Insulin‐like growth factors, angiopoietin‐2, and pigment epithelium–derived growth factor in the hypoxic retina

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Neuroscience Research

• Publication date

  2008-02-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/jnr.21519PMID 17943991
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pigment epithelium‐derived factor acts as an opponent of growth‐stimulatory factors in retinal glial–endothelial cell interactions

  2007cited by this paper
• Insulinlike growth factor I affects ocular development: a study of untreated and treated patients with Laron syndrome.

  2006cited by this paper
• Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF-VEGF receptor 2 binding in diabetic retinopathy.

  2006cited by this paper
• The role of growth hormone, insulin-like growth factor and somatostatin in diabetic retinopathy.

  2006cited by this paper
• Early response of neurons and glial cells to hypoxia in the retina.

  2006influential reference
• Hypoxia-Inducible Factor-1-Dependent and -Independent Regulation of Insulin-Like Growth Factor-1-Stimulated Vascular Endothelial Growth Factor Secretion

  2006cited by this paper
• Geldanamycin treatment reduces neovascularization in a mouse model of retinopathy of prematurity

  2005cited by this paper
• Different effects of angiopoietin‐2 in different vascular beds in the eye: new vessels are most sensitive

  2005cited by this paper
• Pigment epithelium-derived factor is a substrate for matrix metalloproteinase type 2 and type 9: implications for downregulation in hypoxia.

  2005cited by this paper
• Regulation of hypoxia-inducible factor (HIF)-1 activity and expression of HIF hydroxylases in response to insulin-like growth factor I.

  2005cited by this paper
• Transcription factor Ets-1 mediates ischemia- and vascular endothelial growth factor-dependent retinal neovascularization.

  2004cited by this paper
• IGF-1-induced VEGF and IGFBP-3 secretion correlates with increased HIF-1 alpha expression and activity in retinal pigment epithelial cell line D407.

  2004cited by this paper
• The role of VEGF and IGF-1 in a hypercarbic oxygen-induced retinopathy rat model of ROP.

  2004cited by this paper
• PEDF derived from glial Müller cells: a possible regulator of retinal angiogenesis.

  2004cited by this paper
• Hypoxic Regulation of Angiopoietin-2 Expression in Endothelial Cells*

  2004cited by this paper
• Octreotide prevents growth factor-induced proliferation of bovine retinal endothelial cells under hypoxia.

  2004cited by this paper
• Autocrine effects of IGF-I-induced VEGF and IGFBP-3 secretion in retinal pigment epithelial cell line ARPE-19.

  2004cited by this paper
• Neuroprotective and antiangiogenic actions of PEDF in the eye: molecular targets and therapeutic potential.

  2004cited by this paper
• Differential expression of angioregulatory factors in normal and CNV-derived human retinal pigment epithelium

  2004cited by this paper
• Angiopoietin‐2 enhances retinal vessel sensitivity to vascular endothelial growth factor

  2004cited by this paper
• [Angiogenesis and its regulatory factors in brain tissue of neonatal rat hypoxic-ischemic encephalopathy].

  2004cited by this paper
• [Downregulation of the pigment epithelium derived factor by hypoxia and elevated glucose concentration in cultured human retinal pigment epithelial cells].

  2003cited by this paper
• Effect of over-expression of pigment epithelium derived factor (PEDF) on developing retinal vasculature in the mouse.

  2003cited by this paper
• Retinal angiogenesis is mediated by an interaction between the angiotensin type 2 receptor, VEGF, and angiopoietin.

  2003influential reference
• Retinal and choroidal angiogenesis: pathophysiology and strategies for inhibition.

  2003cited by this paper
• The effect of nitric oxide on retinal blood flow during hypoxia in cats.

  2002cited by this paper
• Insulin‐like growth factor‐1 effects on bovine retinal endothelial cell glucose transport: role of MAP kinase

  2002cited by this paper
• Biomedical significance of endothelial cell specific growth factor, angiopoietin

  2002cited by this paper
• Regression of ocular neovascularization in response to increased expression of pigment epithelium-derived factor.

  2002cited by this paper
• Angiopoietin‐2 plays an important role in retinal angiogenesis

  2002cited by this paper
• Inducible nitric oxide synthase mediates the change from retinal to vitreal neovascularization in ischemic retinopathy.

  2001cited by this paper
• Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: Direct correlation with clinical retinopathy of prematurity

  2001cited by this paper
• Insulin‐like growth factor‐I is a potential trophic factor for amacrine cells

  2001cited by this paper
• Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability

  2001cited by this paper
• Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

  2001cited by this paper
• Pigment epithelium-derived factor in the vitreous is low in diabetic retinopathy and high in rhegmatogenous retinal detachment.

  2001cited by this paper
• Loss of the antiangiogenic pigment epithelium-derived factor in patients with angiogenic eye disease.

  2001cited by this paper
• Vascular plasticity – the role of the angiopoietins in modulating ocular angiogenesis

  2001cited by this paper
• Insulin-Like Growth Factor-I Protects Axotomized Rat Retinal Ganglion Cells from Secondary Death via PI3-K-Dependent Akt Phosphorylation and Inhibition of Caspase-3 In Vivo

  2000cited by this paper
• Sensitivity of different vascular beds in the eye to neovascularization and blood-retinal barrier breakdown in VEGF transgenic mice.

  2000cited by this paper
• Inhibition of neuroretinal cell death by insulin-like growth factor-1 and its analogs.

  2000cited by this paper
• Administration of nerve growth factor, brain-derived neurotrophic factor and insulin-like growth factor-II protects phosphate-activated glutaminase in the ischemic and reperfused rat retinas.

  1999cited by this paper
• Pigment epithelium-derived factor: a potent inhibitor of angiogenesis.

  1999cited by this paper
• Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor

  1999influential reference
• Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma.

  1999cited by this paper
• Hypoxia and Vascular Endothelial Growth Factor Selectively Up-regulate Angiopoietin-2 in Bovine Microvascular Endothelial Cells*

  1999influential reference
• Vascular endothelial growth factor (VEGF) and its receptors

  1999cited by this paper
• Expressions of angiopoietins and Tie2 in human choroidal neovascular membranes.

  1999cited by this paper
• Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF.

  1999cited by this paper
• Hypoxia-inducible factor 1: master regulator of O2 homeostasis.

  1998cited by this paper
• Retinal hypoxia in long-term diabetic cats.

  1998cited by this paper
• Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia.

  1998cited by this paper
• Gene expression of insulin-like growth factor-I, its receptor and binding proteins in retina under hypoxic conditions.

  1998cited by this paper
• Growth factors and diabetic retinopathy.

  1997cited by this paper
• Regulation of Vascular Endothelial Growth Factor Expression by Insulin-Like Growth Factor I

  1997cited by this paper
• Decreased nitric oxide production accounts for secondary arteriolar constriction after retinal branch vein occlusion.

  1997cited by this paper
• Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.

  1997cited by this paper
• Localization of mRNAs for insulin-like growth factor-I (IGF-I), IGF-I receptor, and IGF binding proteins in rat eye.

  1996cited by this paper
• Vascular endothelial growth factor and retinal neovascularisation: a new therapeutic approach for diabetic retinopathy.

  1996cited by this paper
• Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate.

  1996cited by this paper
• Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity

  1995cited by this paper
• Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization.

  1995cited by this paper
• Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

  1995cited by this paper
• Insulin-like growth factor I acts as an angiogenic agent in rabbit cornea and retina: comparative studies with basic fibroblast growth factor

  1993cited by this paper
• Insulin‐like Growth Factor I as an Angiogenic Agent In Vivo and In Vitro Studies

  1993cited by this paper
• Antibodies defining rat endothelial cells: RECA-1, a pan-endothelial cell-specific monoclonal antibody.

  1992cited by this paper
• Is Insulinlike Growth Factor I Associated With Diabetic Retinopathy?

  1990cited by this paper
• Expression of IGF-I and IGF-II genes in the adult rat eye.

  1990cited by this paper
• Insulin-Like Growth Factors in Vitreous: Studies in Control and Diabetic Subjects with Neovascularization

  1986cited by this paper
• A CIOMS ethical code for animal experimentation.

  1985cited by this paper
• Clinical and experimental studies on retinal neovascularization. XXXIX Edward Jackson Memorial Lecture.

  1982cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• OCULAR PATHOLOGY IN MACROGLOBULINAEMIA.

  1963cited by this paper
• Retinal vascularization in health and disease: Proctor Award Lecture of the Association for Research in Ophthalmology.

  1957cited by this paper
• Oxygen studies in retrolental fibroplasia. II. The production of the microscopic changes of retrolental fibroplasia in experimental animals.

  1953cited by this paper
• Oxygen studies in retrolental fibroplasia.

  1953cited by this paper
• The mode of development of the vascular system of the retina, with some observations on its significance for certain retinal diseases

  1948cited by this paper

• Role of Angiogenesis in Retinal Diseases and New Advances in Drug Development

  2025cites this paper
• Loss of Pigment Epithelium Derived Factor Sensitizes C57BL/6J Mice to Light-Induced Retinal Damage

  2024cites this paper
• Pharmacognostic Evaluation of Curcumin on Diabetic Retinopathy in Alloxan-induced Diabetes through NF-KB and Brn3a Related Mechanism

  2018cites this paper
• Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells

  2016cites this paper
• Role of the retinal vascular endothelial cell in ocular disease.

  2013cites this paper
• Vasotrophic regulation of age-dependent hypoxic cerebrovascular remodeling.

  2013cites this paper
• Icariin Ameliorates Streptozotocin-Induced Diabetic Retinopathy in Vitro and in Vivo

  2012cites this paper
• Hypoxia‐induced upregulation of pigment epithelium‐derived factor by retinal glial (Müller) cells

  2012influential citation
• Glycomic Signature of Mouse Embryonic Stem Cells During Differentiation

  2012cites this paper
• Oxygen sensing mechanisms in retinal vascular development and disease

  2012cites this paper
• Nuclear lamins are differentially expressed in retinal neurons of the adult rat retina

  2011cites this paper
• Oxygen Sensing in Retinal Health and Disease

  2011cites this paper
• A role for photoreceptors in retinal oedema and angiogenesis: an additional explanation for laser treatment?

  2010cites this paper
• A porcine model of selective retinal capillary closure induced by embolization with fluorescent microspheres.

  2010cites this paper
• Gene expression within the amacrine cell layer of chicks after myopic and hyperopic defocus.

  2010cites this paper
• Effect of subconjuctival and intraocular bevacizumab injection on angiogenic gene expression levels in a mouse model of corneal neovascularization

  2009cites this paper
• Therapeutic monoclonal antibodies in ophthalmology.

  2009cites this paper
• Blood-retinal barrier in hypoxic ischaemic conditions: basic concepts, clinical features and management.

  2008cites this paper