Congenital Diaphragmatic Hernia: Comparison of Animal Models and Relevance to the Human Situation

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Neonatology

• Publication date

  2009-03-27

• Fields of study

  Medicine

• Identifiers
  DOI 10.1159/000209850PMID 19325248
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• The nitrofen/bisdiamine murine model of congenital diaphragmatic hernia has a pulmonary hypertension vascular phenotype consistent with human CDH.

  2025cites this paper
• Antenatal Sildenafil for Congenital Diaphragmatic Hernia: A Systematic Review and Bayesian Meta-Analysis of Preclinical Studies

  2025influential citation
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  2023influential citation
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• The Respiratory Tract

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• Overexpression of YAP and miR-130a is closely related to pulmonary hypertension in congenital diaphragmatic hernia

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• Extracellular vesicles influence the pulmonary arterial extracellular matrix in congenital diaphragmatic hernia

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• Pbx1, Meis1, and Runx1 Expression Is Decreased in the Diaphragmatic and Pulmonary Mesenchyme of Rats with Nitrofen-Induced Congenital Diaphragmatic Hernia

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• Extracellular Vesicles Attenuate Nitrofen-Mediated Human Pulmonary Artery Endothelial Dysfunction: Implications for Congenital Diaphragmatic Hernia

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• Transgenic animal models of congenital diaphragmatic hernia: a comprehensive overview of candidate genes and signaling pathways

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• Effect of antenatal tetramethylpyrazine on lung development and YAP expression in a rat model of experimental congenital diaphragmatic hernia

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• The effects of tracheal occlusion on Wnt signaling in a rabbit model of congenital diaphragmatic hernia.

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• Erkrankungen des Zwerchfells

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  2019influential citation
• Tandem mass tag (TMT) proteomic analysis of fetal lungs revealed differential expression of tight junction proteins in a rat model of congenital diaphragmatic hernia.

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• Expression of dispatched RND transporter family member 1 is decreased in the diaphragmatic and pulmonary mesenchyme of nitrofen-induced congenital diaphragmatic hernia

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• Gata-6 expression is decreased in diaphragmatic and pulmonary mesenchyme of fetal rats with nitrofen-induced congenital diaphragmatic hernia

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• Upregulated EFNB2 and EPHB4 promotes lung development in a nitrofen-induced congenital diaphragmatic hernia rat model

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• Elastase and matrix metalloproteinase activities are associated with pulmonary vascular disease in the nitrofen rat model of congenital diaphragmatic hernia.

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• STATs in Lung Development: Distinct Early and Late Expression, Growth Modulation and Signaling Dysregulation in Congenital Diaphragmatic Hernia

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• Follistatin-like 1 expression is decreased in the alveolar epithelium of hypoplastic rat lungs with nitrofen-induced congenital diaphragmatic hernia.

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• Animal Models for the Study of Neonatal Disease

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• Perturbations in Endothelial Dysfunction-Associated Pathways in the Nitrofen-Induced Congenital Diaphragmatic Hernia Model

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• Prenatal microRNA miR-200b Therapy Improves Nitrofen-induced Pulmonary Hypoplasia Associated With Congenital Diaphragmatic Hernia

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• Mesenchymal expression of the FRAS1/FREM2 gene unit is decreased in the developing fetal diaphragm of nitrofen-induced congenital diaphragmatic hernia

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• Polygenic Causes of Congenital Diaphragmatic Hernia Produce Common Lung Pathologies.

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• Morgagni Hernia: Presentation of 3 Cases and A Short Review of the Literature

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• Decreased Desmin expression in the developing diaphragm of the nitrofen-induced congenital diaphragmatic hernia rat model

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• Decreased expression of monocarboxylate transporter 1 and 4 in the branching airway epithelium of nitrofen-induced congenital diaphragmatic hernia.

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• Increased c-kit and stem cell factor expression in the pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia.

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• Update on novel targets and potential treatment avenues in pulmonary hypertension.

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• Investigation of molecular mechanisms of diaphragmatic defects in the nitrofen-induced rat model of congenital diaphragmatic hernia

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• Pharmacological models and approaches for pathophysiological conditions associated with hypoxia and oxidative stress.

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• The transcriptome of nitrofen-induced pulmonary hypoplasia in the rat model of congenital diaphragmatic hernia

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• Congenital Diaphragmatic Hernia with Delayed Presentation

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• Neuroendocrine factors regulate retinoic acid receptors in normal and hypoplastic lung development

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• Gene Expression of FRAS1-Related Extracellular Matrix 1 Is Decreased in Nitrofen-Induced Congenital Diaphragmatic Hernia

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• Medical interventions to reverse pulmonary hypoplasia in the animal model of congenital diaphragmatic hernia: A systematic review

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• Kif7 expression is decreased in the diaphragmatic and pulmonary mesenchyme of nitrofen-induced congenital diaphragmatic hernia.

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• Intrapulmonary Instillation of Perflurooctylbromide Improves Lung Growth, Alveolarization, and Lung Mechanics in a Fetal Rabbit Model of Diaphragmatic Hernia

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• Evidence for decreased lipofibroblast expression in hypoplastic rat lungs with congenital diaphragmatic hernia

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• Prenatal administration of all-trans retinoic acid upregulates leptin signaling in hypoplastic rat lungs with experimental congenital diaphragmatic hernia

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• Disruption of THY-1 signaling in alveolar lipofibroblasts in experimentally induced congenital diaphragmatic hernia

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• The soluble guanylyl cyclase activator BAY 60-2770 potently relaxes the pulmonary artery on congenital diaphragmatic hernia rabbit model

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• KIF7 Expression Is Decreased in the Diaphragmatic and Pulmonary Mesenchyme of Nitrofen-Induced Congenital Diaphragmatic Hernia

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• Spatiotemporal alterations in Sprouty-2 expression and tyrosine phosphorylation in nitrofen-induced pulmonary hypoplasia.

  2013cites this paper
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  2012cites this paper
• Congenital Diaphragmatic Hernia with Emphasis on Embryology, Subtypes, and Molecular Genetics

  2012cites this paper
• The pulmonary mesenchymal tissue layer is defective in an in vitro recombinant model of nitrofen-induced lung hypoplasia.

  2012cites this paper
• Pax3 gene expression is not altered during diaphragmatic development in nitrofen-induced congenital diaphragmatic hernia.

  2012cites this paper
• Intraluminal tracheal occlusion using a modified 8-mm Z-stent in a sheep model of left-sided congenital diaphragmatic hernia

  2012cites this paper
• Alterations of peroxisome proliferator-activated receptor γ and monocyte chemoattractant protein 1 gene expression in the nitrofen-induced hypoplastic lung.

  2012cites this paper
• Decreased pulmonary c-Cbl expression and tyrosine phosphorylation in the nitrofen-induced rat model of congenital diaphragmatic hernia

  2012cites this paper