Tissue-specific posttranslational processing of pre-prosomatostatin encoded by a metallothionein-somatostatin fusion gene in transgenic mice.

No abstract is available for this paper.

• Publication year

  1985

• Venue

  Cell

• Publication date

  1985-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0092-8674(85)90075-3PMID 2859927
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Neuropeptides derived from prosomatostatin that do not contain the somatostatin-14 sequence.

  1984cited by this paper
• Transmission distortion and mosaicism in an unusual transgenic mouse pedigree.

  1984cited by this paper
• Secretion of human parathyroid hormone from rat pituitary cells infected with a recombinant retrovirus encoding preproparathyroid hormone.

  1984cited by this paper
• Formation of the 3′ end of histone mRNA by post-transcriptional processing

  1984cited by this paper
• Rat pre-prosomatostatin. Structure and processing by microsomal membranes.

  1983cited by this paper
• Expression of the chicken transferrin gene in transgenic mice.

  1983cited by this paper
• Prenatal lethalities in mice homozygous for human growth hormone gene sequences integrated in the germ line.

  1983cited by this paper
• Human beta-globin pre-mRNA synthesized in vitro is accurately spliced in Xenopus oocyte nuclei.

  1983cited by this paper
• Structure of Somatostatin Isolated from Bovine Retina

  1983cited by this paper
• Expressing a human proinsulin cDNA in a mouse ACTH-secreting cell. Intracellular storage, proteolytic processing, and secretion on stimulation.

  1983cited by this paper
• Cloning and characterization of a mRNA-encoding rat preprosomatostatin.

  1983cited by this paper
• Metallothionein-human GH fusion genes stimulate growth of mice.

  1983cited by this paper
• Five cases of somatostatinoma: clinical heterogeneity and diagnostic usefulness of basal and tolbutamide-induced hypersomatostatinemia.

  1983cited by this paper
• Prolonged somatostatin pretreatment desensitizes somatostatin's inhibition of receptor-mediated release of adrenocorticotropin hormone and sensitizes adenylate cyclase.

  1983cited by this paper
• Seven peptides derived from pro-somatostatin in rat brain.

  1982cited by this paper
• Presence of somatostatin-28-(1-12) in hypothalamus and pancreas.

  1982cited by this paper
• Regulation of metallothionein–thymidine kinase fusion plasmids injected into mouse eggs

  1982cited by this paper
• Dramatic growth of mice that develop from eggs microinjected with metallothionein–growth hormone fusion genes

  1982cited by this paper
• Circulating somatostatin acts on the islets of Langerhans by way of a somatostatin-poor compartment.

  1982cited by this paper
• Human somatostatin I: sequence of the cDNA.

  1982cited by this paper
• Differential regulation of metallothionein-thymidine kinase fusion genes in transgenic mice and their offspring.

  1982cited by this paper
• The mouse metallothionein-I gene is transcriptionally regulated by cadmium following transfection into human or mouse cells.

  1982cited by this paper
• The Human Growth Hormone Gene Family: Nucleotide Sequences Show Recent Divergence and Predict a New Polypeptide Hormone

  1981cited by this paper
• Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs.

  1981cited by this paper
• Transcriptional regulation of the mouse metallothionein-I gene by heavy metals.

  1981cited by this paper
• Multiple forms of immunoreactive somatostatin: comparison of distribution in neural and nonneural tissues and portal plasma of the rat.

  1981cited by this paper
• Heterogeneity of somatostatin-like peptides in rat brain, pancreas, and gastrointestinal tract.

  1981cited by this paper
• Somatostatin and diabetes.

  1981cited by this paper
• Neuroendocrine control of thyrotropin secretion.

  1981cited by this paper
• Gastrointestinal secretory, motor, circulatory, and metabolic effects of prosomatostatin.

  1981cited by this paper
• High biological activity of the synthetic replicates of somatostatin-28 and somatostatin-25.

  1981cited by this paper
• Effects of somatostatin-14 and somatostatin-28 on bombesin-stimulated release of gastrin, insulin, and glucagon in the dog.

  1981cited by this paper
• Structure of mouse metallothionein-I gene and its mRNA

  1981cited by this paper
• A sensitive radioimmunoassay for immunoreactive somatostatin in extracted plasma: measurement and characterization of portal and peripheral plasma in the rat.

  1980cited by this paper
• Nonradial m-mode changes in the 53 Persei variable 22 Orionis

  1980cited by this paper
• Synthesis and biological actions of prosomatostatin.

  1980cited by this paper
• Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

  1979cited by this paper
• Somatostatin in hypothalamus, extrahypothalamic brain, and peripheral tissues of the rat.

  1978cited by this paper
• Somatostatin and diabetes.

  1978cited by this paper
• Physiological role of somatostatin in the control of growth hormone and thyrotropin secretion.

  1976cited by this paper
• Detection of specific sequences among DNA fragments separated by gel electrophoresis.

  1975cited by this paper
• Ribonucleic acid isolated by cesium chloride centrifugation.

  1974cited by this paper
• Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone

  1973cited by this paper
• Pituitary hormone releasing or inhibiting activity of metal ions present in hypothalamic extracts.

  1973cited by this paper

• Mouse Models of Receptor Tyrosine Kinases

  2015cites this paper
• Growth Hormone Pulsatility and its Impact on Growth and Metabolism in Humans

  2011cites this paper
• Induction of Epithelial Mesenchimal Transition and Vasculogenesis in the Lenses of Dbl Oncogene Transgenic Mice

  2009cites this paper
• Gene Sequences Direct Gonadotroph-Specific Expression in Transgenic Mice

  2008cites this paper
• Factors regulating growth hormone secretion in humans.

  2007cites this paper
• Cellular specificity of proexendin-4 processing in mammalian cells in vitro and in vivo.

  2002cites this paper
• Pre-Proopiomelanocortin Cells by Herpes Simplex Virus-l Thymidine Kinase Differentially Regulates mRNAs Encoding the Adrenocorticotropin Receptor and Aldosterone Synthase in the Mouse Adrenal Gland

  2001cites this paper
• Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth.

  2001cites this paper
• Somatostatin and behaviour: the need for genetically engineered models.

  2000cites this paper
• Sustained Expression of Exendin-4 Does Not Perturb Glucose Homeostasis, β-Cell Mass, or Food Intake in Metallothionein-Preproexendin Transgenic Mice*

  2000cites this paper
• Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation.

  1999cites this paper
• Oncostatin M transforms lymphoid tissue function in transgenic mice by stimulating lymph node T-cell development and thymus autoantibody production.

  1999cites this paper
• Neuroendocrine control of growth hormone secretion.

  1999cites this paper
• Construction and analysis of multidrug resistance transgenic mice.

  1998cites this paper
• Somatostatin

  1998cites this paper
• Preclinical characterization and in vivo imaging studies of an engineered recombinant technetium-99m-labeled metallothionein-containing anti-carcinoembryonic antigen single-chain antibody.

  1998cites this paper
• The role of galanin and its receptor in the feedback regulation of growth hormone secretion.

  1996cites this paper
• Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors.

  1996cites this paper
• Mammary gland morphogenesis is inhibited in transgenic mice that overexpress cell surface beta1,4-galactosyltransferase.

  1996cites this paper
• Expression of a human insulin transgene in cholinergic neurons of the mouse medial habenula

  1995cites this paper
• Targeted ablation of pituitary pre-proopiomelanocortin cells by herpes simplex virus-1 thymidine kinase differentially regulates mRNAs encoding the adrenocorticotropin receptor and aldosterone synthase in the mouse adrenal gland.

  1995cites this paper
• Differential dependence of the tumorigenicity of chemically transformed rat liver epithelial cells on autocrine production of transforming growth factor alpha.

  1995cites this paper
• Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions.

  1995cites this paper
• Recombinant metallothionein-conjugated streptavidin labeled with 188Re and 99mTc.

  1995cites this paper
• Developmental abnormalities in mice transgenic for bovine oncostatin M

  1995cites this paper
• Growth hormone-releasing hormone: synthesis and signaling.

  1995cites this paper
• DNA regulatory sequences of the rat tyrosine hydroxylase gene direct correct catecholaminergic cell-type specificity of a human growth hormone reporter in the CNS of transgenic mice causing a dwarf phenotype.

  1994cites this paper
• Negative regulation of hypothalamic growth hormone-releasing factor messenger ribonucleic acid by growth hormone and insulin-like growth factor I.

  1994cites this paper
• Overexpressing sperm surface beta 1,4-galactosyltransferase in transgenic mice affects multiple aspects of sperm-egg interactions

  1994cites this paper
• Characterization and Localization of Mouse Hypothalamic Growth Hormone‐Releasing Factor and Effect of Gold Thioglucose‐Induced Hypothalamic Lesions

  1994cites this paper
• Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression

  1994cites this paper
• Overexpression of a human transforming growth factor-alpha (TGF alpha) transgene reveals a dual antagonistic role of TGF alpha in female sexual development.

  1994cites this paper
• Somatostatin Receptors in the Developing Nervous System

  1993cites this paper
• Introduction of a point mutation into the mouse genome by homologous recombination in embryonic stem cells using a replacement type vector with a selectable marker.

  1993cites this paper
• Use of Transgenic Animals in the Study of Neuropeptide Genes

  1993cites this paper
• Transgenic animals in endocrinological investigation

  1993cites this paper
• Dominant negative mutation in cell surface beta 1,4- galactosyltransferase inhibits cell-cell and cell-matrix interactions

  1993cites this paper
• Expression of Human CD4 in Transgenic Mice Does Not Confer Sensitivity to Human Immunodeficiency Virus Infection

  1992cites this paper
• Development of liver tumors in transforming growth factor alpha transgenic mice.

  1992cites this paper
• Development of Liver Tumors in Transforming Growth Factor α Transgenic Mice

  1992cites this paper
• Species-specific kinetics of mouse renin contribute to maintenance of normal blood pressure in transgenic mice with overexpressed human angiotensinogen.

  1992cites this paper
• Regulation of growth hormone secretion.

  1992cites this paper
• Functional analysis of the promoter of a sea urchin metallothionein gene.

  1992cites this paper
• Dominant dysplasia of the lens in transgenic mice expressing the dbl oncogene.

  1991cites this paper
• Biosynthesis of human growth hormone-releasing hormone (hGRH) in the pituitary of hGRH transgenic mice.

  1991cites this paper
• Addition of a C-terminal extension sequence to transforming growth factor-beta 1 interferes with biosynthetic processing and abolishes biological activity.

  1991cites this paper
• The use of transgenic animals to study the role of growth factors in endocrinology.

  1991cites this paper
• Multiple preprosomatostatin sorting signals mediate secretion via discrete cAMP- and tetradecanoylphorbolacetate-responsive pathways.

  1991cites this paper
• 9 – Semiquantitative Analysis of Cellular Somatostatin mRNA Levels by in Situ Hybridization Histochemistry

  1991cites this paper
• Localization and actions of transforming growth factor-beta s in the embryonic nervous system.

  1991cites this paper
• Posttranslational modifications of rat proenkephalin overexpressed in Chinese hamster ovary cells.

  1991cites this paper
• Transgenic regulation in laboratory animals

  1991cites this paper
• Ultradian oscillations in somatostatin and growth hormone-releasing hormone mRNAs in the brains of adult male rats.

  1991cites this paper
• Expression of a cytomegalovirus-human growth hormone-releasing hormone precursor fusion gene in transfected GH3 cells.

  1990cites this paper
• Membrane localization of the pertussis toxin-sensitive G-protein subunits alpha i-2 and alpha i-3 and expression of a metallothionein-alpha i-2 fusion gene in LLC-PK1 cells.

  1990cites this paper
• TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas.

  1990cites this paper
• Transgenic animals for human diseases and gene therapy

  1990cites this paper
• Quenching of the amidolytic activity of one-chain tissue-type plasminogen activator by mutation of lysine-416.

  1990cites this paper
• Rat pro-atrial natriuretic factor expression and post-translational processing in mouse corticotropic pituitary tumor cells.

  1990cites this paper
• Brain-gut peptides, renal function and cell growth.

  1990cites this paper
• Somatostatin

  1989cites this paper
• Induction of calcium currents by the expression of the α1-subunit of the dihydropyridine receptor from skeletal muscle

  1989cites this paper
• Cryptic human growth hormone gene sequences direct gonadotroph-specific expression in transgenic mice.

  1989cites this paper
• Mouse growth-hormone-releasing hormone: precursor structure and expression in brain and placenta.

  1989cites this paper
• Immunohistochemical analysis of human growth hormone-releasing hormone gene expression in transgenic mice.

  1989cites this paper
• Metallothionein-I promoter-directed expression of foreign proteins in a mouse pituitary corticotrope tumor cell line.

  1989cites this paper
• Amino-terminal sequences of prosomatostatin direct intracellular targeting but not processing specificity.

  1989cites this paper
• Transgenic animals.

  1989cites this paper
• The role of transgenic animals in the analysis of various biological aspects of normal and pathologic states.

  1989cites this paper
• Metallothionein-vasopressin fusion gene expression in transgenic mice. Nephrogenic diabetes insipidus and brain transcripts localized to magnocellular neurons.

  1989cites this paper
• Metal-inducible pathology in the liver, pancreas, and kidney of transgenic mice expressing SV40 early region genes.

  1989cites this paper
• Transgenic mice as future tools in risk assessment.

  1989cites this paper
• Evidence of pre-prosomatostatin mRNA in human normal and tumoral anterior pituitary gland.

  1989cites this paper
• [22] - Use of Transgenic Models to Access Neural Lineages in Mammals

  1989cites this paper
• 9 – Gene Transfer Through Embryo Microinjection

  1989cites this paper
• Structure and expression of growth hormone- releasing hormone (GHRH) genes

  1989cites this paper
• Analysis of a transformed cell line using antisense c-fos RNA.

  1988cites this paper
• Transgenic mice: applications to the study of the nervous system.

  1988cites this paper
• Neuronal expression of chimeric genes in transgenic mice.

  1988cites this paper
• Somatostatin: a historical perspective.

  1988cites this paper
• Transgenic mice--a gold mine for furthering knowledge in pathobiology.

  1988cites this paper
• GROWTH HORMONE NEUROREGULATION AND ITS ALTERATIONS IN DISEASE STATES

  1988cites this paper
• Meiotic expression of human ornithine transcarbamylase in the testes of transgenic mice

  1988cites this paper
• Paradoxical growth-promoting effects induced by patterned infusions of somatostatin in female rats.

  1988cites this paper
• GROWTH HORMONE NEUROREGULATION AND ITS ALTERATIONS IN DISEASE STATES

  1988cites this paper
• The Use of Transgenic Animal Techniques for Livestock Improvement

  1988cites this paper
• Dramatic pituitary hyperplasia in transgenic mice expressing a human growth hormone-releasing factor gene.

  1988cites this paper
• Genetic characterization of a brain-specific form of the type I regulatory subunit of cAMP-dependent protein kinase.

  1988cites this paper
• Pro-opiomelanocortin and pro-vasopressin converting enzyme in pituitary secretory vesicles.

  1988cites this paper
• [Gene expression in transgenic mice].

  1987cites this paper
• Somatostatin Is Targeted to Gonadotrophic Secretory Granules in Transgenic Mice Expressing a Metallothionein‐Somatostatin Fusion Gene

  1987cites this paper
• Neuron-specific alternative RNA processing in transgenic mice expressing a metallothionein-calcitonin fusion gene.

  1987cites this paper
• Antisense RNA to the c-fos gene: restoration of density-dependent growth arrest in a transformed cell line.

  1987cites this paper
• Inhibition of intracellular cAMP-dependent protein kinase using mutant genes of the regulatory type I subunit.

  1987cites this paper
• Molecular biology of metallothionein gene expression.

  1987cites this paper
• Post-translational control of alcohol dehydrogenase levels in Drosophila melanogaster.

  1987cites this paper
• Cell-specific processing of preprosomatostatin in cultured neuroendocrine cells.

  1987cites this paper
• Expression and characterization of transforming growth factor alpha precursor protein in transfected mammalian cells

  1987cites this paper
• Butyrate selectively activates the metallothionein gene in teratocarcinoma cells and induces hypersensitivity to metal induction

  1987cites this paper
• Peptides Derived from Mammalian Prosomatostatin

  1987cites this paper