Drosophila Paf1 Modulates Chromatin Structure at Actively Transcribed Genes

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Molecular and Cellular Biology

• Publication date

  2006-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.26.1.250-260.2006PMID 16354696PMCID PMC1317635
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The human PAF complex coordinates transcription with events downstream of RNA synthesis.

  2005cited by this paper
• Histone H2B Ubiquitylation Is Associated with Elongating RNA Polymerase II

  2005cited by this paper
• Interaction between Transcription Elongation Factors and mRNA 3′-End Formation at the Saccharomyces cerevisiae GAL10-GAL7 Locus*

  2005cited by this paper
• Characterization of the grappa Gene, the Drosophila Histone H3 Lysine 79 Methyltransferase

  2005cited by this paper
• The HRPT2 Tumor Suppressor Gene Product Parafibromin Associates with Human PAF1 and RNA Polymerase II

  2005cited by this paper
• Efficient release from promoter-proximal stall sites requires transcript cleavage factor TFIIS.

  2005cited by this paper
• Separation of the Saccharomyces cerevisiae Paf1 Complex from RNA Polymerase II Results in Changes in Its Subnuclear Localization

  2005cited by this paper
• The Parafibromin Tumor Suppressor Protein Is Part of a Human Paf1 Complex

  2005influential reference
• Coordination of transcription, RNA processing, and surveillance by P-TEFb kinase on heat shock genes.

  2004cited by this paper
• Transcriptional elongation control by RNA polymerase II: a new frontier.

  2004cited by this paper
• The Paf1 complex has functions independent of actively transcribing RNA polymerase II.

  2004influential reference
• The link between mRNA processing and transcription: communication works both ways.

  2004cited by this paper
• Histone H 2 B Ubiquitylation Is Associated with Elongating RNA Polymerase II

  2004cited by this paper
• Transcription through chromatin: understanding a complex FACT.

  2004cited by this paper
• ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia

  2004cited by this paper
• Transitions in RNA polymerase II elongation complexes at the 3′ ends of genes

  2004cited by this paper
• Molecular evidence indicating that the yeast PAF complex is required for transcription elongation

  2004cited by this paper
• Histone H3 lysine 4 methylation patterns in higher eukaryotic genes

  2004cited by this paper
• Recent highlights of RNA-polymerase-II-mediated transcription.

  2004cited by this paper
• Modulation of heat shock gene expression by the TAC1 chromatin-modifying complex

  2004influential reference
• The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote.

  2004cited by this paper
• The Rtf1 Component of the Paf1 Transcriptional Elongation Complex Is Required for Ubiquitination of Histone H2B*

  2003influential reference
• Transcriptional Elongation by RNA Polymerase II and Histone Methylation*

  2003cited by this paper
• Tracking FACT and the RNA Polymerase II Elongation Complex Through Chromatin in Vivo

  2003cited by this paper
• Early formation of mRNP: license for export or quality control?

  2003cited by this paper
• Transcription Factor and Polymerase Recruitment, Modification, and Movement on dhsp70 In Vivo in the Minutes following Heat Shock

  2003cited by this paper
• Methylation of Histone H3 by Set2 in Saccharomyces cerevisiae Is Linked to Transcriptional Elongation by RNA Polymerase II

  2003cited by this paper
• Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity.

  2003cited by this paper
• Transcription Elongation Factors Repress Transcription Initiation from Cryptic Sites

  2003cited by this paper
• The Paf1 Complex Is Essential for Histone Monoubiquitination by the Rad6-Bre1 Complex, Which Signals for Histone Methylation by COMPASS and Dot1p*

  2003influential reference
• The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation.

  2003cited by this paper
• Transcription elongation by RNA polymerase II.

  2003influential reference
• Chromatin remodeling protein Chd1 interacts with transcription elongation factors and localizes to transcribed genes

  2003influential reference
• NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in Drosophila.

  2003cited by this paper
• RNA Polymerase II Elongation Factors of Saccharomyces cerevisiae: a Targeted Proteomics Approach

  2002cited by this paper
• Active genes are tri-methylated at K4 of histone H3

  2002cited by this paper
• Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast

  2002influential reference
• The RNA processing exosome is linked to elongating RNA polymerase II in Drosophila

  2002cited by this paper
• The Paf1 complex physically and functionally associates with transcription elongation factors in vivo

  2002influential reference
• Phenotypic analysis of Paf1/RNA polymerase II complex mutations reveals connections to cell cycle regulation, protein synthesis, and lipid and nucleic acid metabolism

  2002cited by this paper
• Interactions between mRNA Export Commitment, 3′-End Quality Control, and Nuclear Degradation

  2002cited by this paper
• Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure.

  2002cited by this paper
• Exchange of RNA polymerase II initiation and elongation factors during gene expression in vivo.

  2002cited by this paper
• High-resolution localization of Drosophila Spt5 and Spt6 at heat shock genes in vivo: roles in promoter proximal pausing and transcription elongation.

  2000cited by this paper
• Synthetic lethal interactions suggest a role for the Saccharomyces cerevisiae Rtf1 protein in transcription elongation.

  2000cited by this paper
• P-TEFb kinase recruitment and function at heat shock loci.

  2000cited by this paper
• A Complex Containing RNA Polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p Plays a Role in Protein Kinase C Signaling

  1999cited by this paper
• The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins

  1999cited by this paper
• Promoter-associated pausing in promoter architecture and postinitiation transcriptional regulation.

  1998cited by this paper
• FACT, a factor that facilitates transcript elongation through nucleosomes.

  1998cited by this paper
• Cdc73p and Paf1p are found in a novel RNA polymerase II-containing complex distinct from the Srbp-containing holoenzyme

  1997cited by this paper
• Paf1p, an RNA polymerase II-associated factor in Saccharomyces cerevisiae, may have both positive and negative roles in transcription

  1996cited by this paper
• Factor-stimulated RNA polymerase II transcribes at physiological elongation rates on naked DNA but very poorly on chromatin templates.

  1992cited by this paper
• Transcription on nucleosomal templates by RNA polymerase II in vitro: inhibition of elongation with enhancement of sequence-specific pausing.

  1991cited by this paper
• Mapping protein-DNA interactions in vivo with formaldehyde: evidence that histone H4 is retained on a highly transcribed gene.

  1988cited by this paper
• Two protein-binding sites in chromatin implicated in the activation of heat-shock genes

  1984cited by this paper
• High-resolution mapping of DNase I-hypersensitive sites of Drosophila heat shock genes in Drosophila melanogaster and Saccharomyces cerevisiae

  1984cited by this paper
• The 5′ ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I

  1980cited by this paper

• Evolutionary conservation and innovations of RNA polymerase II transcription elongation factors

  2026cites this paper
• Structure and function of IWS1 in transcription elongation

  2025cites this paper
• Kinetic control of mammalian transcription elongation

  2025influential citation
• Live-cell imaging of RNA Pol II and elongation factors distinguishes competing mechanisms of transcription regulation.

  2024cites this paper
• Activation loop phosphorylation of Cdk11 is restrained by PNUTS-PP1 and regulates Cdk11 activity and function

  2024cites this paper
• Paralog‐Dependent Specialization of Paf1C Subunit, Ctr9, for Sex Chromosome Gene Regulation and Male Germline Differentiation in Drosophila

  2024influential citation
• NELF focuses sites of initiation and maintains promoter architecture

  2024cites this paper
• Transcriptional elongation control in developmental gene expression, aging, and disease.

  2023cites this paper
• Targeted RNAi screen identifies transcriptional mechanisms that prevent premature degeneration of adult photoreceptors

  2023cites this paper
• Rtf1 Transcriptionally Regulates Neonatal and Adult Cardiomyocyte Biology

  2023cites this paper
• RNAPII driven post-translational modifications of nucleosomal histones.

  2022cites this paper
• Role of the Paf1 complex in the maintenance of stem cell pluripotency and development

  2022cites this paper
• SPT6 functions in transcriptional pause/release via PAF1C recruitment.

  2022cites this paper
• The histone chaperone FACT: a guardian of chromatin structure integrity

  2022cites this paper
• The PAF1 complex promotes 3' processing of pervasive transcripts.

  2022cites this paper
• Epigenetic repression and resetting of a floral repressor, FLC, in the life cycle of winter-annual Arabidopsis

  2021cites this paper
• FACT is recruited to the +1 nucleosome of transcribed genes and spreads in a Chd1-dependent manner.

  2021cites this paper
• FACT is recruited to the +1 nucleosome of transcribed genes and spreads in a Chd1-dependent manner

  2020influential citation
• Structure of complete Pol II–DSIF–PAF–SPT6 transcription complex reveals RTF1 allosteric activation

  2020cites this paper
• Serotonin signaling by maternal neurons upon stress ensures progeny survival

  2020cites this paper
• An improved auxin-inducible degron system preserves native protein levels and enables rapid and specific protein depletion

  2019cites this paper
• Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD.

  2019cites this paper
• Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation

  2019cites this paper
• Drosophila melanogaster tPlus3a and tPlus3b ensure full male fertility by regulating transcription of Y-chromosomal, seminal fluid, and heat shock genes

  2019cites this paper
• New Roles for Canonical Transcription Factors in Repeat Expansion Diseases.

  2019cites this paper
• RNA Polymerase II Independent Recruitment of SPT6 at Transcription Start Sites in Arabidopsis

  2018cites this paper
• Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation

  2018cites this paper
• Cdc73 suppresses genome instability by mediating telomere homeostasis

  2018cites this paper
• Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast

  2018cites this paper
• Structure of activated transcription complex Pol II–DSIF–PAF–SPT6

  2018cites this paper
• The Composition of the Arabidopsis RNA Polymerase II Transcript Elongation Complex Reveals the Interplay between Elongation and mRNA Processing Factors[OPEN]

  2017cites this paper
• The Roles of Factors Modulating PIWI/piRNA Pathway Silencing of Transposons

  2017cites this paper
• Transcription factors that influence RNA polymerases I and II: To what extent is mechanism of action conserved?

  2017cites this paper
• Genetic mechanisms regulating proliferation and cell specification in the Drosophila embryonic CNS

  2017cites this paper
• Insights into the role of the Paf1 complex in promoting H2B monoubiquitylation

  2017cites this paper
• RNA polymerase II pausing and transcriptional regulation of the HSP70 expression.

  2017cites this paper
• The Polymerase Associated Factor Complex-Protein Arginine Methyltransferase Axis: A Mechanism of Acute Leukemia

  2017cites this paper
• Drosophila PAF1 Modulates PIWI/piRNA Silencing Capacity.

  2017cites this paper
• Control of mRNA 3’-end formation during Drosophila neural development: mechanisms and biological roles

  2017cites this paper
• Drosophila CG2469 Encodes a Homolog of Human CTR9 and Is Essential for Development

  2016cites this paper
• Ctr9, a Key Component of the Paf1 Complex, Affects Proliferation and Terminal Differentiation in the Developing Drosophila Nervous System

  2016cites this paper
• Involvement of PARP1 in the regulation of alternative splicing

  2016cites this paper
• PAF Complex Plays Novel Subunit-Specific Roles in Alternative Cleavage and Polyadenylation

  2016cites this paper
• Transcriptional Regulation of Heart Development in Zebrafish

  2016cites this paper
• Quantitative Analysis of Dynamic Protein Interactions during Transcription Reveals a Role for Casein Kinase II in Polymerase-associated Factor (PAF) Complex Phosphorylation and Regulation of Histone H2B Monoubiquitylation*

  2016influential citation
• HSFs, Stress Sensors and Sculptors of Transcription Compartments and Epigenetic Landscapes.

  2015cites this paper
• An RNAi-Based Candidate Screen for Modifiers of the CHD1 Chromatin Remodeler and Assembly Factor in Drosophila melanogaster

  2015influential citation
• Genome-wide errant targeting by Hairy

  2015cites this paper
• RNA polymerase II–associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II

  2015cites this paper
• Characterization of the Human Transcription Elongation Factor Rtf1: Evidence for Nonoverlapping Functions of Rtf1 and the Paf1 Complex

  2015cites this paper
• Structural investigation of the histone chaperone complex FACT using genetically encoded crosslinkers in Saccharomyces cerevisiae

  2015cites this paper
• Chromatin modification by the RNA Polymerase II elongation complex

  2014cites this paper
• The PAF1 complex is involved in embryonic epidermal morphogenesis in Caenorhabditis elegans.

  2014influential citation
• UpSETing chromatin during non-coding RNA production

  2013cites this paper
• Characterization of Drosophila Menin Protein Interactions and a Potential Role for Menin in the Insulin Signalling Pathway

  2013cites this paper
• The PAF Complex and Prf1/Rtf1 Delineate Distinct Cdk9-Dependent Pathways Regulating Transcription Elongation in Fission Yeast

  2013cites this paper
• A feed forward circuit comprising Spt6, Ctk1 and PAF regulates Pol II CTD phosphorylation and transcription elongation

  2013cites this paper
• CAST-ChIP maps cell-type-specific chromatin states in the Drosophila central nervous system.

  2013cites this paper
• The writers, readers, and functions of the RNA polymerase II C-terminal domain code.

  2013cites this paper
• The many roles of the conserved eukaryotic Paf1 complex in regulating transcription, histone modifications, and disease states.

  2013influential citation
• OP-NARE131001 1..12

  2013cites this paper
• UNCOVERING THE MECHANISM OF CHROMATIN ASSOCIATION OF THE PAF1 TRANSCRIPTION ELONGATION COMPLEX

  2013cites this paper
• Identification of Chromatin-Associated Regulators of MSL Complex Targeting in Drosophila Dosage Compensation

  2012cites this paper
• Examining the contribution of chromatin and chromatin associated factors to transcription regulation

  2012cites this paper
• Proteome analysis of a CTR9 deficient yeast strain suggests that Ctr9 has function(s) independent of the Paf1 complex.

  2012cites this paper
• Small region of Rtf1 protein can substitute for complete Paf1 complex in facilitating global histone H2B ubiquitylation in yeast

  2012cites this paper
• Two Widespread DNA Binding Factors Mediate Differential Regulation of Promoter-proximal Pausing in Drosophila.

  2012cites this paper
• Identification of Mutant Versions of the Spt16 Histone Chaperone That Are Defective for Transcription-Coupled Nucleosome Occupancy in Saccharomyces cerevisiae

  2012cites this paper
• The Roles of the Paf1 Complex and Associated Histone Modifications in Regulating Gene Expression

  2011cites this paper
• The Paf1 Complex Represses ARG1 Transcription in Saccharomyces cerevisiae by Promoting Histone Modifications

  2011cites this paper
• The RNA Helicase Rm62 Cooperates with SU(VAR)3-9 to Re-Silence Active Transcription in Drosophila melanogaster

  2011influential citation
• The PAF1 complex differentially regulates cardiomyocyte specification.

  2011influential citation
• Drosophila Set1 is the major histone H3 lysine 4 trimethyltransferase with role in transcription

  2011influential citation
• Chromatin signaling to kinetochores: transregulation of Dam1 methylation by histone H2B ubiquitination.

  2011cites this paper
• Histone Chaperones Spt6 and FACT: Similarities and Differences in Modes of Action at Transcribed Genes

  2011cites this paper
• Pol II waiting in the starting gates: Regulating the transition from transcription initiation into productive elongation.

  2011cites this paper
• Identification of a Role for Histone H2B Ubiquitylation in Noncoding RNA 3′-End Formation Through Mutational Analysis of Rtf1 in Saccharomyces cerevisiae

  2011cites this paper
• RNA polymerase II kinetics in polo polyadenylation signal selection

  2011cites this paper
• IDENTIFICATION AND CHARACTERIZATION OF FACTORS REQUIRED FOR REPRESSION OF THE YEAST SER3 GENE BY SRG1 INTERGENIC TRANSCRIPTION

  2011influential citation
• The roles of the Saccharomyces cerevisiae Paf1 complex in regulating transcriptional repression

  2011cites this paper
• Proliferation control in the central nervous system of Drosophila melanogaster

  2011cites this paper
• The Paf1 Complex Represses SER3 Transcription in Saccharomyces cerevisiae by Facilitating Intergenic Transcription-Dependent Nucleosome Occupancy of the SER3 Promoter

  2011influential citation
• Identification of a role for histone H2B ubiquitylation in non-coding RNA 3’-end formation through mutational analysis of Rtf1 in S. cerevisiae

  2011cites this paper
• The Arabidopsis Paf1c Complex Component CDC73 Participates in the Modification of FLOWERING LOCUS C Chromatin1[C][W][OA]

  2010cites this paper
• c-Myc regulates transcriptional pause release.

  2010cites this paper
• Utilization Of Drosophila Hsp70 Gene For Identification Of Genuine Pol Ii Elongation Factors: Identification Of Spt6 As A Factor That Enhances The Elongation Rate Of Pol Ii In Vivo

  2010cites this paper
• Integration and analysis of phenotypic data from functional screens

  2010cites this paper
• Mechanism of Antitermination by NusG-like Proteins and the Role of RNAP Conformational Mobility in Transcription Cycle

  2010cites this paper
• Heterochromatin protein 1 (HP1) connects the FACT histone chaperone complex to the phosphorylated CTD of RNA polymerase II.

  2010cites this paper
• Characterization of a Novel WDR5-binding Site That Recruits RbBP5 through a Conserved Motif to Enhance Methylation of Histone H3 Lysine 4 by Mixed Lineage Leukemia Protein-1*

  2010cites this paper
• Widespread regulation of gene expression in the Drosophila genome by the histone acetyltransferase dTip60

  2010cites this paper
• The Arabidopsis Paf 1 c Complex Component CDC 73 Participates in the Modification of FLOWERING LOCUS C Chromatin 1 [ C ] [ W ] [ OA ]

  2010cites this paper
• The RNA Polymerase-associated Factor 1 Complex (Paf1C) Directly Increases the Elongation Rate of RNA Polymerase I and Is Required for Efficient Regulation of rRNA Synthesis*

  2010cites this paper
• The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS.

  2010cites this paper
• The PAF1 complex component Leo1 is essential for cardiac and neural crest development in zebrafish.

  2010cites this paper
• Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.

  2010cites this paper
• The Paf1 complex: platform or player in RNA polymerase II transcription?

  2010cites this paper
• Noncanonical Tandem SH2 Enables Interaction of Elongation Factor Spt6 with RNA Polymerase II*

  2010cites this paper
• Transcription through the HIV-1 nucleosomes: effects of the PBAF complex in Tat activated transcription.

  2010cites this paper
• Spt6 enhances the elongation rate of RNA polymerase II in vivo

  2009cites this paper