Temporal relationship of peroxynitrite-induced oxidative damage, calpain-mediated cytoskeletal degradation and neurodegeneration after traumatic brain injury.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Experimental Neurology

• Publication date

  2007-05-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/J.EXPNEUROL.2007.01.023PMID 17349624PMCID PMC1950332
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Role of peroxynitrite in secondary oxidative damage after spinal cord injury

  2007cited by this paper
• Inhibition of Caspase-Mediated Apoptosis by Peroxynitrite in Traumatic Brain Injury

  2006cited by this paper
• Relationship of calpain-mediated proteolysis to the expression of axonal and synaptic plasticity markers following traumatic brain injury in mice.

  2006cited by this paper
• Traumatic mechanical injury to the hippocampus in vitro causes regional caspase-3 and calpain activation that is influenced by NMDA receptor subunit composition.

  2006cited by this paper
• Nitric oxide and peroxynitrite induce cellular death in bovine chromaffin cells: Evidence for a mixed necrotic and apoptotic mechanism with caspases activation

  2006cited by this paper
• Time Course of Post-Traumatic Mitochondrial Oxidative Damage and Dysfunction in a Mouse Model of Focal Traumatic Brain Injury: Implications for Neuroprotective Therapy

  2006cited by this paper
• Spatial and temporal characteristics of neurodegeneration after controlled cortical impact in mice: more than a focal brain injury.

  2005cited by this paper
• The critical role of calpain versus caspase activation in excitotoxic injury induced by nitric oxide

  2005cited by this paper
• Lack of a Gender Difference in Post-Traumatic Neurodegeneration in the Mouse Controlled Cortical Impact Injury Model

  2005cited by this paper
• Peroxynitrite-Mediated Protein Nitration and Lipid Peroxidation in a Mouse Model of Traumatic Brain Injury

  2004cited by this paper
• Peroxynitrite mediates calcium‐dependent mitochondrial dysfunction and cell death via activation of calpains

  2004cited by this paper
• Cytoskeletal protein degradation and neurodegeneration evolves differently in males and females following experimental head injury.

  2003cited by this paper
• Characterization and function of mitochondrial nitric-oxide synthase.

  2003influential reference
• Biochemistry of Mitochondrial Nitric-oxide Synthase*

  2002cited by this paper
• Peroxynitrite reactions and formation in mitochondria.

  2002cited by this paper
• Nitric oxide: an unconventional messenger in the nervous system of an orthopteroid insect.

  2001cited by this paper
• Calpain activity in the rat brain after transient forebrain ischemia.

  2001cited by this paper
• Induction of nitric oxide synthase by traumatic brain injury.

  2001cited by this paper
• Mitochondrial nitric oxide synthase is constitutively active and is functionally upregulated in hypoxia.

  2001cited by this paper
• Neuronal free Ca(2+)and BBB permeability and ultrastructure in head injury with secondary insult.

  2001cited by this paper
• Effects of the Nitrone Radical Scavengers PBN and S-PBN on In vivo Trapping of Reactive Oxygen Species after Traumatic Brain Injury in Rats

  2001cited by this paper
• Application of Silver Degeneration Stains for Neurotoxicity Testing

  2000cited by this paper
• Oxidative Stress Following Traumatic Brain Injury in Rats

  2000cited by this paper
• Direct evidence of nitric oxide presence within mitochondria.

  2000cited by this paper
• Calpain and caspase: can you tell the difference?, by Kevin K.W. Wang

  2000cited by this paper
• 4-Hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (Tempol) inhibits peroxynitrite-mediated phenol nitration.

  2000cited by this paper
• Calmodulin and Cyclic ADP-Ribose Interaction in Ca2+ Signaling Related to Cardiac Sarcoplasmic Reticulum: Superoxide Anion Radical-Triggered Ca2+ Release

  2000cited by this paper
• Calpain and caspase: can you tell the difference?, by kevin K.W. WangVol. 23, pp. 20-26

  2000cited by this paper
• Peroxynitrite formed by mitochondrial NO synthase promotes mitochondrial Ca2+ release.

  2000cited by this paper
• Temporal profiles and cellular sources of three nitric oxide synthase isoforms in the brain after experimental contusion.

  2000cited by this paper
• Calpain and caspase: can you tell the difference?

  2000cited by this paper
• Peroxynitrite Scavengers for the Acute Treatment of Traumatic Brain Injury

  1999cited by this paper
• Oxidant, mitochondria and calcium: an overview.

  1999cited by this paper
• Exacerbation of Damage and Altered NF-κB Activation in Mice Lacking Tumor Necrosis Factor Receptors after Traumatic Brain Injury

  1999cited by this paper
• Neuroprotective Properties of Nitric Oxide

  1999cited by this paper
• The Lipid Peroxidation Product 4‐Hydroxynonenal Inhibits Neurite Outgrowth, Disrupts Neuronal Microtubules, and Modifies Cellular Tubulin

  1999cited by this paper
• Cyclosporin A attenuates acute mitochondrial dysfunction following traumatic brain injury.

  1999cited by this paper
• Mitochondrial nitric-oxide synthase stimulation causes cytochrome c release from isolated mitochondria. Evidence for intramitochondrial peroxynitrite formation.

  1999cited by this paper
• Peroxynitrite reactions and diffusion in biology.

  1998cited by this paper
• Reduction of tyrosine nitration after N(omega)-nitro-L-arginine-methylester treatment of mice with traumatic brain injury.

  1998cited by this paper
• Oxidative Stress Inhibits Calpain Activity in Situ *

  1998cited by this paper
• Inducible nitric oxide synthase expression after traumatic brain injury and neuroprotection with aminoguanidine treatment in rats.

  1998cited by this paper
• Antioxidant, OPC-14117, attenuates edema formation, and subsequent tissue damage following cortical contusion in rats.

  1998cited by this paper
• Calpain: a protease in search of a function?

  1998cited by this paper
• Peroxynitrite: a biologically significant oxidant.

  1998cited by this paper
• Neuroprotection by nitric oxide against hydroxyl radical-induced nigral neurotoxicity.

  1998cited by this paper
• Mechanisms of calpain proteolysis following traumatic brain injury: implications for pathology and therapy: implications for pathology and therapy: a review and update.

  1997cited by this paper
• ‘Oxidation Inhibits Substrate Proteolysis by Calpain I but Not Autolysis*

  1997cited by this paper
• Oxidative stress following traumatic brain injury in rats.

  1997cited by this paper
• Nitric oxide synthase activity in mitochondria

  1997cited by this paper
• Expression of nitric oxide synthase in the cerebral microvasculature after traumatic brain injury in the rat.

  1997cited by this paper
• Immunocytochemical method for investigating in vivo neuronal oxygen radical-induced lipid peroxidation.

  1997cited by this paper
• Mechanisms of Calpain Proteolysis Following Traumatic Brain Injury: Implications for Pathology and Therapy: A Review and Update

  1997cited by this paper
• Oxidative damage and tyrosine nitration from peroxynitrite.

  1996cited by this paper
• Reduction of the Neurological Deficit in Mice with Traumatic Brain Injury by Nitric Oxide Synthase Inhibitors

  1996cited by this paper
• Cytoskeletal Derangements of Cortical Neuronal Processes Three Hours after Traumatic Brain Injury in Rats: An Immunofluorescence Study

  1996cited by this paper
• Cerebroprotective effect of stable nitroxide radicals in closed head injury in the rat.

  1996cited by this paper
• Calpain inhibitor AK295 attenuates motor and cognitive deficits following experimental brain injury in the rat.

  1996cited by this paper
• Nitric Oxide in Neuronal Degeneration

  1996cited by this paper
• Calpain as a novel target for treating acute neurodegenerative disorders.

  1995cited by this paper
• Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver.

  1995cited by this paper
• Nitric oxide signaling in the central nervous system.

  1995cited by this paper
• Glutamate Release and Free Radical Production Following Brain Injury: Effects of Posttraumatic Hypothermia

  1995cited by this paper
• Use of an amino-cupric-silver technique for the detection of early and semiacute neuronal degeneration caused by neurotoxicants, hypoxia, and physical trauma.

  1994cited by this paper
• Direct Measurement of Hydroxyl Radicals, Lipid Peroxidation, and Blood–Brain Barrier Disruption Following Unilateral Cortical Impact Head Injury in the Rat

  1994cited by this paper
• Inhibition of mitochondrial electron transport by peroxynitrite.

  1994cited by this paper
• Generation and Detection of Hydroxyl Radical Following Experimental Head Injury

  1994cited by this paper
• Brain Hydroxyl Radical Generation in Acute Experimental Head Injury

  1993cited by this paper
• Effect of hydrogen peroxide on calcium homeostasis in smooth muscle cells.

  1992cited by this paper
• Peroxidative stress effects on calpain activity in brain of young and adult rats.

  1992cited by this paper
• Calcium-activated neutral protease activities in brain trauma

  1991cited by this paper
• Reaction of NO with O2-. implications for the action of endothelium-derived relaxing factor (EDRF).

  1990cited by this paper
• Oxygen Radicals in Brain Injury

  1986cited by this paper
• Superoxide production in experimental brain injury.

  1986cited by this paper
• Free radicals in biology and medicine

  1985cited by this paper

• Development of a radioiodinated boronic acid probe for the detection of hydrogen peroxide and peroxynitrite

  2026cites this paper
• GFAP Degradation in TBI: Linking Novel Modified Products to Astrocyte Pathology and Patient Outcome

  2025influential citation
• From Acute Injury to Chronic Neurodegeneration: Molecular Mechanisms Linking Secondary Brain Injury to Long-Term Pathology

  2025cites this paper
• Time Course of Mitochondrial Antioxidant Markers in a Preclinical Model of Severe Penetrating Traumatic Brain Injury

  2025cites this paper
• Calpain in Traumatic Brain Injury: From Cinderella to Central Player

  2025influential citation
• Integrative Diagnostic and Prognostic Paradigms in Diffuse Axonal Injury: Insights from Clinical, Histopathological, Biomolecular, Radiological, and AI-Based Perspectives

  2025cites this paper
• Torsion-Induced Traumatic Optic Neuropathy (TITON): A physiologically relevant animal model of traumatic optic neuropathy

  2025cites this paper
• The neuroprotective potential of phytochemicals in traumatic brain injury: mechanistic insights and pharmacological implications

  2024cites this paper
• Mitochondria-Targeted Antioxidant Therapeutics for Traumatic Brain Injury

  2024cites this paper
• Cellular and Molecular Mechanisms and Innovative Neurostimulation Treatments in the Management of Traumatic Brain Injury

  2024cites this paper
• Torsion-Induced Traumatic Optic Neuropathy (TITON): A Physiologically Relevant Animal Model of Traumatic Optic Neuropathy

  2024cites this paper
• Spatial Measurement and Inhibition of Calpain Activity in Traumatic Brain Injury with an Activity-Based Nanotheranostic Platform

  2024cites this paper
• Protective effects of an anti-4-HNE monoclonal antibody against liver injury and lethality of endotoxemia in mice.

  2023cites this paper
• Oxidative stress in the brain and retina after traumatic injury

  2023influential citation
• Raman Spectroscopy as a Tool to Study the Pathophysiology of Brain Diseases

  2023cites this paper
• Identifying the Phenotypes of Diffuse Axonal Injury Following Traumatic Brain Injury

  2023cites this paper
• Repetitive mild traumatic brain injury-induced neurodegeneration and inflammation is attenuated by acetyl-L-carnitine in a preclinical model

  2023cites this paper
• Dietary (Poly)phenols in Traumatic Brain Injury

  2023cites this paper
• Tau Pathology, Metal Dyshomeostasis and Repetitive Mild Traumatic Brain Injury: An Unexplored Link Paving the Way for Neurodegeneration

  2022cites this paper
• Mitoquinone supplementation alleviates oxidative stress and pathologic outcomes following repetitive mild traumatic brain injury at a chronic time point.

  2022cites this paper
• Environmental enrichment improves traumatic brain injury-induced behavioral phenotype and associated neurodegenerative process.

  2022cites this paper
• Raman Spectroscopy as a Neuromonitoring Tool in Traumatic Brain Injury: A Systematic Review and Clinical Perspectives

  2022cites this paper
• Dynamic changes in Beclin-1, LC3B and p62 at various time points in mice with temporary middle cerebral artery occlusion and reperfusion (tMCAO).

  2021cites this paper
• Traumatic Brain Injury: Mechanistic Insight on Pathophysiology and Potential Therapeutic Targets

  2021influential citation
• Biomolecular changes and subsequent time-dependent recovery in hippocampal tissue after experimental mild traumatic brain injury

  2021cites this paper
• “Bioactive molecules isolated from olive pomace extract protect murine cortex neurons from NMDA- mediated cell death”

  2020cites this paper
• Mechanosensation in traumatic brain injury.

  2020cites this paper
• Early Cell Response to Mechanical Stimuli during TBI

  2020cites this paper
• Synchrotron Radiation-Based FTIR Microspectroscopic Imaging of Traumatically Injured Mouse Brain Tissue Slices

  2020cites this paper
• Early Cell Response to Mechanical Stimuli during TBI

  2020cites this paper
• Protective effects of phenelzine administration on synaptic and non-synaptic cortical mitochondrial function and lipid peroxidation-mediated oxidative damage following TBI in young adult male rats.

  2020cites this paper
• Pharmacological inhibition of lipid peroxidative damage by the 21-aminosteroid U-74389G improves cortical mitochondrial function following traumatic brain injury in young adult male rats.

  2020cites this paper
• Developing Successful Neuroprotective Treatments for TBI: Translational Approaches, Novel Directions, Opportunities and Challenges

  2020cites this paper
• Betulinic acid prevents lesion growth after venous ischemia in rats

  2020cites this paper
• Targeting PSD95-nNOS interaction by Tat-N-dimer peptide during status epilepticus is neuroprotective in MAM-pilocarpine rat model.

  2019cites this paper
• Effects of Phenelzine Administration on Mitochondrial Function, Calcium Handling, and Cytoskeletal Degradation after Experimental Traumatic Brain Injury

  2019cites this paper
• Traumatic Brain Injuries: Pathophysiology and Potential Therapeutic Targets

  2019cites this paper
• COX-2 Inhibition by Diclofenac Is Associated With Decreased Apoptosis and Lesion Area After Experimental Focal Penetrating Traumatic Brain Injury in Rats

  2019cites this paper
• NEUROPROTECTIVE STRATEGIES FOLLOWING EXPERIMENTAL TRAUMATIC BRAIN INJURY: LIPID PEROXIDATION-DERIVED ALDEHYDE SCAVENGING AND INHIBITION OF MITOCHONDRIAL PERMEABILITY TRANSITION

  2019influential citation
• Brain tissue saving effects by single-dose intralesional administration of Neuroprotectin D1 on experimental focal penetrating brain injury in rats.

  2019cites this paper
• Comparison of different extraction methods for polysaccharides from Dendrobium officinale stem.

  2018cites this paper
• Combined treatment with GSNO and CAPE accelerates functional recovery via additive antioxidant activities in a mouse model of TBI

  2018cites this paper
• CLARITY reveals a more protracted temporal course of axon swelling and disconnection than previously described following traumatic brain injury

  2018cites this paper
• Continuous Infusion of Phenelzine, Cyclosporine A, or Their Combination: Evaluation of Mitochondrial Bioenergetics, Oxidative Damage, and Cytoskeletal Degradation following Severe Controlled Cortical Impact Traumatic Brain Injury in Rats

  2018cites this paper
• Susceptibility to Oxidative Stress Is Determined by Genetic Background in Neuronal Cell Cultures

  2018cites this paper
• Synaptic Mitochondria are More Susceptible to Traumatic Brain Injury-induced Oxidative Damage and Respiratory Dysfunction than Non-synaptic Mitochondria.

  2018cites this paper
• Synaptic Mitochondria Sustain More Damage than Non-Synaptic Mitochondria after Traumatic Brain Injury and Are Protected by Cyclosporine A

  2017cites this paper
• Does Decorin Protect Neuronal Tissue via Its Antioxidant and Antiinflammatory Activity from Traumatic Brain Injury? An Experimental Study.

  2017cites this paper
• Chronic traumatic encephalopathy‐integration of canonical traumatic brain injury secondary injury mechanisms with tau pathology

  2017influential citation
• Geraniol promotes functional recovery and attenuates neuropathic pain in rats with spinal cord injury.

  2017cites this paper
• Nitric Oxide Donors in Brain Inflammation

  2017cites this paper
• Carbonyl Scavenging as an Antioxidant Neuroprotective Strategy for Acute Traumatic Brain Injury

  2017cites this paper
• Time courses of post‐injury mitochondrial oxidative damage and respiratory dysfunction and neuronal cytoskeletal degradation in a rat model of focal traumatic brain injury

  2017cites this paper
• Cellular Senescence in Mouse Hippocampus After Irradiation and the Role of p53 and p21

  2017cites this paper
• FeTPPS Reduces Secondary Damage and Improves Neurobehavioral Functions after Traumatic Brain Injury

  2017cites this paper
• Long-Term Effects of Sports Concussions: Bridging the Neurocognitive Repercussions of the Injury with the Newest Neuroimaging Data

  2017cites this paper
• The Role of Phosphodiesterase 4B in Inflammation after Traumatic Brain Injury

  2017cites this paper
• Application of FTIR spectroscopy for traumatic axonal injury: a possible tool for estimating injury interval

  2017cites this paper
• Lipid peroxidation in brain or spinal cord mitochondria after injury

  2016cites this paper
• Lipid peroxidation and tyrosine nitration in traumatic brain injury: Insights into secondary injury from redox proteomics

  2016cites this paper
• NOVEL TARGETS FOR MITOCHONDRIAL DYSFUNCTION FOLLOWING TRAUMATIC BRAIN INJURY

  2016cites this paper
• Targeting the nNOS/peroxynitrite/calpain system to confer neuroprotection and aid functional recovery in a mouse model of TBI.

  2016influential citation
• Mitigation of NADPH Oxidase 2 Activity as a Strategy to Inhibit Peroxynitrite Formation*

  2016cites this paper
• Enzyme Analysis of Oxidatively Modified Proteins Post-TBI

  2016cites this paper
• Traumatic Brain Injury Increases the Expression of Nos1, Aβ Clearance, and Epileptogenesis in APP/PS1 Mouse Model of Alzheimer’s Disease

  2016cites this paper
• Advanced and High-Throughput Method for Mitochondrial Bioenergetics Evaluation in Neurotrauma.

  2016cites this paper
• Oxidative stress in experimental traumatic brain injury

  2015cites this paper
• Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate

  2015cites this paper
• Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors

  2015cites this paper
• Characterization of Protein Alterations in Damaged Axons in the Brainstem Following Traumatic Brain Injury Using Fourier Transform Infrared Microspectroscopy: A Preliminary Study

  2015cites this paper
• Propofol Ameliorates Calpain-induced Collapsin Response Mediator Protein-2 Proteolysis in Traumatic Brain Injury in Rats

  2015influential citation
• Neuroprotective effects of N-acetylcysteine amide on experimental focal penetrating brain injury in rats.

  2015cites this paper
• Nrf2-ARE activator carnosic acid decreases mitochondrial dysfunction, oxidative damage and neuronal cytoskeletal degradation following traumatic brain injury in mice.

  2015cites this paper
• From THE DEPARTMENT OF NEUROSCIENCE Karolinska Institutet, Stockholm, Sweden OXIDATIVE STRESS IN EXPERIMENTAL TRAUMATIC BRAIN INJURY

  2015influential citation
• MITOCHONDRIAL AND NEUROPROTECTIVE EFFECTS OF PHENELZINE RELATED TO SCAVENGING OF NEUROTOXIC LIPID PEROXIDATION PRODUCTS

  2015influential citation
• Therapeutic Targeting of Neuronal Mitochondria in Brain Injury

  2015cites this paper
• Chemical Analysis in the Corpus Callosum Following Traumatic Axonal Injury using Fourier Transform Infrared Microspectroscopy: A Pilot Study

  2015cites this paper
• cRGD mediated liposomes enhanced antidepressant-like effects of edaravone in rats.

  2014cites this paper
• Activating Neural Stem and Progenitor Cells to Enhance Neural Repair

  2014cites this paper
• CALPAIN 5: A NON-CLASSICAL CALPAIN HIGHLY EXPRESSED IN THE CNS AND LOCALIZED TO MITOCHONDRIA AND NUCLEAR PML BODIES

  2014cites this paper
• Molecular Hydrogen in Drinking Water Protects against Neurodegenerative Changes Induced by Traumatic Brain Injury

  2014cites this paper
• The Cysteine Protease Cathepsin B Is a Key Drug Target and Cysteine Protease Inhibitors Are Potential Therapeutics for Traumatic Brain Injury

  2014cites this paper
• White Matter Injury in Global Cerebral Ischemia

  2014cites this paper
• Neural Resilience to Traumatic Brain Injury: Identification of Bioactive Metabolites of Docosahexaenoic Acids Involved in Neuroprotection and Recovery

  2014cites this paper
• Temporal and Spatial Dynamics of Nrf2-Antioxidant Response Elements Mediated Gene Targets in Cortex and Hippocampus after Controlled Cortical Impact Traumatic Brain Injury in Mice

  2014cites this paper
• Perspectives on Molecular Biomarkers of Oxidative Stress and Antioxidant Strategies in Traumatic Brain Injury

  2014cites this paper
• Alpha II Spectrin breakdown products in immature Sprague Dawley rat hippocampus and cortex after traumatic brain injury.

  2014cites this paper
• GLP-1 improves neuropathology after murine cold lesion brain trauma

  2014cites this paper
• Depletion of Brain Docosahexaenoic Acid Impairs Recovery from Traumatic Brain Injury

  2014cites this paper
• Different sham procedures for rats in traumatic brain injury experiments induce corresponding increases in levels of trauma markers.

  2013cites this paper
• Pharmacological analysis of the cortical neuronal cytoskeletal protective efficacy of the calpain inhibitor SNJ‐1945 in a mouse traumatic brain injury model

  2013cites this paper
• Attenuation of axonal injury and oxidative stress by edaravone protects against cognitive impairments after traumatic brain injury.

  2013cites this paper
• The Role of Free Radicals in Traumatic Brain Injury

  2013cites this paper
• Axonal pathology in traumatic brain injury.

  2013cites this paper
• Evolution of neuronal and astroglial disruption in the peri-contusional cortex of mice revealed by in vivo two-photon imaging.

  2013cites this paper
• The role of free radicals and reactive species following traumatic brain injury

  2013cites this paper
• Inhibition of Calpains by Calpastatin: Implications for Cellular and Functional Damage Following Traumatic Brain Injury

  2013cites this paper
• Administration of the Nrf2-ARE activators sulforaphane and carnosic acid attenuates 4-hydroxy-2-nonenal-induced mitochondrial dysfunction ex vivo.

  2013cites this paper
• Brain injury‐induced proteolysis is reduced in a novel calpastatin‐overexpressing transgenic mouse

  2013cites this paper
• Pathophysiology of traumatic brain injury.

  2013cites this paper