Disease Modeling in Stem Cell-Derived 3D Organoid Systems.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Trends in Molecular Medicine

• Publication date

  2017-05-01

• Fields of study

  Biology, Medicine, Engineering

• Identifiers
  DOI 10.1016/j.molmed.2017.02.007PMID 28341301
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Organoids as an in vitro model of human development and disease

  2016cited by this paper
• Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus Infection.

  2016cited by this paper
• The Brazilian Zika virus strain causes birth defects in experimental models

  2016cited by this paper
• Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3.

  2016cited by this paper
• Abstract PR01: Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell and patient-derived tumor organoids

  2016cited by this paper
• Understanding How Zika Virus Enters and Infects Neural Target Cells.

  2016cited by this paper
• A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis.

  2016cited by this paper
• Generating Inner Ear Organoids from Mouse Embryonic Stem Cells.

  2016cited by this paper
• Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells.

  2016cited by this paper
• Zika virus impairs growth in human neurospheres and brain organoids

  2016cited by this paper
• Modeling infectious diseases and host-microbe interactions in gastrointestinal organoids.

  2016cited by this paper
• Modeling pancreatic cancer with organoids.

  2016cited by this paper
• A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo.

  2016cited by this paper
• Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling

  2016cited by this paper
• Quantitative proteomic analyses of mammary organoids reveals distinct signatures after exposure to environmental chemicals

  2016cited by this paper
• Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation

  2016cited by this paper
• Molecular Obstacles to Clinical Translation of iPSCs.

  2016cited by this paper
• Promotion of Intestinal Epithelial Cell Turnover by Commensal Bacteria: Role of Short-Chain Fatty Acids

  2016cited by this paper
• Long-term inflammation transforms intestinal epithelial cells of colonic organoids.

  2016cited by this paper
• The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites.

  2016cited by this paper
• Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons.

  2016cited by this paper
• The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites.

  2016cited by this paper
• Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure.

  2016cited by this paper
• Organoid culture systems for prostate epithelial tissue and prostate cancer tissue

  2016cited by this paper
• Pathobiology of Helicobacter pylori-Induced Gastric Cancer.

  2016cited by this paper
• Replication of human noroviruses in stem cell–derived human enteroids

  2016cited by this paper
• Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis

  2016cited by this paper
• Cystic fibrosis from the gastroenterologist's perspective

  2016cited by this paper
• Building pancreatic organoids to aid drug development

  2016cited by this paper
• Retinal Organoids from Pluripotent Stem Cells Efficiently Recapitulate Retinogenesis

  2016cited by this paper
• Alterations in the epithelial stem cell compartment could contribute to permanent changes in the mucosa of patients with ulcerative colitis

  2016cited by this paper
• Model organoids provide new research opportunities for ductal pancreatic cancer

  2016cited by this paper
• Emerging Technologies for Gut Microbiome Research.

  2016cited by this paper
• Tissue-specific mutation accumulation in human adult stem cells during life

  2016cited by this paper
• The promises and challenges of human brain organoids as models of neuropsychiatric disease

  2016cited by this paper
• Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

  2016cited by this paper
• Long-term Inflammation Transforms Intestinal Epithelial Cells of Colonic Organoids

  2016cited by this paper
• Designer matrices for intestinal stem cell and organoid culture

  2016cited by this paper
• Frizzled are colonic epithelial receptors for Clostridium difficile toxin B

  2016cited by this paper
• The Generation of Organoids for Studying Wnt Signaling.

  2016cited by this paper
• Prospective derivation of a living organoid biobank of colorectal cancer patients.

  2015cited by this paper
• Interaction of Salmonella enterica Serovar Typhimurium with Intestinal Organoids Derived from Human Induced Pluripotent Stem Cells

  2015cited by this paper
• In vitro generation of human pluripotent stem cell derived lung organoids

  2015cited by this paper
• Modeling rotavirus infection and antiviral therapy using primary intestinal organoids.

  2015cited by this paper
• Biological and therapeutic impact of intratumor heterogeneity in cancer evolution.

  2015cited by this paper
• Organoids as Model for Infectious Diseases: Culture of Human and Murine Stomach Organoids and Microinjection of Helicobacter Pylori.

  2015cited by this paper
• Characterization of stem/progenitor cell cycle using murine circumvallate papilla taste bud organoid

  2015cited by this paper
• Salmonella Manipulation of Host Signaling Pathways Provokes Cellular Transformation Associated with Gallbladder Carcinoma.

  2015cited by this paper
• FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders.

  2015cited by this paper
• In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.

  2015cited by this paper
• Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids

  2015cited by this paper
• Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs.

  2015cited by this paper
• Chemodetection and Destruction of Host Urea Allows Helicobacter pylori to Locate the Epithelium.

  2015cited by this paper
• The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids

  2015cited by this paper
• Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids

  2015cited by this paper
• Human cerebral organoids recapitulate gene expression programs of fetal neocortex development

  2015cited by this paper
• Organoid models of human and mouse ductal pancreatic cancer.

  2015cited by this paper
• Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

  2015cited by this paper
• Sequential cancer mutations in cultured human intestinal stem cells

  2015cited by this paper
• Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

  2015cited by this paper
• Single-cell messenger RNA sequencing reveals rare intestinal cell types

  2015cited by this paper
• Identification of multipotent luminal progenitor cells in human prostate organoid cultures.

  2014cited by this paper
• Transplantation of Embryonic and Induced Pluripotent Stem Cell-Derived 3D Retinal Sheets into Retinal Degenerative Mice

  2014cited by this paper
• Differential Modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of Host Peripheral Lipid Metabolism and Histone Acetylation in Mouse Gut Organoids

  2014cited by this paper
• Modeling human development and disease in pluripotent stem cell-derived gastric organoids

  2014cited by this paper
• The cytosolic bacterial peptidoglycan sensor Nod2 affords stem cell protection and links microbes to gut epithelial regeneration.

  2014cited by this paper
• Persistence and Toxin Production by Clostridium difficile within Human Intestinal Organoids Result in Disruption of Epithelial Paracellular Barrier Function

  2014cited by this paper
• Epithelial IL-22RA1-Mediated Fucosylation Promotes Intestinal Colonization Resistance to an Opportunistic Pathogen

  2014cited by this paper
• An organized and functional thymus generated from FOXN1-reprogrammed fibroblasts

  2014cited by this paper
• Cystic fibrosis genetics: from molecular understanding to clinical application

  2014cited by this paper
• Salmonella‐infected crypt‐derived intestinal organoid culture system for host–bacterial interactions

  2014cited by this paper
• Generation of cerebral organoids from human pluripotent stem cells

  2014cited by this paper
• Organoid cultures derived from patients with advanced prostate cancer.

  2014cited by this paper
• Single Lgr5- or Lgr6-expressing taste stem/progenitor cells generate taste bud cells ex vivo

  2014cited by this paper
• Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell–derived IFN-γ

  2014cited by this paper
• Organoid cultures for the analysis of cancer phenotypes.

  2014cited by this paper
• Establishment of a Novel Lingual Organoid Culture System: Generation of Organoids Having Mature Keratinized Epithelium from Adult Epithelial Stem Cells

  2013cited by this paper
• Regeneration and Experimental Orthotopic Transplantation of a Bioengineered Kidney

  2013cited by this paper
• Cerebral organoids model human brain development and microcephaly

  2013cited by this paper
• Vascularized and functional human liver from an iPSC-derived organ bud transplant

  2013cited by this paper
• Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

  2013cited by this paper
• Loss of NHE3 alters gut microbiota composition and influences Bacteroides thetaiotaomicron growth.

  2013cited by this paper
• Highly efficient generation of airway and lung epithelial cells from human pluripotent stem cells

  2013cited by this paper
• A functional CFTR assay using primary cystic fibrosis intestinal organoids

  2013cited by this paper
• Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients.

  2013cited by this paper
• In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

  2013cited by this paper
• Stem Cell-Derived Human Intestinal Organoids as an Infection Model for Rotaviruses

  2012cited by this paper
• Self-formation of layered neural structures in three-dimensional culture of ES cells.

  2012cited by this paper
• Stem cell-derived cell cultures and organoids for protozoan parasite propagation and studying host-parasite interaction.

  2012cited by this paper
• Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

  2012cited by this paper
• Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture.

  2011cited by this paper
• Genetic and Epigenetic Alterations in Pancreatic Carcinogenesis

  2011cited by this paper
• Hallmarks of cancer: the next generation.

  2011cited by this paper
• Controlled gene expression in primary Lgr5 organoid cultures

  2011cited by this paper
• Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium.

  2011cited by this paper
• The cancer stem cell: premises, promises and challenges

  2011cited by this paper
• Self-organizing optic-cup morphogenesis in three-dimensional culture

  2011cited by this paper
• Copy number variation and selection during reprogramming to pluripotency

  2011cited by this paper
• Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

  2010cited by this paper
• Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro.

  2010cited by this paper

• Unraveling the Genetic Mysteries of Müllerian Anomalies: Research Approaches and Clinical Significance

  2026cites this paper
• Scar Inhibition in Wound Healing: Mechanisms, Design, and Recent Advances

  2026cites this paper
• Toward Personalized Treatment of Urogenital Cancers: The Role of Patient-Derived Organoids.

  2026cites this paper
• Modeling the pre-metastatic niche of gastric cancer peritoneal metastasis under spatiotemporal resolution and investigating EVs-mediated immune suppression

  2026cites this paper
• Emerging technologies and current challenges in intratumoral microbiota research

  2026cites this paper
• Organoid models in viral hepatitis, primary liver cancer, and non-alcoholic fatty liver disease: Advances and challenges.

  2026cites this paper
• Viral vector research in human gene therapy: basic principles, alternative evaluation models, and clinical applications.

  2026cites this paper
• How to efficiently establish animal models of cholangiocarcinoma: challenges and inspiration

  2026cites this paper
• Taurine suppresses gastric intestinal metaplasia in patient-derived organoids and Atp4a-/- mice

  2026cites this paper
• Advances in three-dimensional fish cell models for aquatic toxicology.

  2026cites this paper
• Organoids in skin wound healing

  2025cites this paper
• Metformin exerted tumoricidal effects on colon cancer tumoroids via the regulation of autophagy pathway

  2025cites this paper
• NSAID-encapsulated nanoparticles as a targeted therapeutic platform for modulating chronic inflammation and inhibiting cancer progression: a review

  2025cites this paper
• Precision Spatial Control of Tumor‐Stroma Interactions in Cancer Models via 3D Bioprinting for Advanced Research and Therapy

  2025cites this paper
• Single-cell RNA-seq reveals the immune response of Co-infection with streptococcus pneumoniae after influenza A virus by a lung-on-chip: The molecular structure and mechanism of tight junction protein ZO-1.

  2025cites this paper
• Patient-derived cornea organoid model to study metabolomic characterization of rare disease: aniridia-associated keratopathy

  2025cites this paper
• Immune and Immune‐Integrated Organoids as NextGeneration Platforms for Disease Modeling

  2025cites this paper
• Advances and Global Trends in Three-Dimensional Human Tissue Models for HIV Research: A Bibliometric Analysis.

  2025cites this paper
• Midbrain microglia-integrated organoids as a next-generation tool for chronic morphine withdrawal research: A pilot study

  2025cites this paper
• Tumor-associated microbiota: Multi-cancer landscape, mechanistic insights and clinical translation (Review)

  2025cites this paper
• Organfit: a multi-scale convolutional model with ellipse fitting for organoid identification

  2025cites this paper
• Hepatobiliary organoid research: the progress and applications

  2025cites this paper
• Effects of hydrogel stiffness and viscoelasticity on organoid culture: a comprehensive review

  2025cites this paper
• An Ocular Gene-Set Expression Library for Heritability Partition and Cell Line Enrichment Analyses

  2025cites this paper
• An Overview on Spheroid and Organoid Models in Applied Studies

  2025cites this paper
• Effect of 2D and 3D ECM and Biomechanical Cues on Human iPSC‐Derived Liver Progenitor Cell Differentiation

  2025cites this paper
• Innovative Therapeutic Approach Targeting Colon Cancer Stem Cells: Transitional Cold Atmospheric Plasma

  2025cites this paper
• A New Perspective on Precision Medicine: The Power of Digital Organoids

  2025cites this paper
• Human corneal organoid has a limbal function that supplies epithelium to the cornea with limbal deficiency

  2025cites this paper
• Organoids for Obesity-related Diseases: Disease Models and Drug Screening.

  2025cites this paper
• Urine-derived stem cells efficiently assemble into micro-bone organoids supported by decellularized bone matrix microparticles for rapidly repairing bone defects through direct filling and paracrine functions

  2025cites this paper
• The use of stem cells and organoids for modeling host-microbe interactions in low-biomass tissues

  2025cites this paper
• Early-life exposure to polypropylene nanoplastics induces neurodevelopmental toxicity in mice and human iPSC-derived cerebral organoids

  2025cites this paper
• Human iPSC-derived cerebral organoids reveal oxytocin-mediated protection against amyloid-β pathology

  2025cites this paper
• Bioprinted Organoids: An Innovative Engine in Biomedicine

  2025cites this paper
• Organoids: physiologically relevant ex vivo models for viral disease research

  2025cites this paper
• A microphysiological systems approach to design gastrointestinal system

  2025cites this paper
• Insulin-producing INS-1 cell cultures on biomimetic 3D scaffolds.

  2025cites this paper
• Applying 3D cultures and high-throughput technologies to study host-pathogen interactions

  2025cites this paper
• Dynamic hydrogel mechanics in organoid engineering: From matrix design to translational paradigms

  2025cites this paper
• A pipeline for rapid, high-throughput imaging and quantitative analysis of human intestinal organoids

  2025cites this paper
• ROS homeostasis in cell fate, pathophysiology, and therapeutic interventions

  2025cites this paper
• Advances and Challenges in Modeling Autosomal Dominant Polycystic Kidney Disease: A Focus on Kidney Organoids

  2025cites this paper
• Artificial Intelligence Virtual Organoids (AIVOs)

  2025cites this paper
• A three-dimensional mouse liver organoid platform for assessing EDCs metabolites simulating liver metabolism.

  2025cites this paper
• Roadmap to Cytotoxicity: Exploring Assays and Mechanisms

  2025cites this paper
• GUT MICROBIOME IN CANCER: THE NEXT BIG OPPORTUNITY FOR BETTER PATIENT OUTCOMES?

  2025cites this paper
• Intelligent Manufacturing for Osteoarthritis Organoids

  2025cites this paper
• Parallel multiOMIC analysis reveals glutamine deprivation enhances directed differentiation of renal organoids

  2025cites this paper
• Development of Low-Cost CNC-Milled PMMA Microfluidic Chips as a Prototype for Organ-on-a-Chip and Neurospheroid Applications

  2025cites this paper
• Progress in the application of organoids for exploring the relationship between macrophages and various lung diseases

  2025cites this paper
• Protocol for the generation and analysis of organoids from Dental pulp stem cells (DPSCs).

  2025cites this paper
• Neuromuscular and cardiac organoids and assembloids: Advanced platforms for drug testing.

  2025cites this paper
• Organoid‐Guided Precision Medicine: From Bench to Bedside

  2025cites this paper
• Sustaining Brain Youth by Neural Stem Cells: Physiological and Therapeutic Perspectives

  2025cites this paper
• 3D Bioprinting Models for Glioblastoma: From Scaffold Design to Therapeutic Application

  2025cites this paper
• Microbial metabolites control self-renewal and precancerous progression of human cervical stem cells

  2025cites this paper
• Digital PCR characterizes epithelial cell populations in murine duodenal organoids

  2025cites this paper
• From Bioreactors to Organoids: Tools for Culturing and Understanding Microbiota

  2025cites this paper
• Qingqi Guxue Decoction induces S cell cycle arrest to inhibit replication of severe fever with thrombocytopenia syndrome virus

  2025cites this paper
• Lung Organoids from hiPSCs Can Be Efficiently Transduced by Recombinant Adeno-Associated Viral and Adenoviral Vectors

  2025cites this paper
• Organoids and organs-on-chips: Recent advances, applications in drug development, and regulatory challenges.

  2025cites this paper
• From in vitro development to accessible luminal interface of neonatal bovine-derived intestinal organoids

  2025influential citation
• Engineering the Future of Regenerative Medicines in Gut Health with Stem Cell-Derived Intestinal Organoids

  2025cites this paper
• State of the Art of Bioengineering Approaches in Beta-Cell Replacement

  2025cites this paper
• Mast cells-intestinal cancer cells crosstalk is mediated by TNF-alpha and sustained by the IL-33/ST2 axis

  2025cites this paper
• An Automated Imaging Method for Quantification of Changes to the Endomembrane System in Mammalian Spheroid Models

  2025cites this paper
• Scutellarin suppresses ovarian cancer progression by targeting METTL5

  2025cites this paper
• Endocrine cancer organoids in basic and translational medical research

  2025cites this paper
• Recent advances in 3D models of the nervous system for neural regeneration research and drug development.

  2025cites this paper
• AI-Assisted Cell Culture System.

  2025cites this paper
• Canine Adrenomedullary and Pheochromocytoma Organoids: A Novel In Vitro Model

  2025cites this paper
• Skeletal muscle, neuromuscular organoids and assembloids: a scoping review

  2025cites this paper
• Female Reproductive Tract Organoids: Applications from Physiology to Pathology

  2025cites this paper
• Establishment of Human Lung Cancer Organoids Using Small Biopsy and Surgical Tissues

  2025cites this paper
• Advancing fatty liver research in dairy cows: Development of a bovine liver organoid model.

  2025cites this paper
• Gastrointestinal tract, its pathophysiology and in-vitro models: A “quick” reference guide to translational studies

  2025cites this paper
• Organoids/organs-on-chips towards biomimetic human artificial skin

  2025cites this paper
• Microencapsulation of pluripotent stem cell-derived pancreatic and liver cells: biological needs and technological solutions.

  2025cites this paper
• Controlling the Organization and Differentiation of Human Neural Stem Cells on Hilbert Microcapillary Scaffolds Fabricated via Two‐Photon Lithography

  2025cites this paper
• Lung organoids as a human system for Mycobacteria infection modeling and drug testing.

  2025cites this paper
• From mechanotransduction to applications: Three-dimensional mechanical stimuli in cell fate regulation

  2025cites this paper
• Harnessing Next‐Generation 3D Cancer Models to Elucidate Tumor‐Microbiome Crosstalk

  2025cites this paper
• Unlocking the Secrets of the Endometrium: Stem Cells, Niches and Modern Methodologies

  2025cites this paper
• Dental Pulp Stem Cell-Derived Organoids: Advancing the Development of 3D Structures

  2025cites this paper
• Human iPSC-derived salivary gland organoids model diabetic salivary gland dysfunction

  2025cites this paper
• LGBP-OrgaNet: Learnable Gaussian Band Pass Fusion of CNN and Transformer Features for Robust Organoid Segmentation and Tracking

  2025cites this paper
• Synergistic enhancement of AAV gene delivery in 2D cells and 3D organoids using polybrene and hydroxychloroquine

  2025cites this paper
• Cartilage organoids: an emerging platform for novel osteoarthritis therapies

  2025cites this paper
• A bioactive calcium silicate nanowire-containing hydrogel for organoid formation and functionalization.

  2024cites this paper
• Promising preclinical models for lung cancer research—lung cancer organoids: a narrative review

  2024cites this paper
• Tumor Organoids: The Era of Personalized Medicine

  2024cites this paper
• Hepatic organoids move from adolescence to maturity

  2024cites this paper
• Emerging microfluidics for the modeling and treatment of arthritis

  2024cites this paper
• Advances in 3D Culture Models to Study Exosomes in Triple-Negative Breast Cancer

  2024cites this paper
• Current and future applications of light-sheet imaging for identifying molecular and developmental processes in autism spectrum disorders

  2024cites this paper
• Establishment of patient‐derived organoids for guiding personalized therapies in breast cancer patients

  2024cites this paper
• Chemically-defined and scalable culture system for intestinal stem cells derived from human intestinal organoids

  2024cites this paper
• Trophoblast stem cell-based organoid models of the human placental barrier

  2024cites this paper
• Progress and perspective of organoid technology in breast cancer research

  2024cites this paper