The effect of blood flow promoting drugs on cochlear blood flow, perilymphatic pO(2) and auditory function in the normal and noise-damaged hypoxic and ischemic guinea pig inner ear.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Hearing Research

• Publication date

  2000-03-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/S0378-5955(00)00005-8PMID 10713508
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Laser-Doppler Blood Flowmetry

  2010cited by this paper
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  2008cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2000cited by this paper
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  1999cited by this paper
• Successful Treatment of Noise‐Induced Cochlear Ischemia, Hypoxia, and Hearing Loss

  1999cited by this paper
• Leupeptin protects sensory hair cells from acoustic trauma.

  1999cited by this paper
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  1998cited by this paper
• The vascular mechanism of action of betahistine in the inner ear of the guinea pig

  1998cited by this paper
• Sarthran Preserves Cochlear Microcirculation and Reduces Temporary Threshold Shifts after Noise Exposure

  1998cited by this paper
• Therapeutic potential of histamine H3 receptor agonists and antagonists.

  1998cited by this paper
• Pentoxifylline and skin inflammation

  1998cited by this paper
• Effects of nimodipine on noise-induced hearing loss.

  1998cited by this paper
• Effect of isobaric oxygen versus hyperbaric oxygen on the normal and noise-damaged hypoxic and ischemic guinea pig inner ear.

  1998cited by this paper
• A review of 12 commonly used medicinal herbs.

  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
• Magnesium: Current Status and New Developments

  1997cited by this paper
• Energy metabolism in cochlear outer hair cells in vitro.

  1997cited by this paper
• Physiopathology of H3-receptors and pharmacology of betahistine.

  1997cited by this paper
• Effect of hyperbaric oxygen treatment on permanent threshold shift in acoustic trauma among rats.

  1997cited by this paper
• Protective Effects of Magnesium on Inner Ear Blood Flow in the Acoustic Trauma. Animal Studies

  1997cited by this paper
• Calcium Channel Blockade Reduces Noise‐Induced Vascular Permeability in Cochlear Stria Vascularis

  1997cited by this paper
• R-phenylisopropyladenosine attenuates noise-induced hearing loss in the chinchilla.

  1997cited by this paper
• [The rheological properties of hydroxyethyl starch].

  1997cited by this paper
• International Union of Pharmacology. XIII. Classification of histamine receptors.

  1997cited by this paper
• The effect of methylprednisolone on acoustic trauma.

  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1994cited by this paper
• Pentoxifylline.

  1994cited by this paper
• [Inner ear blood flow with betahistine--an animal experiment study].

  1994cited by this paper
• Lipid peroxidation inhibitor attenuates noise-induced temporary threshold shifts.

  1994cited by this paper
• Pentoxifylline for Intermittent Claudication

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  1993cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1989cited by this paper
• [A study using laser-Doppler velocimetry of modifications of the labyrinthine microcirculation induced by chemical and physical stimuli].

  1989cited by this paper
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  1988cited by this paper
• The effects of pentoxifylline on cochlear blood flow in normotensive and spontaneously hypertensive rats.

  1988cited by this paper
• Control of inner ear blood flow.

  1988cited by this paper
• Recent Advances in Cochlear Blood Flow Measurements

  1988cited by this paper
• [Calcium antagonists and damage to the organ of Corti in acoustic trauma].

  1987cited by this paper
• Effect of hemodilution on cochlear blood flow measured by laser-Doppler flowmetry.

  1987cited by this paper
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  1986cited by this paper
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  1984cited by this paper
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  1984cited by this paper
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  2019cites this paper
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  2019cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2014cites this paper
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  2008cites this paper
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  2007cites this paper
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  2007influential citation
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  2007cites this paper
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  2007cites this paper
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  2007cites this paper
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  2006cites this paper
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  2005cites this paper
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  2005influential citation
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  2005cites this paper
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  2005cites this paper
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  2005cites this paper
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  2005cites this paper
• [Inner ear damage due to leisure and broadband noise. An experimental study on initial and permanent functional and morphological damage].

  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2003cites this paper
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  2003cites this paper
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  2003cites this paper
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  2003cites this paper
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  2003cites this paper
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  2002cites this paper