  2024cites this paper
• Physical stimuli-responsive polymeric patches for healthcare

  2024cites this paper
• Linking of Chemical Reactions and Silica Nanoparticle Contact Using Synthetic Helical Molecules

  2024cites this paper
• Development of an ultrasound-mediated nano-sized drug-delivery system for cancer treatment: from theory to experiment.

  2024cites this paper
• A comprehensive study of ultrasound-enhanced transdermal drug delivery via microneedle array

  2024cites this paper
• Force-controlled release of small molecules with a rotaxane actuator

  2024cites this paper
• Dual stimuli-responsive polymeric nanoparticles combining soluplus and chitosan for enhanced breast cancer targeting

  2024cites this paper
• Design and applications of polymer-like peptides in biomedical nanogels

  2024cites this paper
• Incorporation of a self-immolative spacer enables mechanically triggered dual payload release

  2023cites this paper
• Advances of Smart Stimulus‐Responsive Microneedles in Cancer Treatment

  2023cites this paper
• Structural Determinants of Stimuli-Responsiveness in Amphiphilic Macromolecular Nano-assemblies.

  2023cites this paper
• Force‐Triggered Self‐Destructive Hydrogels

  2023cites this paper
• Spinning a Liquid Wheel and Driving Surface Thermomagnetic Convection with Light

  2023cites this paper
• Applications of Bioinspired Platforms for Enhancing Immunomodulatory Function of Mesenchymal Stromal Cells

  2023cites this paper
• Ultrasound-mediated nano-sized drug delivery systems for cancer treatment: Multi-scale and multi-physics computational modeling.

  2023cites this paper
• Ductile adhesive elastomers with force-triggered ultra-high adhesion strength.

  2023cites this paper
• Development of delivery strategies for CRISPR‐Cas9 genome editing

  2023cites this paper
• Drug Delivery Systems for Personal Healthcare by Smart Wearable Patch System

  2023cites this paper
• Stimuli-Responsive Functional Micro-/Nanorobots: A Review.

  2023cites this paper
• Multimechanophore Polymers for Mechanically Triggered Small Molecule Release with Ultrahigh Payload Capacity

  2023cites this paper
• Mechanisms of mechanical force aggravating periodontitis: A review.

  2023cites this paper
• Research progress of advanced microneedle drug delivery system and its application in biomedicine.

  2023cites this paper
• Cancer Models on Chip: Paving the Way to Large‐Scale Trial Applications

  2023cites this paper
• Electrophoretic deposition of coatings for local delivery of therapeutic agents

  2023cites this paper
• Ultrasound-mediated nano drug delivery for treating cancer: Fundamental physics to future directions.

  2023cites this paper
• Liposomes Under Shear: Structure, Dynamics, and Drug Delivery Applications

  2023cites this paper
• Breathing-induced stretch enhances the efficacy of an inhaled and orally delivered anti-fibrosis drug in vitro

  2023cites this paper
• Dual drug-loaded PLGA fibrous scaffolds for effective treatment of breast cancer in situ.

  2023cites this paper
• Mechanoresponsive Drug Delivery Systems for Vascular Diseases.

  2023cites this paper
• Functionalisation of Electrospun Cellulose Acetate Membranes with PEDOT and PPy for Electronic Controlled Drug Release

  2023cites this paper
• Smart Biomaterials for Articular Cartilage Repair and Regeneration

  2023cites this paper