Sarcolemmal KATP channel modulators and cardiac arrhythmias.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Current Medicinal Chemistry

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  PMID 21774762
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nicorandil

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• HMR 1098 is not an SUR isotype specific inhibitor of heterologous or sarcolemmal K ATP channels.

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• Both Mitochondrial KATP Channel Opening and Sarcolemmal KATP Channel Blockage Confer Protection Against Ischemia/Reperfusion-Induced Arrhythmia in Anesthetized Male Rats

  2010cited by this paper
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  2010cited by this paper
• Sudden Cardiac Death Prediction and Prevention: Report From a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop

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• Differential K(ATP) channel pharmacology in intact mouse heart.

  2010cited by this paper
• KR-31761, a novel K+(ATP)-channel opener, exerts cardioprotective effects by opening both mitochondrial K+(ATP) and Sarcolemmal K+(ATP) channels in rat models of ischemia/reperfusion-induced heart injury.

  2009cited by this paper
• K(ATP) activation prevents progression of cardiac hypertrophy to failure induced by pressure overload via protecting endothelial function.

  2009cited by this paper
• Mitochondrial KATP opening confers protection against lethal myocardial injury and ischaemia-induced arrhythmias in the rat heart via PI3K/Akt-dependent and -independent mechanisms.

  2009cited by this paper
• PKC‐permitted elevation of sarcolemmal KATP concentration may explain female‐specific resistance to myocardial infarction

  2009cited by this paper
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  2009cited by this paper
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• Ventricular Fibrillation with Prominent Early Repolarization Associated with a Rare Variant of KCNJ8/KATP Channel

  2009cited by this paper
• The cardiac sarcolemmal ATP-sensitive potassium channel as a novel target for anti-arrhythmic therapy.

  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
• KR-31762, a novel KATP channel opener, exerts cardioprotective effects by opening SarcKATP channels in rat models of ischemia/reperfusion-induced heart injury

  2008cited by this paper
• Atrial-selective approaches for the treatment of atrial fibrillation.

  2008cited by this paper
• Role of sarcolemmal ATP-sensitive potassium channel in oxidative stress-induced apoptosis: mitochondrial connection.

  2008cited by this paper
• Role of sarcolemmal ATP‐sensitive K+ channels in the regulation of sinoatrial node automaticity: an evaluation using Kir6.2‐deficient mice

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• Differential Structure of Atrial and Ventricular KATP: Atrial KATP Channels Require SUR1

  2008cited by this paper
• KATP channel knockout worsens myocardial calcium stress load in vivo and impairs recovery in stunned heart.

  2007cited by this paper
• Sex-specific and exercise-acquired cardioprotection is abolished by sarcolemmal KATP channel blockade in the rat heart.

  2007cited by this paper
• Regional and tissue specific transcript signatures of ion channel genes in the non‐diseased human heart

  2007cited by this paper
• KATP channel mutation confers risk for vein of Marshall adrenergic atrial fibrillation

  2007cited by this paper
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  2007cited by this paper
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  2006cited by this paper
• Structure-activity relationships of K(ATP) channel openers.

  2006cited by this paper
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  2006cited by this paper
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• P-1075 Exerts Diverse Modulatory Effects on Mitochondrial ATP-Sensitive K+ Channels in Rabbit Ventricular Myocytes

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• L-364,373 fails to activate the slow delayed rectifier K+ current in canine ventricular cardiomyocytes

  2006cited by this paper
• K+-independent Actions of Diazoxide Question the Role of Inner Membrane KATP Channels in Mitochondrial Cytoprotective Signaling*

  2006cited by this paper
• Effects of the blockade of cardiac sarcolemmal ATP-sensitive potassium channels on arrhythmias and coronary flow in ischemia-reperfusion model in isolated rat hearts.

  2006cited by this paper
• Sex differences in myocardial infarct size are abolished by sarcolemmal KATP channel blockade in rat.

  2006cited by this paper
• 5‐Hydroxydecanoate is metabolised in mitochondria and creates a rate‐limiting bottleneck for β‐oxidation of fatty acids

  2005cited by this paper
• A role of opening of mitochondrial ATP-sensitive potassium channels in the infarct size-limiting effect of ischemic preconditioning via activation of protein kinase C in the canine heart.

  2005cited by this paper
• Susceptibility of the heart to ischaemia–reperfusion injury and exercise‐induced cardioprotection are sex‐dependent in the rat

  2005cited by this paper
• Plasma‐membrane KATP channel‐mediated cardioprotection involves posthypoxic reductions in calcium overload and contractile dysfunction: mechanistic insights into cardioplegia

  2005cited by this paper
• Role of ATP-sensitive K+ channels in electrophysiological alterations during myocardial ischemia: a study using Kir6.2-null mice.

  2005cited by this paper
• BMS-191095, a cardioselective mitochondrial katp opener, inhibits human platelet aggregation by opening mitochondrial katp channels

  2005cited by this paper
• Mitochondrial K(ATP) channels in cell survival and death.

  2005cited by this paper
• K(ATP) channel therapeutics at the bedside.

  2005cited by this paper
• Is the sarcolemmal or mitochondrial K(ATP) channel activation important in the antiarrhythmic and cardioprotective effects during acute ischemia/reperfusion in the intact anesthetized rabbit model?

  2005cited by this paper
• Lifetime Risk for Development of Atrial Fibrillation: The Framingham Heart Study

  2004cited by this paper
• Sarcolemmal K(ATP) channels in ageing.

  2004cited by this paper
• Intravenous nicorandil can reduce the occurrence of ventricular fibrillation and QT dispersion in patients with successful coronary angioplasty in acute myocardial infarction.

  2004cited by this paper
• Effect of the Cardioselective, Sarcolemmal KATP Channel Blocker HMR 1098 on Atrial Electrical Remodeling During Pacing-Induced Atrial Fibrillation in Dogs

  2004cited by this paper
• Electrophysiologic Effects of Nicorandil on the Guinea Pig Long QT1 Syndrome Model

  2004cited by this paper
• KATP channel openers: Structure‐activity relationships and therapeutic potential

  2004cited by this paper
• Risk of Ventricular Proarrhythmia with Selective Opening of the Myocardial Sarcolemmal versus Mitochondrial ATP-Gated Potassium Channel

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• What Causes Sudden Death in Heart Failure?

  2004cited by this paper
• Pharmacological activation of plasma‐membrane KATP channels reduces reoxygenation‐induced Ca2+ overload in cardiac myocytes via modulation of the diastolic membrane potential

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• Nicorandil Protects Against Lethal Ischemic Ventricular Arrhythmias and Up-regulates Endothelial Nitric Oxide Synthase Expression and Sulfonylurea Receptor 2 mRNA in Conscious Rats with Acute Myocardial Infarction

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  2004cited by this paper
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• Replacing potassium with nicorandil in cold St. Thomas' Hospital cardioplegia improves preservation of energetics and function in pig hearts.

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• Inhibitors of ATP-sensitive potassium channels in guinea pig isolated ischemic hearts

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• Ischemic preconditioning is not cardioprotective in senescent human myocardium.

  2003cited by this paper
• Selective Block of Sarcolemmal IKATP in Human Cardiomyocytes Using HMR 1098

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• Effect of the sarcolemmal K(ATP) channel blocker HMR1098 on arrhythmias induced by programmed electrical stimulation in canine old myocardial infarction model: comparison with glibenclamide.

  2003cited by this paper
• Knockout of Kir6.2 negates ischemic preconditioning-induced protection of myocardial energetics.

  2003cited by this paper
• Resting Membrane Potential Regulates Na+–Ca2+ Exchange‐Mediated Ca2+ Overload during Hypoxia–Reoxygenation in Rat Ventricular Myocytes

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• Effects of Sulfonylurea Hypoglycemic Agents and Adenosine Triphosphate Dependent Potassium Channel Antagonists on Ventricular Arrhythmias in Patients with Decompensated Heart Failure

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  2003cited by this paper
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• Amiodarone Inhibits Sarcolemmal but Not Mitochondrial KATP Channels in Guinea Pig Ventricular Cells

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• Selective mitochondrial K(ATP) channel activation results in antiarrhythmic effect during experimental myocardial ischemia/reperfusion in anesthetized rabbits.

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• Unique Topographical Distribution of M Cells Underlies Reentrant Mechanism of Torsade de Pointes in the Long-QT Syndrome

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