NHE-1: still a viable therapeutic target.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Journal of Molecular and Cellular Cardiology

• Publication date

  2013-08-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.yjmcc.2013.02.006PMID 23429008
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Myocardial Na+/H+ Exchanger

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• Inhibition of Na+/H+ Exchanger Isoform 1 Is Neuroprotective in Neonatal Hypoxic Ischemic Brain Injury

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• The Na(+)/H(+) exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction. Results of the evaluation of the safety and cardioprotective effects of eniporide in acute myocardial infarction (ESCAMI) trial.

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• The myocardial Na+/H+ exchanger: a potential therapeutic target for the prevention of myocardial ischaemic and reperfusion injury and attenuation of postinfarction heart failure.

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• Na(+)/H(+) exchange inhibition attenuates hypertrophy and heart failure in 1-wk postinfarction rat myocardium.

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• Inhibition of the Sodium-Hydrogen Exchanger With Cariporide to Prevent Myocardial Infarction in High-Risk Ischemic Situations: Main Results of the GUARDIAN Trial

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• The myocardial Na(+)-H(+) exchange: structure, regulation, and its role in heart disease.

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• Intracellular sodium accumulation during ischemia as the substrate for reperfusion injury.

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• Blocking Na(+)-H+ exchange by cariporide reduces Na(+)-overload in ischemia and is cardioprotective.

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• Inhibition of the Na(+)/H(+) exchanger confers greater cardioprotection against 90 minutes of myocardial ischemia than ischemic preconditioning in dogs.

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• Sodium-Hydrogen Exchange and Platelet Function

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• Dose-dependent reduction of myocardial infarct mass in rabbits by the NHE-1 inhibitor cariporide (HOE 642).

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• A rapid ischemia-induced apoptosis in isolated rat hearts and its attenuation by the sodium-hydrogen exchange inhibitor HOE 642 (cariporide).

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• Regulation of the Na+/H+ exchanger isoform NHE1: role of phosphorylation.

  1996cited by this paper
• Preischaemic as well as postischaemic application of a Na+/H+ exchange inhibitor reduces infarct size in pigs.

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• NMR measurements of Na+ and cellular energy in ischemic rat heart: role of Na(+)-H+ exchange.

  1993cited by this paper
• Amiloride delays the ischemia-induced rise in cytosolic free calcium.

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• 23Na-NMR measurements of intracellular sodium in intact perfused ferret hearts during ischemia and reperfusion.

  1990cited by this paper
• Amiloride enhances postischemic ventricular recovery: possible role of Na+-H+ exchange.

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