Modulation of apoptosis with cytokines in B-cell chronic lymphocytic leukaemia.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Leukemia and Lymphoma

• Publication date

  1996-05-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.3109/10428199609093434PMID 9172801
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Signal Transduction Pathways in Apoptosis

  1996cited by this paper
• Effect of anti-APO1 on spontaneous apoptosis of B cells in chronic lymphocytic leukaemia: the role of bcl-2 and interleukin 4.

  1995cited by this paper
• Effect of interleukins on the proliferation and survival of B cell chronic lymphocytic leukaemia cells.

  1995cited by this paper
• Pharmacological inhibition of programmed lymphocyte death.

  1994cited by this paper
• Cytokine-induced modulation of tumor suppressor gene expression in ovarian cancer cells: up-regulation of p53 gene expression and induction of apoptosis by tumor necrosis factor-alpha.

  1994cited by this paper
• Cytogenetic and molecular abnormalities in chronic lymphocytic leukaemia.

  1994cited by this paper
• Oxidative stress as a mediator of apoptosis.

  1994cited by this paper
• Involvement of protein kinase C-epsilon in glucocorticoid-induced apoptosis in thymocytes.

  1994cited by this paper
• Oncogenes and cell death.

  1994cited by this paper
• Interferon‐alpha up‐regulates bcl‐2 expression and protects B‐CLL cells from apoptosis in vitro and in vivo

  1994cited by this paper
• BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

  1994cited by this paper
• Involvement of protein kinase C-ɛ in glucocorticoid-induced apoptosis in thymocytes

  1994cited by this paper
• Signal transduction pathways in apoptosis.

  1994cited by this paper
• Interleukin-5 (IL-5) increases spontaneous apoptosis of B-cell chronic lymphocytic leukemia cells in vitro independently of bcl-2 expression and is inhibited by IL-4.

  1994cited by this paper
• Alpha‐interferon (α‐IFN) protects B‐chronic lymphocytic leukaemia cells from apoptotic cell death in vitro

  1994cited by this paper
• The nature of the B lymphocyte in B-chronic lymphocytic leukemia.

  1993cited by this paper
• Tumour necrosis factor-α enhances cAMP-induced programmed cell death in mouse thymocytes

  1993cited by this paper
• Autocrine and paracrine growth loops in chronic lymphocytic leukemia.

  1993cited by this paper
• APO-1-induced apoptosis of leukemia cells from patients with adult T-cell leukemia.

  1993cited by this paper
• Interleukin‐4 inhibits apoptotic cell death and loss of the bcl‐2 protein in B‐chronic lymphocytic leukaemia cells in vitro

  1993cited by this paper
• Interleukin-2 prevents programmed cell death in chronic lymphocytic leukemia cells.

  1993cited by this paper
• APO‐1 mediated apoptosis or proliferation in human chronic B lymphocytic leukemia: Correlation with bcl‐2 oncogene expression

  1993cited by this paper
• Normal and aberrant expression of cytokines in neoplastic cells from chronic lymphocytic leukemias.

  1993cited by this paper
• Protein tyrosine phosphorylation is mandatory for CD40‐mediated rescue of germinal center B cells from apoptosis

  1993cited by this paper
• Programmed cell death, apoptosis and killer genes.

  1993cited by this paper
• Tumour necrosis factor-alpha enhances cAMP-induced programmed cell death in mouse thymocytes.

  1993cited by this paper
• Abnormal response to IL-5 in B-cell chronic lymphocytic leukemia.

  1993cited by this paper
• Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production.

  1993cited by this paper
• Human interleukin‐5 induces staphylococcal A Cowan 1 strain‐activated human B cells to secrete IgM

  1993cited by this paper
• Role of protein phosphorylation in TNF‐induced apoptosis: Phosphatase inhibitors synergize with TNF to activate DNA fragmentation in normal as well as TNF‐resistant U937 variants

  1993cited by this paper
• Inhibitors of tyrosine phosphorylation induce apoptosis in human leukemic cell lines.

  1993cited by this paper
• Coregulation of the APO-1 antigen with intercellular adhesion molecule-1 (CD54) in tonsillar B cells and coordinate expression in follicular center B cells and in follicle center and mediastinal B-cell lymphomas.

  1993cited by this paper
• bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death.

  1993cited by this paper
• Interferon gamma inhibits apoptotic cell death in B cell chronic lymphocytic leukemia

  1993cited by this paper
• Expression and functional role of tumor necrosis factor receptors on leukemic cells from patients with type B chronic lymphoproliferative disorders.

  1993cited by this paper
• Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity.

  1993cited by this paper
• Expression and Functional Role of Tumor Necrosis Factor Receptors on Leukemic Cells From Patients With Type B Chronic Lymphoproliferative Disorders

  1993cited by this paper
• Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.

  1993cited by this paper
• Functional differences of T cells in B-chronic lymphocytic leukemia.

  1993cited by this paper
• Apoptosis in the development of the immune system: Growth factors, clonal selection and bcl-2

  1992cited by this paper
• Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas.

  1992cited by this paper
• Bcl-2 confers growth and survival advantage to interleukin 7-dependent early pre-B cells which become factor independent by a multistep process in culture.

  1992cited by this paper
• Apoptotic cell death induced by c-myc is inhibited by bcl-2

  1992cited by this paper
• Growth- and differentiation-associated expression of bcl-2 in B-chronic lymphocytic leukemia cells.

  1992cited by this paper
• Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression

  1992cited by this paper
• Apoptosis: final control point in cell biology.

  1992cited by this paper
• DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement.

  1992cited by this paper
• Apoptosis induced by anticancer drugs

  1992cited by this paper
• Interleukin-4 inhibits both paracrine and autocrine tumor necrosis factor-alpha-induced proliferation of B chronic lymphocytic leukemia cells.

  1992cited by this paper
• Induction of apoptosis in fibroblasts by c-myc protein.

  1992cited by this paper
• Interleukin-5 is an autocrine growth factor for Epstein-Barr virus-transformed B lymphocytes.

  1992cited by this paper
• Cooperative interaction between c-myc and bcl-2 proto-oncogenes

  1992cited by this paper
• A role for calcium in regulating apoptosis in rat thymocytes irradiated in vitro.

  1992cited by this paper
• Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killing.

  1992cited by this paper
• Expression of interleukin 5 by the CD4+CD45R0+ subset of human T cells.

  1992cited by this paper
• Cytokine receptors and signal transduction

  1992cited by this paper
• Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene.

  1992cited by this paper
• Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen.

  1992cited by this paper
• Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

  1992cited by this paper
• Glucocorticoid-induced DNA fragmentation: role of protein-kinase-C activity.

  1992cited by this paper
• Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens.

  1992cited by this paper
• bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes.

  1991cited by this paper
• IMMUNOREGULATION BY INTERLEUKIN‐4 IN MAN

  1991cited by this paper
• Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

  1991cited by this paper
• Tumor Necrosis Factor Production in B Cell Chronic Lymphocytic Leukemia.

  1991cited by this paper
• The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis.

  1991cited by this paper
• Long-term human B cell lines dependent on interleukin-4 and antibody to CD40.

  1991cited by this paper
• Evidence for early induction of calmodulin gene expression in lymphocytes undergoing glucocorticoid-mediated apoptosis.

  1991cited by this paper
• Antiproliferative effect of interleukin-4 in B chronic lymphocytic leukemia.

  1991cited by this paper
• Increased spontaneous secretion of IL‐6 from B cells of patients with B chronic lymphatic leukaemia (B‐CLL) and autoimmunity

  1991cited by this paper
• Prognostic importance of flow cytometric immunophenotyping of 540 consecutive patients with B-cell chronic lymphocytic leukemia.

  1991cited by this paper
• Expression of interleukin-1 alpha, interleukin-1 beta and interleukin-6 in chronic B lymphocytic leukaemia (B-CLL) cells from patients at different stages of disease progression.

  1991cited by this paper
• Induction of DNA fragmentation in chronic B-lymphocytic leukemia cells.

  1991cited by this paper
• Programmed cell death in the immune system.

  1991cited by this paper
• Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.

  1991cited by this paper
• Chronic lymphocytic leukemia: new insights into biology and therapy.

  1990cited by this paper
• Cellular signalling in programmed cell death (apoptosis).

  1990cited by this paper
• Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2

  1990cited by this paper
• Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population

  1990cited by this paper
• The role of growth factors in self-renewal and differentiation of haemopoietic stem cells.

  1990cited by this paper
• Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

  1990cited by this paper
• Anti‐immunoglobulin antibodies induce apoptosis in immature B cell lymphomas

  1990cited by this paper
• Interleukin 1 inhibits T cell receptor-mediated apoptosis in immature thymocytes.

  1990cited by this paper
• Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

  1990cited by this paper
• Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

  1990cited by this paper
• Protein kinase-C involvement in thymocyte apoptosis induced by hydrocortisone.

  1990cited by this paper
• IL-4 inhibits IL-2 receptor expression and IL-2-dependent proliferation of human T cells.

  1990cited by this paper
• Cytotoxic mechanism of tumor necrosis factor‐α

  1990cited by this paper
• Growth- and tumor-promoting effects of deregulated BCL2 in human B-lymphoblastoid cells.

  1989cited by this paper
• Tumor necrosis factor induces proliferation of neoplastic B cells from chronic lymphocytic leukemia.

  1989cited by this paper
• bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation.

  1989cited by this paper
• Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

  1989cited by this paper
• Proliferation of B cells from chronic lymphocytic leukemia is selectively promoted by B cell growth factor.

  1989cited by this paper
• Proliferative response of highly purified B chronic lymphocytic leukemia cells in serum free culture to interleukin-2 and tumor necrosis factors alpha and beta.

  1989cited by this paper
• Inhibition of DNA fragmentation in thymocytes and isolated thymocyte nuclei by agents that stimulate protein kinase C.

  1989cited by this paper
• The bcl-2 candidate proto-oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14;18) translocation

  1989cited by this paper
• Induction of proliferation and blast transformation by interferon in human malignant and non-malignant lymph node B cells.

  1989cited by this paper
• T-cell activation and subset patterns are altered in B-CLL and correlate with the stage of the disease.

  1989cited by this paper
• Favorable response of early stage B CLL patients to treatment with IFN-alpha 2.

  1989cited by this paper
• Interleukin 5 regulation of peritoneal Ly‐1 B lymphocyte proliferation, differentiation and autoantibody secretion

  1989cited by this paper

• Activation of Interferon Signaling in Chronic Lymphocytic Leukemia Cells Contributes to Apoptosis Resistance via a JAK-Src/STAT3/Mcl-1 Signaling Pathway

  2021cites this paper
• Clinico-Biological Implications of Modified Levels of Cytokines in Chronic Lymphocytic Leukemia: A Possible Therapeutic Role

  2020cites this paper
• Integrated Cellular and Plasma Proteomics of Contrasting B-cell Cancers Reveals Common and Systemic Tumour Signatures

  2017cites this paper
• Integrated Cellular and Plasma Proteomics of Contrasting B-cell Cancers Reveals Common, Unique and Systemic Signatures*

  2017cites this paper
• Intracellular IL-4 and IFN-γ expression in iNKT cells from patients with chronic lymphocytic leukemia

  2017cites this paper
• Assessment of IL-6 Cytokine Level in Rheumatoid Arthritis Patients Associated with Anemia

  2017cites this paper
• Derived IFN- - Express CD38 in Response to Th1 Cell Chronic Lymphocytic Leukemia Cells

  2015cites this paper
• Chronic Lymphocytic Leukemia Cells Express CD38 in Response to Th1 Cell–Derived IFN-γ by a T-bet–Dependent Mechanism

  2015cites this paper
• The Expression of Sphingosine-1 Phosphate Receptor-1 in Chronic Lymphocytic Leukemia Cells Is Impaired by Tumor Microenvironmental Signals and Enhanced by Piceatannol and R406

  2014cites this paper
• Microenvironmental Signals and Enhanced Leukemia Cells Is Impaired by Tumor Receptor-1 in Chronic Lymphocytic The Expression of Sphingosine-1 Phosphate

  2014cites this paper
• B-cell chronic lymphocytic leukemia (B-CLL) cells The natural product Honokiol induces caspase-dependent apoptosis in

  2013cites this paper
• Paper de la proteïna ZAP-70 en la regulació de la interacció de la leucèmia limfàtica crònica amb el microambient

  2013cites this paper
• Breaking T-cell tolerance in chronic lymphocytic leukaemia

  2013cites this paper
• Identification and validation of potential targets for the diagnosis and therapy of chronic lymphocytic leukaemia

  2013cites this paper
• HCD122, on human chronic lymphocytic leukemia cells The antileukemia activity of a human anti-CD40 antagonist antibody,

  2013cites this paper
• Umbelliprenin Induces Apoptosis in CLL Cell Lines

  2012cites this paper
• ARTICLE UMBELLIPRENIN INDUCES APOPTOSIS IN CLL CELL LINES

  2012cites this paper
• hTERT, CD23 und CD229 als Tumorantigene bei der B-CLL

  2012cites this paper
• Leucemia linfocítica crónica de células B: el papel de las señales del microambiente en la patogénesis de la enfermedad

  2012cites this paper
• Physical contact with endothelial cells through β1- and β2- integrins rescues chronic lymphocytic leukemia cells from spontaneous and drug-induced apoptosis and induces a peculiar gene expression profile in leukemic cells

  2012cites this paper
• Potential role of serum level of soluble CD44 and IFN-γ in B-cell chronic lymphocytic leukemia

  2011cites this paper
• in chronic lymphocytic leukemia CD160 signaling mediates PI3K-dependent survival and growth signals

  2011cites this paper
• ROLE OF GSH METABOLISM IN MEDIATING STROMAL-LEUKEMIA INTERACTION AND PROMOTING CELL SURVIVAL AND DRUG RESISTANCE IN CHRONIC LYMPHOCYTIC LEUKEMIA

  2011cites this paper
• CD160 signaling mediates PI3K-dependent survival and growth signals in chronic lymphocytic leukemia.

  2010cites this paper
• IFN Gamma Gene Polymorphism May Contribute to the Susceptibility to CLL

  2010cites this paper
• Interleukin‐1B (IL1B) and interleukin‐6 (IL6) gene polymorphisms are associated with risk of chronic lymphocytic leukaemia

  2008cites this paper
• The antileukemia activity of a human anti-CD40 antagonist antibody, HCD122, on human chronic lymphocytic leukemia cells.

  2008cites this paper
• Modulation of the human equilibrative nucleoside transporter1 (hENT1) activity by IL-4 and PMA in B cells from chronic lymphocytic leukemia.

  2008cites this paper
• B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase CbetaII.

  2007cites this paper
• B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase C II

  2006cites this paper
• Bcl‐2 regulatory pathway is functional in chronic lymphocytic leukemia

  2005cites this paper
• Immunophenotypic Differential Diagnosis and Cell Cycle Analysis

  2004cites this paper
• Interleukin 4 production by peripheral blood lymphocytes in patients with classical Hodgkin lymphoma.

  2004cites this paper
• Loss of PKR activity in chronic lymphocytic leukemia

  2004cites this paper
• Cytokines and Soluble Molecules in CLL

  2004cites this paper
• Post-transcriptional regulation of inducible nitric oxide synthase in chronic lymphocytic leukemia B cells in pro- and antiapoptotic culture conditions

  2004cites this paper
• The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells.

  2004cites this paper
• The in-vitro effects of medroxyprogesterone acetate on acidic pH induced apoptosis of periferal blood mononuclear cells.

  2004cites this paper
• The Effects of Medroxyprogesterone Acetate on Apoptosis of CD34+ Cells

  2003cites this paper
• Intracellular cytokine profiles by peripheral blood CD3+ T-cells in patients with classical Hodgkin lymphoma.

  2003cites this paper
• Prolegomenon for Chronic Lymphocytic Leukaemia

  2003cites this paper
• IL-4 and interferon gamma regulate expression of inducible nitric oxide synthase in chronic lymphocytic leukemia cells

  2003cites this paper
• Sensibilisation de cellules à l'apoptose par bloquage selective de cytokines

  2003cites this paper
• Production of intracellular IL-2, TNF-alpha, and IFN-gamma by T cells in B-CLL.

  2003cites this paper
• STAT1 mediates differentiation of chronic lymphocytic leukemia cells in response to Bryostatin 1.

  2003cites this paper
• Production of intracellular IL‐2, TNF‐α, and IFN‐γ by T cells in B‐CLL

  2003cites this paper
• Apoptosis induction by hypercross-linking of the surface antigen CD5 with anti-CD5 monoclonal antibodies in B cell chronic lymphocytic leukemia

  2002cites this paper
• Th1/Th2 Cytokine Expression and its Relationship with Tumor Growth in B Cell Non-Hodgkin's Lymphoma (NHL)

  2002cites this paper
• REVIEW ARTICLE B-CHRONIC LYMPHOCYTIC LEUKEMIA: PRACTICAL ASPECTS

  2002cites this paper
• B‐chronic lymphocytic leukemia: practical aspects

  2002cites this paper
• The role of death receptor, litigation and signal transduction inhibition in the killing of leukaemia cells by cytotoxic drugs and radiation.

  2002cites this paper
• Inflammatory cytokines and cytokine gene polymorphisms in chronic lymphocytic leukaemia, in primary Sjögren's syndrome and in healthy subjects

  2002influential citation
• Contribution of Nitric Oxide to the Apoptotic Process in Human B Cell Chronic Lymphocytic Leukaemia

  2001cites this paper
• The Relevance of Circulating Interleukin-5 (IL-5) in Lymphoproliferative Disorders

  2001cites this paper
• New aspects on the pathogenesis, diagnostic procedures, and therapeutic management of chronic lymphocytic leukemia

  2001cites this paper
• γ-Linolenic Acid Induces Apoptosis in B-Chronic Lymphocytic Leukaemia Cells in Vitro

  2001cites this paper
• Interleukin 4 content in chronic lymphocytic leukaemia (CLL) B cells and blood CD8+ T cells from B‐CLL patients: impact on clonal B‐cell apoptosis

  2001cites this paper
• Effect of interferon-α on CD20 antigen expression of B-cell chronic lymphocytic leukemia

  2000cites this paper
• Effect of interferon-alpha on CD20 antigen expression of B-cell chronic lymphocytic leukemia.

  2000cites this paper
• Biology of chronic lymphocytic leukemia.

  2000cites this paper
• New Concepts in the Pathogenesis, Diagnosis, Prognostic Factors and Clinical Presentation of Chronic Lymphocytic Leukemia

  2000cites this paper
• Release of interleukin-6 in cultured B-chronic lymphocytic leukaemia cells is associated with both activation and cell death via apoptosis.

  1999cites this paper
• Serum levels of IL-6 type cytokines and soluble IL-6 receptors in active B-cell chronic lymphocytic leukemia and in cladribine induced remission.

  1999cites this paper
• B-cell chronic lymphocytic leukemia: a bird of a different feather.

  1999cites this paper
• Modulation of apoptosis by cytokines in B-cell chronic lymphocytic leukemia.

  1999cites this paper
• Pre-clinical evaluation of SN-38 and novel camptothecin analogs against human chronic B-cell lymphocytic leukemia lymphocytes.

  1999cites this paper
• Adhesion to bone marrow stroma inhibits apoptosis of chronic lymphocytic leukemia cells.

  1999cites this paper
• MEC1 and MEC2: two new cell lines derived from B-chronic lymphocytic leukaemia in prolymphocytoid transformation.

  1999cites this paper
• Cytokine expression in B-CLL in relation to disease progression andin vitro activation

  1999cites this paper
• Increased apoptosis of T cell subsets in aging humans: altered expression of Fas (CD95), Fas ligand, Bcl-2, and Bax.

  1998cites this paper
• Differential expression of human histone deacetylase mRNAs in response to immune cell apoptosis induction by trichostatin A and butyrate.

  1998cites this paper
• Prognostic significance of the cell cycle inhibitor p27Kip1 in chronic B-cell lymphocytic leukemia.

  1998cites this paper
• B-cell chronic lymphocytic leukemia cells express a functional inducible nitric oxide synthase displaying anti-apoptotic activity.

  1998cites this paper
• Fludarabine ability to down‐regulate Bcl‐2 gene product in CD5+ leukaemic B cells: in vitro/in vivo correlations

  1997cites this paper
• B-cell chronic lymphocytic leukemia: recent progress in biology, diagnosis, and therapy.

  1997cites this paper
• Involvement of CED-3/ICE proteases in the apoptosis of B-chronic lymphocytic leukemia cells.

  1997cites this paper