O-GlcNAc: a regulatory post-translational modification.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  2003-03-14

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0006-291X(03)00175-XPMID 12615051
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A role for N-acetylglucosamine as a nutrient sensor and mediator of insulin resistance

  2003cited by this paper
• Identification and Cloning of a Novel Family of Coiled-coil Domain Proteins That Interact with O-GlcNAc Transferase*

  2003cited by this paper
• Insulin Resistance of Glycogen Synthase Mediated byO-Linked N-Acetylglucosamine*

  2003cited by this paper
• High glucose and insulin promote O-GlcNAc modification of proteins, including α-tubulin

  2003cited by this paper
• Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression.

  2002cited by this paper
• Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes

  2002cited by this paper
• Insulin-Dependent Activation of Endothelial Nitric Oxide Synthase Is Impaired by O-Linked Glycosylation Modification of Signaling Proteins in Human Coronary Endothelial Cells

  2002cited by this paper
• Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia

  2002cited by this paper
• Enhanced O-GlcNAc protein modification is associated with insulin resistance in GLUT1-overexpressing muscles.

  2002cited by this paper
• Dynamic interplay between O-glycosylation and O-phosphorylation of nucleocytoplasmic proteins: alternative glycosylation/phosphorylation of THR-58, a known mutational hot spot of c-Myc in lymphomas, is regulated by mitogens.

  2002cited by this paper
• Diverse regulation of protein function by O-GlcNAc: a nuclear and cytoplasmic carbohydrate post-translational modification.

  2002cited by this paper
• Flux through the hexosamine pathway is a determinant of nuclear factor kappaB- dependent promoter activation.

  2002cited by this paper
• The emerging significance of O-GlcNAc in cellular regulation.

  2002cited by this paper
• Dynamic O-Glycosylation of Nuclear and Cytosolic Proteins

  2002cited by this paper
• Mapping Sites of O-GlcNAc Modification Using Affinity Tags for Serine and Threonine Post-translational Modifications*

  2002cited by this paper
• Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site.

  2001cited by this paper
• Cytosolic O‐glycosylation is abundant in nerve terminals

  2001cited by this paper
• Glycosylation of Nucleocytoplasmic Proteins: Signal Transduction and O-GlcNAc

  2001cited by this paper
• Cytoplasmic O‐glycosylation prevents cell surface transport of E‐cadherin during apoptosis

  2001cited by this paper
• O-linkage of N-acetylglucosamine to Sp1 activation domain inhibits its transcriptional capability

  2001cited by this paper
• Reciprocity between O-GlcNAc and O-phosphate on the carboxyl terminal domain of RNA polymerase II.

  2001cited by this paper
• Excessive Hexosamines Block the Neuroprotective Effect of Insulin and Induce Apoptosis in Retinal Neurons*

  2001cited by this paper
• Dynamic O-Glycosylation of Nuclear and Cytosolic Proteins

  2001cited by this paper
• Protection of translation initiation factor eIF2 phosphorylation correlates with eIF2-associated glycoprotein p67 levels and requires the lysine-rich domain I of p67.

  2001cited by this paper
• Characterization of a mouse monoclonal antibody specific for O-linked N-acetylglucosamine.

  2001cited by this paper
• Simultaneous detection and identification of O-GlcNAc-modified glycoproteins using liquid chromatography-tandem mass spectrometry.

  2000cited by this paper
• Glucose stimulates protein modification by O-linked GlcNAc in pancreatic beta cells: linkage of O-linked GlcNAc to beta cell death.

  2000cited by this paper
• Decreased UDP‐GlcNAc levels abrogate proliferation control in EMeg32‐deficient cells

  2000cited by this paper
• Evidence for genetic linkage of Alzheimer's disease to chromosome 10q.

  2000cited by this paper
• The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny.

  2000cited by this paper
• Alternative O-glycosylation/O-phosphorylation of the murine estrogen receptor beta.

  2000cited by this paper
• Glycosylation of the murine estrogen receptor-α

  2000cited by this paper
• Functional Expression of O-linked GlcNAc Transferase

  2000cited by this paper
• O-Glycosylation of Nuclear and Cytosolic Proteins

  2000cited by this paper
• Glucose stimulates protein modification by O-linked GlcNAc in pancreatic β cells: Linkage of O-linked GlcNAc to β cell death

  2000cited by this paper
• Glycosylation of the murine estrogen receptor-alpha.

  2000cited by this paper
• O-GlcNAc and the control of gene expression.

  1999cited by this paper
• The tetratricopeptide repeat: a structural motif mediating protein-protein interactions.

  1999cited by this paper
• Glycosylation Sites Flank Phosphorylation Sites on Synapsin I

  1999cited by this paper
• O-linked N-acetylglucosamine levels in cerebellar neurons respond reciprocally to pertubations of phosphorylation.

  1999cited by this paper
• Regulation of a Cytosolic and Nuclear O-GlcNAc Transferase

  1999cited by this paper
• Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle.

  1999cited by this paper
• A nutrient-sensing pathway regulates leptin gene expression in muscle and fat

  1998cited by this paper
• Modulation of O-LinkedN-Acetylglucosamine Levels on Nuclear and Cytoplasmic Proteins in Vivo Using the PeptideO-GlcNAc-β-N-acetylglucosaminidase InhibitorO-(2-Acetamido-2-deoxy-dglucopyranosylidene)amino-N-phenylcarbamate*

  1998cited by this paper
• Insulin and glucosamine infusions increase O-linked N-acetyl-glucosamine in skeletal muscle proteins in vivo.

  1998cited by this paper
• Analytical methods for the study of O-GlcNAc glycoproteins and glycopeptides.

  1998cited by this paper
• Reduced O glycosylation of Sp1 is associated with increased proteasome susceptibility

  1997cited by this paper
• Dynamic Glycosylation of Nuclear and Cytosolic Proteins

  1997cited by this paper
• O-Linked GlcNAc Transferase Is a Conserved Nucleocytoplasmic Protein Containing Tetratricopeptide Repeats*

  1997cited by this paper
• High Molecular Weight Microtubule-associated Proteins Contain O-Linked N-Acetylglucosamine (*)

  1996cited by this paper
• Regulation of specific DNA binding by p53: evidence for a role for O-glycosylation and charged residues at the carboxy-terminus.

  1996cited by this paper
• The Microtubule-associated Protein Tau Is Extensively Modified with O-linked N-acetylglucosamine*

  1996cited by this paper
• Selective detection and site-analysis of O-GlcNAc-modified glycopeptides by beta-elimination and tandem electrospray mass spectrometry.

  1996cited by this paper
• Identification of O-Linked N-Acetylglucosamine Modification of AnkyrinG Isoforms Targeted to Nodes of Ranvier*

  1996cited by this paper
• Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules

  1996cited by this paper
• Hexosamines and Insulin Resistance

  1996cited by this paper
• β‐Amyloid precursor protein is modified with O‐linked N‐acetylglucosamine

  1995cited by this paper
• O-linked N-acetylglucosamine: the "yin-yang" of Ser/Thr phosphorylation? Nuclear and cytoplasmic glycosylation.

  1995cited by this paper
• Glycosylation of the c-Myc transactivation domain.

  1995cited by this paper
• O-Linked N-Acetylglucosamine: The “Yin-Yang” of Ser/Thr Phosphorylation?

  1995cited by this paper
• Identification and Mutational Analysis of the Glycosylation Sites of Human Keratin 18 (*)

  1995cited by this paper
• Specific isolation of O-linked N-acetylglucosamine glycopeptides from complex mixtures.

  1995cited by this paper
• Clathrin assembly protein AP-3 is phosphorylated and glycosylated on the 50-kDa structural domain.

  1994cited by this paper
• RNA polymerase II is a glycoprotein. Modification of the COOH-terminal domain by O-GlcNAc.

  1993cited by this paper
• Glycosylation of mammalian neurofilaments. Localization of multiple O-linked N-acetylglucosamine moieties on neurofilament polypeptides L and M.

  1993cited by this paper
• hnRNP G: sequence and characterization of a glycosylated RNA-binding protein.

  1993cited by this paper
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  1992cited by this paper
• The cytoskeletal protein talin is O-glycosylated.

  1992cited by this paper
• Protein glycosylation.

  1992cited by this paper
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  1991cited by this paper
• Nuclear localization of an O-glycosylated protein phosphotyrosine phosphatase from human cells.

  1991cited by this paper
• Enzymatic addition of O-GlcNAc to nuclear and cytoplasmic proteins. Identification of a uridine diphospho-N-acetylglucosamine:peptide beta-N-acetylglucosaminyltransferase.

  1990cited by this paper
• O-N-acetyl-D-glucosamine moiety on discrete peptide of multiple protein 4.1 isoforms regulated by alternative pathways.

  1989cited by this paper
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  1989cited by this paper
• A glycosylated liver-specific transcription factor stimulates transcription of the albumin gene.

  1989cited by this paper
• O-glycosylation of eukaryotic transcription factors: implications for mechanisms of transcriptional regulation.

  1988cited by this paper
• O-linked N-acetylglucosamine is attached to proteins of the nuclear pore. Evidence for cytoplasmic and nucleoplasmic glycoproteins.

  1987cited by this paper
• The subcellular distribution of terminal N-acetylglucosamine moieties. Localization of a novel protein-saccharide linkage, O-linked GlcNAc.

  1986cited by this paper
• Topography and polypeptide distribution of terminal N-acetylglucosamine residues on the surfaces of intact lymphocytes. Evidence for O-linked GlcNAc.

  1984cited by this paper
• The tissue distribution of hexosaminidase S and hexosaminidase C

  1977cited by this paper

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• Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

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• Keratinocyte-specific deletion of O-GlcNAc transferase reduces the subcutaneous adipocyte layer in mice.

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• Expression of the glucose transporter 1 is associated with increased glucose uptake by granulosa cells during ovulation in mice.

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• Influence of O-GlcNAcylation on KGN cell function

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• O-GlcNAc transferase modulates the cellular endocytosis machinery by controlling the formation of clathrin-coated pits

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• Advances in Bacterial Oligosaccharyltransferase Structure Elucidation and Potential Application to Glycoconjugate Vaccine Design.

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• Transient receptor potential canonical type 6 (TRPC6) O-GlcNAcylation at Threonine-221 plays potent role in channel regulation

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• O-GlcNAc transferase modulates formation of clathrin-coated pits

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• Constitutive Inhibition of Transient Receptor Potential Canonical Type 6 (TRPC6) by O-GlcNAcylation at Threonine-221

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