Widespread Gene Delivery and Structure-Specific Patterns of Expression in the Brain after Intraventricular Injections of Neonatal Mice with an Adeno-Associated Virus Vector

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of Virology

• Publication date

  2001-12-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.75.24.12382-12392.2001PMID 11711628PMCID PMC116134
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Changes in the total number of dentate granule cells in juvenile and adult rats: A correlated volumetric and 3H-thymidine autoradiographic study

  2004cited by this paper
• Evidence that late-generated granule cells do not simply replace earlier formed neurons in the rat dentate gyrus

  2004cited by this paper
• 3H-thymidine-radiographic studies of neurogenesis in the rat olfactory bulb

  2004cited by this paper
• In utero transplantation of fetal liver cells in the mucopolysaccharidosis type VII mouse results in low-level chimerism, but overexpression of beta-glucuronidase can delay onset of clinical signs.

  2001cited by this paper
• Engraftment of genetically engineered amniotic epithelial cells corrects lysosomal storage in multiple areas of the brain in mucopolysaccharidosis type VII mice.

  2001cited by this paper
• Intracranial injection of recombinant adeno-associated virus improves cognitive function in a murine model of mucopolysaccharidosis type VII.

  2001cited by this paper
• Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system.

  2000cited by this paper
• Infectious Entry Pathway of Adeno-Associated Virus and Adeno-Associated Virus Vectors

  2000cited by this paper
• Mammalian neural stem cells.

  2000cited by this paper
• Reversal of Pathology in the Entire Brain of Mucopolysaccharidosis Type VII Mice after Lentivirus-Mediated Gene Transfer

  2000cited by this paper
• In vivo transduction of cerebellar Purkinje cells using adeno-associated virus vectors.

  2000cited by this paper
• Recombinant Adeno-Associated Virus-Mediated Correction of Lysosomal Storage within the Central Nervous System of the Adult Mucopolysaccharidosis Type VII Mouse

  2000cited by this paper
• Systemic Hyperosmolality Improves β-Glucuronidase Distribution and Pathology in Murine MPS VII Brain Following Intraventricular Gene Transfer

  1999cited by this paper
• Elimination of lysosomal storage in brains of MPS VII mice treated by intrathecal administration of an adeno-associated virus vector

  1999cited by this paper
• Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains.

  1999cited by this paper
• Adeno-Associated Virus-Mediated Gene Transfer to the Brain: Duration and Modulation of Expression

  1999cited by this paper
• Sustained production of beta-glucuronidase from localized sites after AAV vector gene transfer results in widespread distribution of enzyme and reversal of lysosomal storage lesions in a large volume of brain in mucopolysaccharidosis VII mice.

  1999cited by this paper
• Systemic and Central Nervous System Correction of Lysosomal Storage in Mucopolysaccharidosis Type VII Mice

  1999cited by this paper
• Identification of a neural stem cell in the adult mammalian central nervous system.

  1999cited by this paper
• Neonatal gene transfer leads to widespread correction of pathology in a murine model of lysosomal storage disease.

  1999cited by this paper
• Membrane-Associated Heparan Sulfate Proteoglycan Is a Receptor for Adeno-Associated Virus Type 2 Virions

  1998cited by this paper
• Direct Interaction of CASK/LIN-2 and Syndecan Heparan Sulfate Proteoglycan and Their Overlapping Distribution in Neuronal Synapses

  1998cited by this paper
• Characterization of Intrastriatal Recombinant Adeno-Associated Virus-Mediated Gene Transfer of Human Tyrosine Hydroxylase and Human GTP-Cyclohydrolase I in a Rat Model of Parkinson’s Disease

  1998cited by this paper
• Adeno-Associated Virus Vector-Mediated Transgene Integration into Neurons and Other Nondividing Cell Targets

  1998cited by this paper
• Selective and Rapid Uptake of Adeno-Associated Virus Type 2 in Brain

  1998cited by this paper
• Fluorescent Virions: Dynamic Tracking of the Pathway of Adenoviral Gene Transfer Vectors in Living Cells

  1998cited by this paper
• Neuron-specific transduction in the rat septohippocampal or nigrostriatal pathway by recombinant adeno-associated virus vectors.

  1998cited by this paper
• Gene transfer by adeno-associated virus vectors into the central nervous system.

  1997cited by this paper
• Developmental changes in GABA neurons of the rat dentate gyrus: An in situ hybridization and birthdating study

  1997cited by this paper
• Decreased lysosomal storage in the adult MPS VII mouse brain in the vicinity of grafts of retroviral vector-corrected fibroblasts secreting high levels of β-glucuronidase

  1997cited by this paper
• Vsx‐1 and Vsx‐2: Differential expression of two Paired‐like homeobox genes during zebrafish and goldfish retinogenesis

  1997cited by this paper
• Recombinant adeno-associated virus for muscle directed gene therapy

  1997cited by this paper
• Adeno-associated viral vector gene transfer into leptomeningeal xenografts

  1997cited by this paper
• Postnatal mouse subventricular zone neuronal precursors can migrate and differentiate within multiple levels of the developing neuraxis.

  1997cited by this paper
• Regulation of neuronal birth, migration and death in the rat dentate gyrus.

  1996cited by this paper
• Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector.

  1996cited by this paper
• Protocols for gene transfer in neuroscience : towards gene therapy of neurological disorders

  1996cited by this paper
• Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis

  1996cited by this paper
• Effects of Gamma Irradiation on the Transduction of Dividing and Nondividing Cells in Brain and Muscle of Rats by Adeno-Associated Virus Vectors

  1996cited by this paper
• Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors

  1996cited by this paper
• Adenovirus-mediated gene delivery into neuronal precursors of the adult mouse brain.

  1996cited by this paper
• High level expression and export of beta-glucuronidase from murine mucopolysaccharidosis VII cells corrected by a double-copy retrovirus vector.

  1995cited by this paper
• Neural progenitor cell engraftment corrects lysosomal storage throughout the MRS VII mouse brain

  1995cited by this paper
• Long-distance neuronal migration in the adult mammalian brain.

  1994cited by this paper
• Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors

  1993cited by this paper
• Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone.

  1993cited by this paper
• Highly polysialylated neural cell adhesion molecule (NCAM-H) is expressed by newly generated granule cells in the dentate gyrus of the adult rat

  1993cited by this paper
• Widespread dispersion of neuronal clones across functional regions of the cerebral cortex.

  1992cited by this paper
• Correction of murine mucopolysaccharidosis VII by a human beta-glucuronidase transgene.

  1990cited by this paper
• Clonally related cortical cells show several migration patterns.

  1988cited by this paper
• Variation in ten lysosomal hydrolase enzyme activities in inbred mouse strains

  1986cited by this paper
• Expression of beta-glucuronidase haplotypes in prototype and congenic mouse strains.

  1982cited by this paper
• An autoradiographic study of the time of origin and the pattern of granule cell migration in the dentate gyrus of the rat

  1975cited by this paper
• The Synaptic Organization of the Brain: An Introduction

  1975cited by this paper
• Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb

  1969cited by this paper
• Autoradiographic study of histogenesis in the mouse olfactory bulb I. Time of origin of neurons and neuroglia

  1968cited by this paper
• Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats

  1965cited by this paper

• Advances and Challenges in Adeno-Associated Virus Gene Therapy Applications of Localized Delivery Strategies

  2025cites this paper
• Artificial enforcement of the unfolded protein response (UPR) reduces disease features in multiple preclinical models of ALS/FTD.

  2025cites this paper
• Variants in Lrrk2 and Snca deficiency do not alter the course of primary encephalitis due to neurotropic reovirus T3D in newborn mice

  2024cites this paper
• Cell type–specific gene therapy confers protection against motor neuron disease caused by a TFG variant

  2024cites this paper
• Disease-Associated Q159X Mutant Prion Protein Is Sufficient to Cause Fatal Degenerative Disease in Mice

  2024cites this paper
• Adeno-associated viral tools to trace neural development and connectivity across amphibians.

  2024cites this paper
• Quantifying Dendritic Arbors In Vitro and In Vivo in Rodent Models.

  2024cites this paper
• Deletion of VPS50 protein in mouse brain impairs synaptic function and behavior

  2024cites this paper
• Adeno-associated virus vector delivery to the brain: Technology advancements and clinical applications.

  2024cites this paper
• The influence of the prolactin/vasoinhibin axis on post‐stroke lesion volume, astrogliosis, and survival

  2024cites this paper
• Stable, neuron-specific gene expression in the mouse brain

  2024cites this paper
• Impact of KDM6B mosaic brain knockout on synaptic function and behavior

  2024cites this paper
• Simple improvements in vector design afford substantial gains in AAV delivery of aggregation-slowing Aβ variants

  2024cites this paper
• Deletion of VPS50 protein in mice brain impairs synaptic function and behavior

  2023cites this paper
• Intraperitoneal Injection of Neonatal Mice

  2023cites this paper
• Strong ubiquitous micro-promoters for recombinant adeno-associated viral vectors

  2023cites this paper
• Recent Advances in In Vivo Somatic Cell Gene Modification in Newborn Pups

  2023cites this paper
• KMT2C knockout generates ASD-like behaviors in mice

  2023cites this paper
• Experimental approaches for manipulating choroid plexus epithelial cells

  2022cites this paper
• In vivo targeting of a variant causing vanishing white matter using CRISPR/Cas9

  2022cites this paper
• Routes of administration for adeno-associated viruses carrying gene therapies for brain diseases

  2022influential citation
• Overexpression of Brain- and Glial Cell Line-Derived Neurotrophic Factors Is Neuroprotective in an Animal Model of Acute Hypobaric Hypoxia

  2022cites this paper
• A Historical Review of Brain Drug Delivery

  2022cites this paper
• Glycation modulates glutamatergic signaling and exacerbates Parkinson’s disease-like phenotypes

  2022cites this paper
• Ultrasound-Mediated Blood-Brain Barrier Opening Improves Whole Brain Gene Delivery in Mice

  2021cites this paper
• Completion of neuronal remodeling prompts myelination along developing motor axon branches

  2021cites this paper
• Glycation modulates glutamatergic signaling and exacerbates Parkinson’s disease-like phenotypes

  2021cites this paper
• Viral alpha-synuclein knockdown prevents spreading synucleinopathy

  2021cites this paper
• GLP-2 restores impairments in spatial working memory and hippocampal LTD via the MEK/ERK pathway in juvenile-onset diabetes rats.

  2021cites this paper
• Can early treatment of twitcher mice with high dose AAVrh10-GALC eliminate the need for BMT?

  2021cites this paper
• Delivery Platforms for CRISPR/Cas9 Genome Editing of Glial Cells in the Central Nervous System

  2021cites this paper
• Insulin-like growth factor 2 (IGF2) protects against Huntington’s disease through the extracellular disposal of protein aggregates

  2020cites this paper
• Transverse sinus injections drive robust whole-brain expression of transgenes

  2020cites this paper
• Building research in diet and cognition (BRIDGE): Baseline characteristics of older obese African American adults in a randomized controlled trial to examine the effect of the Mediterranean diet with and without weight loss on cognitive functioning

  2020cites this paper
• Conditions for combining gene therapy with bone marrow transplantation in murine Krabbe disease

  2020cites this paper
• Translating CRISPR-Cas Therapeutics: Approaches and Challenges

  2020cites this paper
• Ex Vivo Imaging of Mitochondrial Dynamics and Trafficking in Astrocytes

  2020cites this paper
• Plasmid DNA gene therapy of the Niemann-Pick C1 mouse with transferrin receptor-targeted Trojan horse liposomes

  2020cites this paper
• ExBoX – a simple Boolean exclusion strategy to drive expression in neurons

  2020cites this paper
• Alternative Anesthesia of Neonatal Mice for Global rAAV Delivery in the Brain With Non-detectable Behavioral Interference in Adults

  2020cites this paper
• CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage

  2019cites this paper
• Regulation of protein homeostasis in acute and chronic stress

  2019cites this paper
• Insulin-like growth factor 2 (IGF2) protects against HD through the extracellular disposal of protein aggregates

  2019cites this paper
• Advanced nanotherapies to promote neuroregeneration in the injured newborn brain.

  2019cites this paper
• Astrocyte transduction is required for rescue of behavioral phenotypes in the YAC128 mouse model with AAV-RNAi mediated HTT lowering therapeutics.

  2019cites this paper
• In Situ Hybridization for Detection of AAV-Mediated Gene Expression.

  2019cites this paper
• Cross-species genetic screens to identify kinase targets for APP reduction in Alzheimer's disease.

  2019cites this paper
• Fetal gene therapy for neurodegenerative disease of infants

  2018cites this paper
• A CRISPR/Cas9 based strategy to manipulate the Alzheimer’s amyloid pathway

  2018cites this paper
• Combinatorial Effects of Alpha- and Gamma-Protocadherins on Neuronal Survival and Dendritic Self-Avoidance

  2018cites this paper
• Distribution and Penetration of Intracerebroventricularly Administered 2′OMePS Oligonucleotide in the Mouse Brain

  2017cites this paper
• Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis.

  2017cites this paper
• A Molecular Reporter for Monitoring Autophagic Flux in Nervous System In Vivo.

  2017cites this paper
• Challenges and Advances in Gene Therapy Approaches for Neurodegenerative Disorders.

  2017cites this paper
• Neonatal AAV delivery of alpha-synuclein induces pathology in the adult mouse brain

  2017cites this paper
• Sustained viral gene delivery from a micro-fibrous, elastomeric cardiac patch to the ischemic rat heart.

  2017cites this paper
• Targeted P2X7R shRNA delivery attenuates sympathetic nerve sprouting and ameliorates cardiac dysfunction in rats with myocardial infarction

  2017cites this paper
• Cellular selectivity of AAV serotypes for gene delivery in neurons and astrocytes by neonatal intracerebroventricular injection

  2017influential citation
• Corrigendum: Better Targeting, Better Efficiency for Wide-Scale Neuronal Transduction with the Synapsin Promoter and AAV-PHP.B

  2016cites this paper
• Biology of AAV vectors in the central nervous system

  2016cites this paper
• Widespread Neuronal Transduction of the Rodent CNS via Neonatal Viral Injection.

  2016cites this paper
• Virus-mediated Delivery of the Fmr1 Gene as a Tool for the Treatment of Fragile X Syndrome

  2016cites this paper
• Lung-specific RNA interference of coupling factor 6, a novel peptide, attenuates pulmonary arterial hypertension in rats

  2016cites this paper
• Better Targeting, Better Efficiency for Wide-Scale Neuronal Transduction with the Synapsin Promoter and AAV-PHP.B

  2016cites this paper
• Increased brain hemopexin levels improve outcomes after intracerebral hemorrhage

  2016cites this paper
• von Willebrand factor contributes to poor outcome in a mouse model of intracerebral haemorrhage

  2016cites this paper
• rAAV Gene Therapy in a Canavan's Disease Mouse Model Reveals Immune Impairments and an Extended Pathology Beyond the Central Nervous System.

  2016cites this paper
• Isoflurane-induced inactivation of CREB through histone deacetylase 4 is responsible for cognitive impairment in developing brain.

  2016cites this paper
• FMRP Expression Levels in Mouse Central Nervous System Neurons Determine Behavioral Phenotype

  2016cites this paper
• Mucopolysaccharidosis IIIB confers enhanced neonatal intracranial transduction by AAV8 but not by 5, 9 or rh10

  2015cites this paper
• Cytomegalovirus initiates infection selectively from high-level β1 integrin-expressing cells in the brain.

  2015cites this paper
• Intravenous injection of AAVrh10-GALC after the neonatal period in twitcher mice results in significant expression in the central and peripheral nervous systems and improvement of clinical features.

  2015cites this paper
• Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice

  2015cites this paper
• rAAV-Mediated Gene Transfer For Study of Pathological Mechanisms and Therapeutic Intervention in Canavan's Disease: A Dissertation

  2014cites this paper
• Biology of adeno-associated viral vectors in the central nervous system

  2014cites this paper
• A new method to measure autophagy flux in the nervous system

  2014cites this paper
• Dynamic and extensive metabolic state-dependent regulation of cytokine expression and circulating levels.

  2014cites this paper
• idespread neuron-specific transgene expression in brain and spinal ord following synapsin promoter-driven AAV 9 neonatal ntracerebroventricular injection esse

  2014cites this paper
• The effect of brief neonatal cryoanesthesia on physical development and adult cognitive function in mice.

  2014cites this paper
• Quantitative, noninvasive, in vivo longitudinal monitoring of gene expression in the brain by co-AAV transduction with a PET reporter gene

  2014cites this paper
• Neonatal immune-tolerance in mice does not prevent xenograft rejection.

  2014cites this paper
• Silencing Mutant Huntingtin by Adeno-Associated Virus-Mediated RNA Interference Ameliorates Disease Manifestations in the YAC128 Mouse Model of Huntington's Disease

  2014cites this paper
• Intracerebroventricular viral injection of the neonatal mouse brain for persistent and widespread neuronal transduction.

  2014cites this paper
• Gene therapy in mouse models of spinal muscular atrophy

  2013cites this paper
• Capsid Serotype and Timing of Injection Determines AAV Transduction in the Neonatal Mice Brain

  2013cites this paper
• Enhancement of SMN protein levels in a mouse model of spinal muscular atrophy using novel drug-like compounds

  2013cites this paper
• In Vitro and In Vivo Characterization of the Infection Efficiency of a Modified Retrovirus Envelope Glycoprotein for Targeting Gene Transduction

  2013cites this paper
• C1q/TNF-related Protein 4 (CTRP4) Is a Unique Secreted Protein with Two Tandem C1q Domains That Functions in the Hypothalamus to Modulate Food Intake and Body Weight*

  2013cites this paper
• Viral transduction of the neonatal brain delivers controllable genetic mosaicism for visualising and manipulating neuronal circuits in vivo

  2013cites this paper
• Measurement of autophagy flux in the nervous system in vivo

  2013cites this paper
• Opposing Action of Nuclear Factor κB and Polo-like Kinases Determines a Homeostatic End Point for Excitatory Synaptic Adaptation

  2013cites this paper
• Dysregulation of Gene Expression in a Lysosomal Storage Disease Varies between Brain Regions Implicating Unexpected Mechanisms of Neuropathology

  2012cites this paper
• Alteration of brain volume in IL‐6 overexpressing mice related to autism

  2012cites this paper
• BDNF mediates competitive interactions among individual cortical neurons

  2012cites this paper
• Brain IL-6 elevation causes neuronal circuitry imbalances and mediates autism-like behaviors.

  2012cites this paper
• Efficacy of Increased Ube3a Protein Levels in the Brain in Rescuing the Phenotype of an Angelman Syndrome Mouse

  2012cites this paper
• Characterization of a rat model of Huntington’s disease based on targeted expression of mutant huntingtin in the forebrain using adeno‐associated viral vectors

  2012cites this paper
• Bifunctional RNAs targeting the intronic splicing silencer N1 increase SMN levels and reduce disease severity in an animal model of spinal muscular atrophy.

  2012cites this paper
• A comprehensive concept of optogenetics.

  2012cites this paper
• Extended normal life after AAVrh10-mediated gene therapy in the mouse model of Krabbe disease.

  2012cites this paper