Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Molecules and Cells

• Publication date

  2000-08-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S1097-2765(00)00037-XPMID 10983984
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A Novel Positive Feedback Loop Mediated by the Docking Protein Gab1 and Phosphatidylinositol 3-Kinase in Epidermal Growth Factor Receptor Signaling

  2000cited by this paper
• Signaling by distinct classes of phosphoinositide 3-kinases.

  1999cited by this paper
• DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides.

  1999cited by this paper
• The pleckstrin homology domains of protein kinase B and GRP1 (general receptor for phosphoinositides-1) are sensitive and selective probes for the cellular detection of phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 3,4,5-trisphosphate in vivo.

  1999cited by this paper
• Distinct Phosphatidylinositol 3-Kinase Lipid Products Accumulate upon Oxidative and Osmotic Stress and Lead to Different Cellular Responses*

  1999cited by this paper
• Akt/PKB localisation and 3' phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction.

  1999cited by this paper
• Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate.

  1999cited by this paper
• Expression Cloning of Protein Targets for 3-Phosphorylated Phosphoinositides*

  1999cited by this paper
• Phosphatidylinositol 3-Kinase-dependent Membrane Association of the Bruton’s Tyrosine Kinase Pleckstrin Homology Domain Visualized in Single Living Cells*

  1999cited by this paper
• Phosphatidylinositol‐3,4,5‐trisphosphate (PtdIns‐3,4,5‐P3)/Tec kinase‐dependent calcium signaling pathway: a target for SHIP‐mediated inhibitory signals

  1998cited by this paper
• Identification and analysis of PH domain‐containing targets of phosphatidylinositol 3‐kinase using a novel in vivo assay in yeast

  1998cited by this paper
• Pleckstrin homology domains.

  1998cited by this paper
• Nerve growth factor- and epidermal growth factor-stimulated translocation of the ADP-ribosylation factor-exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of phosphatidylinositol 3-kinase and the GRP1 pleckstrin homology domain.

  1998cited by this paper
• SHIP modulates immune receptor responses by regulating membrane association of Btk.

  1998cited by this paper
• Crystallography & NMR system: A new software suite for macromolecular structure determination.

  1998cited by this paper
• Pleckstrin homology domains: a common fold with diverse functions.

  1998cited by this paper
• Specificity and Promiscuity in Phosphoinositide Binding by Pleckstrin Homology Domains*

  1998cited by this paper
• Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.

  1998cited by this paper
• Activation of phospholipase Cγ by PI 3‐kinase‐induced PH domain‐mediated membrane targeting

  1998cited by this paper
• A Novel Integrin-activated Pathway Forms PKB/Akt- stimulatory Phosphatidylinositol 3,4-Bisphosphate via Phosphatidylinositol 3-Phosphate in Platelets*

  1998cited by this paper
• [20] Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• [33] AMoRe: An automated molecular replacement program package.

  1997cited by this paper
• High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity*

  1997cited by this paper
• Characterization of the pleckstrin homology domain of Btk as an inositol polyphosphate and phosphoinositide binding domain.

  1997cited by this paper
• Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

  1997cited by this paper
• Raster3D: photorealistic molecular graphics.

  1997cited by this paper
• Signaling by Phosphoinositide-3,4,5-Trisphosphate Through Proteins Containing Pleckstrin and Sec7 Homology Domains

  1997cited by this paper
• Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.

  1996cited by this paper
• Methods used in the structure determination of bovine mitochondrial F1 ATPase.

  1996cited by this paper
• Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain.

  1995cited by this paper
• Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain.

  1995cited by this paper
• Specificity of the purified inositol (1,3,4,5) tetrakisphosphate‐binding protein from porcine platelets

  1995cited by this paper
• Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation.

  1995cited by this paper
• Crystal structure at 2.2 A resolution of the pleckstrin homology domain from human dynamin.

  1994cited by this paper
• Solution structure of a pleckstrin-homology domain

  1994cited by this paper
• Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system?

  1993cited by this paper
• Improved methods for building protein models in electron density maps and the location of errors in these models.

  1991cited by this paper
• Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

  1991cited by this paper
• A program to produce both detailed and schematic plots of protein structures

  1991cited by this paper
• Culture Medium for Enterobacteria

  1974cited by this paper

• A new functional assay reveals that membrane binding is critical for overactivation of the phosphoinositide 3-kinase H1047R mutant.

  2026cites this paper
• Structural and mechanistic basis of mTORC2 activation of protein kinase AKT/PKB.

  2026cites this paper
• Vacuolar Phosphatidylinositol 3,4,5-trisphosphate controls fusion through binding Vam7, and membrane microdomain assembly

  2025cites this paper
• The Structural Basis for Pacs1-Wdr37 Complex Assembly and Stability

  2025cites this paper
• Lysosomal PIP3 revealed by genetically encoded lipid biosensors

  2025cites this paper
• Cooperativity of PIP2 and PS Lipids Modulates PH Domain Binding.

  2025cites this paper
• Discovery of novel inhibitors targeting the PH domain of PcORP1: Virtual screening, structural optimization, biological evaluation.

  2025cites this paper
• Linking phosphoinositide function to mitosis.

  2024cites this paper
• Structural investigation of Trypanosoma cruzi Akt-like kinase as drug target against Chagas disease

  2024influential citation
• Gossypium hirsutum gene of unknown function Gohir.A03G007700.1 encodes a potential VAN3-binding protein with a phosphoinositide-binding site

  2023cites this paper
• Glucuronic acid metabolites of phenolic acids target AKT-PH domain to improve glucose metabolism

  2023cites this paper
• Alchemical Free Energy Calculations on Membrane-Associated Proteins

  2023cites this paper
• FERM domains recruit ample PI(4,5)P2s to form extensive protein-membrane attachments.

  2023cites this paper
• Switching Roles: Beneficial Effects of Adipose Tissue-Derived Mesenchymal Stem Cells on Microglia and Their Implication in Neurodegenerative Diseases

  2022cites this paper
• The type Iα inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane

  2022cites this paper
• Specific interactions of peripheral membrane proteins with lipids: what can molecular simulations show us?

  2022cites this paper
• Two cooperative binding sites sensitize PI(4,5)P2 recognition by the tubby domain

  2022cites this paper
• Resurgence of phosphotyrosine binding domains: Structural and functional properties essential for understanding disease pathogenesis.

  2021cites this paper
• Systematic simulation of the interactions of pleckstrin homology domains with membranes

  2021cites this paper
• A second PI(4,5)P2 binding site determines PI(4,5)P2 sensitivity of the tubby domain

  2020cites this paper
• It Takes Two to Tango: Activation of Protein Kinase D by Dimerization

  2020cites this paper
• Multiple lipid binding sites determine the affinity of PH domains for phosphoinositide-containing membranes

  2020cites this paper
• Structure of the bovine BBSome complex

  2020cites this paper
• Nuclear Phosphatidylinositol 3,4,5-Trisphosphate Interactome Uncovers an Enrichment in Nucleolar Proteins

  2020cites this paper
• Structural basis for the association of PLEKHA7 with membrane-embedded phosphatidylinositol lipids

  2020cites this paper
• Coordination of Grp1 recruitment mechanisms by its phosphorylation

  2020cites this paper
• The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple Negative Breast Cancer.

  2020cites this paper
• A Legionella effector kinase is activated by host inositol hexakisphosphate

  2020cites this paper
• Identification of PtdIns(3,4)P2 effectors in human platelets using quantitative proteomics.

  2019cites this paper
• Defining the molecular mechanisms mediating class IA phosphoinositide 3-kinase (PI3K) regulation and their role in human disease

  2019cites this paper
• Research progress on oxysterol binding protein based novel piperidinylthiazole pesticide development

  2019cites this paper
• Structure and activation mechanism of the BBSome membrane protein trafficking complex

  2019cites this paper
• Structure, activation and biological effects of AKT or protein kinase B

  2019cites this paper
• Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes

  2019cites this paper
• Free Energy of Binding of GRP 1 PH Domain with Phosphatidylinositol Phosphate-Containing Model Bilayers

  2018cites this paper
• Syntrophins entangled in cytoskeletal meshwork: Helping to hold it all together

  2018cites this paper
• Exploration des mécanismes responsables de la dichotomie entre la chimiotaxie et la division cellulaire

  2018cites this paper
• Modeling, dynamics and phosphoinositide binding of the pleckstrin homology domain of two novel PLCs: η1 and η2.

  2018cites this paper
• Structure of the tandem PX-PH domains of Bem3 from Saccharomyces cerevisiae

  2018cites this paper
• Polyphosphoinositide-Binding Domains: Insights from Peripheral Membrane and Lipid-Transfer Proteins.

  2018cites this paper
• The Binding Mechanism Between Inositol Phosphate (InsP) and the Jasmonate Receptor Complex: A Computational Study

  2018cites this paper
• Molecular Dissection of Neurobeachin Function at Excitatory Synapses

  2018cites this paper
• Dynamic interactions between a membrane binding protein and lipids induce fluctuating diffusivity

  2017cites this paper
• Structural Dynamics Control Allosteric Activation of Cytohesin Family Arf GTPase Exchange Factors

  2017cites this paper
• PI3K-Akt Signal Transduction Molecules Maybe Involved in Downregulation of Erythroblasts Apoptosis and Perifosine Increased Its Apoptosis in Chronic Mountain Sickness

  2017cites this paper
• Computational and theoretical approaches for studies of a lipid recognition protein on biological membranes

  2017cites this paper
• CARMIL family proteins as multidomain regulators of actin-based motility

  2017cites this paper
• Aromatic amino acids and their relevance in the specificity of the PH domain

  2017cites this paper
• Vesicular PtdIns(3,4,5)P3 and Rab7 are key effectors of sea urchin zygote nuclear membrane fusion

  2017cites this paper
• Modes of Interaction of Pleckstrin Homology Domains with Membranes: Toward a Computational Biochemistry of Membrane Recognition.

  2017cites this paper
• Phosphatidylinositol 3-phosphate–binding protein AtPH1 controls the localization of the metal transporter NRAMP1 in Arabidopsis

  2017cites this paper
• Phospholipid binding to the FAK catalytic domain impacts function

  2017cites this paper
• Structural insights into nonvesicular lipid transport by the oxysterol binding protein homologue family.

  2016cites this paper
• Regulation of B cell metabolic activation, germinal center responses and autoimmunity by Tandem PH domain-containing proteins

  2016cites this paper
• Computational studies of the binding profile of phosphoinositide PtdIns (3,4,5) P3 with the pleckstrin homology domain of an oomycete cellulose synthase

  2016cites this paper
• Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway.

  2016cites this paper
• Interactions of Pleckstrin Homology Domains with Membranes: Adding Back the Bilayer via High-Throughput Molecular Dynamics

  2016cites this paper
• Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.

  2016influential citation
• Association of Peripheral Membrane Proteins with Membranes: Free Energy of Binding of GRP1 PH Domain with Phosphatidylinositol Phosphate-Containing Model Bilayers.

  2016cites this paper
• Structure and lipid-binding properties of the kindlin-3 pleckstrin homology domain

  2016cites this paper
• Ionic Hydrogen Bonds and Lipid Packing Defects Determine the Binding Orientation and Insertion Depth of RecA on Multicomponent Lipid Bilayers.

  2016cites this paper
• Role of Host Type IA Phosphoinositide 3-Kinase Pathway Components in Invasin-Mediated Internalization of Yersinia enterocolitica

  2016cites this paper
• Phosphatidylinositol-3-phosphate is light-regulated and essential for survival in retinal rods

  2016cites this paper
• Synthesis of an inositol hexakisphosphate (IP6) affinity probe to study the interactome from a colon cancer cell line.

  2016cites this paper
• Novel Inhibitors Induce Large Conformational Changes of GAB1 Pleckstrin Homology Domain and Kill Breast Cancer Cells

  2015influential citation
• Phosphoinositide binding by the SNX27 FERM domain regulates its localization at the immune synapse of activated T-cells

  2015cites this paper
• Anomalous Dynamics of a Lipid Recognition Protein on a Membrane Surface

  2015cites this paper
• Specificity of Collybistin-Phosphoinositide Interactions

  2015cites this paper
• Membrane and Protein Interactions of the Pleckstrin Homology Domain Superfamily

  2015cites this paper
• Phosphoinositide-dependent perimembrane mechanisms of regulating cellular processes

  2015cites this paper
• Structural basis of dynamic membrane recognition by trans-Golgi network specific FAPP proteins.

  2015cites this paper
• Bridging of partially negative atoms by hydrogen bonds from main‐chain NH groups in proteins: The crown motif

  2015cites this paper
• Intracellular Generation of Reactive Oxygen Species during Testicular Ischemia Reperfusion Injury and Effectiveness of Antioxidants in Rats.

  2014cites this paper
• An Integrated Structural Mechanism for Relief of Autoinhibition and Membrane Targeting in Cytohesin Family Guanine Nucleotide Exchange Factors: A Dissertation

  2014cites this paper
• Elucidation of different inhibition mechanism of small chemicals on PtdInsP-binding domains using in silico docking experiments.

  2014cites this paper
• University of Birmingham Structural insights into the activation of the RhoA GTPase by the Lymphoid blast crisis (Lbc) oncoprotein

  2014cites this paper
• Crystal structure of the Rab9A-RUTBC2 RBD complex reveals the molecular basis for the binding specificity of Rab9A with RUTBC2.

  2014cites this paper
• Chemical Inhibitors of Phosphatidylinositol Transfer Proteins Enable Highly Selective Interference With Specific Pathways of Phosphoinositide Signaling in Cells

  2014cites this paper
• The links between AKT and two intracellular proteolytic cascades: ubiquitination and autophagy.

  2014cites this paper
• Specificity and commonality of the phosphoinositide-binding proteome analyzed by quantitative mass spectrometry.

  2014cites this paper
• TIPE3 is the transfer protein of lipid second messengers that promote cancer.

  2014cites this paper
• Turning off AKT: PHLPP as a drug target.

  2014influential citation
• Homology Fold Adopt a Pleckstrin Toxoplasma gondii Replication of the Apicomplexan Parasite Sub-compartment Proteins Critical for The Inner Membrane Complex Protein Structure and Folding :

  2014cites this paper
• MeTaDoR: Online Resource and Prediction Server for Membrane Targeting Peripheral Proteins

  2014cites this paper
• The Inner Membrane Complex Sub-compartment Proteins Critical for Replication of the Apicomplexan Parasite Toxoplasma gondii Adopt a Pleckstrin Homology Fold*

  2014cites this paper
• Chemical and Physical Determinants of Cell Migration

  2014cites this paper
• The Cdc42 Guanine Nucleotide Exchange Factor FGD6 Coordinates Cell Polarity and Endosomal Membrane Recycling in Osteoclasts*

  2014cites this paper
• Structural basis for PI(4)P-specific membrane recruitment of the Legionella pneumophila effector DrrA/SidM.

  2014cites this paper
• A PH domain in ACAP1 possesses key features of the BAR domain in promoting membrane curvature.

  2014cites this paper
• Lipid-mediated Protein Signaling

  2013cites this paper
• Synergistic Activation of p21-activated Kinase 1 by Phosphatidylinositol 4,5-Bisphosphate and Rho GTPases*

  2013cites this paper
• Functional characterization of cancer-associated Gab1 mutations

  2013cites this paper
• CARMIL leading edge localization depends on a non-canonical PH domain and dimerization

  2013cites this paper
• Structural Insights into the Activation of the RhoA GTPase by the Lymphoid Blast Crisis (Lbc) Oncoprotein

  2013cites this paper
• Structural basis for autoinhibition of the guanine nucleotide exchange factor FARP2.

  2013influential citation
• Role of phosphatidylinositol 3,4,5-trisphosphate in cell signaling.

  2013cites this paper
• Elucidating G protein signaling and ubiquitin conjugation in Entamoeba histolytica

  2013cites this paper
• Role of PTEN in modulation of ADP-dependent signaling pathways in vascular endothelial cells.

  2013cites this paper
• Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors

  2013cites this paper
• Structural Analysis of Pathogenic Variations and Their Prevalence Across Protein-Protein Interface Regions of Human BTK Protein

  2013cites this paper