Mechanism of the superoxide-producing oxidase of neutrophils. O2 is necessary for the fast reduction of cytochrome b-245 by NADPH.

No abstract is available for this paper.

• Publication year

  1985

• Venue

  Biochemical Journal

• Publication date

  1985-03-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1042/BJ2260881PMID 2985050PMCID PMC1144791
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The superoxide-generating oxidase of leucocytes. NADPH-dependent reduction of flavin and cytochrome b in solubilized preparations.

  1984cited by this paper
• Molecular mechanisms in tumor-cell killing by activated macrophages.

  1983cited by this paper
• Absence of cytochrome b-245 in chronic granulomatous disease. A multicenter European evaluation of its incidence and relevance.

  1983cited by this paper
• The role of particles in the pathogenesis of joint disease.

  1982cited by this paper
• The enzymic reduction and kinetics of oxidation of cytochrome b-245 of neutrophils.

  1982cited by this paper
• Functional relationship of the cytochrome b to the superoxide-generating oxidase of human neutrophils.

  1982cited by this paper
• Superoxide-forming NADPH oxidase preparation of pig polymorphonuclear leucocyte.

  1982cited by this paper
• Characteristics of the cofactor requirements for the superoxide-generating NADPH oxidase of human polymorphonuclear leukocytes.

  1981cited by this paper
• Oxidation-reduction properties of the cytochrome b found in the plasma-membrane fraction of human neutrophils. A possible oxidase in the respiratory burst.

  1981cited by this paper
• Subcellular localization of the superoxide-forming enzyme in human neutrophils.

  1979cited by this paper
• Oxygen-dependent microbial killing by phagocytes (first of two parts).

  1978cited by this paper
• Oxygen "pulsed" cytochrome c oxidase: functional properties and catalytic relevance.

  1977cited by this paper
• The particulate superoxide-forming system from human neutrophils. Properties of the system and further evidence supporting its participation in the respiratory burst.

  1976cited by this paper
• The reaction of ferrocytochrome c with cytochrome oxidase: A new look

  1972cited by this paper
• The biochemical basis of phagocytosis. I. Metabolic changes during the ingestion of particles by polymorphonuclear leukocytes.

  1959cited by this paper

• NADPH Oxidases: Redox Regulation of Cell Homeostasis & Disease.

  2025cites this paper
• NADPH Oxidases (NOX): An Overview from Discovery, Molecular Mechanisms to Physiology and Pathology

  2021cites this paper
• A thermodynamically-constrained mathematical model for the kinetics and regulation of NADPH oxidase 2 complex-mediated electron transfer and superoxide production.

  2019cites this paper
• The intimate and controversial relationship between voltage‐gated proton channels and the phagocyte NADPH oxidase

  2016cites this paper
• Modulation de l’activité du flavocytochrome b₅₅₈ : étude fonctionnelle

  2014cites this paper
• Elementary tetrahelical protein design for diverse oxidoreductase functions.

  2013cites this paper
• Phänotyp der chronischen Granulomatose assoziiert mit einem schweren G6PD-Mangel in Granulozyten

  2008cites this paper
• Oxidative Burst in Suspension Culture of Taxus cuspidataInduced by a Laminar Shear Stress in Short‐Term

  2008cites this paper
• Regulation of Nox and Duox enzymatic activity and expression.

  2007cites this paper
• Translocation of proteins homologous to human neutrophil p47phox and p67phox to the cell membrane in activated hemocytes of Galleria mellonella.

  2007cites this paper
• Evaluation of two anti-gp91phox antibodies as immunoprobes for Nox family proteins: mAb 54.1 recognizes recombinant full-length Nox2, Nox3 and the C-terminal domains of Nox1-4 and cross-reacts with GRP 58.

  2005cites this paper
• The pH dependence of NADPH oxidase in human eosinophils

  2005cites this paper
• Structural organization of the neutrophil NADPH oxidase: phosphorylation and translocation during priming and activation

  2005cites this paper
• Regulation and termination of NADPH oxidase activity

  2005cites this paper
• The NADPH oxidase of professional phagocytes--prototype of the NOX electron transport chain systems.

  2004cites this paper
• Nox protein expression, purification and structure analysis

  2004cites this paper
• The effects of fatty acids and antioxidants on U937 monocytes used as a model for the lipid disturbance in schizophrenia.

  2003cites this paper
• Voltage-gated proton channels and other proton transfer pathways.

  2003cites this paper
• Interactions between NADPH oxidase and voltage‐gated proton channels: why electron transport depends on proton transport

  2003cites this paper
• Chronic granulomatous disease.

  2003cites this paper
• The Production and Use of Reactive Oxidants by Phagocytes

  2002cites this paper
• The neutrophil NADPH oxidase.

  2002cites this paper
• The superoxide-generating NADPH oxidase: structural aspects and activation mechanism

  2002cites this paper
• Superoxide anion burst and taxol production induced by Ce4+ in suspension cultures of Taxus cuspidata

  2002cites this paper
• Essential Requirement of Cytosolic Phospholipase A2for Stimulation of NADPH Oxidase-associated Diaphorase Activity in Granulocyte-like Cells*

  2001cites this paper
• A critical investigation of NADPH oxidase activity in human spermatozoa.

  2001cites this paper
• Dual Role of Plasma Membrane Electron Transport Systems in Defense

  2000cites this paper
• NADPH oxidase: a universal oxygen sensor?

  2000cites this paper
• Genetic, biochemical, and clinical features of chronic granulomatous disease.

  2000cites this paper
• Activation of the neutrophil respiratory burst oxidase.

  1999cites this paper
• Simultaneous Presence of p47 phox and Flavocytochrome b −245 Are Required for the Activation of NADPH Oxidase by Anionic Amphiphiles

  1999cites this paper
• NADPH oxidase: an update.

  1999cites this paper
• Electron transfer in the superoxide-generating NADPH oxidase complex reconstituted in vitro.

  1997cites this paper
• [Oxidative stress and molecular biology in ulcerative colitis and cancer].

  1997cites this paper
• NADPH oxidase of neutrophils.

  1996cites this paper
• The NADPH oxidase of phagocytic cells is an electron pump that alkalinises the phagocytic vacuole

  1995cites this paper
• Modulation of the Heme Environment of Neutrophil Cytochrome b to a Cytochrome P450-like Structure by Pyridine (*)

  1995cites this paper
• Phagocytic NADPH oxidase and its role in chronic granulomatous disease.

  1995cites this paper
• The Cytosolic Activating Factors p47phox and p67phox Have Distinct Roles in the Regulation of Electron Flow in NADPH Oxidase(*)

  1995cites this paper
• Electron Spin Resonance Studies on Neutrophil Cytochrome b558.

  1995cites this paper
• Aerobic and anaerobic functioning of superoxide-producing cytochrome b-559 reconstituted with phospholipids.

  1995cites this paper
• Role of oxygen free radicals in altitude-related disorders.

  1994cites this paper
• The respiratory burst oxidase

  1994cites this paper
• Chronic granulomatous disease.

  1994cites this paper
• Assays of plasma membrane NADPH oxidase.

  1994cites this paper
• The respiratory burst oxidase.

  1994cites this paper
• Mechanisms for the activation/electron transfer of neutrophil NADPH-oxidase complex and molecular pathology of chronic granulomatous disease

  1994cites this paper
• The superoxide-generating system of human neutrophils possesses a novel diaphorase activity. Evidence for distinct regulation of electron flow within NADPH oxidase by p67-phox and p47-phox.

  1994cites this paper
• [Oxidative stress and protein degradation].

  1994cites this paper
• The regulation of superoxide production by the NADPH oxidase of neutrophils and other mammalian cells

  1994cites this paper
• Stoichiometry of O2 metabolism and NADPH oxidation of the cell-free latent oxidase reconstituted from cytosol and solubilized membrane from resting human neutrophils.

  1993cites this paper
• Regulation of the electrogenic H+ channel in the plasma membrane of neutrophils: possible role of phospholipase A2, internal and external protons.

  1993cites this paper
• The cytochrome b-558 molecules involved in the fibroblast and polymorphonuclear leucocyte superoxide-generating NADPH oxidase systems are structurally and genetically distinct.

  1993cites this paper
• Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase.

  1993cites this paper
• Superoxide-producing cytochrome b. Enzymatic and electron paramagnetic resonance properties of cytochrome b558 purified from neutrophils.

  1993cites this paper
• Composition and organization of the NADPH oxidase of phagocytes and other cells.

  1993cites this paper
• Neutrophil signal transduction and activation of the respiratory burst.

  1993cites this paper
• The respiratory burst oxidase and the molecular genetics of chronic granulomatous disease.

  1993cites this paper
• The mechanism of the production of superoxide by phagocytes.

  1993cites this paper
• The reduction of cytochrome b558 and the activity of the respiratory burst oxidase from human neutrophils.

  1992cites this paper
• Electron paramagnetic resonance studies on cytochrome b-558 and peroxidases of pig blood granulocytes.

  1992cites this paper
• Phorbol 12-myristate 13-acetate activates an electrogenic H(+)-conducting pathway in the membrane of neutrophils.

  1992cites this paper
• Subcellular distribution of the Rap1A protein in human neutrophils: colocalization and cotranslocation with cytochrome b559.

  1992cites this paper
• The respiratory burst oxidase.

  1992cites this paper
• Cell-free translocation of recombinant p47-phox, a component of the neutrophil NADPH oxidase: effects of guanosine 5'-O-(3-thiotriphosphate), diacylglycerol, and an anionic amphiphile.

  1992cites this paper
• Human neutrophil cytochrome b contains multiple hemes. Evidence for heme associated with both subunits.

  1992cites this paper
• CHAPTER 5 – Composition of NADPH Oxidase of Phagocytes and Other Cell Types: Role of Flavoprotein in Proton Translocation and Oxidase Activity

  1992cites this paper
• CHAPTER 1 – Composition and Function of the NADPH Oxidase of Phagocytic Cells with Particular Reference to Redox Components Located within the Plasma Membrane

  1992cites this paper
• Evidence that cellobiose oxidase from Phanerochaete chrysosporium is primarily an Fe(III) reductase. Kinetic comparison with neutrophil NADPH oxidase and yeast flavocytochrome b2.

  1992cites this paper
• THE COMPONENTS OF THE RESPIRATORY BURST OXIDASE OF HUMAN NEUTROPHILS

  1991cites this paper
• Mechanisms of Oxidase Activation in Neutrophils

  1991cites this paper
• The Elusive Oxidase The Respiratory Burst Oxidase of Human Phagocytes

  1991cites this paper
• Resonance Raman and electron paramagnetic resonance structural investigations of neutrophil cytochrome b558.

  1991cites this paper
• The superoxide-generating oxidase of phagocytic cells

  1991cites this paper
• Differential effect of cyclosporine A on respiratory burst by several types of human leukocytic cells.

  1991cites this paper
• Enzymic mechanisms of superoxide production.

  1991cites this paper
• The superoxide-generating oxidase of phagocytic cells. Physiological, molecular and pathological aspects.

  1991cites this paper
• Oxygen radical production by transformed B lymphocytes.

  1991cites this paper
• Superoxide production by cytochrome b558 purified from neutrophils in a reconstituted system with an exogenous reductase.

  1991cites this paper
• The Superoxide-Forming NADPH Oxidase of Phagocytes

  1991cites this paper
• Purification and some properties of the 45 kDa diphenylene iodonium-binding flavoprotein of neutrophil NADPH oxidase.

  1990cites this paper
• The human neutrophil respiratory burst oxidase.

  1990cites this paper
• Reconstitution of the partially purified membrane component of the superoxide-generating NADPH oxidase of pig neutrophils with phospholipid.

  1990cites this paper
• Detection and isolation of the NADPH-binding protein of the NADPH:O2 oxidoreductase complex of human neutrophils.

  1990cites this paper
• Properties of the superoxide-generating oxidase of B-lymphocyte cell lines. Determination of Michaelis parameters.

  1989cites this paper
• Antioxidants and the influence of free radical damage to proteins on proteolysis in and around mammalian cells.

  1989cites this paper
• Studies on the electron-transfer mechanism of the human neutrophil NADPH oxidase.

  1989cites this paper
• The electron transport chain of the microbicidal oxidase of phagocytic cells and its involvement in the molecular pathology of chronic granulomatous disease.

  1989cites this paper
• The electron transport chain of the microbicidal oxidase of phagocytic cells and its involvement in the molecular pathology of chronic granulomatous disease.

  1989cites this paper
• Cyclosporin A inhibits phorbol ester-induced activation of superoxide production in resident mouse peritoneal macrophages.

  1989cites this paper
• The lateral organization of components of the membrane skeleton and superoxide generation in the plasma membrane of stimulated human neutrophils.

  1989cites this paper
• Leukocytic oxygen activation and microbicidal oxidative toxins.

  1989cites this paper
• Relationship of protein phosphorylation to the activation of the respiratory burst in human neutrophils. Defects in the phosphorylation of a group of closely related 48-kDa proteins in two forms of chronic granulomatous disease.

  1988cites this paper
• Phagocyte NADPH-oxidase. Studies with flavin analogues as active site probes in triton X-100-solubilized preparations.

  1988cites this paper
• The Respiratory Burst

  1988cites this paper
• The Effects of Marginal and Severe Dietary Magnesium and Copper Deficiencies on Immune Function.

  1988cites this paper
• The quaternary structure of the plasma membrane b-type cytochrome of human granulocytes.

  1988cites this paper
• Immunodeficiency and Disease

  1988cites this paper
• Polymorphonuclear leukocytes in acute inflammation

  1988cites this paper
• Isolation of the respiratory burst oxidase: The role of a flavoprotein component

  1988cites this paper