CXCL13 is a plasma biomarker of germinal center activity

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2016-02-23

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.1520112113PMID 26908875PMCID PMC4790995
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Germinal Centers

  2017cited by this paper
• Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort

  2016cited by this paper
• D-101 HIV-1 neutralizing antibodies induced by native-like envelope trimers

  2016cited by this paper
• Cutting Edge: T Follicular Helper Cell Differentiation Is Defective in the Absence of Bcl6 BTB Repressor Domain Function

  2015cited by this paper
• Antibody responses to envelope glycoproteins in HIV-1 infection

  2015cited by this paper
• New approaches to HIV vaccine development.

  2015cited by this paper
• Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen

  2015cited by this paper
• CXCL13 antibody for the treatment of autoimmune disorders

  2015cited by this paper
• HIV-1 Single-Stranded RNA Induces CXCL13 Secretion in Human Monocytes via TLR7 Activation and Plasmacytoid Dendritic Cell–Derived Type I IFN

  2015cited by this paper
• HIV-1 neutralizing antibodies induced by native-like envelope trimers

  2015cited by this paper
• Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice.

  2015cited by this paper
• Decreased T Follicular Regulatory Cell/T Follicular Helper Cell (TFH) in Simian Immunodeficiency Virus–Infected Rhesus Macaques May Contribute to Accumulation of TFH in Chronic Infection

  2015cited by this paper
• T follicular helper cell differentiation, function, and roles in disease.

  2014influential reference
• Early Preservation of CXCR5+ PD-1+ Helper T Cells and B Cell Activation Predict the Breadth of Neutralizing Antibody Responses in Chronic HIV-1 Infection

  2014cited by this paper
• Diminished Viral Control during Simian Immunodeficiency Virus Infection Is Associated with Aberrant PD-1hi CD4 T Cell Enrichment in the Lymphoid Follicles of the Rectal Mucosa

  2014cited by this paper
• Early Lymphoid Responses and Germinal Center Formation Correlate with Lower Viral Load Set Points and Better Prognosis of Simian Immunodeficiency Virus Infection

  2014cited by this paper
• Structural basis for the prion-like MAVS filaments in antiviral innate immunity

  2014cited by this paper
• Clonal selection in the germinal centre by regulated proliferation and hypermutation

  2014cited by this paper
• PD-1HIGH Follicular CD4 T Helper Cell Subsets Residing in Lymph Node Germinal Centers Correlate with B Cell Maturation and IgG Production in Rhesus Macaques

  2014cited by this paper
• Progress in HIV-1 vaccine development.

  2014cited by this paper
• Induction of ICOS+CXCR3+CXCR5+ TH Cells Correlates with Antibody Responses to Influenza Vaccination

  2013cited by this paper
• Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization.

  2013cited by this paper
• The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies

  2013cited by this paper
• Effects of CXCL13 inhibition on lymphoid follicles in models of autoimmune disease

  2013cited by this paper
• A randomized, double-blind, controlled trial of the 17D yellow fever virus vaccine given in combination with immune globulin or placebo: comparative viremia and immunogenicity.

  2013cited by this paper
• Macaque Paneth Cells Express Lymphoid Chemokine CXCL13 and Other Antimicrobial Peptides Not Previously Described as Expressed in Intestinal Crypts

  2013cited by this paper
• Bcl6 Expressing Follicular Helper CD4 T Cells Are Fate Committed Early and Have the Capacity To Form Memory

  2013cited by this paper
• Apoptosis and other immune biomarkers predict influenza vaccine responsiveness

  2013cited by this paper
• Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses.

  2013cited by this paper
• Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure.

  2013cited by this paper
• Expansion of HIV-specific T follicular helper cells in chronic HIV infection.

  2012cited by this paper
• A Blueprint for HIV Vaccine Discovery.

  2012cited by this paper
• Bcl6 and Maf Cooperate To Instruct Human Follicular Helper CD4 T Cell Differentiation

  2012influential reference
• Neutralizing Antibodies and Control of HIV: Moves and Countermoves

  2012cited by this paper
• Type I IFN Induced by Adenovirus Serotypes 28 and 35 Has Multiple Effects on T Cell Immunogenicity

  2012cited by this paper
• Germinal centers.

  2012cited by this paper
• Follicular dendritic cells help establish follicle identity and promote B cell retention in germinal centers

  2011cited by this paper
• HIV-DNA Priming Alters T Cell Responses to HIV-Adenovirus Vaccine Even When Responses to DNA Are Undetectable

  2011cited by this paper
• Programming the magnitude and persistence of antibody responses with innate immunity

  2010cited by this paper
• Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter.

  2010cited by this paper
• Serum BLC/CXCL13 Concentrations and Renal Expression of CXCL13/CXCR5 in Patients with Systemic Lupus Erythematosus and Lupus Nephritis

  2010cited by this paper
• Elevated Production of B Cell Chemokine CXCL13 is Correlated with Systemic Lupus Erythematosus Disease Activity

  2009cited by this paper
• Human Immunodeficiency Virus Type 1 Elite Neutralizers: Individuals with Broad and Potent Neutralizing Activity Identified by Using a High-Throughput Neutralization Assay together with an Analytical Selection Algorithm

  2009cited by this paper
• Germinal-center T-helper-cell markers PD-1 and CXCL13 are both expressed by neoplastic cells in angioimmunoblastic T-cell lymphoma.

  2009cited by this paper
• Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

  2009cited by this paper
• Increased serum levels of the chemokine CXCL13 and up-regulation of its gene expression are distinctive features of HCV-related cryoglobulinemia and correlate with active cutaneous vasculitis.

  2008cited by this paper
• Chemokine CXCL13 is overexpressed in the tumour tissue and in the peripheral blood of breast cancer patients

  2008cited by this paper
• Germinal-center organization and cellular dynamics.

  2007influential reference
• Innate Inflammatory Signals Induced by Various Pathogens Differentially Dictate the IFN-I Dependence of CD8 T Cells for Clonal Expansion and Memory Formation1

  2006cited by this paper
• Follicular B helper T cell activity is confined to CXCR5hiICOShi CD4 T cells and is independent of CD57 expression

  2006cited by this paper
• Serum Levels of the Homeostatic B Cell Chemokine, CXCL13, Are Elevated During HIV Infection

  2005cited by this paper
• Aberrant High Expression of B Lymphocyte Chemokine (Blc/Cxcl13) by C11b+Cd11c+ Dendritic Cells in Murine Lupus and Preferential Chemotaxis of B1 Cells towards Blc

  2001cited by this paper
• A chemokine-driven positive feedback loop organizes lymphoid follicles

  2000influential reference

• Prospective Biomarkers of SARS-CoV-2 Vaccine Seroconversion in Patients with Haematological Malignancies

  2026cites this paper
• Proteotranscriptomic Dissection of Breast Cancer T Cell States Identifies CD103+ Tfh-derived Cytotoxic Cells Linked to Immunotherapy Response

  2026cites this paper
• Co-expression pattern of CD8, CXCR5 and CXCL13 in tumor microenvironment predicts favorable efficacy of immunotherapy in lung adenocarcinoma.

  2026cites this paper
• Protein-Capturing Microgel-Integrated Microneedle Array Patches for Enhanced Tip-Loading, Storage Stability, and Transdermal Delivery of Recombinant Proteins.

  2026cites this paper
• Cigarette smoke exposure sets up a pro-inflammatory circuit in the lung that induces the hyper-activation of myelin-specific T helper cells

  2025cites this paper
• Lung NR3C1+ and CXCR6high T cells distinguish immunopathogenesis of human emphysema

  2025cites this paper
• Highly immunogenic DNA/LION nanocarrier vaccine potently activates lymph nodes inducing long-lasting immunity in macaques

  2025cites this paper
• T Peripheral Helper Cells in Lymphoid Aggregate and Tertiary Lymphoid Structure Formation

  2025cites this paper
• Myeloid cell recruitment and activation through systemic and mucosae‐directed cytokine therapy

  2025cites this paper
• Distinct features of a peripheral T helper subset that drives the B cell response in dengue virus infection

  2025cites this paper
• Coordinated circulating and tissue-based T cell responses precede xenograft rejection

  2025cites this paper
• Safety and Immunogenicity of aerosolized adenovirus-vectored COVID-19 vaccine and intramuscular mRNA vaccine bivalent boosters: a randomized open-label clinical trial

  2025cites this paper
• Prediction, prevention, and precision treatment of immune checkpoint inhibitor neurological toxicity using autoantibodies, cytokines, and microbiota

  2025cites this paper
• Single‐Cell Sequencing Reveals That CD4 + T Cells Eliminate Senescent Prostate Epithelium to Delay Progression of Benign Prostatic Hyperplasia

  2025cites this paper
• Activation of CXCR3+ Tfh cells and B cells in lymph nodes during acute HIV-1 infection correlates with HIV-specific antibody development

  2025cites this paper
• Biomarker expression level changes within rectal gut-associated lymphoid tissues in spinal cord-injured rats

  2025cites this paper
• A three-dose MVA-BN mpox vaccination series improves the quality of anti-monkeypox virus immunity

  2025cites this paper
• CXCL13 as a Prognostic Biomarker and Modulator of the Tumor Microenvironment in Colorectal Cancer

  2025cites this paper
• Persistent myeloid cell reprogramming despite miltefosine treatment in leishmania-infected macaques

  2025cites this paper
• Bronchus-associated lymphoid tissue: a review of its development and function, including recent findings on the impact of environmental particulate exposure

  2025cites this paper
• Mesenchymal stromal cells attenuate primary sjogren’s syndrome by modulating PD-1+CXCR5− T peripheral helper cells via galectin-1

  2025cites this paper
• Selective S1P Receptor Modulation in Multiple Sclerosis Alters CXCL13:CXCR5-Associated Immune Activities Without Impacting Anti-SARS-CoV-2 Immunity

  2025cites this paper
• New Mechanisms and Therapeutic Targets in Systemic Lupus Erythematosus

  2025cites this paper
• A safe, T cell-inducing heterologous vaccine against elephant endotheliotropic herpesvirus in a proof-of-concept study

  2025cites this paper
• CXCL13 as a Biomarker of Complex Common Variable Immunodeficiency

  2025cites this paper
• Follicular helper T cells (Tfh): heterogeneity in spatial distribution and phenotypic characteristics

  2025cites this paper
• Dysregulated lymphocyte localization in idiopathic multicentric Castleman disease

  2025cites this paper
• IL-1β signaling modulates T follicular helper and regulatory cells in human lymphoid tissues

  2025cites this paper
• High-dimensional single-cell phenotyping unveils persistent differences in immune cell profiles between severe and moderate seasonal influenza

  2025cites this paper
• Tissue‐Resident T Cells That Promote Humoral Immunity: Emerging From the Shadow of T Follicular Helper Cells

  2025cites this paper
• Adjunctive ruxolitinib attenuates inflammation and enhances antiparasitic immunity in human volunteers experimentally infected with Plasmodium falciparum

  2025cites this paper
• Modeling memory B cell responses in a lymphoid organ-chip to evaluate mRNA vaccine boosting

  2024cites this paper
• Sex-Based Differences in Thyroid Plasma B Cell Infiltration: Implications for Autoimmune Disease Susceptibility.

  2024cites this paper
• Chemokine CXCL13 facilitates anti-FVIII inhibitory antibody development in hemophilia A patients and murine models.

  2024cites this paper
• Tumor-specific antibodies elicited by engineered bacteria promote bladder cancer immunotherapy

  2024cites this paper
• CXCL13 promotes broad immune responses induced by circular RNA vaccines

  2024cites this paper
• Lymph Node-on-Chip Technology: Cutting-Edge Advances in Immune Microenvironment Simulation

  2024cites this paper
• Correlation of cTfh cells and memory B cells with AMR after renal transplantation.

  2024cites this paper
• High serum levels of CXCL13 predict lower response to csDMARDs in both ACPA-positive and ACPA-negative early rheumatoid arthritis.

  2024cites this paper
• Long trimer-immunization interval and appropriate adjuvant reduce immune responses to the soluble HIV-1-envelope trimer base

  2024cites this paper
• Immunogenicity and safety of an Entamoeba histolytica adjuvanted protein vaccine candidate (LecA+GLA-3M-052 liposomes) in rhesus macaques

  2024cites this paper
• Exploring the pathogenesis of RA through the gut‐articular axis‐dysbiosis a potential factor

  2024cites this paper
• The Laws of Attraction: Chemokines as Critical Mediators in Cancer Progression and Immunotherapy Response in Bladder Cancer

  2024cites this paper
• Cellular pathways and molecular events that shape autoantibody production in COVID-19.

  2024cites this paper
• Cell-Mediated Proteomics, and Serological and Mucosal Humoral Immune Responses after Seasonal Influenza Immunization: Characterization of Serological Responders and Non-Responders

  2024cites this paper
• The mechanism of gut-lung axis in pulmonary fibrosis

  2024cites this paper
• Disruption of IL-17-mediated immunosurveillance in the respiratory mucosa results in invasive Streptococcus pyogenes infection

  2024cites this paper
• Advances in the study of tertiary lymphoid structures in the immunotherapy of breast cancer

  2024cites this paper
• Pathogenic roles of follicular helper T cells in IgG4-related disease and implications for potential therapy

  2024cites this paper
• Upregulation of IL4‐induced gene 1 enzyme by B2 cells during melanoma progression impairs their antitumor properties

  2024cites this paper
• Preservation of memory B cell homeostasis in an individual producing broadly neutralising antibodies against HIV-1

  2024cites this paper
• Harnessing Immunomodulatory Polymers for Treatment of Autoimmunity, Allergy, and Transplant Rejection.

  2024cites this paper
• Interferon subverts an AHR–JUN axis to promote CXCL13+ T cells in lupus

  2024cites this paper
• The activity of tertiary lymphoid structures in high grade serous ovarian cancer is governed by site, stroma, and cellular interactions.

  2024cites this paper
• Antibody-mediated immunological memory correlates with long-term Lyme veterinary vaccine protection in mice

  2024cites this paper
• Immunology and targeted therapy in Castleman disease

  2024cites this paper
• Recapitulating memory B cell responses in a Lymphoid Organ-Chip to evaluate mRNA vaccine boosting strategies

  2024cites this paper
• Single-cell sequencing reveals immune features of treatment response to neoadjuvant immunochemotherapy in esophageal squamous cell carcinoma

  2024cites this paper
• C4BP(β-)-mediated immunomodulation attenuates inflammation in DSS-induced murine colitis and in myeloid cells from IBD patients.

  2023cites this paper
• Infection pre-Ad26.COV2.S-vaccination primes greater class switching and reduced CXCR5 expression by SARS-CoV-2-specific memory B cells

  2023cites this paper
• Early B cell development and B cell maturation are impaired in patients with active hemophagocytic lymphohistiocytosis.

  2023cites this paper
• MetaTiME: Meta-components of the Tumor Immune Microenvironment

  2023cites this paper
• Macrophage Implication in IPF: Updates on Immune, Epigenetic, and Metabolic Pathways

  2023cites this paper
• Host immunity associated with spontaneous suppression of viremia in therapy-naïve young rhesus macaques following neonatal SHIV infection

  2023cites this paper
• Advanced precision modeling reveals divergent responses of hepatocellular carcinoma to combinatorial immunotherapy

  2023cites this paper
• Repetitive mRNA vaccination is required to improve the quality of broad-spectrum anti–SARS-CoV-2 antibodies in the absence of CXCL13

  2023cites this paper
• MetaTiME integrates single-cell gene expression to characterize the meta-components of the tumor immune microenvironment

  2023cites this paper
• Neonatal SHIV infection in rhesus macaques elicited heterologous HIV-1-neutralizing antibodies

  2023cites this paper
• Cerebrospinal Fluid CXCL13 as Candidate Biomarker of Intrathecal Immune Activation, IgG Synthesis and Neurocognitive Impairment in People with HIV

  2023cites this paper
• Lymphoid stromal cells - potential implications for the pathogenesis of CVID

  2023influential citation
• HCC-1 accelerates atherosclerosis by inducing endothelial cells and macrophages pyroptosis and serves as an early diagnostic biomarker

  2023cites this paper
• Dysregulation of circulating CD4 + CXCR5 + PD-1+ T cells in diabetic retinopathy.

  2023cites this paper
• Revisiting the Role of the CXCL13/CXCR5-Associated Immune Axis in Melanoma: Potential Implications for Anti-PD-1-Related Biomarker Research

  2023cites this paper
• An mRNA-based T-cell-inducing antigen strengthens COVID-19 vaccine against SARS-CoV-2 variants

  2023cites this paper
• Identification of key biomarkers in RF-negative polyarticular and oligoarticular juvenile idiopathic arthritis by bioinformatic analysis

  2023cites this paper
• Rapid transient and longer-lasting innate cytokine changes associated with adaptive immunity after repeated SARS-CoV-2 BNT162b2 mRNA vaccinations

  2023cites this paper
• Obinutuzumab Effectively Depletes Key B-cell Subsets in Blood and Tissue in End-stage Renal Disease Patients

  2023cites this paper
• Conjugation of HIV-1 envelope to hepatitis B surface antigen alters vaccine responses in rhesus macaques

  2023cites this paper
• Immune checkpoint status and exhaustion‐related phenotypes of CD8+ T cells from the tumor‐draining regional lymph nodes in breast cancer

  2023cites this paper
• CXC chemokine ligand 13 and galectin-9 plasma levels collaboratively provide prediction of disease activity and progression-free survival in chronic lymphocytic leukemia

  2023cites this paper
• Immune surveillance and humoral immune responses in kidney transplantation – A look back at T follicular helper cells

  2023cites this paper
• Step-dose IL-7 treatment promotes systemic expansion of T cells and alters immune cell landscape in blood and lymph nodes

  2023cites this paper
• Vpr attenuates antiviral immune responses and is critical for full pathogenicity of SIVmac239 in rhesus macaques

  2023cites this paper
• Additive efficacy of a bispecific anti–TNF/IL-6 nanobody compound in translational models of rheumatoid arthritis

  2023cites this paper
• Efficacy and safety of iscalimab, a novel anti-CD40 monoclonal antibody, in moderate-to-severe myasthenia gravis: A phase 2 randomized study.

  2023cites this paper
• TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures.

  2022cites this paper
• Integrated analysis of prognostic immune-related genes in the tumor microenvironment of ovarian cancer

  2022cites this paper
• PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine

  2022cites this paper
• Baseline circulating unswitched memory B cells and B-cell related soluble factors are associated with overall survival in patients with clear cell renal cell carcinoma treated with nivolumab within the NIVOREN GETUG-AFU 26 study

  2022cites this paper
• The lymph node transcriptome of unicentric and idiopathic multicentric Castleman disease

  2022cites this paper
• The Correlation of CD4+ T-Lymphocyte Count and Chemokine Ligand 13 Levels in Human Immunodeficiency Virus Patients Receiving Anti-retrovirus Therapy in Sanglah Central General Hospital

  2022cites this paper
• Development and immunogenicity evaluation of porcine deltacoronavirus inactivated vaccine with different adjuvants in mice

  2022cites this paper
• Cervical lymph nodes and ovarian teratomas as germinal centres in NMDA receptor-antibody encephalitis

  2022cites this paper
• Effect of morroniside on the transcriptome profiles of rat in injured spinal cords.

  2022cites this paper
• Ectopic Lymphoid Follicle Formation and Human Seasonal Influenza Vaccination Responses Recapitulated in an Organ‐on‐a‐Chip

  2022cites this paper
• Articles Implications of the accumulation of CXCR5 NK cells in lymph nodes of HIV-1 infected patients

  2022cites this paper
• T follicular cells: the regulators of germinal centre homeostasis.

  2022cites this paper
• Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals

  2022cites this paper
• Potential Role of CXCL13/CXCR5 Signaling in Immune Checkpoint Inhibitor Treatment in Cancer

  2022cites this paper
• Long-Term Analysis of Pertussis Vaccine Immunity to Identify Potential Markers of Vaccine-Induced Memory Associated With Whole Cell But Not Acellular Pertussis Immunization in Mice

  2022cites this paper